检索结果-南通市图书馆

Protein arginine methyltransferase-6 regulates heterogeneous nuclear ribonucleoprotein-F expression and is a potential target for the treatment of neuropathic pain

引用

Neural Regeneration Research 2025年第9期20卷 2682-2696页

作者： Xiaoyu Zhang Yuqi Liu fangxia Xu Chengcheng zhou Kaimei Lu Bin fang Lijuan Wang Lina Huang Zifeng Xu Department of Anesthesiology International Peace Maternity and Child Health HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of Anesthesiology Shanghai General HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Shanghai Key Laboratory of Embryo Original Diseases ShanghaiChina

Protein arginine methyltransferase-6 participates in a range of biological functions,particularly RNA processing,transcription,chromatin remodeling,and endosomal ***,it remains unclear whether protein arginine methyl transferase-6 modifies neuropathic pain and,if so,what the mechanisms of this *** this study,protein arginine methyltransferase-6 expression levels and its effect on neuropathic pain were investigated in the spared nerve injury model,chronic constriction injury model and bone cancer pain model,using immunohistochemistry,western blotting,immunoprecipitation,and label-free proteomic *** results showed that protein arginine methyltransferase-6 mostly co-localized withβ-tubulinⅢin the dorsal root ganglion,and that its expression decreased following spared nerve injury,chronic constriction injury and bone cancer *** addition,PRMT6 knockout(Prmt6~(-/-))mice exhibited pain ***,the development of spared nerve injury-induced hypersensitivity to mechanical pain was attenuated by blocking the decrease in protein arginine methyltransferase-6 ***,when protein arginine methyltransferase-6 expression was downregulated in the dorsal root ganglion in mice without spared nerve injury,increased levels of phosphorylated extracellular signal-regulated kinases were observed in the ipsilateral dorsal horn,and the response to mechanical stimuli was ***,protein arginine methyltransferase-6 appeared to contribute to spared nerve injury-induced neuropathic pain by regulating the expression of heterogeneous nuclear ***,protein arginine methyltransfe rase-6-mediated modulation of hete rogeneous nuclear ribonucleoprotein-F expression required amino atids 319 to 388,but not classical H3R2 *** findings indicated that protein arginine methyltransferase-6 is a potential therapeutic target fo r the treatment of peripheral neuro pathic pain.

关键词： dorsal root ganglion heterogeneous nuclear ribonucleoprotein F neuropathic pain protein arginine methyltransferase-6 sensory neurons

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Multi boron-doping effects in hard carbon toward enhanced sodium ion storage

引用

Journal of Energy Chemistry 2025年第1期100卷 730-738页

作者： Peng Zheng Wang zhou ying Mo Biao Zheng Miaomiao Han Qin Zhong Wenwen Yang Peng Gao Lezhi Yang Jilei Liu College of Materials Science and Engineering Hunan Joint International Laboratory of Advanced Materials and Technology for Clean Energy Hunan Province Key Laboratory for Advanced Carbon Materials and Applied Technology Hunan University Greater Bay Area Institute for Innovation Hunan University Changsha Research Institute of Mining & Metallurgy Co. LTD.

Hard carbon （HC） has been considered as promising anode material for sodium-ion batteries （SIBs）.The optimization of hard carbon’s microstructure and solid electrolyte interface （SEI） property are demonstrated effective in enhancing the Na+storage capability,however,a one-step regulation strategy to achieve simultaneous multi-scale structures optimization is highly ***,we have systematically investigated the effects of boron doping on hard carbon’s microstructure and interface chemistry.A variety of structure characterizations show that appropriate amount of boron doping can increase the size of closed pores via rearrangement of carbon layers with improved graphitization degree,which provides more Na+storage ***-situ Fourier transform infrared spectroscopy/electrochemical impedance spectroscopy （FTIR/EIS） and X-ray photoelectron spectroscopy （XPS） analysis demonstrate the presence of more BC3and less B–C–O structures that result in enhanced ion diffusion kinetics and the formation of inorganic rich and robust SEI,which leads to facilitated charge transfer and excellent rate *** a result,the hard carbon anode with optimized boron doping content exhibits enhanced rate and cycling *** general,this work unravels the critical role of boron doping in optimizing the pore structure,interface chemistry and diffusion kinetics of hard carbon,which enables rational design of sodium-ion battery anode with enhanced Na+storage performance.

关键词： X ray photoelectron spectroscopy

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

朱祥麟研究——以宣统《镇海虹桥朱氏重修族谱》为中心

引用

宁波大学学报（人文科学版） 2014年第4期27卷 67-72页

作者：应芳舟宁波市天一阁博物馆浙江宁波315010

通过宁波市镇海区档案馆藏宣统《镇海虹桥朱氏重修族谱》所载朱祥麟史料,并结合光绪年间地方志,考订其生卒年代、军旅活动,以及家族、婚育和封赠等情况,纠正一些流行已久的误说。通过对朱祥麟的研究,丰富我们对其次子、宁波帮代表人物... 详细信息

通过宁波市镇海区档案馆藏宣统《镇海虹桥朱氏重修族谱》所载朱祥麟史料,并结合光绪年间地方志,考订其生卒年代、军旅活动,以及家族、婚育和封赠等情况,纠正一些流行已久的误说。通过对朱祥麟的研究,丰富我们对其次子、宁波帮代表人物朱葆三的家庭出身、赴上海学艺背景和家族封赠等方面认识。

关键词：朱祥麟《镇海虹桥朱氏重修族谱》朱葆三定海宁波帮

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

朱葆三慈善事业述论

引用

浙江海洋学院学报（人文科学版） 2008年第1期25卷 43-49页

作者：应芳舟天一阁博物馆浙江宁波315010

朱葆三是清末民初著名实业慈善家。面对多灾多难的近代中国,作为一名民族资产阶级人士,朱葆三表现出了较强的救世济民的社会责任感,对当时的政治、经济、社会活动都产生过重要影响。他对当时上海、宁波经济发展、社会慈善组织良性运作... 详细信息

朱葆三是清末民初著名实业慈善家。面对多灾多难的近代中国,作为一名民族资产阶级人士,朱葆三表现出了较强的救世济民的社会责任感,对当时的政治、经济、社会活动都产生过重要影响。他对当时上海、宁波经济发展、社会慈善组织良性运作、教育近代化等功不可没。

关键词：朱葆三宁波帮民族资产阶级慈善事业

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

向道深致朱彬绳书札中的朱葆三史料考释

引用

宁波大学学报（人文科学版） 2019年第1期32卷 79-87页

作者：应芳舟宁波市天一阁博物馆浙江宁波315010

通过对近年公开的向道深致朱彬绳书札中的朱葆三史料进行逐一解读,把朱葆三置于特定的时代背景,立足书札包含的史料信息,辅以方志、家谱、年谱、报刊等文献,分析信札的书写年代以及这期间他的社会交际、与宗族成员之间的关系。

关键词：朱葆三朱彬绳向道深书札宁波帮

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

上海“朱葆三路”考——以地方志为中心

引用

宁波职业技术学院学报 2010年第1期14卷 54-59页

作者：应芳舟宁波市天一阁博物馆浙江宁波315010

通过翻检新修地方志,考证得出位于近代上海法租界内的朱葆三路曾经历过命名——改名——复名——再改名等阶段,首度命名始于1922年,中止时间为1943年10月9日。大约从抗战胜利初期至20世纪50年代又被复名使用,总计使用时间30年左右。

关键词：朱葆三路朱葆三宁波帮上海法租界方志

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Evidence-based assessment of acupuncture skills using a newly developed simulation-based test:A validation study

引用

World Journal of Acupuncture-Moxibustion 2022年第4期32卷 298-304页

作者： Su-jun XIE Zheng WANG ying-fang zhou Lars KONGE Lai-siqi WAN Xi-jun CAO Xing WAN Yun HU fang fang Kang-bai HUANG Liang ZHANG Xun ZHUANG Guangzhou University of Chinese Medicine Guangzhou 510006China Guangdong Academy for Medical Simulation(GAMS) Guangzhou 510620China The Third Affiliated Hospital of Guangzhou Medical University Guangzhou 510150China Copenhagen Academy for Medical Education and Simulation(CAMES) University of CopenhagenCopenhagen DK 2100Denmark The Second Affiliated Hospital of Guangzhou University of Chinese Medicine Guangzhou 510120China Sir Run Run Hospital Nanjing Medical UniversityNanjing 211000China The First Affiliated Hospital of Guangzhou University of Chinese Medicine Guangzhou 510405China

Objective:Acupuncture is an efficient treatment modality for many different training,but the technique can be challenging to *** of the different acupuncture points can now be practiced in a standardized and patient-safe simulation-based *** aim to gather additional evidence regarding simulation-based training of acupuncture skills and hope that the simulation-based test developed and will be used for simulation-based mastery learning in future ***:The aim of this study was to develop a test of acupuncture skills using the TCM(Traditional Chinese Medicine) Meridians & Acupoints Anatomy Teaching Platform and gather validity evidence using Messick’s *** medical students without prior experience in acupuncture(n=43),intermediate medical students who had finished the mandatory acupuncture course(n=24),and skilled acupuncture doctors(n=17) were included in the ***-hundred and seven acupuncture points were presented to the participants in identical randomized order and they were asked to identify each point by touching the correct anatomical location on the *** simulator automatically registered the accuracy of participants’ ***:The reliability of the final test(66 acupuncture points) was at a high level with a Cronbach’s alpha of 0.98 and only 16 acupuncture points were needed to ensure a reliability of *** test could discriminate significantly between all three groups and a credible pass/fail-score of 34 points was determined which resulted in eight out of 43(19%) novices passing the test and only two out of 17(12%)experienced failing the *** consequences were statistically significant(P <0.001).Conclusion:Based on Messick’s framework we demonstrated strong validity evidence for a newly developed simulation-based test of acupuncture points localization *** test can be used as an aid to decide when trainees are ready to progress to more advanced training and clinical prac

关键词： Acupuncture Simulation Assessment Validity Mastery learning

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Dietary carbohydrate intake and risk of type 2 diabetes:a 16-year prospective cohort study

引用

Science China Life Sciences 2025年

作者： Lu Gan Yi Yang Bin Zhao Kai Yu Kehua Guo fang fang Zhiguang zhou Demetrius Albanes Jiaqi Huang Key Laboratory of Diabetes Immunology Ministry of Education and Department of Metabolism and Endocrinology The Second Xiangya Hospital of Central South University CSU-Sinocare Research Center for Nutrition and Metabolic Health Xiangya School of Public Health Central South UniversityFurong Laboratory Division of Cancer Epidemiology and Genetics National Cancer Institute NIH Department of Health and Human Services School of Computer Science and Engineering Central South University Institute of Environmental Medicine Karolinska Institute National Clinical Research Center for Metabolic Diseases Key Laboratory of Diabetes Immunology Ministry of Education and Department of Metabolism and Endocrinology The Second Xiangya Hospital of Central South University

Despite considerable research underscoring the importance of carbohydrate intake in relation to the risk of type 2 diabetes(T2D), a comprehensive assessment of this relationship is currently lacking. We aimed to examine the associations of various types and food sources of dietary carbohydrate intake with the risk of T2D, to evaluate potential effect modification by other factors, including genetic susceptibility,and to explore the potential mediators for such associations. The present study included 161,872 participants of the UK Biobank who were free of prevalent cancer, cardiovascular disease, or diabetes, and had at least one validated 24-h dietary recall assessment. Multivariableadjusted age-stratified Cox proportional hazard regression models were applied to estimate hazard ratios(HRs) and 95% confidence intervals(CI) for the associations of various types and food sources of dietary carbohydrate intake with risk of T2D. During a median follow-up of13.6 years, 4,176 incident cases of T2D were identified. In the multivariable-adjusted models, a greater intake of fiber, carbohydrates from whole grains, and carbohydrates from non-starchy vegetables was significantly associated with a lower risk of T2D(highest vs. lowest quantile, HR [95% CI]=0.70 [0.62–0.79], 0.74 [0.67–0.82], and 0.83 [0.75–0.92], respectively, all P for trend <0.005). In contrast, a higher intake of starch and carbohydrate from starchy vegetables was associated with an increased risk of T2D(highest vs. lowest quantile, HR [95%CI]=1.31 [1.16–1.48] and 1.19 [1.09–1.31], respectively, both P for trend <0.005). Replacing one serving of refined grains or starchy vegetables with an equal amount of whole grains or non-starchy vegetables was associated with 4% to 10% lower risk of T2D(all P values <0.001).The observed associations were generally similar across population subgroups, including individuals with different genetic susceptibility to T2D. Mediation analyses of the inverse association between T

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Aligning enhanced feature representation for generalized zero-shot learning

引用

Science China(Information Sciences) 2025年

作者： Zhiyu fang Xiaobin ZHU Chun YANG Hongyang zhou Jingyan QIN Xucheng YIN School of Computer&Communication Engineering University of Science and Technology Beijing

Abstract Constructing an effective common latent embedding by aligning the latent spaces of cross-modal variational autoencoders （VAEs） is a popular strategy for generalized zero-shot learning （GZSL）.However,due to the lack of fine-grained instance-wise annotations,existing VAE methods can easily suffer from the posterior collapse *** this paper,we propose an innovative asymmetric VAE network by aligning enhanced feature representation （AEFR） for *** from general VAE structures,we designed two asymmetric encoders for visual and semantic observations and one decoder for visual ***,we propose a simple yet effective gated attention mechanism （GAM） in the visual encoder for enhancing the information interaction between observations and latent variables,alleviating the possible posterior collapse problem *** addition,we propose a novel distributional decoupling-based contrastive learning （D2-CL） to guide learning classification-relevant information while aligning the representations at the taxonomy level in the latent representation *** experiments on publicly available datasets demonstrate the state-of-the-art performance of our *** source code is available at https://***/seeyourmind/AEFR.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

舟山、宁波朱葆三文物遗存及保护、利用设想

引用

宁波职业技术学院学报 2008年第3期12卷 54-58页

作者：应芳舟宁波市天一阁博物馆浙江宁波315010

朱葆三作为舟山、宁波两市共有的宁波帮知名人士,而且时至今日在两地尚散布有一批珍贵文物遗存,因此两市可在保护文物资源、弘扬宁波帮精神的基础上,共同制定一项朱葆三文物遗存保护发展规划。舟山的朱葆三墓和宁波的朱葆三宅具有很好... 详细信息

朱葆三作为舟山、宁波两市共有的宁波帮知名人士,而且时至今日在两地尚散布有一批珍贵文物遗存,因此两市可在保护文物资源、弘扬宁波帮精神的基础上,共同制定一项朱葆三文物遗存保护发展规划。舟山的朱葆三墓和宁波的朱葆三宅具有很好的文物资源互补性。舟山、宁波两市今后在制定保护发展规划时,应做到功能差别、定位互补,并形成良好对接。

关键词：朱葆三舟山宁波文物设想纪念馆宁波帮

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：