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Comparative study of anti-inflammatory effects of different processed products through the COX-2/PGE2 signaling pathway: based on network pharmacology and molecular docking

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Pharmacology Discovery 2024年第2期4卷 32-45页

作者： ping Chen Yun-Yun Quan An-Qi Zeng ying Dai Jin Zeng Translational Chinese Medicine Key Laboratory of Sichuan Province Sichuan Academy of Chinese Medicine SciencesChengdu 610041China Translational Chinese Medicine Key Laboratory of Sichuan Province Sichuan Institute for Translational Chinese MedicineChengdu 610041China

Background:Radix Aconiti Lateralis Preparata(Fu-zi)is a traditional Chinese medicinal herb,which has been widely used in the clinic and has potent anti-inflammatory *** aimed to explore the mechanisms of extract containing alkaloids from different Fu-zi Processed Products(FPP)in treating inflammation,especially rheumatoid arthritis(RA).Methods:Firstly,using network pharmacology technology,the ingredients,and targets of Fu-zi were obtained by searching and screening,the targets involving RA were acquired,the intersection targets were constructed a"component-target-pathway"network.A comprehensive investigation was conducted on the anti-rheumatoid arthritis mechanisms of 5 FPPs in lipopolysaccharide(LPS)induced RAW264.7 cells,which serve as a model for *** production of NO and inflammatory cytokines were measured by ELISA *** Real-time PCR(qRT-PCR)was utilized to measure the mRNA ***-2/PGE2 signaling pathway-associated proteins were determined by western ***:According to a network pharmacological study,16 chemical components and 43 common targets were found in Fu-zi and 6 key targets including PTGS2 were closely related to the mechanism of Fu-zi in treating *** in vitro study revealed that the levels of NO,TNF-α,and IL-1βwere substantially decreased by the 5 *** 5 FPPs significantly suppressed the expression of proteins COX-2,iNOS,and NF-κB,with particularly notable effects observed for PFZ and ***:Altogether,these results demonstrated that the 5 PPS containing alkaloids have a good anti-RA-related inflammatory effect,and the mechanism may be related to COX-2/PGE2 signaling pathway,particularly,Fu-zi prepared utilizing a traditional Chinese technique.

关键词： Radix Aconiti Lateralis Preparata(Fu-zi) rheumatoid arthritis anti-inflammatory network pharmacology COX-2/PGE2 signaling pathway

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微内核操作系统互斥量模块功能正确性的形式化验证

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软件学报 2024年第9期35卷 4179-4192页

作者：张林雁李希萌施智平关永曹钦翔张倩颖首都师范大学信息工程学院北京100048 电子系统可靠性技术北京市重点实验室(首都师范大学) 北京100048 北京成像理论与技术高精尖创新中心(首都师范大学) 北京100048 上海交通大学约翰霍普克罗夫特计算机科学中心上海200030

操作系统在许多安全攸关领域为软件系统提供关键性底层支撑,操作系统中一个微小的错误或漏洞都可能引起整个软件系统的重大故障,造成巨大经济损失或危及人身安全.为了减少此类安全事故的发生,对操作系统正确性进行验证十分必要.传统测... 详细信息

操作系统在许多安全攸关领域为软件系统提供关键性底层支撑,操作系统中一个微小的错误或漏洞都可能引起整个软件系统的重大故障,造成巨大经济损失或危及人身安全.为了减少此类安全事故的发生,对操作系统正确性进行验证十分必要.传统测试手段无法穷尽系统中的所有潜在错误,因而操作系统验证有必要使用具有严格数学理论基础的形式化方法.在操作系统中,互斥量可协调多任务对资源的访问,是一种常用的任务同步方式,其功能正确性对于保障多任务应用的正确性十分关键.基于定理证明方法,在交互式定理证明器Coq中对某抢占式微内核操作系统的互斥量模块进行代码级形式化建模,给出其接口函数的形式化规范,并实现这些接口函数的功能正确性验证.

关键词：互斥量功能正确性形式化验证定理证明 Coq定理证明器

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Amplified circularly polarized luminescence of chiral metal-organic frameworks via post-synthetic installing pillars

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Chinese Chemical Letters 2024年第10期35卷 485-489页

作者： Xue-Zhi Wang Yi-Tong Liu Chuang-Wei Zhou Bei Wang Dong Luo Mo Xie Meng-ying Sun Yong-Liang Huang jie Luo Yan Wu Shuixing Zhang Xiao-ping Zhou Dan Li Department of Radiology The First Affiliated HospitalJinan UniversityGuangzhou 510632China College of Chemistry and Materials Science and Guangdong Provincial Key Laboratory of Functional Supramolecular Coordination Materials and ApplicationsJinanUniversityGuangzhou510632China Department of Medicinal Chemistry Shantou University Medical CollegeShantou 515041China Department of Anesthesiology The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 50080China

Post-synthetic installation strategy is an effective approach to improve the functions of metal-organic frameworks(MOFs).Herein,a pair of chiral MOFs is successfully constructed through solvothermal subcomponent self-assembly and exhibit circularly polarized luminescence(CPL).These MOFs contain coordinatively unsaturated Zn sites and channels,which allow the installation of pyridyl-terminated pillars into the original *** a post-synthetic installation process reinforces the MOFs'rigidity and increases the photoluminescence quantum yields(PLQYs).Furthermore,the luminescence dissymmetry factors(glum)of these post-modified MOFs are amplified after installing the *** work provides an appealing strategy for boosting the CPL performance of chiral MOFs.

关键词： Chiral metal-organic frameworks Circularlypolarized luminescence Post-synthetic installation Pyridyl-terminated pillars Chirality transfer

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汉代“大一统”背景下董仲舒的政治伦理建构

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伦理学研究 2024年第3期 52-58页

作者：关健英黄影黑龙江大学哲学学院黑龙江大学马克思主义学院

“大一统”是中华文明的悠久传统。董仲舒回应汉代一统的政治诉求,深探《春秋》奥蕴,构建了儒家德治立场、公羊学方法、以大一统为核心的政治伦理体系。他论证大一统合法性源自天道,为“大一统”建立起天经地义的哲学依据。董仲舒认为... 详细信息

“大一统”是中华文明的悠久传统。董仲舒回应汉代一统的政治诉求,深探《春秋》奥蕴,构建了儒家德治立场、公羊学方法、以大一统为核心的政治伦理体系。他论证大一统合法性源自天道,为“大一统”建立起天经地义的哲学依据。董仲舒认为道德为政治之本,大一统系于天子之正。他主张限制权贵阶层与民争利,为大一统扫除隐患。他突破公羊学夷夏观,认为爱及四夷是大一统应有之义。董仲舒的政治伦理是基于对原始儒学继承与创新而构建的汉代新儒家伦理体系。经过董仲舒的创造性阐发,西汉的春秋公羊学发展为春秋董氏学,成为具有汉代思想特质的政治哲学,成为汉代权力一统、疆域一统、思想一统和汉代民族融合的伦理内核,对中国社会产生重要影响。

关键词：大一统董仲舒政治伦理公羊学夷夏观

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The FAST all sky HI survey(FASHI):The first release of catalog

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Science China(Physics,Mechanics & Astronomy) 2024年第1期67卷 112-133页

作者： Chuan-Peng Zhang Ming Zhu Peng Jiang Cheng Cheng Jing Wang Jie Wang Jin-Long Xu Xiao-Lan Liu Nai-ping Yu Lei Qian Haiyang Yu Mei Ai yingjie Jing Chen Xu Ziming Liu Xin guan Chun Sun Qingliang Yang Menglin Huang Qiaoli Hao FAST Collaboration Guizhou Radio Astronomical Observatory Guizhou UniversityGuiyang 550000China National Astronomical Observatories Chinese Academy of Sciences(CAS)Beijing 100101China Chinese Academy of Sciences South America Center for Astronomy National Astronomical ObservatoriesCASBeijing 100101China Kavli Institute for Astronomy and Astrophysics Peking UniversityBeijing 100871China

The FAST All Sky HI survey(FASHI)was designed to cover the entire sky observable by the Five-hundred-meter Aperture Spherical radio Telescope(FAST),spanning approximately 22000 square degrees of declination between-14°and+66°,and in the frequency range of 1050-1450 MHz,with the expectation of eventually detecting more than 100000 HI *** August 2020 and June 2023,FASHI had covered more than 7600 square degrees,which is approximately 35%of the total sky observable by *** has a median detection sensitivity of around 0.76 m Jy beam-1and a spectral line velocity resolution of~6.4 km s-1at a frequency of~1.4 *** of now,a total of 41741 extragalactic HI sources have been detected in the frequency range 1305.5-1419.5 MHz,corresponding to a redshift limit of z■*** cross-matching FASHI sources with the Siena Galaxy Atlas(SGA)and the Sloan Digital Sky Survey(SDSS)catalogs,we found that 16972(40.7%)sources have spectroscopic redshifts and 10975(26.3%)sources have only photometric *** of the remaining 13794(33.0%)HI sources are located in the direction of the Galactic plane,making their optical counterparts difficult to identify due to high extinction or high contamination of Galactic stellar *** on current survey results,the FASHI survey is an unprecedented blind extragalactic H I *** has higher spectral and spatial resolution and broader coverage than the Arecibo Legacy Fast ALFA Survey(ALFALFA).When completed,FASHI will provide the largest extragalactic HI catalog and an objective view of HI content and large-scale structure in the local universe.

关键词： surveys redshifts galaxies telescope radio lines HI line

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Evaluation of development potential of pumped hydroelectric storage and geothermal utilization system in abandoned coal mine

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Journal of Central South University 2024年第8期31卷 2872-2890页

作者： WANG Meng GUO ping-ye JIN Xin DANG guan-jie GUO Yi-chen LI Yi State Key Laboratory for Tunnel Engineering China University of Mining and Technology-BeijingBeijing 100083China School of Mechanics and Civil Engineering China University of Mining and Technology-BeijingBgijing 100083China

Every year in China,a significant number of mines are closed or *** pumped hydroelectric storage(PHS)and geothermal utilization are vital means to efficiently repurpose resources in abandoned *** this work,the development potentials of the PHS and geothermal utilization systems were *** the geological conditions and meteorological data available of Jiahe abandoned mine,a simple evaluation model for PHS and geothermal utilization was *** average efficiency of the PHS system exceeds 70%and the regulatable energy of a unit volume is over 1.53 kW·h/m^(3).The PHS system achieves optimal performance when the wind/solar power ratio reaches 0.6 and 0.3 in daily and year scale,*** the geothermal utilization system,the outlet temperature and heat production are significantly affected by the injection flow *** heat production performance is more stable at lower rate flow,and the proportion of heat production is higher in the initial stage at greater flow *** the operating time increases,the proportion of heat production gradually *** cyclic heat storage status has obvious advantages in heat generation and ***,the energy-saving and emission reduction benefits of PHS and geothermal utilization systems were calculated.

关键词： abandoned mine underground reservoir wind/solar energy pumped hydroelectric storage geothermal

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Platinum-based chemotherapy for metastatic insulinoma harboring germline mutation in DNA damage repair pathway: a case report

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胰腺病学杂志(英文) 2024年第2期07卷 167-169页

作者： Yang Kaili ying Hongyan guan Mei Wang Lina Xu Jia Cheng Yuejuan Department of Gastroenterology Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China Department of Medical Oncology Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China Beijing Chaoyang Integrative Medicine Rescue and First Aid Hospital Beijing China Department of Radiology Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China

Malignant insulinomas are rare neuroendocrine tumors that require management for both symptomatic control and tumor reduction. It is clinically challenging to optimize treatment strategies for refractory malignant insulinoma. We report a case of metastatic grade 3 insulinoma presented with recurrent hypoglycemia in a 23-year-old female with RAD51D p.Q192 germline mutation. During the disease course of 5 years, the tumor has continuously progressed despite locoregional therapy and multiple lines of systemic treatment. However, oxaliplatin-based chemotherapy achieved a partial response, which was maintained for 2 years. The hypoglycemic symptoms were controlled after the treatment response and did not recur. The platinum-based regimen could be a feasible therapeutic strategy for malignant insulinoma. The relationship between germline mutation in the DNA damage repair pathway and treatment response to platinum-based regimens in neuroendocrine tumors warrants further investigation.

关键词： Chemotherapy DNA damage repair Germline mutation Malignant insulinoma

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多层光纤线包结构稳定性高效计算模型与分析

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兵工学报 2024年第8期45卷 2554-2563页

作者：李小东孟磊周平闫英大连理工大学高性能精密制造全国重点实验室辽宁大连116024

光纤线包的结构稳定性显著影响光纤系统的服役状态,为解决以有限单元法为代表的数值分析方法,因光纤线包缠绕层数多、非线性强等因素导致的计算时间长、效率低等问题,根据光纤层间仅受压的特点建立光纤线包结构稳定性的高效计算模型,分... 详细信息

光纤线包的结构稳定性显著影响光纤系统的服役状态,为解决以有限单元法为代表的数值分析方法,因光纤线包缠绕层数多、非线性强等因素导致的计算时间长、效率低等问题,根据光纤层间仅受压的特点建立光纤线包结构稳定性的高效计算模型,分析光纤的缠绕制度和线径的均匀程度对光纤线包结构稳定性的影响规律,给出线包失稳的线径均匀性临界值。研究结果表明:相比于有限元仿真,该模型在不损失计算精度的前提下计算效率可提升约100倍;等残余张力缠绕制度更有利于线包的结构稳定性;当线径的偏差值超过标准线径的±3%时,光纤位移急剧增大,严重影响光纤线包的结构稳定性;此研究对于多层光纤线包绕制工艺的实时分析和控制具有重要的意义。

关键词：光纤线包稳定性高效计算模型等残余张力线径均匀性

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Effectiveness of fecal DNA syndecan-2 methylation testing for detection of colorectal cancer in a high-risk Chinese population

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1361-1373页

作者： Wen-Feng Luo Yu-Ting Jiao Xiao-Ling Lin ying Zhao Sheng-Bo Wang Jian Shen Jie Deng Yu-Feng Ye Ze-ping Han Fang-Mei Xie Jin-Hua He Yu Wan Central Laboratory of Panyu Central Hospital Guangzhou Panyu Central HospitalGuangzhou 511400Guangdong ProvinceChina South China Normal University-Panyu Central Hospital Joint Laboratory of Translational Medical Research Guangzhou Panyu Central HospitalGuangzhou 511400Guangdong ProvinceChina Digestive Disease Center Guangzhou Panyu Central HospitalGuangzhou 511400Guangdong ProvinceChina Shunde Vocational and Technical College Foshan 528300Guangdong ProvinceChina Medical Imaging Institute of Panyu Guangzhou Panyu Central HospitalGuangzhou 511400Guangdong ProvinceChina

BACKGROUND Colorectal cancer(CRC)is among the most prevalent and life-threatening malignancies ***-2 methylation(mSDC2)testing has emerged as a widely used biomarker for early detection of CRC in stool and serum ***(CRC)is among the most prevalent and life-threatening malignancies ***2 testing has emerged as a widely used biomarker for early detection of CRC in stool and serum *** To validate the effectiveness of fecal DNA mSDC2 testing in the detection of CRC among a high-risk Chinese population to provide evidence-based data for the development of diagnostic and/or screening guidelines for CRC in *** A high-risk Chinese cohort consisting of 1130 individuals aged 40-79 years was selected for evaluation via fecal mSDC2 *** and specificity for CRC,advanced adenoma(AA)and advanced colorectal neoplasia(ACN)were ***-risk factors for the incidence of colorectal lesions were determined and a logistic regression model was constructed to reflect the efficacy of the *** A total of 1035 high-risk individuals were included in this study according to established *** them,16 suffered from CRC(1.55%),65 from AA(6.28%)and 189 from non-AAs(18.26%);150 patients were diagnosed with polyps(14.49%).Diagnoses were established based upon colonoscopic and pathological *** of the mSDC2 test for CRC and AA were 87.50%and 40.00%,respectively;specificities were 95.61%for other *** predictive values of the mSDC2 test for CRC,AA and ACN were 16.09%,29.89%and 45.98%,respectively;the negative predictive value for CRC was 99.79%.After adjusting for other high-risk covariates,mSDC2 test positivity was found to be a significant risk factor for the occurrence of ACN(P<0.001).CONCLUSION Our findings confirmed that offering fecal mSDC2 testing and colonoscopy in combination for CRC screening is effective for earlier detection of malignant colorectal lesions in a high

关键词： Colorectal cancer Syndecan-2 DNA methylation Chinese population

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Expert consensus on the diagnosis and treatment of macrolide-resistant Mycoplasma pneumoniae pneumonia in children

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World Journal of Pediatrics 2024年第9期20卷 901-914页

作者： ying-Shuo Wang Yun-Lian Zhou guan-Nan Bai Shu-Xian Li Dan Xu Li-Na Chen Xing Chen Xiao-Yan Dong Hong-Min Fu Zhou Fu Chuang-Li Hao Jian-Guo Hong En-Mei Liu Han-Min Liu Xiao-Xia Lu Zheng-Xiu Luo Lan-Fang Tang Man Tian Yong Yin Xiao-Bo Zhang Jian-Hua Zhang Hai-Lin Zhang De-Yu Zhao Shun-ying Zhao Guo-Hong Zhu ying-Xue Zou Quan Lu Yuan-Yuan Zhang Zhi-Min Chen Department of Pulmonology Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310052China Department of Child Health Care Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310052China Department of Pediatric Pulmonology and Immunology West China Second University HospitalSichuan UniversityChengdu 610041China Department of Pediatrics Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021China Department of Pulmonology Shanghai Children’s HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200062China Department of Pulmonary and Critical Care Medicine Kunming Children’s HospitalKunming 650034China Department of Respiratory Medicine Children’s Hospital of Chongqing Medical UniversityChongqing 400014China Department of Pulmonology Children’s Hospital of Soochow UniversitySuzhou 215003China Department of Pediatrics Shanghai General Hospital Affiliated to Shanghai Jiaotong University School of MedicineShanghai 200080China Department of Respiratory Medicine Wuhan Children’s HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430015China Department of Respiratory Medicine Children’s Hospital of Nanjing Medical UniversityNanjing 210008China Department of Respiratory Medicine Shanghai Children’s Medical CenterShanghai Jiao Tong University School of MedicineShanghai 200127China Department of Respiratory Medicine Children’s Hospital of Fudan UniversityShanghai 201102China Department of Pediatric Pulmonology Xinhua HospitalShanghai Jiaotong University School of MedicineShanghai 201102China Department of Pediatric Respiratory Medicine The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityWenzhou 325027China National Clinical Research Center for Respiratory Diseases Beijing Children’s HospitalCapital Medical UniversityBeijing 100045China Departmen

Background Mycoplasma pneumoniae(***)is a significant contributor to community-acquired pneumonia among *** 1968,when a strain of *** resistant to macrolide antibiotics was initially reported in Japan,macrolide-resistant ***(MRMP)has been documented in many countries worldwide,with varying incidence *** infections lead to a poor response to macrolide antibiotics,frequently resulting in prolonged fever,extended antibiotic treatment,increased hospitalization,intensive care unit admissions,and a significantly higher proportion of patients receiving glucocorticoids or second-line *** 2000,the global incidence of MRMP has gradually increased,especially in East Asia,which has posed a serious challenge to the treatment of *** infections in children and attracted widespread attention from ***,there is still no global consensus on the diagnosis and treatment of MRMP in *** We organized 29 Chinese experts majoring in pediatric pulmonology and epidemiology to write the world’s first consensus on the diagnosis and treatment of pediatric MRMP pneumonia,based on evidence *** evidence searches and reviews were conducted using electronic databases,including PubMed,Embase,Web of Science,CNKI,Medline,and the Cochrane *** used variations in terms for“macrolide-resistant”,“Mycoplasma pneumoniae”,“MP”,“***”,“pneumonia”,“MRMP”,“lower respiratory tract infection”,“Mycoplasma pneumoniae infection”,“children”,and“pediatric”.Results Epidemiology,pathogenesis,clinical manifestations,early identification,laboratory examination,principles of antibiotic use,application of glucocorticoids and intravenous immunoglobulin,and precautions for bronchoscopy are *** and rapid identification of gene mutations associated with MRMP is now available by polymerase chain reaction and fluorescent probe techniques in respiratory *** the resistance rate to mac

关键词： Child Macrolide-resistant Mycoplasma pneumoniae Recommendation Diagnosis Treatment

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