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Alterations in the frequency of trinucleotide repeat dynamic mutations in offspring conceived through assisted reproductive technology

第七次全国妇科内分泌学术会议

作者： Fang Le Pei-pei Pan Ning Wang Li-ya Wang Le-jun Li ying-ming zheng Hang-ying Lou Cheng-xia Hu Shu-yuan Liu Xiao-zhen Liu Xiang-rong Xu He-feng Huang Fan Jin Center of Reproductive Medicine Women’s HospitalSchool of MedicineZhejiang University

Objective Epidemiological studies have reported a higher incidence of growth disorders among newborns conceived by in vitro fertilization(IVF),suggesting that IVF may be disruptive to the process of embryonic and feta...

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Alterations in the frequency of trinucleotide repeat dynamic...

2013浙江省医学遗传学学术年会

作者： ying-ming zheng Li Li Pei-Pei Pan Fang Le Yi-Yun Lou Kai Yan Le-Jun Li Li-Ya Wang Shu-Yuan Liu Xin-Yun Yang Min-Hao Hu Song-Chang Chen Chen-ming Xu Fan Jin Department of Reproductive Endocrinology Women's HospitalZhejiang University School of Medicine Key Laboratory of Reproductive Genetics National Ministry of Education(Zhejiang University)Women's Reproductive Healthy Laboratory of Zhejiang Province

Background:This study investigates possible changes in the frequency of trinucleotide repeat dynamic mutations in offspring conceived through assisted reproductive technology(ART) in comparison with matched controls from spontaneous pregnancies. Methods:A prospective clinical observational study was performed on two hundred and forty-six families recruited from the in vitro fertilisation centre at a tertiary -care,university -affiliated,teaching hospital. Parental,peripheral and umbilical cord blood samples were collected and the trinucleotide repeat dynamic mutation genes of ATNl,AR,ATXNl,ATXN3,Huntington,DMPK and FMR-1 were investigated between *** frequencies and sizes of the mutational repeats of intergenerational instability were measured. Results:A total of 2,466 transmissions were identified in ART offspring,with 2.11%(n=52/2,466) of alleles being unstable upon *** the control group,the frequency of dynamic mutation was 0.77% (n=10/l,300).Statistical significance was found between the ART group and the control group(P 0.05).The repeat copy numbers of examined genes in all parents and their babies were found to be within the normal ranges. Conclusions:Our results illustrated that more significant alterations in the frequency of trinucleotide repeat dynamic mutations in offspring conceived through *** studies determining the factors that influence instability of genome in ART procedure are urgently needed.

关键词： assisted reproductive technology offspring dynamic mutation trinucleotide repeat

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微压过滤冲洗池的污物处理能力研究

节水灌溉 2017年第2期 39-43,47页

作者：陶洪飞马英杰洪明郑文强新疆农业大学水利与土木工程学院乌鲁木齐830052

针对目前处理地表水中污物难的问题,提出了微压过滤冲洗池,并进行了动水试验。试验结果表明:微压过滤冲洗池可以处理泥沙、锯末、树叶、草籽等污物;当含沙量范围为3.1~3.6、13.9~14.4及20.6~21.1 kg/m3时,微压过滤冲洗池的过滤时间分别... 详细信息

针对目前处理地表水中污物难的问题,提出了微压过滤冲洗池,并进行了动水试验。试验结果表明:微压过滤冲洗池可以处理泥沙、锯末、树叶、草籽等污物;当含沙量范围为3.1~3.6、13.9~14.4及20.6~21.1 kg/m3时,微压过滤冲洗池的过滤时间分别达到420、60、10 min时开始排污;微压过滤冲洗池的泥沙去除率在80%以上,泥沙粒径范围为0.15~1 mm时,级效率达到100%,中值粒径D50由0.23 mm变为0.058 mm左右,粗端粒径D98由0.97 mm变为0.13 mm左右,从泥沙去除率、级效率、过滤前后的泥沙粒径变化可知,微压过滤冲洗池的污物处理能力很高,过滤后的水满足灌溉需水和水质要求;水箱中的水深随过滤时间的变化规律包含3个阶段,即水深恒定、水深快速增加和水深急速增加阶段。并在试验结果的基础上,对过滤网不易堵塞的机理进行了初步分析。

关键词：微压过滤冲洗池过滤网含沙量过滤时间水深

Deciphering fungal metabolon coupling tandem inverse-electrondemand Diels-Alder reaction and semipinacol rearrangement for the biosynthesis of spiro polycyclic alkaloids

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Science China Chemistry 2025年第01期 288-296页

作者： Shuai Liu Wen-Qiang Xu ying-Tong Di Man-Cheng Tang Ding-Kang Chen ming-ming Cao Yao-Wen Chang Hong-Yu Tang Chun-Mao Yuan Jun-Bo Yang Zhi-Li Zuo Han Guo Zi-Fei Xu ying Zeng Yun-Dong Wu Xiao-Jiang Hao Key Laboratory of Phytochemistry and Natural Medicines (Chinese Academy of Sciences) Kunming Institute of Botany Chinese Academy of Sciences University of Chinese Academy of Sciences Lab of Computational Chemistry and Drug Design State Key Laboratory of Chemical Oncogenomics Peking University Shenzhen Graduate School Shenzhen Bay Laboratory State Key Laboratory of Microbial Metabolism School of Life Sciences & Biotechnology Shanghai Jiao Tong University State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical University Molecular Biology Experimental Center Germplasm Bank of Wild Species in Southwest China Kunming Institute of Botany Chinese Academy of Sciences Yunnan Key Laboratory for Wild Plant Resources Kunming Institute of Botany Chinese Academy of Sciences Research Unit of Chemical Biology of Natural Anti-Virus Products Chinese Academy of Medical Sciences

In the intricate process of natural product biosynthesis, a metabolon can enhance metabolic flux by associating sequential enzymes. A fungal metabolon, comprising of flavin-dependent monooxygenase Spe F and P450 monooxygenase Spe G, is identified in the biosynthesis of spiro polycyclic alkaloids(+)-notoamide B and its diastereomer(+)-versicolamide B. Using notoamide E as a substance, Spe F/Spe G metabolon can control the stereoselectivity of its 2,3-epoxidation, followed by hydrogen atom ion at C-17 to generate reactive epoxide tau-m A with dienyl iminium unit. Subsequently,(+)-notoamide B and(+)-versicolamide B are produced via tandem nonenzymatic inverse-electron-demand Diels-Alder reaction and semipinacol rearrangement. This provides the first example of metabolon in the biosynthesis of spiro-prenylated indole alkaloids.

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晚期鼻咽癌的原癌基因c-MetmRNA表达与其生物学行为及预后的关系

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海南医学 2010年第8期21卷 3-5页

作者：刘崇梅林明晖应明政岳阳市二人民医院岳阳市肿瘤医院病理科湖南岳阳414000 岳阳市肿瘤医院耳鼻咽喉科湖南岳阳414000

目的探讨晚期鼻咽分化型非角化性鳞癌中c-metmRNA的表达与生物学行为及预后的关系。方法应用原位杂交检测晚期鼻咽分化型非角化性鳞癌标本55例c-metmRNA的表达。结果55份晚期鼻咽分化型非角化性鳞癌中,总阳性率为65.5%(35/55),生存期在... 详细信息

目的探讨晚期鼻咽分化型非角化性鳞癌中c-metmRNA的表达与生物学行为及预后的关系。方法应用原位杂交检测晚期鼻咽分化型非角化性鳞癌标本55例c-metmRNA的表达。结果55份晚期鼻咽分化型非角化性鳞癌中,总阳性率为65.5%(35/55),生存期在5年以下的患者c-metmRNA高表达占8.6%(18/37),5年以上患者占16.7%(3/18),两组间差异有统计学意义(x2=5.25、P<0.05)。c-metmRNA表达在有颅底侵袭组为74.4%(32/43),无颅底侵袭组为33.3%(4/12),两组间差异有统计学意义(P<0.05)。c-metmRNA表达在颅神经损伤组为77.7%(35/45),无颅神经损伤组为10.0%(1/10),两组间差异有统计学意义(P<0.05)。结论本组晚期鼻咽分化型非角化性鳞癌患者中c-metmRNA的表达与其侵袭有密切的关系,c-met在鼻咽癌的预后中有重要价值,可作为临床治疗、预后的参考指标。

关键词：肝细胞生长因子受体 c—metmRNA 鼻咽癌侵袭

Homologous CoS2 interface with directed electron transfer and strong chloridion repulsion for efficient seawater oxidation

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Science China Chemistry 2025年

作者： Yuan Tian Jiang-Bo Chen Jie ying Ge Tian Yu-Xuan Xiao Yi Lu Si-ming Wu Wei Geng Ling Shen Xiao-Yu Yang State Key Laboratory of Advanced Technology for Materials Synthesis and Processing and School of Materials Science and Engineering and Shenzhen Research Institute & Laoshan Laboratory Wuhan University of Technology School of Chemical Engineering and Technology Sun Yat-Sen University National Energy Key Laboratory for New Hydrogen-Ammonia Energy Technologies Foshan Xianhu Laboratory

Seawater electrolysis is a highly promising method to produce high energy density hydrogen,especially in dry areas that have scarce freshwater ***,application of seawater electrolysis is confronted by two major problems associated with catalysts employed for the anodic oxygen evolution reaction （OER） including the competitive hypochlorite evolution reaction（HCER） and strong chloridion （Cl–） triggered *** studies aimed at overcoming these problems,a facile method has been developed to synthesize a homologous CoS2heterojunction as an OER *** to a difference in work functions at the interface and increased electron density,this material has directed electron transfer and strong chloridion repulsion properties,*** have shown that CoS2achieves low overpotentials of 289 and 322 mV at 10 mA cm-2current density in respective alkaline （1 M KOH） and alkaline simulated seawater ***,the outstanding stability of CoS2is reflected in a negligible decline in activity during promotion of the OER for 100 *** of density functional theory calculations reveal that the homologous CoS2heterojunction promotes directed electron transport for optimizing adsorption/desorption of reactive species and heightens the Cl-adsorption energy for strongly repulsing Cl-,phenomena that enhance OER performance in alkaline simulated seawater.

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Temporal Change of Runoff and Sediment Load and their Differential Response to Human Activities:A Case Study for a Well-vegetated Mountain Watershed of Southern China

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Journal of Mountain Science 2014年第1期11卷 73-85页

作者： zheng ming-guo SUN Li-ying YAN ming Key Laboratory of Water Cycle and Related Land Surface Processes Institute of Geographic Sciences & Natural Resources ResearchChinese Academic of Sciences

This study examined the temporal trends of runoff and sediment load and their differential response to human activities in the Lishui river,a tributary of the Yangtze river in southern *** long-term observation data at four gauging stations,generally involving two periods from 1954 to 1985 and from 2007 to 2011,were *** detected no significant temporal trend for both the annual runoff volume(Q) and the annual suspended Sediment Load(SL) over more than 30 years before *** flow duration curves and the Suspended Sediment Concentration(SSC) also hold constant before *** with the period before 1985,SL has decreased by about 80% though Q remains unchanged for the period after *** examination shows that the flow duration curves after 2007 have changed with a significant decrease in the high-flow component,which acts as a major cause for the decreasing *** addition,SSC has decreased by several times,which also contributes to the decrease in SL after *** decreases in high-flow discharges and in SSC can be linked with recent human activities,mainly including vegetation establishment and dam *** constant Q and the decreasing SL are also reported for the main stream of the Yangtze River and other major rivers in southern China,although they are orders of magnitude larger than our study area in drainage area *** present study highlights the importance of high-flow discharges on SL and suggests that the use of SL is more appropriate to reflect environmental change than Q.

关键词： Runoff Sediment load Reservoirs Environmental change Afforestation Lishui River

重复控制性卵巢刺激(COS)-IVF/ICSI治疗对卵巢储备功能及反应性的影响

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生殖与避孕 2013年第10期33卷 707-711页

作者：朱玉蓉吴晓云郑英明金帆浙江大学附属妇产科医院生殖医学中心杭州310006 浙江湖州市妇幼保健院生殖中心湖州313000

目的:探讨年轻女性在接受反复控制性卵巢刺激(COS)-IVF/ICSI治疗对卵巢储备功能及其反应性的变化。方法:回顾性分析连续3次接受COS-IVF/ICSI-ET治疗周期的0.05);第2次和第3次治疗周期使用促性腺激素(gonadotropin,Gn)剂量明显高于第1次... 详细信息

目的:探讨年轻女性在接受反复控制性卵巢刺激(COS)-IVF/ICSI治疗对卵巢储备功能及其反应性的变化。方法:回顾性分析连续3次接受COS-IVF/ICSI-ET治疗周期的0.05);第2次和第3次治疗周期使用促性腺激素(gonadotropin,Gn)剂量明显高于第1次治疗,差异具有统计学意义(P<0.05)。结论:<35周岁重复COS-IVF/ICSI周期对卵巢储备功能无影响,对其卵巢反应性有一定影响。

关键词：重复COS—IVF ICSI 卵巢反应性卵巢储备促性腺激素剂量

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Video-based measurement and data analysis of traffic flow on urban expressways

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Acta Mechanica Sinica 2011年第3期27卷 346-353页

作者： Xian-Qing zheng zheng Wu Shi-Xiong Xu ming-Min Guo Zhan-Xi Lin ying-ying Zhang Department of Mechanics and Engineering Science Fudan University 200433 Shanghai China

A new video-based measurement is proposed to collect and investigate traffic flow parameters. The output of the measurement is velocity-headway distance data pairs. Because density can be directly acquired by the reciprocal of headway distance, the data pairs have the advantage of better simultaneity than those from common detectors. By now, over 33 000 pairs of data have been collected from two road sections in the cities of Shanghai and zhengzhou. Through analyzing the video files recording traffic movements on urban expressways, the following issues are studied：laws of vehicle velocity changing with headway distance, proportions of di0erent driving behaviors in the traffic system, and characteristics of traffic flow in snowy days. The results show that the real road traffic is very complex, and factors such as location and climate need to be taken into consideration in the formation of traffic flow models.

关键词： Traffic flow mode - Video-based - Vehicle recog- nition. Driving behavior - Snowy day traffic

Microstructure homogenization control of Nb-bearing X65 pipeline steel by the CSP process

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International Journal of Minerals,Metallurgy and Materials 2011年第1期18卷 35-41页

作者： ming-yang Li Ya-zheng Liu Tao Zhu ying Wang School of Materials Science and Engineering University of Science and Technology Beijing Beijing 100083 China Technology Center of Masteei Co. Ltd. Maanshan 243000 China

In order to get the controlled methods of microstructure homogenization and high strengthening-toughening combination by compact strip production （CSP） rolling,the dynamic recrystallization characteristics of each pass were obtained during CSP rolling using a Gleeble-1500 thermal mechanical ***,the CSP process was simulated by laboratory rolling *** thermal mechanical simulation experiment and laboratory rolling experiment,a design idea of Nb-bearing pipeline steel by CSP can be obtained as the following：the level of dynamic recrystallization behavior should be increased through the reasonable balance of high deformation temperature and deformation amount in F1 and F2 passes,and F3-F7 passes should be controlled in the austenite non-recrystallization ***,X65 pipeline steel with microstructure uniformity and good properties was produced by *** yield strength is up to 497 MPa,the tensile strength is up to 563 MPa,the elongation is 30% on average,and the toughness is very good whose Charpy impact value is 110 J on average and drop-weight tear test shearing areas are all 100% at -60,-40,-20,0,and 20℃.

关键词： pipeline steel hot rolling dynamic recrystallization precipitation microstructure mechanical properties