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Use of First-phase Insulin Secretion in Early Diagnosis of Thyroid Diabetes and Type 2 Diabetes Mellitus

Chinese Medical Journal 2017年第7期130卷 798-804页

作者： Li-Heng Meng Yao Huang Jia Zhou Xing-Huan Liang Jing Xian Li Li ying-fen qin Department of Endocrine The First Affiliated Hospital of Guangxi Medical University Nanning Guangxi 530021 China

Background：A relationship between hyperthyroidism and insulin secretion in type 2 diabetes mellitus （T2DM） has been ***,this study explored the use of first-phase insulin secretion in the differential diagnosis of thyroid diabetes （TDM） and ***：In total,101 patients with hyperthyroidism were divided into hyperthyroidism with normal glucose tolerance （TNGT）,hyperthyroidism with impaired glucose regulation （TIGR）,and diabetes （TDM） ***,96 patients without hyperthyroidism were recruited as control groups （normal glucose tolerance [NGT],impaired glucose regulation [IGR],and T2DM）.The following parameters were evaluated：homeostasis model assessment （HOMA）-IR,HOMA-β,modified β-cell function index （MBCI）,peak insulin/fasting insulin （IP/I0）,AUCins-OGTT,and AUCins-OGTr/AUCglu-OGTT from the oral glucose tolerance test （OGTT） insulin release test were utilized to assess the second-phase insulin secretion,while the IP/I0,AIR0＇-10＇,and AUCins-IVGTT from the intravenous glucose tolerance test （IVGTT） insulin release test were used to assess the first-phase insulin ***：In the OGTT,the HOMA-β values of the TNGT and TDM groups were higher than those of the NGT and T2DM groups （all P 〈 0.05）.In the hyperthyroidism groups,the MBCI of the TDM group was lower than that of the TNGT and TIGR groups （all P 〈 0.05）.Among the control groups,the MBCI values of the IGR and T2DM groups were lower than that of the normal glucose tolerance （NGT） group （all P 〈 0.05）.In the IVGTT,insulin secretion peaked for all groups at 2-4 min,except for the T2DM group,which showed a low plateau and no secretion *** IPvalues of the TNGT,TIGR,and TDM groups were higher than those of the NGT,IGR,and T2DM groups （all P 〈 0.05）.The IP/I0,AIR0＇-10＇,and AUCins-IVGTT values of the TDM group were higher than those of the T2DM group but were lower than those of the TNGT,TIGR,NGR,and IGR groups （all P 〈 0.05）.Compared with the other five groups,the IP/I0 AIR0＇-10

关键词： Diabetes Mellitus First-phase Insulin Secretion: Intravenous Glucose: Oral Glucose: Thyroid Diabetes

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Stretchable and self-healing conductive fibers from hierarchical silver nanowires-assembled network

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Nano Research 2024年第2期17卷 763-770页

作者： ying-ying Wu Hong Chen Fan Zhang Pan Guo Haili qin Huai-Ping Cong Anhui Province Key Laboratory of Advanced Catalytic Materials and Reaction Engineering School of Chemistry and Chemical EngineeringHefei University of TechnologyHefei 230009China

Conductive fibers(CFs)with features of high conductivity,stretchability,self-healability,and electromechanical stability are key components of the increasingly popular wearable ***,since the lack of structural design of conductive network and interfacial interaction between soft polymer and conductive additives,it is still hard to enable CFs to meet above ***,we describe a facial drawing method from a hydrogel reservoir which is remolded into ultrathin and stretchable CFs with excellent multi-responsive *** hydrogel reservoir was fabricated in synergy of an ice-templating method and in situ polymerization using the assembled framework as a *** on the effective fabrication mechanism,the diameter of CFs could be well-tuned from 90 to 400μm by adjusting the dipping depth of the glass rod,accompanied with conductivity increased from 0.75 to 2.5 S/*** the hierarchical network structure was well maintained in the CFs,professional performances have been proved on the stretchability and electromechanical *** presence of massive hydrogen bonding and Ag–S bond enabled the CFs with excellent self-healability under the conditions of contact,electric field,and near infrared light,***,the CFs with high sensing property could be integrated into an advanced textile sensor through an effective healing-induced integration strategy,demonstrating its great potentials as superior two-dimensional(2D)electronic skins.

关键词： conductive fibers self-assembled silver nanowires Ag–S coordination self-healing flexible sensors

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Microstructure and mechanical properties of Ti/Al/Ti clad plates prepared via powder-in-tube method

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Journal of Iron and Steel Research International 2024年第3期31卷 670-687页

作者： Xian-lei Hu qin-cheng Xie Yi Yuan ying Zhi State Key Laboratory of Rolling and Automation Northeastern UniversityShenyang 110819LiaoningChina Suzhou Dongbao Haixing Metal Material Technology Co. Ltd.Suzhou 215600JiangsuChina School of Material Science and Engineering Northeastern UniversityShenyang 110819LiaoningChina

The Ti/Al/Ti clad plates exhibit a broad spectrum of potential ***,the conventional techniques of hot-pressing composite and explosive composite are intricate and environmentally hazardous.A novel method was introduced for preparing clad plates,namely,the powder-in-tube *** method involves a combination of cold rolling,annealing at a temperature of 550℃,and double *** morphology of the intermetallic compound layer was analyzed through the utilization of interface stripping test,tensile test,and microscopic *** interface morphology,interface bonding properties,tensile fracture structures,and properties of plates under the first and second rolling were compared,along with the effects of intermetallic compounds on the interface *** results indicate that the powder-in-tube method,when annealed at 550℃,can produce a composite plate featuring a complete and uniform Ti/Al *** obtained plate exhibits a peeling strength of 21.5 N/mm,tensile strength of 424 MPa,and elongation of 11.5%.Furthermore,a systematic analysis was conducted to determine the causes of performance degra-dation observed during annealing at temperatures of 600 and 650℃.

关键词： Powder-in-tube method-Ti/Al/Ti clad plate Annealing Cold rolling-Mechanical property

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Clinical prediction of insufficient vaults after implantable collamer lens implantation

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International Journal of Ophthalmology(English edition) 2024年第7期17卷 1300-1306页

作者： Jun Zhu Dan Cheng Xue-ying Zhu fen-fen Li Ye Yang Yu-feng Ye National Clinical Research Center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina

AIM:To determine the factors related to preoperative ocular characters that are predictive of insufficient vault(<250μm)after implantable collamer lens(ICL V4c;STAAR Surgical)***:The participants underwent ICL surgery and were divided into the low(<250μm)and normal(250-1000μm)vault groups based on the postoperative vault at *** preoperative biometric parameters and clinical outcomes were compared between the two *** relationship between the 3-month vault values and preoperative ocular parameters were evaluated by Generalized estimating ***:Sixteen(23 eyes)and 36 patients(63 eyes)were in the low and normal vault groups,*** implantation procedures were uneventful with no cataract formation in the early postoperative *** sulcusto-sulcus lens rise(STSL)and iris ciliary angle(ICA)were correlated with vault at 3mo after *** 0.1 mm increase in STSL was associated with 38.9μm decrease in the postoperative 3-month vault.A rise of 1 degree in ICA is associated with a reduction of 4μm in ***:Eyes with a narrow ciliary sulcus are associated with a higher rate of low vault after ICL implantation,suggesting a need for adjustments to the ICL size in these *** the characteristics of the ciliary sulcus contributes valuable information to predict low vault after surgery.

关键词： insufficient vault implantable collamer lens ciliary body posterior chamber

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Alkyl dimethyl betaine activates the low-temperature collection capacity of sodium oleate for scheelite

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International Journal of Minerals,Metallurgy and Materials 2024年第1期31卷 71-80页

作者： Xu Wang Zhengquan Zhang Yanfang Cui Wei Li Congren Yang Hao Song Wenqing qin fen Jiao School of Minerals Processing and Bioengineering Central South UniversityChangsha 410083China Key Laboratory of Hunan Province for Clean and Efficient Utilization of Strategic Calcium-containing Mineral Resources Central South UniversityChangsha 410083China College of Engineering Drexel UniversityPhiladelphiaPA 19102USA Luoyang Zhenbei Industry and Trade Co. Ltd.Luoyang 47100China

The impact of alkyl dimethyl betaine (ADB) on the collection capacity of sodium oleate (NaOl) at low temperatures was evaluated using flotation tests at various scales. The low-temperature synergistic mechanism of ADB and NaOl was explored by infrared spectroscopy, X-ray photoelectron spectroscopy, surface tension measurement, foam performance test, and flotation reagent size *** flotation tests revealed that the collector mixed with octadecyl dimethyl betaine (ODB) and NaOl in a mass ratio of 4:96 exhibited the highest collection capacity. The combined collector could increase the scheelite recovery by 3.48% at low temperatures of 8–12℃. This is particularly relevant in the Luanchuan area, which has the largest scheelite concentrate output in China. The results confirmed that ODB enhanced the collection capability of NaOl by improving the dispersion and foaming performance. Betaine can be introduced as an additive to NaOl to improve the recovery of scheelite at low temperatures.

关键词： scheelite betaine low temperature synergistic effect dispersion foamability

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Resolution Enhancement of SOHO/MDI Magnetograms

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Research in Astronomy and Astrophysics 2024年第6期24卷 358-367页

作者： ying qin Kai-Fan Ji Hui Liu Xiao-Guang Yu Yunnan Observatories Chinese Academy of SciencesKunming 650011China University of Chinese Academy of Sciences Beijing 100049China Yunnan Key Laboratory of Solar Physics and Space Science Kunming 650216China Key Laboratory for the Structure and Evolution of Celestial Objects Chinese Academy of SciencesKunming 650216China

Research on the solar magnetic field and its effects on solar dynamo mechanisms and space weather events has benefited from the continual improvements in instrument resolution and measurement *** augmentation and assimilation of historical observational data timelines also play a significant role in understanding the patterns of solar magnetic field *** the realm of astronomical data processing,super-resolution(SR)reconstruction refers to the process of using a substantial corpus of training data to learn the nonlinear mapping between low-resolution(LR)and high-resolution(HR)images,thereby achieving higherresolution astronomical *** paper is an application study in high-dimensional nonlinear *** learning models were employed to perform SR modeling on SOHO/MDI magnetograms and SDO/HMI magnetograms,thus reliably achieving resolution enhancement of full-disk SOHO/MDI magnetograms and enhancing the image resolution to obtain more detailed *** this study,a data set comprising 9717pairs of data from 2010 April to 2011 February was used as the training set,1332 pairs from 2011 March were used as the validation set and 1034 pairs from 2011 April were used as the test *** data preprocessing,we randomly cropped 128×128 sub-images as the LR cases from the full-disk MDI magnetograms,and the corresponding 512×512 sub-images as HR ones from the HMI full-disk magnetograms for model *** tests conducted have shown that the study successfully produced reliable 4×SR reconstruction of full-disk MDI *** MESR model's results(0.911)were highly correlated with the target HMI magnetographs as indicated by the correlation coefficient ***,the method achieved the best PSNR,SSIM,MAE and RMSE values,indicating that the MESR model can effectively reconstruct magnetograms.

关键词： magnetic fields techniques:image processing virtual observatory tools Sun:magnetic fields

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LRP6 Bidirectionally Regulates Insulin Sensitivity through Insulin Receptor and S6K Signaling in Rats with CG-IUGR

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Current Medical Science 2023年第2期43卷 274-283页

作者： Xue-mei XIE Qiu-li CAO Yu-jie SUN Jie ZHANG Kai-li LIU ying-fen qin Wen-jun LONG Zuo-jie LUO Xiao-wei LI Xing-huan LIANG Guan-dou YUAN Xiao-ping LUO Xiu-ping XUAN Department of Endocrinology the First Affiliated Hospital of Guangxi Medical UniversityNanning530021China Department of Pediatrics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Division of Hepatobiliary Surgery the First Affiliated Hospital of Guangxi Medical UniversityNanning530021China

Objective Intrauterine growth restriction followed by postnatal catch-up growth(CG-IUGR)increases the risk of insulin resistance-related ***-density lipoprotein receptor-related protein 6(LRP6)plays a substantial role in glucose ***,whether LRP6 is involved in the insulin resistance of CG-IUGR is *** study aimed to explore the role of LRP6 in insulin signaling in response to *** The CG-IUGR rat model was established via a maternal gestational nutritional restriction followed by postnatal litter size *** mRNA and protein expression of the components in the insulin pathway,LRP6/β-catenin and mammalian target of rapamycin(mTOR)/S6 kinase(S6K)signaling,was *** tissues were immunostained for the expression of LRP6 andβ-***6 was overexpressed or silenced in primary hepatocytes to explore its role in insulin *** Compared with the control rats,CG-IUGR rats showed higher homeostasis model assessment for insulin resistance(HOMA-IR)index and fasting insulin level,decreased insulin signaling,reduced mTOR/S6K/insulin receptor substrate-1(IRS-1)serine307 activity,and decreased LRP6/β-catenin in the liver *** knockdown of LRP6 in hepatocytes from appropriate-for-gestational-age(AGA)rats led to reductions in insulin receptor(IR)signaling and mTOR/S6K/IRS-1 serine307 *** contrast,LRP6 overexpression in hepatocytes of CG-IUGR rats resulted in elevated IR signaling and mTOR/S6K/IRS-1 serine307 *** LRP6 regulated the insulin signaling in the CG-IUGR rats via two distinct pathways,IR and mTOR-S6K ***6 may be a potential therapeutic target for insulin resistance in CG-IUGR individuals.

关键词： intrauterine growth restriction followed by postnatal catch-up growth insulin signaling lipoprotein receptor-related protein 6 Wnt signaling mammalian target of rapamycin/S6 kinase signaling

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Efficacy and Safety of Sanjie Analgesic Capsule in Patients with Endometriosis-Associated Pain:A Multicenter,3:1 Randomized,Double-Blind,Placebo-Controlled Trial

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Chinese Journal of Integrative Medicine 2024年第9期30卷 780-787页

作者： LENG Jin-hua DUAN Hua GUAN Zheng ZHOU ying-fang QU Hong XU Kai-hong ZHANG Shao-fen ZHANG qin WANG Xin LIN Kai-qing LANG Jing-he Department of Obstetrics and Gynecology Peking Union Medical College HospitalBeijing100730China Department of Gynecology Beijing Obstetrics and Gynecology HospitalCapital Medical UniversityBeijing100006China Department of Gynecology Chinese PLA General HospitalBeijing100039China Department of Gynecology Peking University First HospitalBeijing100034China Department of Gynecology Beijing Chao-yang HospitalBeijing100020China Department of Gynecology Womens Hospital School of Medicine Zhejiang UniversityHangzhouZhejiang Province310006China Department of Gynecology Obstetrics and Gynecology Hospital of Fudan UniversityShanghai200090China Department of Gynecology Hangzhou Hospital of Traditional Chinese MedicineHangzhou310007China Department of Gynecology Affiliated Hospital of Liaoning University of Traditional Chinese MedicineShenyang110032China

Objective:To assess the efficacy and safety of Sanjie Analgesic Capsule(SAC)in Chinese patients with endometriosis-associated ***:This was a multicenter,randomized,double-blind,placebo-controlled trial conducted at 15 centers between November 2013 and July 2017 in *** 323 patients with endometriosis were randomized at a 3:1 ratio to the SAC group(241 cases)and placebo group(82 cases)by stratified block *** in the SAC or placebo groups were given SAC or placebo 1.6 g 3 times per day,orally,respectively since the first day of menstruation for 3 consecutive menstrual *** primary endpoint was clinical response to dysmenorrhea evaluated using a 10-point Visual Analogue Scale at 3 and 6 *** secondary endpoint was the pain score evaluated by VAS(chronic pelvic pain,defecation pain,and dyspareunia)at 3 and 6 months,and the pain recurrence rate at 6 *** events(AEs)were recorded during the ***:A total of 241 women were included in the SAC group,and 82 were in the placebo *** these women,217(90.0%)and 71(86.6%)completed the intervention,*** 3 months,overall response rate(ORR)was significantly higher in women administered SAC(80.1%)compared with those who received a placebo(30.5%,P<0.01).Six months after treatment,the ORR for dysmenorrhea was 62.7%in the SAC group and 31.7%in the placebo group(P<0.01).Chronic pelvic pain and defecation pain were significantly improved by SAC compared with placebo(both P<0.05).The incidence rates of total AEs events in the SAC and placebo groups were 6.6%and 9.8%,respectively,and no significant difference was shown between the two groups(P=0.339).Conclusion:SAC is well-tolerated and may improve dysmenorrhea in women with endometriosis-associated pain.

关键词： endometriosis pain Sanjie Analgesic Capsule randomized controlled trial Chinese medicine

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Journal of Genetics and Genomics in 2023:progresses and beyond

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Journal of Genetics and Genomics 2024年第1期51卷 1-2页

作者： Xiu-fen Song Xiaoxuan Guo Jing Zhao Yutian Zhang Yuan qin Jianru Zuo Journal of Genetics and Genomics Institute of Genetics and Developmental BiologyChinese Academy of Sciences&the Genetics Society of ChinaBeijing 100101China

Journal of Genetics and Genomics(JGG),launched in 1974,celebrates its 50th birthday in *** continuous support from our authors,reviewers,readers,and the editorial board,JGG has made remarkable progress in the past year by publishing 122 papers covering major disciplines in life sciences and medical genetics with exciting *** is worthwhile to note that we have recruited 66 young talents to join JGG as junior editors,resulting in significant improvement in manuscript evaluation and journal ***,we summarize major progresses reported in JGG in 2023 fromaneditorial view.

关键词： journal beyond promotion

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Low-energy-consumption temperature swing system for CO_(2) capture by combining passive radiative cooling and solar heating

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Green Energy & Environment 2024年第3期9卷 507-515页

作者： ying-Xi Dang Peng Tan Bin Hu Chen Gu Xiao-qin Liu Lin-Bing Sun State Key Laboratory of Materials-Oriented Chemical Engineering Jiangsu National Synergetic Innovation Center for Advanced Materials(SICAM)College of Chemical EngineeringNanjing Tech UniversityNanjing211816China

Temperature-swing adsorption(TSA)is an effective technique for CO_(2) capture,but the temperature swing procedure is ***,we report a low-energy-consumption system by combining passive radiative cooling and solar heating for the uptake of CO_(2) on commercial activated carbons(CACs).During adsorption,the adsorbents are coated with a layer of hierarchically porous poly(vinylidene fluoride-co-hexafluoropropene)[P(VdF-HFP)HP],which cools the adsorbents to a low temperature under sunlight through radiative *** desorption,CACs with broad absorption of the solar spectrum are exposed to light irradiation for *** heating and cooling processes are completely driven by solar *** tests under mimicked sunlight using the CACs show that the performance of this system is comparable to that of the traditional ***,under real sunlight irradiation,the adsorption capacity of the CACs can be well maintained after multiple *** present work may inspire the development of new temperature swing procedures with little energy consumption.

关键词： CO_(2)capture Solar heating Passive radiative cooling Temperature swing adsorption

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