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Systematic review and meta-analysis of the efficacy and safety of immunosuppressive pulse therapy in the treatment of paraquat poisoning

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2019年第7期20卷 588-597页

作者： ying-ge xu Yuan-qiang LU Department of Emergency Medicine the First Affiliated Hospital School of Medicine Zhejiang University

Paraquat(PQ),a highly effective herbicide,is widely used *** poisoning can cause multiple organ failure,in which the lung is the primary target *** PQ poisoning,the patient mortality rate is as high as 90%,and there is currently no specific *** main clinical treatment is the use of glucocorticoids and cyclophosphamide for pulse therapy,but its effectiveness and safety are still *** investigated the effectiveness and safety of immunosuppressive pulse therapy with glucocorticoids and cyclophosphamide to evaluate the treatment value in patients with acute PQ *** meta-analysis,combined with seven trials that enrolled a total of 426 patients,showed that immunosuppressive pulse therapy with glucocorticoids and cyclophosphamide for PQ poisoning significantly reduced mortality of the study group(59.3%,134/226) compared with the control group(81.0%,162/200).There was no significant difference of hepatitis or renal failure between the control and study groups,indicating that immunosuppressive pulse therapy was relatively *** patients were reported to have leukopenia and returned to normal after 1-2 weeks without any *** cases of non-fatal sepsis were reported and considered to be a side effect of the immunosuppressive pulse ***,immunosuppressive pulse therapy can efficiently reduce the mortality of PQ poisoning and it is relatively safe.

关键词： Paraquat Glucocorticoids Cyclophosphamide Immunosuppressive pulse therapy Meta-analysis

Use of Tripterygium wilfordii Hook F for immune-mediated inflammatory diseases: progress and future prospects

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2020年第4期21卷 280-290页

作者： Cong-ying SONG ying-ge xu Yuan-qiang LU Department of Emergency Medicine the First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310003China Department of geriatric Medicine the First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310003China Zhejiang Provincial Key Laboratory for Diagnosis and Treatment of Aging and Physic-chemical Injury Diseases the First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310003China

Tripterygium wilfordii Hook F has significant anti-inflammatory and immunosuppressive properties and is widely used for treating autoimmune and inflammatory diseases such as rheumatoid arthritis, systemic lupus erythematosus, and kidney disease, especially in traditional Chinese medicine. The mechanisms underlying its effects may be diverse but they remain unclear, and its toxicity and side effects limit its wider clinical application. This review summarizes the clinical application of Tripterygium wilfordii Hook F in recent years, as well as the results of studies into its mechanisms and toxicity, to provide a reference for its future clinical application.

关键词： Tripterygium wilfordii Hook F Anti-inflammation Immunosuppression

Comparative transcriptomic analysis of vascular endothelial cells after hypoxia/re-oxygenation induction based on microarray technology

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2020年第4期21卷 291-304页

作者： Jia xu Jiu-kun JIANG Xiao-lin LI Xiao-peng YU ying-ge xu Yuan-qiang LU Department of Emergency Medicine the First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310003China Department of geriatric Medicine the First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310003China Zhejiang Provincial Key Laboratory for Diagnosis and Treatment of Aging and Physic-chemical Injury Diseases the First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310003China State Key Laboratory for Diagnosis and Treatment of Infectious Diseases the First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310003China

Objective: To provide comprehensive data to understand mechanisms of vascular endothelial cell(VEC) response to hypoxia/re-oxygenation. Methods: Human umbilical vein endothelial cells(HUVECs) were employed to construct hypoxia/re-oxygenation-induced VEC transcriptome profiling. Cells incubated under 5% O2, 5% CO2, and 90% N2 for 3 h followed by 95% air and 5% CO2 for 1 h were used in the hypoxia/re-oxygenation group. Those incubated only under 95% air and 5% CO2 were used in the normoxia control group. Results: By using a well-established microarray chip consisting of 58 339 probes, the study identified 372 differentially expressed genes. While part of the genes are known to be VEC hypoxia/re-oxygenation-related, serving as a good control, a large number of genes related to VEC hypoxia/re-oxygenation were identified for the first time. Through bioinformatic analysis of these genes, we identified that multiple pathways were involved in the reaction. Subsequently, we applied real-time polymerase chain reaction(PCR) and western blot techniques to validate the microarray data. It was found that the expression of apoptosis-related proteins, like pleckstrin homology-like domain family A member 1(PHLDA1), was also consistently up-regulated in the hypoxia/re-oxygenation group. STRING analysis found that significantly differentially expressed genes SLC38A3, SLC5A5, Lnc-SLC36 A4-1, and Lnc-PLEKHJ1-1 may have physical or/and functional protein–protein interactions with PHLDA1. Conclusions: The data from this study have built a foundation to develop many hypotheses to further explore the hypoxia/re-oxygenation mechanisms, an area with great clinical significance for multiple diseases.

关键词： Human umbilical vein endothelial cells(HUVECs) Hypoxia Re-oxygenation Microarray Pleckstrin homology-like domain family A member 1(PHLDA1) Long non-coding RNA(lncRNA)

Multi-model ensemble learning for battery state-of-health estimation:Recent advances and perspectives

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Journal of Energy Chemistry 2025年第1期100卷 739-759页

作者： Chuanping Lin Jun xu Delong Jiang Jiayang Hou ying Liang Zhongyue Zou xuesong Mei State Key Laboratory for Manufacturing Systems Engineering Xi'an Jiaotong University Shaanxi Key Laboratory of Intelligent Robots School of Mechanical Engineering Xi'an Jiaotong University Department of Electrical Engineering and Automation Luoyang Institute of Science and Technology School of Mechanical Engineering Hangzhou Dianzi University

The burgeoning market for lithium-ion batteries has stimulated a growing need for more reliable battery performance monitoring. Accurate state-of-health(SOH) estimation is critical for ensuring battery operational performance. Despite numerous data-driven methods reported in existing research for battery SOH estimation, these methods often exhibit inconsistent performance across different application scenarios. To address this issue and overcome the performance limitations of individual data-driven models,integrating multiple models for SOH estimation has received considerable attention. Ensemble learning(EL) typically leverages the strengths of multiple base models to achieve more robust and accurate outputs. However, the lack of a clear review of current research hinders the further development of ensemble methods in SOH estimation. Therefore, this paper comprehensively reviews multi-model ensemble learning methods for battery SOH estimation. First, existing ensemble methods are systematically categorized into 6 classes based on their combination strategies. Different realizations and underlying connections are meticulously analyzed for each category of EL methods, highlighting distinctions, innovations, and typical applications. Subsequently, these ensemble methods are comprehensively compared in terms of base models, combination strategies, and publication trends. Evaluations across 6 dimensions underscore the outstanding performance of stacking-based ensemble methods. Following this, these ensemble methods are further inspected from the perspectives of weighted ensemble and diversity, aiming to inspire potential approaches for enhancing ensemble performance. Moreover, addressing challenges such as base model selection, measuring model robustness and uncertainty, and interpretability of ensemble models in practical applications is emphasized. Finally, future research prospects are outlined, specifically noting that deep learning ensemble is poised to advance ens

关键词： Lithium-ion battery State-of-health estimation Data-driven Machine learning Ensemble learning Ensemble diversity

金属桩和纤维桩用于前牙残根残冠修复的比较研究

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中国现代医学杂志 2016年第18期26卷 100-103页

作者：徐革英米振林青海省第五人民医院口腔科青海西宁810007

目的分析金属桩和纤维桩用于前牙残根残冠修复的效果差异。方法选取2010年11月-2014年8月青海省第五人民医院进行前牙残根残冠修复的患者92例(共108颗牙)作为研究对象,随机分为观察组及对照组,对照组患者接受金属桩修复治疗,观察组患者... 详细信息

目的分析金属桩和纤维桩用于前牙残根残冠修复的效果差异。方法选取2010年11月-2014年8月青海省第五人民医院进行前牙残根残冠修复的患者92例(共108颗牙)作为研究对象,随机分为观察组及对照组,对照组患者接受金属桩修复治疗,观察组患者接受纤维桩修复治疗,对比两组患者的治疗成功率、治疗后咀嚼功能和牙龈情况、龈沟局部炎症状态等差异。结果观察组患者接受治疗后的成功率高于对照组患者,松动脱落、根尖周炎、桩折、根折等失败事件发生率低于对照组患者(P<0.05);观察组患者接受治疗后的咬合力、咀嚼效率、牙龈指数高于对照组患者,出血指数低于对照组患者(P<0.05);观察组患者接受治疗后的龈沟局部IL-6、IL-8及TNF-α水平值均低于对照组患者(P<0.05)。结论前牙残根残冠患者接受纤维桩修复,不仅可以增加治疗成功率,还可以优化牙龈状态。

关键词：前牙残根残冠修复金属桩纤维桩

Dialog vario嵌体修复和e-max铸瓷嵌体用于牙邻面牙体缺损的治疗

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中国现代医学杂志 2015年第28期25卷 90-93页

作者：徐革英李冬梅青海省第五人民医院口腔科青海西宁810007 第四军医大学口腔医院特诊科陕西西安710032

目的分析Dialog vario嵌体修复和e-max铸瓷嵌体用于牙邻面牙体缺损治疗的效果差异。方法选择在该院接受治疗的牙邻面牙体缺损患者作为研究对象,随机分为接受e-max铸瓷嵌体修复的对照组、接受Dialog vario嵌体修复的观察组,比较两组患者... 详细信息

目的分析Dialog vario嵌体修复和e-max铸瓷嵌体用于牙邻面牙体缺损治疗的效果差异。方法选择在该院接受治疗的牙邻面牙体缺损患者作为研究对象,随机分为接受e-max铸瓷嵌体修复的对照组、接受Dialog vario嵌体修复的观察组,比较两组患者的嵌体临床评价、咀嚼功能和牙龈情况及龈沟液炎症因子水平等差异。结果观察组患者接受Dialog vario嵌体修复后的边缘密合度、修复完整性等级高于对照组,继发龋比例低于对照组患(P<0.05)。观察组患者接受Dialog vario嵌体修复牙邻面牙体缺损后,咬合力及咀嚼效率评分明显高于对照组,牙龈指数、出血指数及菌斑指数评分显著低于对照组患者(P<0.05)。观察组患者接受Dialog vario嵌体修复治疗后,龈沟液中IL-6、IL-8及TNF-α水平均显著低于对照组患者(P<0.05)。结论Dialog vario嵌体是一种良好的牙体缺损修复材料,可以提升修复质量并减少牙龈炎症反应。

关键词：牙体缺损 Dialog vario e-max 嵌体

EZH2-dependent myelination following sciatic nerve injury

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Neural Regeneration Research 2025年第8期20卷 2382-2394页

作者： Hui Zhu Li Mu Xi xu Tianyi Huang ying Wang Siyuan xu Yiting Wang Wencong Wang Zhiping Wang Hongkui Wang Chengbin xue Research Center of Clinical Medicine Affiliated Hospital of Nantong UniversityKey Laboratory of Neuroregeneration of Jiangsu and Ministry of EducationCo-innovation Center of NeuroregenerationNMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology ProductsNantong UniversityNantongJiangsu ProvinceChina Medical School of Nantong University NantongJiangsu ProvinceChina Department of Neurology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Department of Rehabilitation Medicine Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Department of Critical Care Medicine Nantong Fourth People’s HospitalNantongJiangsu ProvinceChina

Demyelination and remyelination have been major focal points in the study of peripheral nerve regeneration following peripheral nerve ***,the gene regulatory network of regenerated myelin differs from that of native *** of enhancer of zeste homolog 2(EZH2)hinders the differentiation,maturation,and myelination of Schwann cells in *** further determine the role of EZH2 in myelination and recovery post-peripheral nerve injury,conditional knockout mice lacking Ezh2 in Schwann cells(Ezh2^(fl/fl);Dhh-Cre and Ezh2^(fl/fl);Mpz-Cre)were *** results show that a significant proportion of axons in the sciatic nerve of Ezh2-depleted mice remain *** highlights the crucial role of Ezh2 in initiating Schwann cell ***,we observed that 21 days after inducing a sciatic nerve crush injury in these mice,most axons had remyelinated at the injury site in the control nerve,while Ezh2^(fl/fl);Mpz-Cre mice had significantly fewer remyelinated axons compared with their wild-type *** suggests that the absence of Ezh2 in Schwann cells impairs myelin formation and *** conclusion,EZH2 has emerged as a pivotal regulatory factor in the process of demyelination and myelin regeneration following peripheral nerve *** EZH2 activity during these processes may offer a promising therapeutic target for the treatment of peripheral nerve injuries.

关键词： demyelination EZH2 myelination peripheral nerve injury PRC2 remyelination Schwann cells sciatic nerve crush sciatic nerve transection

Recent Advances in Fibrous Materials for Hydroelectricity generation

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Nano-Micro Letters 2025年第2期17卷 109-133页

作者： Can ge Duo xu Xiao Feng Xing Yang Zheheng Song Yuhang Song Jingyu Chen yingcun Liu Chong Gao Yong Du Zhe Sun Weilin xu Jian Fang College of Textile and Clothing Engineering Soochow UniversitySuzhou 215123People’s Republic of China National Engineering Laboratory for Modern Silk Soochow UniversitySuzhou 215123People’s Republic of China State Key Laboratory of New Textile Materials and Advanced Processing Technologies Wuhan Textile UniversityWuhan 430200People’s Republic of China Institute of Functional Nano&Soft Materials(FUNSOM) Soochow UniversitySuzhou 215123People’s Republic of China Department of Electrical and Computer Engineering University of MassachusettsAmherstMA 01003USA Department of Materials Imperial College LondonSouth Kensington CampusLondon SW72AZUK College of Textile Science and Engineering Zhejiang Sci-Tech UniversityHangzhou 310018People’s Republic of China School of Materials Science and Engineering Shanghai Institute of Technology100 Haiquan RoadShanghai 201418People’s Republic of China

Depleting fossil energy sources and conventional polluting power generation pose a threat to sustainable *** generation from ubiquitous and spontaneous phase transitions between liquid and gaseous water has been considered a promising strategy for mitigating the energy *** materials with unique flexibility,processability,multifunctionality,and practicability have been widely applied for fibrous materials-based hydroelectricity generation(FHG).In this review,the power generation mechanisms,design principles,and electricity enhancement factors of FHG are first ***,the fabrication strategies and characteristics of varied constructions including 1D fiber,1D yarn,2D fabric,2D membrane,3D fibrous framework,and 3D fibrous gel are ***,the advanced functions of FHG during water harvesting,proton dissociation,ion separation,and charge accumulation processes are analyzed in ***,the potential applications including power supply,energy storage,electrical sensor,and information expression are also ***,some existing challenges are considered and prospects for future development are sincerely proposed.

关键词： Hydroelectricity Fibrous material Streaming potential Ion diffusion

Observation of topological charge transformations in acoustic vortex using passive periodic systems

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 140-147页

作者： Di-Chao Chen Xie Liu Changqing xu Da-Jian Wu ying Cheng Xiao-Jun Liu School of Physics and Technology Nanjing Normal University Key Laboratory of Modern Acoustics School of Physics Nanjing University

Vortex transmutation utilizes a periodic system, which not only enables the alteration of the topological charge(TC) of unstable input vortices but also facilitates their transformation into stable structures. This approach is crucial for investigating the characteristics of vortices in various wave systems. Here, we achieve acoustic vortex TC transmutation by employing a welldesigned dual-structured plate external system(DPES). The interactions between the acoustic vortex and the finite-order discrete rotational symmetry lead to the transformation of its topological charge when complete rotational symmetry is broken to Nthorder discrete symmetry. Our results experimentally demonstrate the acoustic vortex TC transmutation based on passive artificial structures, enabling numerous applications in particle manipulation and information multiplexing as well as advancing our understanding and control over free-space acoustic vortices.

关键词： acoustic vortex topological charge transformation artificial structure