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ZNF582 hypermethylation promotes metastasis of nasopharyngeal carcinoma by regulating the transcription of adhesion molecules Nectin-3 and NRXN3

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Cancer Communications 2020年第12期40卷 721-737页

作者： Yin Zhao Xiao-Hong Hong Kang li ying-qing li ying-qin li Shi-Wei He Pan-Pan Zhang Jun-Yan li Qian li Ye-lin liang Yang Chen Jun Ma Na liu Yu-Pei Chen Experimental Research Department Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center of Cancer MedicineGuangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapyGuangzhouGuangdong 510060P.R.China Center for Translational Medicine The First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong 510080P.R.China

Background:Epigenetic regulation plays an important role in the development and progression of nasopharyngeal carcinoma(NPC).However,the epigenetic mechanisms underlying NPC metastasis remains poorly *** aimed to find functional genes which regulate the metastasis of NPC and identify therapeutic targets for NPC ***:Bisulfite pyrosequencing was used to analyze zinc finger protein 582(ZNF582)methylation in NPC tissues and cell *** reverse transcription-polymerase chain reaction(qRT-PCR)and Western blotting were used to determine the expression of *** vitro and in vivo experiments were performed to evaluate the biological function of ZNF582 in ***582-targeting genes were identified by chromatin immunoprecipitation sequencing(ChIP-seq)and were confirmed by ChIP-qPCR and luciferase ***:ZNF582 promoter was hypermethylated in NPC,and both the mRNA and protein levels of ZNF582 were down-regulated in NPC tissues and cell *** restoration of ZNF582 inhibited NPC migration,invasion,and metastasis,while the knockdown of ZNF582 promoted NPC migration,invasion,and metastasis in vitro and in ***582 directly regulated the transcription and expression of adhesion molecules Nectin-3 and *** Nectin-3 and NRXN3 were identified as functional targets of ZNF582,and the restoration or abrogation of these genes reversed the tumor suppressor effect of ZNF582 in NPC ***:ZNF582 acts as a tumor suppressor gene in NPC by regulating the transcription and expression of adhesion molecules Nectin-3 and NRXN3,which may provide novel therapeutic targets for NPC treatment.

关键词： Metastasis Nasopharyngeal carcinoma Nectin-3 NRXN3 ZNF582

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Evaluation of the Spasticity after Botulinum Toxin Injection Using Paired-Pulse Transcranial Magnetic Stimulation

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Chinese Medical Journal 2018年第22期131卷 2763-2764页

作者： Chin-Hsuan Chia Fang li qin-ying li Wen-Ting qin Department of Rehabilitation Medicine Huashan HospitalFudan UniversityShanghai 200040China Department of Rehabilitation Medicine Renhe HospitalBaoshan DistrictShanghai 200431China Department of Rehabilitation Medicine Jingan Branch Huashan HospitalFudan UniversityShanghai 200040China

To the Editor:Spasticity is a common movement disorder after *** 1 to 6 weeks after the stroke,approximately 40% of the stroke patients develop the spasticity on the affected ***,we report a stroke patient with spasticity using paired-pulse transcmnial magnetic stimulation to explore the central mechanism of the release of the spasticity after botulinum toxin injection.

关键词： Evaluation of the Spasticity

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Correction to: ZNF582 hypermethylation promotes metastasis of nasopharyngeal carcinoma by regulating the transcription of adhesion molecules Nectin-3 and NRXN3

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Cancer Communications 2022年第3期42卷 281-283页

作者： Yin Zhao Xiao-Hong Hong Kang li ying-qing li ying-qin li Shi-Wei He Pan-Pan Zhang Jun-Yan li Qian li Ye-lin liang Yang Chen Jun Ma Na liu Yu-Pei Chen Experimental Research Department Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center of Cancer MedicineGuangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapyGuangzhou 510060GuangdongP.R.China CenterforTranslationalMedicine TheFirstAffiliatedHospitalSunYat-senUniversityGuangzhou510080GuangdongP.R.China

Following publication of this article[1],the authors noticed that the mismatched images were inadvertently included in Figure 5(migration assays of SUNE1-shNRXN3-#2 group in Figure 5I)and Figure 6(invasion assays of S... 详细信息

关键词： invasion metastasis Figure

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An efficient quantum proactive incremental learning algorithm

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 49-57页

作者： lingxiao li Jing li Yanqi Song Sujuan qin Qiaoyan Wen Fei Gao State Key Laboratory of Networking and Switching Technology Beijing University of Posts and Telecommunications School of Cyberspace Security Beijing University of Posts and Telecommunications

In scenarios where a large amount of data needs to be learned, incremental learning can make full use of old knowledge, significantly reduce the computational cost of the overall learning process, and maintain high performance. In this paper, taking the MaxCut problem as our example, we introduce the idea of incremental learning into quantum computing, and propose a Quantum Proactive Incremental Learning algorithm(QPIL). Instead of a one-off training of quantum circuit, QPIL contains a multi-phase training on gradually-increased subgraphs of all vertices, proactively reducing large-scale problems to smaller ones to solve in steps, providing an efficient solution for MaxCut. Specifically, some vertices and corresponding edges are randomly selected for training to obtain optimized parameters of the quantum circuit at first. Then, in each incremental phase, the remaining vertices and corresponding edges are gradually added and the parameters obtained from the previous phase are reused in the parameter initialization of the current phase. We perform experiments on 120 different small-scale graphs, and it shows that QPIL performs superior to prevalent quantum and classical baselines in terms of approximation ratio(AR), time cost, anti-forgetting, and solving stability. In particular, QPIL's AR surpasses 20% of mainstream quantum baselines, and the time cost is less than 1/5 of them. The idea of QPIL is expected to inspire efficient and high-quality solutions in large-scale Max Cut and other combinatorial optimization problems.

关键词： variational quantum algorithm incremental learning multi-phase training MaxCut quantum computing

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The gut-eye axis:from brain neurodegenerative diseases to age-related macular degeneration

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Neural Regeneration Research 2025年第10期20卷 2741-2757页

作者： Qianzi Jin Suyu Wang Yujia Yao qin Jiang Keran li Department of Ophthalmology The Affiliated Eye Hospital of Nanjing Medical UniversityNanjingJiangsu ProvinceChina The Fourth School of Clinical Medicine Nanjing Medical UniversityNanjingJiangsu ProvinceChina

Age-related macular degeneration is a serious neurodegenerative disease of the retina that significantly impacts ***,the specific pathogenesis remains unclear,and effective early treatment options are consequently *** microbiome is defined as a large ecosystem of microorganisms living within and coexisting with a *** intestinal microbiome undergoes dynamic changes owing to age,diet,genetics,and other *** dysregulation of the intestinal flora can disrupt the microecological balance,resulting in immunological and metabolic dysfunction in the host,and affecting the development of many *** recent decades,significant evidence has indicated that the intestinal flora also influences systems outside of the digestive tract,including the ***,several studies have demonstrated the critical role of the gut-brain axis in the development of brain neurodegenerative diseases,including Alzheimer’s disease and Parkinson’s ***,the role of the“gut-eye axis”has been confirmed to play a role in the pathogenesis of many ocular ***,age-related macular degeneration and many brain neurodegenerative diseases have been shown to share several risk factors and to exhibit comparable *** such,the intestinal flora may play an important role in age-related macular *** the above context,the present review aims to clarify the gut-brain and gut-eye connections,assess the effect of intestinal flora and metabolites on age-related macular degeneration,and identify potential diagnostic markers and therapeutic ***,direct research on the role of intestinal flora in age-related macular degeneration is still relatively limited,while studies focusing solely on intestinal flora are insufficient to fully elucidate its functional role in age-related macular ***-on-a-chip technology has shown promise in clarifying the gut-eye interactions,while integrating analysis of the inte

关键词： age-related macular degeneration biological agents blinding eye disease dietary nutrition fecal microbial transplantation gut-eye axis intestinal flora metabolite microecology neurodegenerative disease

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Enhancing m^(6)A modification in the motor cortex facilitates corticospinal tract remodeling after spinal cord injury

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Neural Regeneration Research 2025年第6期20卷 1749-1763页

作者： Tian qin Yuxin Jin Yiming qin Feifei Yuan Hongbin Lu Jianzhong Hu Yong Cao Chengjun li Department of Spine Surgery and Orthopedics Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Key Laboratory of Organ Injury Aging and Regenerative Medicine of Hunan ProvinceChangshaHunan ProvinceChina National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Department of Sports Medicine Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina

Spinal cord injury typically causes corticospinal tract disruption. Although the disrupted corticospinal tract can self-regenerate to a certain degree, the underlying mechanism of this process is still unclear. N6-methyladenosine(m^(6)A) modifications are the most common form of epigenetic regulation at the RNA level and play an essential role in biological processes. However, whether m^(6)A modifications participate in corticospinal tract regeneration after spinal cord injury remains unknown. We found that expression of methyltransferase 14 protein(METTL14) in the locomotor cortex was high after spinal cord injury and accompanied by elevated m^(6)A levels. Knockdown of Mettl14 in the locomotor cortex was not favorable for corticospinal tract regeneration and neurological recovery after spinal cord injury. Through bioinformatics analysis and methylated RNA immunoprecipitation-quantitative polymerase chain reaction, we found that METTL14 regulated Trib2 expression in an m^(6)A-regulated manner, thereby activating the mitogen-activated protein kinase pathway and promoting corticospinal tract regeneration. Finally, we administered syringin, a stabilizer of METTL14, using molecular docking. Results confirmed that syringin can promote corticospinal tract regeneration and facilitate neurological recovery by stabilizing METTL14. Findings from this study reveal that m^(6)A modification is involved in the regulation of corticospinal tract regeneration after spinal cord injury.

关键词： corticospinal tract remodeling epigenetic regulations locomotor cortex m^(6)A modification methyltransferase 14 protein(METTL14) mitogen-activated protein kinase neural regeneration spinal cord injury syringin TRIB2

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线路中间带并联电抗器的线路差动保护

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电力系统自动化 2006年第7期30卷 31-36页

作者：李斌贺家李郭征黄少锋秦应力徐振宇天津大学电气与自动化工程学院天津市300072 上海市电力公司浦东供电分公司上海市200122 北京四方继保自动化股份有限公司北京市100085

特高压长线路可能在线路中间接入并联电抗器,从而有效补偿线路电容电流,抑制空载线路过电压。提出了在特高压长线路中间带并联电抗器时的线路分相电流差动保护原理。该原理基于输电线路的贝瑞隆模型,分析推导了区内外故障时各相动作量... 详细信息

特高压长线路可能在线路中间接入并联电抗器,从而有效补偿线路电容电流,抑制空载线路过电压。提出了在特高压长线路中间带并联电抗器时的线路分相电流差动保护原理。该原理基于输电线路的贝瑞隆模型,分析推导了区内外故障时各相动作量的表达式。理论分析与仿真验证都证明新原理不受长线路分布电容电流的影响,具有很高的灵敏性和可靠性。

关键词：特高压输电线路并联电抗器分相电流差动保护贝瑞隆模型

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Pre-injection of small interfering RNA promotes c-Jun gene silencing and decreases the survival rate of axotomy-injured spinal motoneurons in adult mice

Pre-injection of small interfering RNA promotes c-Jun gene s...

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中国解剖学会2019年年会

作者： ying-qin li Fa-huan Song Ke Zhong Guang-yin Yu Prince Last Mudenda Zilundu ying-ying Zhou Rao Fu ying Tang Ze-min ling Xiaoying Xu li-hua Zhou Department of Anatomy Zhongshan School of MedicineSun Yat-sen University

＜正＞In a previous study,we observed the overexpression of c-Jun in motoneurons of the spinal cord ventral horn after brachial plexus injury in ***,the relevance of c-Jun expression with respect to the fate of axotomy-induced branchial plexus injury in adult mice remains *** the present study,we explored the function of c-Jun in motoneuron recovery after *** pre-injected small interfering RNA

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Multi boron-doping effects in hard carbon toward enhanced sodium ion storage

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Journal of Energy Chemistry 2025年第1期100卷 730-738页

作者： Peng Zheng Wang Zhou ying Mo Biao Zheng Miaomiao Han qin Zhong Wenwen Yang Peng Gao Lezhi Yang Jilei liu College of Materials Science and Engineering Hunan Joint International Laboratory of Advanced Materials and Technology for Clean Energy Hunan Province Key Laboratory for Advanced Carbon Materials and Applied Technology Hunan University Greater Bay Area Institute for Innovation Hunan University Changsha Research Institute of Mining & Metallurgy Co. LTD.

Hard carbon （HC） has been considered as promising anode material for sodium-ion batteries （SIBs）.The optimization of hard carbon’s microstructure and solid electrolyte interface （SEI） property are demonstrated effective in enhancing the Na+storage capability,however,a one-step regulation strategy to achieve simultaneous multi-scale structures optimization is highly ***,we have systematically investigated the effects of boron doping on hard carbon’s microstructure and interface chemistry.A variety of structure characterizations show that appropriate amount of boron doping can increase the size of closed pores via rearrangement of carbon layers with improved graphitization degree,which provides more Na+storage ***-situ Fourier transform infrared spectroscopy/electrochemical impedance spectroscopy （FTIR/EIS） and X-ray photoelectron spectroscopy （XPS） analysis demonstrate the presence of more BC3and less B–C–O structures that result in enhanced ion diffusion kinetics and the formation of inorganic rich and robust SEI,which leads to facilitated charge transfer and excellent rate *** a result,the hard carbon anode with optimized boron doping content exhibits enhanced rate and cycling *** general,this work unravels the critical role of boron doping in optimizing the pore structure,interface chemistry and diffusion kinetics of hard carbon,which enables rational design of sodium-ion battery anode with enhanced Na+storage performance.

关键词： X ray photoelectron spectroscopy

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A mutation specific polymerase chain reaction for detecting hepatitis B virus genome mutations at nt551

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World Journal of Gastroenterology 2003年第3期9卷 509-512页

作者： Chun-ling Ma De-Xing Fang Hua-Biao Chen Fa-qing li Hui-ying Jin Su-qin li Wei-Guo Tan Huadong Research Institute for Medical Biotcchnics, Nanjing 210002, Jiangsu Province, China Huadong Research Institute for Medical Biotechnics Nanjing 210002 China. mchunling@***

AIM: The hepatitis B surface antigen (HBsAg) is considered to be one of the best markers for the diagnosis of acute and chronic HBV infection. But in some patients, this antigen cannot be detected by routine serological assays despite the presence of virus. One of the most important explanations for the lack of detectable HBsAg is that mutations which occur within the 'a' determinant of HBV S gene can alter expression of HBsAg and lead to changes of antigenicity and immunogenicity of HBsAg accordingly. As a result, these mutants cannot be detected by diagnosis assays. Thus, it is essential to find out specific and sensitive methods to test the new mutants and further investigate their distribution. This study is to establish a method to investigate the distribution of the HBsAg mutant at ***: A mutation specific polymerase chain reaction (msPCR) was established for amplifying HBV DNA with a mutation at nt551. Four sets of primer pairs, P551A-PPS,P551G-PPS, P551C-PPS and P551T-PPS, with the same sequences except for one base at 3' terminus were designed and synthesized according to the known HBV genome sequences and the popular HBV subtypes, adr and adw, in China. At the basis of regular PCR method, we explored the specific conditions for amplifying HBV DNAs with a mutation at nt551 by regulating annealing temperature and the concentration of these primers. 126 serum samples from patients of hepatitis B were collected, among which 16 were positive for HBV S DNA in the nested PCR amplification. These 16 HBV S DNAs were detected by using the msPCR ***: When the annealing temperature was raised to 71 °C, nt551A and nt551G were amplified specifically by P551A-PPS and P551G-PPS; At 72 °C and 5 pmole of the primers (each) in reaction of 25 μl volume, nt551C and nt551T were amplified specifically by P551C-PPS and P551TPPS. 16 of HBV S gene fragments were characterized by using this method. 14 of them were positive for nt551A, one was positive for nt551G

关键词：乙型肝炎病毒基因突变聚合酶链反应乙型肝炎表面抗原血清学检查

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