检索结果-南通市图书馆

Modeling tactile perceived intensity for vibration from a coin eccentric rotating mass motor

Science China Technological Sciences 2025年

作者： Yun FANG Jingchen huang Yujun WU Jiaqi DONG Weichao GUO Xinjun SHENG State Key Laboratory of Mechanical System and Vibration School of Mechanical Engineering Shanghai Jiao Tong University Meta Robotics Institute Shanghai Jiao Tong University

Establishing the relationship between vibrotactile parameters and perceived intensity（PI） is of great significance in the regulation of desired sensations, which contribute to haptic interfaces in practical applications. Coin eccentric rotating mass（ERM） motors are routinely utilized due to their lightweight design and efficient ability to evoke strong tactile sensations. By adjusting input voltages, ERMs can yield different stimuli, but the effects of their physical properties on PI remain ***, we developed the physical model of the ERM-skin system and optimized the parameters affecting PI. Moreover, the relationship between stimulus and perception was derived based on Fechner?s law. Three experiments were conducted on fifteen subjects（ten males and five females, aged 24.40 ± 2.87 years） to identify the vibration parameters and corresponding PI to verify the proposed PI model. ERMs in this study were attached to phantom skin/forearm with slim adhesive tape to minimize the interference. Experiment 1 performed vibration calibration with ERM attached to the skin phantom to simulate the actual configuration. Then, the relative and absolute PI of subjects on specific stimuli were acquired in Experiments 2 and *** fitting reliability of the proposed PI model was evaluated on fifteen subjects with R2of 0.73 ± 0.07 and root mean squared error（RMSE） of 1.35 ± 0.28. Overall, the proposed PI model established the quantitative relationship between stimulus parameters（vibration parameters and physical parameters） and subjective PI, which provided theoretical support for ERM optimization and vibrotactile modulation.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Systematic Acupuncture Explains Acupuncture at Baihui(GV20) and Fengchi(GB20) Targeting the Inflammatory Response to Regulate Migraine

引用

Journal of Traditional Chinese Medicine 2025年

作者： MIN Yu ZHENG Meifeng SUN Ju PENG Zetong CAO Zhixian huang Xiaohua Medical College of Acu-Moxi and Rehabilitation， Guangzhou University of Chinese Medicine department of Rehabilitation Medicine， the Affiliated Panyu Central Hospital of Guangzhou Medical University

Objective: To take Baihui (GV20) and Fengchi (GB20) targeting inflammatory response to regulate migraine as an example to describe a new method for studying the mechanism of stimulating ***: The target information of Baihui (GV20) and Fengchi (GB20) was retrieved， and after intersection with migraine， Kyoto Encyclopedia of Genes and Genomes (KEGG)， Reactome， and UniProt Keywords were used for functional enrichment. After selecting the main pathway， rats were selected and nitroglycerin was used for modeling， and the behavioral scores， inflammatory factors， heme oxygenase 1 (HMOX1)， protein kinase B (AKT1)， signal transducer and activator of transcription 3 (STAT3)， phosphorylated extracellular signal-regulated kinase 1/2 (P-ERK1/ERK2) and other states of the rats in the acupuncture， twisting， and electroacupuncture groups were ***: A total of 135 Baihui (GV20) targets and 27 Fengchi (GB20) targets were collected. A total of 73 target information were obtained after the intersection of these targets in migraine. These 73 targets have three main pathways: hypoxia-inducible factor 1 (HIF-1) signaling pathway， signaling by interleukins and inflammatory response. The main targets in the pathway were verified and found that interleukin-1 beta (IL-1β)， interleukin-6 (IL-6)， tumor necrosis factor-alpha (TNF-α) and HMOX1， AKT1， STAT3， P-ERK1/ERK2 can be regulated by Baihui (GV20) and Fengchi (GB20).Conclusion: Baihui (GV20) and Fengchi (GB20) can regulate migraine by regulating inflammatory factors and HMOX1， AKT1， STAT3， P-ERK1/ERK2 and other changes in HIF-1 signaling pathway， Signaling by Interleukins and Inflammatory response pathways. Based on systems biology and network pharmacology， and with the model of "acupoint-target-disease"， explore the research methods of systematic acupuncture and moxibustion. We believe this is a usable research direction for exploring the mechanism of acupuncture stimulation.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

defining the biosynthesis of ketocarotenoids in Chromochloris zofingiensis

引用

Plant Diversity 2020年第1期42卷 61-66页

作者： ying Ye Jun-Chao huang department of Economic Plants and Biotechnology Yunnan Key Laboratory for Wild Plant ResourcesKunming Institute of BotanyChinese Academy of SciencesKunming650201People's Republic of China University of Chinese Academy of Sciences Beijing100049People's Republic of China

Carotenoids are important pigments in photosynthetic organisms where they play essential roles in photoreception and *** zofingiensis is a unicellular green alga that is able to accumulate high amounts of ketocarotenoids including astaxanthin,canthaxanthin and ketolutein when growing heterotrophically or mixotrophically with glucose as a carbon *** we elucidate the ketocarotenoid biosynthesis pathway in *** by analyzing five algal *** mutants were shown to have a single nucleotide insertion or substitution in β-carotene ketolase(BKT) gene 1,which resulted in a lack of ketocarotenoid production in Cz-bktl-1,and decreased ketocarote noid co ntent in the other four *** mutants accumulated much higher amounts of non-ketocarotenoids(β-carotene,zeaxanthin and lutein).Interestingly,the Cz-bktl-5 mutant synthesized 2-fold the ketolutein and only 1/30 of the canthaxanthin and astaxanthin as its parent strain,suggesting that the mutated BKT1 exhibits much higher activity in catalyzing lutein to ketolutein but lower activity in ketolating β-carotene and *** and WT BKT2 gene sequences did not *** together,we conclude that BKT1 is the key gene involved in ketocarotenoid biosynthesis in *** study provides insight into the biosynthesis of ketocarotenoids in green ***,Cz-bktl mutants may serve as a natural source for the production of zeaxanthin,lutein,and β-carotene.

关键词： Chromochloris zofingiensis Astaxanthin Ketocarotenoid β-carotene ketolase

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Perspectives on relativistic quantum chaos

引用

Communications in Theoretical Physics 2020年第4期72卷 112-137页

作者： Liang huang ying-Cheng Lai School of Physical Science and Technology and Key Laboratory for Magnetism and Magnetic Materials of MOELanzhou UniversityLanzhouGansu 730000China School of Electrical Computerand Energy EngineeringArizona State UniversityTempeAZ 85287United States of America department of Physics Arizona State UniversityTempeAZ 85287United States of America

Quantum Chaos has been investigated for about a half *** is an old yet vigorous interdisciplinary field with new concepts and interesting topics emerging *** years have witnessed a growing interest in quantum chaos in relativistic quantum systems,leading to the still developing field of relativistic quantum *** purpose of this paper is not to provide a thorough review of this area,but rather to outline the basics and introduce the key concepts and methods in a concise way.A few representative topics are discussed,which may help the readers to quickly grasp the essentials of relativistic quantum chaos.A brief overview of the general topics in quantum chaos has also been provided with rich references.

关键词： quantum chaos relativistic quantum systems Dirac billiards

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Microstructure evolution and formation mechanism of CoCrCu1.2FeNi high entropy alloy during the whole process of semi-solid billet preparation

引用

Journal of Materials Science & Technology 2022年第25期120卷 172-185页

作者： Jufu Jiang Minjie huang ying Wang yingze Liu ying Zhang School of Materials Science and Engineering Harbin Institute of TechnologyHarbin 150001China School of Mechatronics Engineering Harbin Institute of TechnologyHarbin 150001China

Dual face-centered cubic(FCC)CoCrCuFeNi semi-solid billets were prepared by semisolid isothermal treatment of wrought high entropy alloy(HEA)(SSITWH)method,and the microstructure evolution in the whole process of billets preparation was systematically investigated by optical microscopy,scanning electron microscopy,electron backscatter diffraction and transmission electron *** hot deformed feedstock was mainly composed of deformation structure with preferred orientations and a small number of dynamically recrystallized grains of FCC1 *** the semi-solid stage,the effect of temperature and soaking time on semi-solid microstructure was studied in the range of 1130-1250℃and 5-120 *** semi-solid microstructure was evaluated *** average grain size and average shape factor increased with the increase of soaking time and isothermal *** isothermal heat treatment,the segregation of Cu in FCCphase reduced to a certain ***-solid coarsening kinetics analysis showed that the alloy had low coarsening *** the temperatures were1130℃,1175℃,1200℃,1225℃and 1250℃,the coarsening coefficients were 1.08μm~3/s,5.95μm~3/s,6.17μm~3/s,17.58μm~3/s,38.67μm~3/s,respectively.A coarsening kinetic equation describing solid grain growth was *** heating up,FCCand FCCphase recrystallized *** higher temperature,FCCphase was spheroidized to a certain *** temperature was raised to semisolid range,the grains of FCCphase coalesced,grew up and spheroidized and the preferred orientations basically *** types of semi-solid melting characteristics of HEAs were summarized in this *** semi-solid melting behavior of alloys is essentially affected by phase structure,phase number,phase volume content and composition.

关键词： High entropy alloy Semi-solid billets Microstructure Grain coarsening Formation mechanism

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

deep learning identification of novel autophagic protein-protein interactions and experimental validation of Beclin 2-Ubiquilin 1 axis in triple-negative breast cancer

引用

Oncology research 2025年第1期33卷 67-81页

作者： Xiang Li Wenke Jin Lifeng Wu Huan Wang Xin Xie Wei huang B O Liu State Key Laboratory of Southwestern Chinese Medicine Resources School of Pharmacy and College of Medical Technology Chengdu University of Traditional Chinese Medicine Chengdu 611137 China. department of Biotherapy Cancer Center and State Key Laboratory of Biotherapy West China Hospital Sichuan University Chengdu 610041 China.

Background:Triple-negative breast cancer (TNBC), characterized by its lack of traditional hormone receptors and HER2, presents a significant challenge in oncology due to its poor response to conventional therapies. Autophagy is an important process for maintaining cellular homeostasis, and there are currently autophagy biomarkers that play an effective role in the clinical treatment of tumors. In contrast to targeting protein activity, intervention with protein-protein interaction (PPI) can avoid unrelated crosstalk and regulate the autophagy process with minimal interference pathways.Methods:Here, we employed Naive Bayes, decision Tree, and k-Nearest Neighbors to elucidate the complex PPI network associated with autophagy in TNBC, aiming to uncover novel therapeutic targets. Meanwhile, the candidate proteins interacting with Beclin 2 were initially screened in MDA-MB-231 cells using Beclin 2 as bait protein by immunoprecipitation-mass spectrometry assay, and the interaction relationship was verified by molecular docking and CO-IP experiments after intersection. Colony formation, cellular immunofluorescence, cell scratch and 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) tests were used to predict the clinical therapeutic effects of manipulating candidate PPI.Results:By developing three PPI classification models and analyzing over 13,000 datasets, we identified 3733 previously unknown autophagy-related PPIs. Our network analysis revealed the central role of Beclin 2 in autophagy regulation, uncovering its interactions with 39 newly identified proteins. Notably, the CO-IP studies identified the substantial interaction between Beclin 2 and Ubiquilin 1, which was anticipated by our model and discovered in immunoprecipitation-mass spectrometry assay results. Subsequently, investigations showed that overexpressing Beclin 2 increased Ubiquilin 1, promoted autophagy-dependent cell death, and inhibited proliferation and metastasis in MDA-MB-231 cells.

关键词： Artificial intelligence (AI) Autophagy Beclin 2 Protein-protein interactions (PPI) Triple-negative breast cancer (TNBC) Ubiquilin 1

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

基于反应气混合物的ICP-MS/MS测定原油中的钒和镍

引用

光谱学与光谱分析 2025年第1期45卷 101-106页

作者：蔡松韬黄莹秀袁亮代宇宣莫垚坤黄建华湖南工学院材料科学与工程学院湖南衡阳421002 湖南省中医药研究院中药研究所湖南长沙410013

原油中金属元素钒和镍(V和Ni)的含量和比值可为深入了解原油的沉积环境特征和有机质类型发挥重要作用。在原油炼制过程中,V和Ni作为原油催化裂化过程中的有害金属元素,会降低催化剂的活性,严重时会导致催化剂中毒,会严重腐蚀设备,在精... 详细信息

原油中金属元素钒和镍(V和Ni)的含量和比值可为深入了解原油的沉积环境特征和有机质类型发挥重要作用。在原油炼制过程中,V和Ni作为原油催化裂化过程中的有害金属元素,会降低催化剂的活性,严重时会导致催化剂中毒,会严重腐蚀设备,在精炼之前必须对原油中的V和Ni进行脱除处理。V和Ni具有致突变性和致癌性,识别或监测原油中V和Ni进入环境的潜在危险变得越来越重要,对原油中V和Ni的含量进行高灵敏精准测定具有重要意义。采用电感耦合等离子体串联质谱(ICP-MS/MS)测定原油中V和Ni的新策略。原油样品经航空煤油简单稀释后直接采用ICP-MS/MS进行分析,针对V和Ni受到的质谱干扰,在MS/MS模式下,采用由NH_(3)/He(He为缓冲气)和H_(2)组成的反应气混合物(NH_(3)/He/H_(2))作为反应气,基于V^(+)与NH_(3)/He/H_(2)不发生反应,而V^(+)的干扰离子与NH_(3)/He/H_(2)发生反应,采用原位质量法消除干扰,选择V^(+)进行测定;基于Ni^(+)与NH_(3)/He/H_(2)发生反应,采用质量转移法消除干扰,选择无干扰团簇离子Ni(NH_(3))_(3)^(+)进行测定。通过与NH_(3)/He反应模式进行对比研究发现,对于V的测定,加入H_(2)为反应气能快速去除氩基离子的干扰,并能协同NH_(3)消除氧化物离子的干扰;对于Ni的测定,加入H_(2)为反应气能促进全氢加合物(-NH_(3))的形成,从而提高生成Ni(NH_(3))_(3)^(+)的产率。在NH_(3)/He/H_(2)反应模式下,V和Ni的背景等效浓度(BEC)更低,Ni的灵敏度更高,V和Ni的检出限(LOD)分别低至0.83和3.76 ng·kg^(-1),定量限(LOQ)分别为2.77和12.5 ng·kg^(-1)。通过分析标准参考物质NIST SRM 1634c并进行加标回收实验评价方法的准确度和精密度,结果显示,方法的测定结果与标准参考物质的认证值基本一致,V和Ni的加标回收率分别为97.7%和103%,相对标准偏差(RSD)分别为1.8%和1.9%。所建立的分析方法避免了繁琐的样品预处理过程,具有操作简单快速、灵敏度高、准确度和精密度好的特点,适用于原油中V和Ni的检测,能为原油深加工中V和Ni的脱除提供理论依据。

关键词：原油电感耦合等离子体串联质谱钒(V) 镍(Ni) 氨气/氦气/氢气(NH_(3)/He/H_(2))

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Preparation and characterization of novel carbon molecular sieve membrane/PSSF composite by pyrolysis method for toluene adsorption

引用

Frontiers of Chemical Science and Engineering 2019年第4期13卷 772-783页

作者： ying Yan Peng huang Huiping Zhang School of Chemistry and Chemical Engineering Guangdong Provincial Key Laboratory of Green Chemical Product TechnologySouth China University of TechnologyGuangzhou 510640China School of Chemical Engineering and Analytical Science The University of ManchesterManchesterM139PLUK

Carbon molecular sieve membrane(CMSM)/paper-like stainless steel fibers(PSSF)has been manufactured by pyrolyzing poly(fiirfuryl alcohol)(PFA)coated on the metal *** was synthesized using oxalic acid dihydrate as a catalyst and coated on microfibers by dip coating *** the purpose of investigating the effects of final carbonization temperature,the composites were carbonized between 400℃ and 800℃ under flowing *** morphology and microstructure were examined by X-ray diffraction,Fourier transforms infrared spectroscopy,scanning electron microscopy,thermogravimetric analysis,N2 adsorption and desorption,Raman spectra and X-ray photoelectron *** consequences of characterization showed that the CMSM containing mesopores o f 3.9 nm were *** specific surface area of the CMSM/PSSF fabricated in different pyrolysis temperature varies from 26.5 to 169.1 m^2·g^-1 and pore volume varies from 0.06 to 0.23 cm^3·g^-*** pyrolysis temperature exceeds 600℃,the specific surface,pore diameter and pore volume decreased as carbonization temperature ***,the degree of graphitization in carbon matrix increased with rising pyrolysis *** adsorption experiments on different structured fixed bed that was padded by CMSM/PSSF and granular activated carbon(GAC)were *** the sake of comparison,adsorption test was also performed on fixed bed packed with *** experimental results indicated that the rate constant κ′ was dramatically increased as the proportion of CMCM/PSSF composites increased on the basis of Yoon-Nelson model,which suggested that structured fixed bed padded with CMSM/PSSF composite offered higher adsorption rate and mass transfer efficiency.

关键词： carbon molecular sieve membrane stainless steel fibers pyrolysis structured fixed bed toluene

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cooperative-Guided Ant Colony Optimization with Knowledge Learning for Job Shop Scheduling Problem

引用

Tsinghua Science and Technology 2024年第5期29卷 1283-1299页

作者： Wei Li Xiangfang Yan ying huang School of Information Engineering Jiangxi University of Science and TechnologyGanzhou 341000China School of Mathematics and Computer Science Gannan Normal UniversityGanzhou 341000China

With the advancement of the manufacturing industry,the investigation of the shop floor scheduling problem has gained increasing *** Job shop Scheduling Problem(JSP),as a fundamental scheduling problem,holds considerable theoretical research ***,finding a satisfactory solution within a given time is difficult due to the NP-hard nature of the JSP.A co-operative-guided ant colony optimization algorithm with knowledge learning(namely KLCACO)is proposed to address this *** algorithm integrates a data-based swarm intelligence optimization algorithm with model-based JSP schedule knowledge.A solution construction scheme based on scheduling knowledge learning is proposed for *** problem model and algorithm data are fused by merging scheduling and planning knowledge with individual scheme construction to enhance the quality of the generated individual solutions.A pheromone guidance mechanism,which is based on a collaborative machine strategy,is used to simplify information learning and the problem space by collaborating with different machine processing ***,the KLCACO algorithm utilizes the classical neighborhood structure to optimize the solution,expanding the search space of the algorithm and accelerating its *** KLCACO algorithm is compared with other highperformance intelligent optimization algorithms on four public benchmark datasets,comprising 48 benchmark test cases in *** effectiveness of the proposed algorithm in addressing JSPs is validated,demonstrating the feasibility of the KLCACO algorithm for knowledge and data fusion in complex combinatorial optimization problems.

关键词： Ant Colony Optimization(ACO) Job shop Scheduling Problem(JSP) knowledge learning cooperative guidance

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Differential distribution of PINK1 and Parkin in the primate brain implies distinct roles

引用

Neural Regeneration Research 2025年第4期20卷 1124-1134页

作者： Yanting Liu Wei huang Jiayi Wen Xin Xiong Ting Xu Qi Wang Xiusheng Chen Xianxian Zhao Shihua Li Xiaojiang Li Weili Yang Guangdong Key Laboratory of Non-human Primate Research Key Laboratory of CNS Regeneration(Ministry of Education)Guangdong-Hongkong-Macao CNS Regeneration Institute of Jinan UniversityJinan UniversityGuangzhouGuangdong ProvinceChina

The vast majority of in vitro studies have demonstrated that PINK1 phosphorylates Parkin to work together in mitophagy to protect against neuronal ***,it remains largely unclear how PINK1 and Parkin are expressed in mammalian *** has been difficult to address because of the intrinsically low levels of PINK1 and undetectable levels of phosphorylated Parkin in small *** this issue is critical for elucidating the in vivo roles of PINK1 and ***,we showed that the PINK1 kinase is selectively expressed as a truncated form(PINK1–55)in the primate *** the present study,we used multiple antibodies,including our recently developed monoclonal anti-PINK1,to validate the selective expression of PINK1 in the primate *** found that PINK1 was stably expressed in the monkey brain at postnatal and adulthood stages,which is consistent with the findings that depleting PINK1 can cause neuronal loss in developing and adult monkey ***1 was enriched in the membrane-bound fractionations,whereas Parkin was soluble with a distinguishable *** double staining experiments showed that PINK1 and Parkin did not colocalize under physiological conditions in cultured monkey astrocytes,though they did colocalize on mitochondria when the cells were exposed to mitochondrial *** findings suggest that PINK1 and Parkin may have distinct roles beyond their well-known function in mitophagy during mitochondrial damage.

关键词： neurodegeneration Parkin Parkinson’s disease PINK1 subcellular distribution

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：