检索结果-南通市图书馆

Evidence-Based Dampness-Heat ZHENG(Syndrome) in Cancer: Current Progress toward Establishing Relevant Animal Model with Pancreatic Tumor

引用

Chinese Journal of Integrative Medicine 2024年第1期30卷 85-95页

作者： JIAO Ju-ying chenG Chien-shan CAO Zhang-qi chen Lian-yu chen Zhen Department of Integrative Oncology Fudan University Shanghai Cancer CenterShanghai(200032)China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghai(200032)China

Cancer is one of the deadliest diseases affecting the health of human beings. With limited therapeutic options available, complementary and alternative medicine has been widely adopted in cancer management and is increasingly becoming accepted by both patients and healthcare workers alike. Chinese medicine characterized by its unique diagnostic and treatment system is the most widely applied complementary and alternative medicine. It emphasizes symptoms and ZHENG(syndrome)-based treatment combined with contemporary disease diagnosis and further stratifies patients into individualized medicine subgroups. As a representative cancer with the highest degree of malignancy, pancreatic cancer is traditionally classified into the "amassment and accumulation". Emerging perspectives define the core pathogenesis of pancreatic cancer as "dampness-heat" and the respective treatment "clearing heat and resolving dampness" has been demonstrated to prolong survival in pancreatic cancer patients, as has been observed in many other cancers. This clinical advantage encourages an exploration of the essence of dampness-heat ZHENG(DHZ) in cancer and investigation into underlying mechanisms of action of herbal formulations against dampness-heat. However, at present, there is a lack of understanding of the molecular characteristics of DHZ in cancer and no standardized and widely accepted animal model to study this core syndrome in vivo. The shortage of animal models limits the ability to uncover the antitumor mechanisms of herbal medicines and to assess the safety profile of the natural products derived from them. This review summarizes the current research on DHZ in cancer in terms of the clinical aspects, molecular landscape, and animal models. This study aims to provide comprehensive insight that can be used for the establishment of a future standardized ZHENG-based cancer animal model.

关键词： cancer Chinese medicine syndrome ZHENG dampness-heat syndrome animal model pancreatic tumor evaluation methods

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Fractionated Crystallization Kinetics and Polymorphic Homocrystalline Structure of Poly(_(L)-lactic acid)/Poly(_(D)-lactic acid)Blends:Effect of Blend Ratio

引用

Chinese Journal of Polymer Science 2022年第6期40卷 567-575页

作者： Wang-Kai Xiang Qing Xie shan-shan Xu chen-Xuan Sun cheng-Tao Yu ying Zheng Peng-Ju Pan State Key Laboratory of Chemical Engineering College of Chemical and Biological EngineeringZhejiang UniversityHangzhou 310027China Institute of Zhejiang University-Quzhou Quzhou 324000China

Stereocomplex(SC)crystallization has been an effective way to improve the physical performances of stereoregular ***,the competition between homo and SC crystallizations can lead to more complicated crystallization kinetics and polymorphic crystalline structure in stereocomplexable polymers,which influences the physical properties of obtained ***,we select the medium-molecular-weight(MMW)poly(L-lactic acid)/poly(D-lactic acid)(PLLA/PDLA)asymmetric blends with different PDLA fractions(f_(D)=0.01-0.5)as the model system and investigate the effects of f_(D) and crystallization temperature(T_(c))on the crystallization kinetics and polymorphic crystalline *** observe the fractionated(i.e.,multistep)crystallization kinetics and the formation of peculiar β-form homocrystals(HCs)in the asymmetric blends under quiescent conditions,which are strongly influenced by both f_(D) and T_(c).Precisely,crystallization of β-form HCs is favorable in the MMW PLLA/PDLA blends with high f_(D)(≥0.2)at a low T_(c)(80-100℃).It is proposed that the formation of metastable β-form HCs is attributed to the conformational matching between β-form HCs and SCs,and the stronger constrain effects of precedingly-formed SCs in the early stage of *** effects can also cause the multistep crystallization kinetics of MMW PLLA/PDLA asymmetric blends in the heating process.

关键词： Poly(lactic acid) Stereocomplex crystallization Polymorphic structure Crystallization kinetics

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Success of intravenous immunoglobulin and steroids in managing severe COVID-19 following lung transplantation:A case report

引用

World Journal of Transplantation 2025年第1期15卷 178-184页

作者： Yen-Shou Kuo Kuan-Hsun Lin ying-Yi chen Yuan-Ming Tsai Ti-Hui Wu Hsu-Kai Huang Tsai-Wang Huang Division of Thoracic Surgery Department of SurgeryTri-Service General HospitalNational Defense Medical CenterTaipei 114202Taiwan

BACKGROUND Coronavirus disease 2019(COVID-19)pneumonia with severe septic shock and acute respiratory distress syndrome(ARDS)are critical illnesses for patients following *** immunoglobulin(IVIG)plays a role in both immune support and inflammation control,especially in immunocompromised *** case report describes the first successful experience using IVIG and pulse steroids to manage this critical condition following lung *** SUMMARY A 65-year-old male patient reported a history of chronic obstructive pulmonary disease and poor lung function and received bilateral sequential lung ***,he developed COVID-19 pneumonia,severe septic shock,and *** recovered from this critical condition after empirical antibiotics administration and veno-venous extracorporeal membrane oxygenation,in addition to IVIG and pulse *** IVIG is a valuable adjunct in managing severe sepsis in lung transplant recipients after COVID-19 *** aim,for the first time,to report the success of such a management approach for COVID-19 ARDS and sepsis in the post-lung transplant *** further investigations,this is a starting point for wider analysis of such an approach in this setting and consequently helps guide clinical practice for such a challenging patient population moving forward.

关键词： COVID-19 Septic shock Intravenous immunoglobulin Lung transplantation Post-transplant complications Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Crystal Engineering of Multiple-component Organic Compound： Organic co-Crystals of the Functional Groups of Carboxyl and Amino with Persistent Hydrogen Bonding Motifs

引用

Chemical Research in Chinese Universities 2013年第3期29卷 408-413页

作者： SONG Ge BAI Feng-ying XING Na chen chen shan Hui XING Yong-heng College of Chemistry and Chemical Engineering College of Life Science Liaoning Normal University Dalian 116029 P. R. China

Three small organic molecular co-crystal compounds （C3N6H6）·（C6H10O4）·H2O（I）, C3HsN2O（3） and （H4btec）2.（4,4＇-bipy）（4）（H4btec=1,2,4,5-benzenetetracarboxylic acid, 4,4＇-bipy=4,4＇-bipyridine） and one coordination supramolecular compound [Mn（CEO4）（HEO）E]＇C6HllNO2（2） were synthesized by hydrothermal reaction. They were characterized by elemental analysis, infrared（IR） spectroscopy and single crystal X-ray diffraction（XRD）. Structural analyses reveal that these 2D or 3D supramolecular networks of the compounds were formed by C--H…O, N--H…O, N--H…N, O--H…O and O-H…N hydrogen bonds. Therein, the functional groups of--COOH, --NH2 and --OH play important roles in constructing supramolecular architectures.

关键词： co-Crystal compound Hydrogen bond Hydrothermal reaction

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advances in ethnopharmacology,phytochemistry and pharmacology of Erigerontis Herba and its Chinese medicine prescriptions

引用

Traditional Medicine Research 2025年第1期10卷 44-61页

作者： Yang Zhou Yuan-Yan Huang Ding-Yue shang ying chen Meng Tian cheng-Yu Jin Xin Lu Bing-Chun Yan Han-Qing Pang Institute of Translational Medicine School of MedicineYangzhou UniversityYangzhou 225009China Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases Yangzhou UniversityYangzhou 225009China School of Medicine Nanjing University of Chinese MedicineNanjing 210023China State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources Guangxi Normal UniversityGuiling 541004China.

Erigerontis Herba(EH),the dried whole plant of Erigeron breviscapus,is well-known for circulating blood,activating meridians to alleviate pain,expelling wind,and clearing away *** has been extensively utilized in southern China for the treatment of stroke hemiplegia,chest stuffiness and pains,rheumatic arthralgia,headache,and *** review focuses on the botany,ethnopharmacology,phytochemistry,pharmacology and toxicity of EH and its related prescriptions to offer new insights for prospective research of *** information about EH was retrieved from ancient records and books,PubMed,China National Knowledge Infrastructure,Chinese Pharmacopoeia,Web of Science,Doctoral and Master’s Theses,and various electronic *** is a member of Compositae family and is mainly grown in southern *** Chinese medicine records that EH has the effects of circulating blood and removing blood stasis,expelling wind,and removing cold,as well as relieving rigidity of muscle and relieving *** now,nearly 200 ingredients have been characterized from EH,including flavonoids,caffeoyls,aromatic acids,coumarins,pentacyclic terpenoids,volatile oil and other *** extracts,EH related prescriptions(Dengzhan Xixin injection,Dengzhan Shengmai capsules,etc.)or compounds(scutellarin,scutellarein,etc.)possessed obvious therapeutic effects of ischemic stroke,cerebral hemorrhage,myocardial infarction,Alzheimer’s disease,diabetes and its complications,gastric cancer,bone,and joint degenerative ***,the major active compound of EH,has been used as a quality *** no obvious toxicity of EH has been *** to its traditional applications,ethnopharmacology,phytochemistry,pharmacology,and toxicity,EH was applied as a valuable herb for clinical application in food and medicine *** several compounds have been shown to possess diverse biological activities,the underlying mechanisms of their actions remain *** fully exploi

关键词： Erigeron breviscapus traditional applications ethnopharmacology phytochemistry pharmacology

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Spraying Arginine at 5 Days before Harvest Delays Postharvest Broccoli Senescence via Nutrient Accumulation

引用

食品科学 2025年第1期46卷 131-141页

作者： SUN Yupeng chen ying shanG Qingwen GUO Yanyin ZHANG Yuxiao WANG Yunqiao XUE Qingyue College of Agricultural Engineering and Food Science Shandong University of TechnologyZibo 255049China Zichuan District Agricultural and Rural Affairs Service Center Zibo 255049China

To determine the effects of preharvest arginine spraying on the nutritional level of broccoli and the mechanism of action of arginine in improving the storage quality of broccoli,arginine spraying(5 mmol/L)was conducted at 0,1,3,and 5 days before *** appearance,respiration rate,mass-loss rate,electrolyte leakage,glucosinolate,ascorbic acid,total phenol,total flavonoid,total sugar and sucrose contents,and sucrose phosphate synthase(SPS),invertase(INV),sucrose synthase synthesis(SSS)and cleavage(SSC)activities of broccoli samples were observed after 0,2,4,6,8,and 10 days of *** results showed that spraying arginine at 5 days preharvest(5-ARG)helped to inhibit broccoli respiration during storage,delay electrolyte leakage,and maintain broccoli ***,during the growth stage,total sugar accumulation was higher in the 5-ARG *** addition,during the storage period,sucrose synthesis was accelerated,while sucrose cleavage was inhibited,resulting in more sucrose retention in postharvest *** conclusion,5-ARG resulted in the accumulation of more nutrients during the growth process and effectively delayed the quality decline during storage,thereby prolonging the shelf life of ***,this study provides a theoretical basis for improving postharvest storage characteristics of broccoli through preharvest treatments.

关键词： arginine broccoli preharvest spraying nutrient accumulation storage quality postharvest senescence

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

利用单个元件实现相干光Walsh变换

引用

物理学报 1984年第11期 1599-1604页

作者：王玉堂李秀英姜长山陈岩松中国科学院物理研究所

利用扫描曝光法制备的单个元件实现了二维相干光Walsh变换。其特点是能量利用率高、光路简单。文中给出了原理及实验结果。

关键词：相干光变换系统弱光 Walsh

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

5’tiRNA-Pro-TGG,a novel tRNA halve,promotes oncogenesis in sessile serrated lesions and serrated pathway of colorectal cancer

引用

World Journal of Gastrointestinal Oncology 2023年第6期15卷 1005-1018页

作者： Xin-Yuan Wang Yu-Jie Zhou Hai-ying chen Jin-Nan chen shan-shan chen Hui-Min chen Xiao-Bo Li Division of Gastroenterology and Hepatology Renji HospitalShanghai Jiaotong University School of MedicineShanghai 200000China Department of Spleen and Stomach and Rheumatology Affiliated Traditional Chinese Medicine Hospital of Southwest Medical UniversityLuzhou 646000Sichuan ProvinceChina

BACKGROUND Transfer RNA(tRNA)-derived small RNAs(tsRNAs)are small fragments that form when tRNAs *** halves(tiRNAs),a subcategory of tsRNA,are involved in the oncogenic processes of many ***,their specific role in sessile serrated lesions(SSLs),a precancerous lesion often observed in the colon,has not yet been *** To identify SSL-related tiRNAs and their potential role in the development of SSLs and serrated pathway of colorectal cancer(CRC).METHODS Small-RNA sequencing was conducted in paired SSLs and their adjacent normal control(NC)*** expression levels of five SSL-related tiRNAs were validated by q-polymerase chain *** counting kit-8 and wound healing assays were performed to detect cell proliferation and *** target genes and sites of tiRNA-1:33-Pro-TGG-1(5′tiRNA-Pro-TGG)were predicted by TargetScan and miRanda ***-associated and immune-related pathways were analyzed by single-sample gene set enrichment *** analyses were performed to establish the roles of 5′tiRNA-Pro-TGG based on the target *** In total,we found 52 upregulated tsRNAs and 28 downregulated tsRNAs in SSLs compared to *** expression levels of tiRNA-1:33-Gly-CCC-2,tiRNA-1:33-Pro-TGG-1,and tiRNA-1:34-Thr-TGT-4-M25′tiRNAs were higher in SSLs than those in NC,while that of 5′tiRNA-Pro-TGG was associated with the size of *** was demonstrated that 5′tiRNAPro-TGG promoted cell proliferation and migration of RKO cell in ***,heparanase 2(HPSE2)was identified as a potential target gene of 5′*** lower expression was associated with a worse prognosis in ***,lower expression of HPSE2 was observed in SSLs compared to normal controls or conventional adenomas and in BRAF-mutant CRC compared to BRAF-wild *** analyses revealed that its low expression was associated with a low interferonγresponse and also with many metabolic pathways such as riboflavin,retinol,and cy

关键词： Noncoding RNA tRNA halves Sessile serrated lesions Colon cancer Serrated pathway

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Association between non-culprit healed plaque and plaque progression in acute coronary syndrome patients:an optical coherence tomography study

引用

Journal of Geriatric Cardiology 2021年第8期18卷 631-644页

作者： Wei-Jun YIN Jing JING ying-Qian ZHANG Feng TIAN Tao ZHANG shan-shan ZHOU Yun-Dai chen Department of Cardiology Chinese PLA General HospitalBeijingChina

BACKGROUND Healed plaques are frequently found in patients with acute coronary syndrome,but the prognostic value is *** study investigated the clinical features of non-culprit healed plaques detected by optical coherence tomography(OCT)with the aim of predicting plaque progression of healed *** This study retrospectively analyzed 113 non-culprit lesions from 85 patients who underwent baseline OCT ima-ging and follow-up angiography from January 2015 to December *** progression predictors were assessed by multivariate *** Among 113 non-culprit lesions,27 healed plaques(23.9%)were *** with non-culprit healed plaques had prior antiplatelet therapy(65.0%vs.33.8%,P=0.019),hypertension(85.0%vs.50.7%,P=0.009),and dyslipidemia(70.0%vs.41.5%,P=0.04)which were more frequently than those without healed *** thickness(r=0.674,P<0.001),arc(r=0.736,P<0.001),and volume(r=0.541,P=0.004)of healed plaque were correlated with minimum lumen diameter *** a mean follow-up of 11.5 months,the non-culprit healed plaques had a lower minimum lumen diameter(1.61±0.46 mm vs.1.91±0.73 mm,P=0.016),lower average lumen diameter(1.86 mm vs.2.10 mm,P=0.033),and a higher degree of diameter stenosis(41.4%±11.9%vs.35.5%±13.1%,P=0.031)when compared to baseline *** plaque progression rate was higher in the healed plaque group(33.3%vs.8.1%,P=0.002),and multivariate analysis identified healed plaques[odds ratio(OR)=8.49,95%CI:1.71−42.13]and lumen thrombus(OR=10.69,95%CI:2.21−51.71)as predictors of subsequent lesion *** Healed plaques were a predictor for rapid plaque *** quantitative parameters of healed plaque showed a good agreement with plaque *** with healed plaque were associated with prior antiplatelet therapy and high level of low-density lipoprotein *** lesions might be the predilection sites of healed plaques.

关键词： patients coronary acute

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Drag Force on a String Fastened to a Sphere Moving in a Viscous Fluid

引用

Chinese Physics Letters 1996年第9期13卷 689-692页

作者： shan-tarng chen Department of Physics National Chung-Hsing UniversityTaichungTaiwan

The viscous drag force acting on a thin cotton string fastened to a sphere moving in glycerin has been determined by using a photogate apparatus,showing that the force acting on the string agrees with a simplified 2-d... 详细信息

关键词： simplified viscous apparatus

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：