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The Forecast and Regional Analysis of the Private Motor Vehicle Market in China

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Systems Science and Systems Engineering 1999年第4期9卷 120-130页

作者： fang Bi\|qi,\ zhou Yong,\ SUN Liu\|quan Institute of Applied Mathematics, Academia Sinica,Beijing 100080, China

This paper investigates the private motor vehicle market in China, which has been developed since 1984. Combined forecasting for the number of motor vechicles owned by individuals is made from several least squares regression equations and a Logistic model. Regional analysis is made on the data of the thirty areas by hierarchical cluster, revealing various types of the development of the regional markets.

关键词： regression Logistic model combined forecasting cluster motor vehicle

Design of the Feedback in Decision Support Systems

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Systems Science and Systems Engineering 1998年第4期8卷 425-431页

作者： zhou Hong fang Weiguo FENG Yuncheng(Beijing University of Aeronautics and Astronautics, Beijing, 100083, P.R.China)

Theoretical and practical aspects of the feedback designed for decision support systems(DSS) are studied in this paper. Two kinds of feedback concepts, the decision state feedback and thedecision simulation feedback, are introduced, and their implementation schemes are proposed as *** addition, the effects of the two kinds of feedback on the decision process are studied with ***, two examples are analyzed, concluding that the feedback can well improve the performanceand the effectiveness of decision making.

关键词： decision support system feedback decision process

Photoacoustic and magnetic resonance imaging-based gene and photothermal therapy using mesoporous nanoagents

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Bioactive Materials 2022年第3期7卷 157-167页

作者： Hao Huang Guotao Yuan ying Xu Yuan Gao Qiulian Mao Yin Zhang Lu Bai Weijie Li Anqing Wu Wentao Hu Yue Pan Guangming zhou State Key Laboratory of Radiation Medicine and Protection School of Radiation Medicine and ProtectionCollaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education InstitutionsSoochow UniversitySuzhou215123China Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Guangdong-Hong Kong Joint Laboratory for RNA MedicineMedical Research CenterSun Yat-Sen Memorial HospitalSun Yat-Sen UniversityGuangzhou510120PR China Department of Nutrition and Food Hygiene Soochow University of Public HealthSuzhou215123China

The integration of photothermal therapy(PTT)with gene therapy(GT)in a single nanoscale platform demonstrates great potential in cancer *** iron oxide nanoagents(PIONs)are widely used as magnetic nanoagents in the drug delivery field and also serve as a photothermal nanoagent for photothermal ***,the therapeutic efficacy of PIONs-mediated GT has not been *** long noncoding RNA(lncRNA)CRYBG3(LNC CRYBG3),a lncRNA induced by heavy ion irradiation in lung cancer cells,has been reported to directly bind to globular actin(G-actin)and cause degradation of cytoskeleton and blocking of cytokinesis,thus indicating its potential for use in GT by simulating the effect of heavy ion irradiation and functioning as an antitumor *** the present study,we investigated the possibility of combining PIONs-mediated PTT and LNC CRYBG3-mediated GT to destroy non-small cell lung cancer(NSCLC)cells both in vitro and in *** combination therapy showed a high cancer cell killing efficacy,and the cure rate was better than that achieved using PTT or GT ***,as a type of magnetic nanoagent,PIONs can be used for magnetic resonance imaging(MRI)and photoacoustic imaging(PAI)both in vitro and in *** findings indicate that the new combination therapy has high potential for cancer treatment.

关键词： Gene therapy(GT) Porous iron oxide nanoagents(PIONs) Photothermal therapy(PTT) Long noncoding RNA CRYBG3

Superior grains determined by grain weight are not fully correlated with the flowering order in rice

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Journal of Integrative Agriculture 2015年第5期14卷 847-855页

作者： PENG Ting L Qiang ZHAO Ya-fan SUN Hong-zheng HAN ying-chun DU Yan-xiu ZHANG Jing LI Jun-zhou WANG Lin-lin ZHAO Quan-zhi Collaborative Innovation Center of Henan Grain Crops Henan Agricultural University Research Center for Rice Engineering in Henan Province Henan Agricultural University College of Agronomy Henan University of Science and Technology

Rice panicles are composed of many branches with two types of extreme grains,the superior and the ***,it has been well accepted that earlier flowers result in superior grains and late flowers generate inferior ***,these correlations have never been strictly examined in *** order to determine the accurate relationship between superior and inferior grains and the flowering order,we localized all the seeds in a panicle in four distinct rice species and systematically documented the rice flowering order,flower locations and the final grain weight for their *** results demonstrated that the grain weight is more heavily determined by the position of the seeds than by the flowering *** earlier flowering has a positive correlation with the grain weight in general,grains from flowers blooming on the second day after anthesis generally gained the highest *** suggests earlier flowers may not result in superior ***,we concluded that superior and inferior grains,commonly determined by grain weight,are not fully correlated with the flowering order in *** the order of the grain weight,the superior grains are generally localized at the middle parts of the primary branches,whereas inferior grains were mainly on the last two secondary branches of the lower half part of the *** addition,the weight of inferior grains were affected by spikelet thinning and spraying with exogenous plant growth regulators,indicating that physiological incompetence might be the major reason for the occurrence of the inferior grains.

关键词： flowering grains panicle inferior branches physiological flowers exogenous filling thinning

甲巯咪唑治疗儿童甲状腺功能亢进症不良反应的观察

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中国当代儿科杂志 2022年第11期24卷 1252-1258页

作者：周娴辛颖中国医科大学附属盛京医院小儿内分泌遗传代谢内科辽宁沈阳110000

目的研究甲巯咪唑治疗儿童甲状腺功能亢进症(简称“甲亢”)不良反应发生情况。方法回顾性分析中国医科大学附属盛京医院2015年1月—2021年5月住院的304例甲亢患儿的临床资料。统计甲巯咪唑治疗相关不良反应的发生情况,探讨常见不良反应... 详细信息

目的研究甲巯咪唑治疗儿童甲状腺功能亢进症(简称“甲亢”)不良反应发生情况。方法回顾性分析中国医科大学附属盛京医院2015年1月—2021年5月住院的304例甲亢患儿的临床资料。统计甲巯咪唑治疗相关不良反应的发生情况,探讨常见不良反应的危险因素。结果304例患儿中,出现甲巯咪唑治疗相关不良反应87例(28.6%),其中男性20例(23%),女性67例(77%)。较常见的不良反应有粒细胞减少(12.8%)、皮疹(11.8%)、丙氨酸氨基转移酶升高(9.5%)及关节疼痛(3.0%),部分患儿可同时或间断出现多种不良反应。粒细胞减少主要出现在用药后3个月内(25/39,64%);丙氨酸氨基转移酶升高主要发生在用药后1个月内(17/29,59%);皮疹主要发生在用药后3个月内(30/36,83%)。对症治疗后上述不良反应大部分可恢复正常。多因素logistic回归分析显示,年龄小、治疗前中性粒细胞绝对计数低是甲巯咪唑治疗后粒细胞减少的危险因素(P<0.05)。结论甲巯咪唑治疗儿童甲亢不良反应较常见,多发生在用药后3个月内,多数经过对症治疗可缓解。年龄越小,中性粒细胞绝对计数基线值越低,越容易发生粒细胞减少。

关键词：甲状腺功能亢进症甲巯咪唑不良反应儿童

Survivors of COVID-19 exhibit altered amplitudes of low frequency fluctuation in the brain: a resting-state functional magnetic resonance imaging study at 1-year follow-up

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Neural Regeneration Research 2022年第7期17卷 1576-1581页

作者： Yan-Yao Du Wei Zhao Xiang-Lin zhou Mu Zeng Dan-Hui Yang Xing-Zhi Xie Si-Hong Huang ying-Jia Jiang Wen-Han Yang Hu Guo Hui Sun Ji-Yang Liu Ping Liu Zhi-Guo zhou Hong Luo Jun Liu Department of Radiology The Second Xiangya Hospital of Central South UniversityChangshaHunan ProvinceChina Department of Pulmonary and Critical Care Medicine The Second Xiangya Hospital of Central South UniversityChangshaHunan ProvinceChina Department of Respiratory Medicine The First Hospital of ChangshaChangshaHunan ProvinceChina Clinical Research Center for Medical Imaging in Hunan Province ChangshaHunan ProvinceChina Department of Radiology Quality Control Center Hunan ProvinceChangshaHunan ProvinceChina

Although some short-term follow-up studies have found that individuals recovering from coronavirus disease 2019(COVID-19)exhibit anxiety,depression,and altered brain microstructure,their long-term physical problems,neuropsychiatric sequelae,and changes in brain function remain *** observational cohort study collected 1-year follow-up data from 22 patients who had been hospitalized with COVID-19(8 males and 11 females,aged 54.2±8.7 years).Fatigue and myalgia were persistent symptoms at the 1-year *** resting state functional magnetic resonance imaging revealed that compared with 29 healthy controls(7 males and 18 females,aged 50.5±11.6 years),COVID-19 survivors had greatly increased amplitude of low-frequency fluctuation(ALFF)values in the left precentral gyrus,middle frontal gyrus,inferior frontal gyrus of operculum,inferior frontal gyrus of triangle,insula,hippocampus,parahippocampal gyrus,fusiform gyrus,postcentral gyrus,inferior parietal angular gyrus,supramarginal gyrus,angular gyrus,thalamus,middle temporal gyrus,inferior temporal gyrus,caudate,and *** values in the left caudate of the COVID-19 survivors were positively correlated with their Athens Insomnia Scale scores,and those in the left precentral gyrus were positively correlated with neutrophil count during *** long-term follow-up results suggest that the ALFF in brain regions related to mood and sleep regulation were altered in COVID-19 *** can help us understand the neurobiological mechanisms of COVID-19-related neuropsychiatric *** study was approved by the Ethics Committee of the Second Xiangya Hospital of Central South University(approval No.2020 S004)on March 19,2020.

关键词： amplitude of low-frequency fluctuation clinical study coronavirus disease 2019 follow-up functional magnetic resonance imaging long-term physical consequences neuropsychiatric sequelae resting‐state function

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聚吡咯复合织物的软模板法制备及其性能

纺织学报 2019年第12期40卷 93-97,103页

作者：陈莹周爽韦恬静方浩霞李宇菲北京服装学院材料设计与工程学院

为改善聚吡咯复合织物的导电性和疏水性,采用不同软模板制备聚吡咯复合棉及涤纶织物。借助扫描电子显微镜对聚吡咯复合材料的微观形貌进行表征,测试了聚吡咯/棉织物和聚吡咯/涤纶织物的表面电阻、电导率、接触角、K/S值、干摩擦等级以... 详细信息

为改善聚吡咯复合织物的导电性和疏水性,采用不同软模板制备聚吡咯复合棉及涤纶织物。借助扫描电子显微镜对聚吡咯复合材料的微观形貌进行表征,测试了聚吡咯/棉织物和聚吡咯/涤纶织物的表面电阻、电导率、接触角、K/S值、干摩擦等级以及断裂强力等性能变化。结果表明:制备聚吡咯/棉织物和聚吡咯/涤纶织物电导率最高的软模板均为蒽醌-2-磺酸钠盐,聚吡咯/棉织物电导率较大;棉织物以甲基橙为软模板,涤纶织物以木质素磺酸钠为软模板时疏水效果最好;棉织物以十二烷基苯磺酸钠和十六烷基三甲基溴化铵为软模板时耐摩擦等级效果最好,聚吡咯/涤纶织物的干摩擦等级均很低,需要进一步提高其耐摩擦性能。

关键词：聚吡咯软模板电导率接触角导电性能疏水性能涤纶织物棉织物

Synthesis, Luminescence and Electrochemical Properties of Two Phenothiazine Derivatives

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Chinese Journal of Chemistry 2005年第11期23卷 1483-1489页

作者： LI, Dong-Mei zhou, Hong-Ping PU, Ji-Qin FENG, Xiao-Juna WU, Jie-ying TIAN, Yu-Peng YU, Xiao-Qiang TAO, Xu-Tang JIANG, Min-Hua Department of Chemistry Anhui University Hefei Anhui 230039 China State Key Laboratory of Crystal Materials Shandong University Jinan Shandong 250100 China State Key Laboratory of Coordination Chemistry Nanfing University Nanfing Jiangsu 210093 China

The synthesis, luminescence and electrochemical properties of two novel phenothiazine derivatives were presented, which exhibit good one-photon fluorescence emission. The quantum yields and solvent effects of them were studied in detail. Compound 3,7-bis（2-4＇-imidazolylbenzylidenehydrazonoethyl）-（0-ethylphenothiazine）（5） was used as an effective initiator, of which two-photon fluorescence spectra were investigated under 800 nm fs laser pulse and the measured two-photon absorption cross-section was 18 × 10^-50 cm^4·s per photon. Two-photon initiated polymerization microfabrication experiments were carried out. X-ray diffraction analyses revealed that the shape of the compound 3,7-bis（2-pyrid-4＇-ylmethylidenehydrazonoethyl）-（0-ethylphenothiazine）（4） looks like a butterfly with nearly planar wings. The dihedral angle of the two benzene rings is 37.6° and there is an obvious π-π stacking interaction between the molecules in the crystal.

关键词： two-photon absorption two-photon initiated polymerization electrochemical property π-π stacking interaction

Genomic Epidemiology of Carbapenemaseproducing Klebsiella pneumoniae in China

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Genomics, Proteomics & Bioinformatics 2022年第6期20卷 1154-1167页

作者： Cuidan Li Xiaoyuan Jiang Tingting Yang yingjiao Ju Zhe Yin Liya Yue Guannan Ma Xuebing Wang ying Jing Xinhua Luo Shuangshuang Li Xue Yang Fei Chen Dongsheng zhou CAS Key Laboratory of Genome Sciences&Information Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and EpidemiologyBeijing 100071China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Pathogenesis Prevention and Treatment of High Incidence Diseases in Central AsiaUrumqi 830011China Beijing Key Laboratory of Genome and Precision Medicine Technologies Beijing 100101China

The rapid spread of carbapenemase-producing Klebsiella pneumoniae(cpKP)poses serious threats to public health;however,the underlying genetic basis for its dissemination is still *** conducted a comprehensive genomic epidemiology analysis on 420 cpKP isolates collected from 70 hospitals in 24 provinces/autonomous regions/municipalities of China during 2009–2017 by short-/long-read *** results showed that most cpKP isolates were categorized into clonal group 258(CG258),in which ST11 was the dominant *** analysis revealed three major clades including the top one of Clade 3 for CG258 cpKP ***,carbapenemase gene analysis indicated that blaKPC was dominant in the cpKP isolates,and most blaKPC genes were located in five major incompatibility(Inc)groups of blaKPC-harboring ***,three advantageous combinations of host–blaKPC-carrying plasmid(Clade 3.1+3.2–IncFIIpHN7A8,Clade 3.1+3.2–IncFIIpHN7A8:IncR,and Clade 3.3–IncFIIpHN7A8:IncpA1763-KPC)were identified to confer cpKP isolates the advantages in both genotypes(strong correlation/coevolution)and phenotypes(resistance/growth/competition)to facilitate the nationwide spread of ST11/CG258 ***,Bayesian skyline analysis illustrated that the three advantageous combinations might be directly associated with the strong population expansion during 2007–2008 and subsequent maintenance of the population of ST11/CG258 cpKP after *** then examined drug resistance profiles of these cpKP isolates and proposed combination treatment regimens for CG258/non-CG258 cpKP ***,the findings of our systematical analysis shed light on the molecular epidemiology and genetic basis for the dissemination of ST11/CG258 cpKP in China,and much emphasis should be given to the close monitoring of advantageous cpKP–plasmid combinations.

关键词： Klebsiella pneumoniae Drug resistance Carbapenemase Plasmid Genomic epidemiology