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Establishment and evaluation of prediction model of recurrence after laparoscopic choledocholithotomy

World Journal of Gastrointestinal Surgery 2024年第9期16卷 2823-2828页

作者： ying-jie wu Department of Hepatobiliary Pancreatic Surgery The First Affiliated Hospital of Ningbo UniversityNingbo 315000Zhejiang ProvinceChina

BACKGROUND Choledocholithiasis is a common clinical bile duct disease,laparoscopic choledocholithotomy is the main clinical treatment method for ***,the recurrence of postoperative stones is a big challenge for patients and *** To explore the related risk factors of gallstone recurrence after laparoscopic choledocholithotomy,establish and evaluate a clinical prediction *** A total of 254 patients who underwent laparoscopic choledocholithotomy in the First Affiliated Hospital of Ningbo University from December 2017 to December 2020 were selected as the research *** data of the patients were collected,and the recurrence of gallstones was recorded based on the postope-rative *** results were analyzed and a clinical prediction model was *** Postoperative stone recurrence rate was 10.23%(26 patients).Multivariate Logistic regression analysis showed that cholangitis,the diameter of the common bile duct,the diameter of the stone,number of stones,lithotripsy,preoperative total bilirubin,and T tube were risk factors associated with postoperative recurrence(P<0.05).The clinical prediction model was ln(p/1-p)=-6.853+1.347×cholangitis+1.535×choledochal diameter+2.176×stone diameter+1.784×stone number+2.242×lithotripsy+0.021×preoperative total bilirubin+2.185×T *** Cholangitis,the diameter of the common bile duct,the diameter of the stone,number of stones,lithotripsy,preoperative total bilirubin,and T tube are the associated risk factors for postoperative recurrence of *** prediction model in this study has a good prediction effect,which has a certain reference value for recurrence of gallstone after laparoscopic choledocholi-thotomy.

关键词： Choledocholithiasis Laparoscopic choledocholithotomy Recurrence Risk factors Clinical prediction model

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Single-structure 3-axis Lorentz force magnetometer based on an AlN-on-Si MEMS resonator

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Microsystems & Nanoengineering 2024年第3期10卷 75-86页

作者： Cheng Tu Xu-heng Ou-Yang ying-jie wu Xiao-sheng Zhang School of Integrated Circuit Science and Engineering University of Electronic Science and Technology of ChinaChengdu 611731China

This work presents a single-structure 3-axis Lorentz force magnetometer(LFM)based on an AlN-on-Si MEMS *** operation of the proposed LFM relies on the flexible manipulation of applied excitation currents in different directions and frequencies,enabling the effective actuation of two mechanical vibration modes in a single device for magnetic field measurements in three ***,the excited out-of-plane drum-like mode at 277 kHz is used for measuring the x-and y-axis magnetic fields,while the in-plane square-extensional mode at 5.4 MHz is used for measuring the z-axis magnetic *** different configurations of applied excitation currents ensure good crossinterference immunity among the three *** to conventional capacitive LFMs,the proposed piezoelectric LFM utilizes strong electromechanical coupling from the AlN layer,which allows it to operate at ambient pressure with a high *** understand and analyze the measured results,a novel equivalent circuit model for the proposed LFM is also reported in this work,which serves to separate the effect of Lorentz force from the unwanted capacitive *** demonstrated 3-axis LFM exhibits measured magnetic responsivities of 1.74 ppm/mT,1.83 ppm/mT and 6.75 ppm/mT in the x-,y-and z-axes,respectively,which are comparable to their capacitive counterparts.

关键词： resonator Lorentz structure

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Two-photon Pumped Up-conversion Lasing Properties of A Series of Organic Salts with Different Side-chains

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Chinese Chemical Letters 2001年第7期12卷 631-634页

作者： Yu Peng TIAN Fu ying HAO jie ying wu Qi FANG Min Hua JIANG Department of Chemistry Anhui UniversityHefei 230039 State Key Laboratory of Coordination Chemistry Nanjing University 210093 Institute of Crystal Materials Shandong Universityjinan 250100

The synthesis and upconverted fluorescent properties of a series of organic compounds with the structure: donor/bridge/acceptor, and different side-chains are reported. The results show that the compounds with different side-chains exhibit different two-photon induced fluorescent properties, although they have the same main donor/bridge/acceptor structure.

关键词： Two-photon upconverted fluorescence side chain

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A novel real-time cell electronic analysis technology for the authentication and quality control of natural medicines

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Chinese Chemical Letters 2013年第12期24卷 1140-1144页

作者： Guo-Jun Yan Xin Mei Jin Yang Jenny Zhu jie-ying wu Jin-Huo Pan College of Pharmacy Nanjing University of Chinese Medicine ACEA Biosciences Inc. ACEA BIO (Hangzhou) Co. Ltd.Hangzhou High Throughput Drug Screening Center

The study was designed to explore the potential applications of the real-time cell electronic analysis technology in the quality evaluation of natural medicines. The natural medicinal Flos Carthami was discussed as a methodological example and the specific time/dose-dependent cell response profiles （TCRPs） were produced by the real-time cell electronic analysis technology. The similarity and bioactivity were obtained by analyzing all TCRPs. Meanwhile, an HPLC method according to the Chinese Pharmacopeia （edition 2010） was used to evaluate the quality of Flos Carthami. The correlation was obtained by comparing the results produced by the two different approaches. By analyzing the data, five different samples ofFlos Carthami can produce remarkably similar TCRPs. The quality ofFlos Carthami was evaluated by both the HPLC and the TCRPs analysis-based approaches and similar results were obtained. The results suggest that the same natural medicine from different locations could produce similar TCRPs. By analyzing the TCRPs, the bioactivity and quality evaluation of natural medicines can be obtained. This technology is a physiologically relevant approach for the quality evaluation of natural medicines. The ultimate aim of our study is to establish a new standard for quality evaluation.

关键词： Time]dose-dependent cell response profiles (TCRPs) Quality standard Bioactivity Physiologically relevant approach Flos Carthami

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A Novel Biferrocene Trinuclear Complex with Cis-Configuration

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Chinese Chemical Letters 1999年第3期10卷 251-254页

作者： jie ying wu Yu Peng TIAN Fu Xin XIE Shi Sheng NI(Department of Chemistry, Anhui University, Hefei 230039) Anhui Univ Dept Chem Hefei 230039 Peoples R China

A novel biferocene trinuclear complex for Schiff base ligand S-methyl-N- (ferrocenyl-1-methyl -methylidene) dithiocarbazate thereafter abbreviated as HL) is described. X-ray diffraction studies established the structure of the palladium complex, PdL2. The geometry of Pd (II) in the complex is close to square planar and in novel cis-configuration with two ferrocene moieties on the same side. Degenerate four-wave mixing (DFWM) measurements show that the complex exhibit obvious nonlinear optical response.

关键词： palladium complex cis-configuration biferrocene third-order nonlinear optical property

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Coexpression of TLR9 and VEGF-C is associated with lymphatic metastasis in prostate cancer

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Asian Journal of Andrology 2022年第4期24卷 380-385页

作者： Xian-Zi Zeng Zhan-Sen Huang Hong-Peng Fang jie-ying wu Qun-Xiong Huang Chu-Bin Zhuang Jing Zhou Jin-Ming Di Department of Urology The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China Department of Infertility and Sexual Medicine The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China Department of Pathology The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China

Prostate cancer(PCa)is one of the most frequent cancers in men,and its biomolecular targets have been extensively *** study aimed to analyze the expression of toll-like receptor 9(TLR9)and vascular endothelial growth factor C(VEGF-C)and the clinical value of the coexpression of TLR9 and VEGF-C in *** retrospectively evaluated 55 patients with clinically localized,intermediate-risk,or high-risk PCa who underwent laparoscopic radical prostatectomy(LRP)and extended pelvic lymph node dissection(ePLND)without neoadjuvant hormonal therapy at a single institution from June 2013 to December *** all 55 patients,the median number of lymph nodes(LNs)resected was 23(range:18-31),and a total of 1269 LNs were removed,of which 78 LNs were *** patients had positive LNs,with a positive rate of 30.9%.In addition,the immunohistochemical results in the above patients revealed that high TLR9 expression was correlated with higher Gleason score(GS)(P=0.049),increased LN metastasis(P=0.004),and more perineural invasion(PNI)(P=0.033).Moreover,VEGF-C expression was associated with GS(P=0.040),pathological stage(pT stage)(P=0.022),LN metastasis(P=0.003),and PNI(P=0.001).Furthermore,a significant positive correlation between TLR9 and VEGF-C was found(P<0.001),and the TLR9/VEGF-C phenotype was associated with LN metastasis(P=0.047).Collectively,we propose that TLR9 stimulation may promote LN metastasis in PCa cells through the upregulation of VEGF-C expression,thereby affecting the prognosis of PCa ***,these markers may serve as valuable targets for the treatment of PCa.

关键词： biochemical progression-free survival coexpression lymphatic metastasis prostate cancer toll-like receptor 9 vascular endothelial growth factor C

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Antioxidant activity of alcohol aqueous extracts of Crypthecodinium cohnii and Schizochytrium sp.

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2017年第9期18卷 797-806页

作者： Jin-hui YU Yu WANG jie SUN Fei BIAN Gao CHEN Yan ZHANG Yu-ping BI ying-jie wu Institute of Genome Engineered Animal Models for Human Disease Dalian Medical University Shandong Center of Crop Germplasm Resources College of Integrative Medicine Dalian Medical University Biotechnology Research Center Shandong Academy of Agricultural Sciences School of Life Sciences Shandong University

Crypthecodinium cohnii(dinoflagellate) and Schizochytrium sp.(thraustochytrid) are the main sources for docosahexaenoic acid(DHA). The present study aimed to evaluate the antioxidant activity of petroleum ether, ethyl acetate, n-butanol, and water fractions of alcohol aqueous extracts of these two microalgae and to provide a theoretical basis for comprehensive utilization. The antioxidant activity was determined by total antioxidant capacity(TAC) determination, 2,2-diphenyl-1-picrylhydrazyl(DPPH) radical scavenging assay, ferrous ion-chelating ability(FICA) assay, and reducing power(RP) assay. The total phenolic content(TPC) and total flavonoid content(TFC) were also measured by the Folin-Ciocalteu and spectrophotometry methods, respectively. The results indicated that the extracts from these two microalgae possessed good antioxidant capacity. Analysis showed that most antioxidant performance indicators(TAC, DPPH, and RP) were positively correlated with the TPC of the extracts, suggesting that the phenolics might be the major components in C. cohnii and Schizochytrium sp., contributing to their antioxidative function. Therefore, the polar fractions of C. cohnii and Schizochytrium sp. could be further examined and considered for application in health products or cosmetics.

关键词： Crypthecodinium cohnii Schizochytrium sp. Alcohol aqueous extract Antioxidant activity Total phenolics

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New Complex Nonlinear optical Crystal-Bis(4-methoxybenzaldehyde thiosemicarbazone) Zinc Chloride(ZnL_2Cl_2)

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Chinese Chemical Letters 1998年第2期9卷 215-217页

作者： Yu Peng TIAN jie ying wu Fu Xin XIE and Shi Sheng NI(Department of Chemistry, Anhui University, Hefei 230093Coordination Chemistry Institute, State Key Laboratory of Nanjing University. Nanjing 210093) Anhui Univ Dept Chem Hefei 230093 Peoples R China Nanjing Univ State Key Lab Inst Coordinat Chem Nanjing 210093 Peoples R China

The structure of ZnL2Cl2 (L=4-methoxybenzaldehyde thiosemicarbazone) has beenobtained by x-ray diffraction. The compound crystallized in space group Cc with Z=4, in a unit cellof dimensions, a=9.08909(10), b=22. l420(10), c=11 .7890(l0)A,β=90.050(10)°, v=2374.6(12)A3,Dc=1 .552gcm-3. H=1 .463mm-1. R=0.0338. and Rw=0.0418. The structure contains individualZnL2Cl2 distorted tetrahedral units in which L molecules are S-bonded as monodentate to the metalions; chloride ions are also coordinated. The nonlinear optical properties of the zinc complex arealso presented in this letter.

关键词： zinc complex- nonlinear optical crystal thiosemicarbazone derivative

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SYNTHESIS AND CRYSTAL STRUCTURE FOR PALLADIUM(Ⅱ) DITHIOCARBIMATO COMPLEX

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Chinese Chemical Letters 1996年第1期7卷 87-88页

作者： jie ying wu and Yu Pang TIAN (Department of Chemistry, Fuyang Normal College,236032 bCoordination Chemistry Institute,State Key Laboratory of Coordination Chemistry, Naming University, Nanjing, 210093)Hoong Kun FUN and Boon Chuan YIP(X-ray Crystallograp

The title complex crystallized in space group P21 / c with Z = 2 in a unit cell of dimensions, a= 9.811(1)A, b= 16.851(2)A, c= 15.855(3)A; g= 98.71(l) °, v= 2591.0(6)A3Dc = l.225gcm-3, F(000) = 1024, μ = o.55mm-1, R = 0.0338, Rw = 0.0631. The geometry of the Pd(Ⅱ )complex is square-planar configuration. The S2C= NPhNH2 group coordinated as asymmetric bidcntatc ligand forming a stable four member ring by chclation through the two sulphur atoms.

关键词：

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特发性黄斑前膜形成机制及其术后视功能影响因素的研究进展

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国际眼科杂志 2018年第11期18卷 1999-2002页

作者：吴瑛洁雍红芳左玲吉林大学第二医院中国吉林省长春市130000

特发性黄斑前膜(IMEM)是一种与年龄相关,以视力下降、视物变形症状为特点的常见的黄斑区疾病。随着我国人口老龄化的加速, IMEM发病率也逐年增高。目前,IMEM确切的发病机制尚不清楚,且缺乏有效的治疗药物,玻璃体切割术是其有效的治疗方... 详细信息

特发性黄斑前膜(IMEM)是一种与年龄相关,以视力下降、视物变形症状为特点的常见的黄斑区疾病。随着我国人口老龄化的加速, IMEM发病率也逐年增高。目前,IMEM确切的发病机制尚不清楚,且缺乏有效的治疗药物,玻璃体切割术是其有效的治疗方法,但术后视功能的改善差异很大。本文就IMEM的发病机制及影响预后的相关因素进行综述,以期为临床采取更加准确、有效的预防及治疗措施提供参考依据。

关键词：特发性黄斑前膜发病机制视功能

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