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Cortical neurogenesis in adult rats after ischemic brain injury: most new neurons fail to mature

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Neural Regeneration Research 2015年第2期10卷 277-285页

作者： Qing-quan li Guan-qun Qiao Jun Ma Hong-wei Fan ying-bin li Department of Neurosurgery the Second Affiliated Hospital of Nanjing Medical University Department of Neurosurgery the First Hospital of Nanjing Medical University

The present study examines the hypothesis that endogenous neural progenitor cells isolated from the neocortex of ischemic brain can differentiate into neurons or glial cells and contribute to neural regeneration. We performed middle cerebral artery occlusion to establish a model of cerebral ischemia/reperfusion injury in adult rats. Immunohistochemical staining of the cortex 1, 3, 7, 14 or 28 days after injury revealed that neural progenitor cells double-positive for nestin and sox-2 appeared in the injured cortex 1 and 3 days post-injury, and were also positive for glial ifbrillary acidic protein. New neurons were labeled using bromodeoxyuridine and different stages of maturity were identiifed using doublecortin, microtubule-associated protein 2 and neuronal nuclei antigen immunohistochemistry. Immature new neurons coexpressing doublecortin and bromodeoxyuridine were observed in the cortex at 3 and 7 days post-injury, and semi-mature and mature new neurons double-positive for microtubule-associated protein 2 and bromode-oxyuridine were found at 14 days post-injury. A few mature new neurons coexpressing neuronal nuclei antigen and bromodeoxyuridine were observed in the injured cortex 28 days post-injury. Glial ifbrillary acidic protein/bromodeoxyuridine double-positive astrocytes were also found in the injured cortex. Our ifndings suggest that neural progenitor cells are present in the damaged cortex of adult rats with cerebral ischemic brain injury, and that they differentiate into astrocytes and immature neurons, but most neurons fail to reach the mature stage.

关键词： nerve regeneration middle cerebral artery occlusion brain injury neurons astrocytes oligodendrocytes neural progenitor cells proliferation differentiation neurogenesis neural regeneration

Determination of soluble solid content and acidity of loquats based on FT-NIR spectroscopy

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2009年第2期10卷 120-125页

作者： Xia-ping FU Jian-ping li ying ZHOU Yi-bin ying li-juan XIE Xiao-ying NIU Zhan-ke YAN Hai-yan YU College of Biosystem Engineering and Food Science Zhejiang University Hangzhou 310029 China

The near infrared （NIR） spectroscopy technique has been applied in many fields because of its advantages of simple preparation, fast response, and non-destructiveness. We investigated the potential of NIR spectroscopy in diffuse reflectance mode for determining the soluble solid content （SSC） and acidity （pH） of intact loquats. Two cultivars of loquats （Dahongpao and Jiajiaozhong） harvested from two orchards （Tangxi and Chun＇an, Zhejiang, China） were used for the measurement of NIR spectra between 800 and 2500 nm. A total of 400 loquats （100 samples of each cultivar from each orchard） were used in this study. Relationships between NIR spectra and SSC and acidity of loquats were evaluated using partial least square （PLS） method. Spectra preprocessing options included the first and second derivatives, multiple scatter correction （MSC）, and the standard normal variate （SNV）. Three separate spectral windows identified as full NIR （800-2500 nm）, short NIR （800-1100 rim）, and long NIR （1100-2500 nm） were studied in factorial combination with the preprocessing options. The models gave relatively good predictions of the SSC of loquats, with root mean square error of prediction （RMSEP） values of 1.21, 1.00, 0.965, and 1.16 °Brix for Tangxi-Dahongpao, Tangxi-Jiajiaozhong, Chun＇an-Dahongpao, and Chun＇an-Jiajiaozhong, respectively. The acidity prediction was not satisfactory, with the RMSEP of 0.382, 0.194, 0.388, and 0.361 for the above four loquats, respectively. The results indicate that NIR diffuse reflectance spectroscopy can be used to predict the SSC and acidity of loquat fruit.

关键词： Near infrared (NIR) spectroscopy Loquats Soluble solid content (SSC) Acidity Partial least square (PLS) Modeling Spectra preprocessing

Advanced Design of Soft Robots with Artificial Intelligence

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Nano-Micro Letters 2024年第10期16卷 474-521页

作者： ying Cao bingang Xu bin li Hong Fu Nanotechnology Center School of Fashion and TextilesThe Hong Kong Polytechnic UniversityHong Kong 999077People's Republic of China Department of Mathematics and Information Technology The Education University of Hong KongHong Kong 999077People's Republic of China Bioinspired Engineering and Biomechanics Center Xi'an Jiaotong UniversityXi'an 710049People's Republic of China

In recent years,breakthrough has been made in the field of artificial intelligence(AI),which has also revolutionized the industry of *** robots featured with high-level safety,less weight,lower power consumption have always been one of the research ***,multifunctional sensors for perception of soft robotics have been rapidly developed,while more algorithms and models of machine learning with high accuracy have been optimized and *** of soft robots with AI have also been advanced ranging from multimodal sensing,human-machine interaction to effective actuation in robotic ***-less,comprehensive reviews concerning the new developments and strategies for the ingenious design of the soft robotic systems equipped with AI are ***,the new development is systematically reviewed in the field of soft robots with ***,background and mechanisms of soft robotic systems are briefed,after which development focused on how to endow the soft robots with AI,including the aspects of feeling,thought and reaction,is ***,applications of soft robots with AI are systematically summarized and discussed together with advanced strategies proposed for performance *** thoughts for future intelligent soft robotics are pointed ***,some perspectives are put forward.

关键词： Soft robotic systems Artificial intelligence Design tactics Review and perspective

Development and assessment of quantitative structure-activity relationship models for bioconcentration factors of organic pollutants

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Chinese Science Bulletin 2009年第4期54卷 628-634页

作者： QIN Hong CHEN JingWen WANG ying WANG bin li XueHua li Fei WANG YaNan Key Laboratory of Industrial Ecology and Environmental Engineering (Ministry of Education) Department of Environmental Scienceand Technology Dalian University of Technology Dalian 116024 China

Bioconcentration factors (BCFs) are of great importance for ecological risk assessment of organic chemicals. In this study, a quantitative structure-activity relationship (QSAR) model for fish BCFs of 8 groups of compounds was developed employing partial least squares (PLS) regression, based on linear solvation energy relationship (LSER) theory and theoretical molecular structural descriptors. The guidelines for development and validation of QSAR models proposed by the Organization for Economic Cooperation and Development (OECD) were followed. The model results show that the main factors governing logBCF are Connolly molecular area (CMA), average molecular polarizability (α) and molecular weight (MW). Thus molecular size plays a critical role in affecting the bioconcentration of organic pollutants in fish. For the established model, the multiple correlation coefficient square (RY2) = 0.868, the root mean square error (RMSE) = 0.553 log units, and the leave-many-out cross-validated Q2CUM = 0.860, indicating its good goodness-of-fit and robustness. The model predictivity was evaluated by external validation, with the external explained variance (QE2XT) = 0.755 and RMSE = 0.647 log units. Moreover, the applicability domain of the developed model was assessed and visualized by the Williams plot. The developed QSAR model can be used to predict fish logBCF for organic chemicals within the application domain.

关键词：生物浓缩因子定量结构活动关系有机污染物生态学风险评估

Numerical Investigation on Heat Transfer Characteristics of Microencapsulated Phase Change Material Slurry in a Rectangular Minichannel

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Journal of Thermal Science 2024年第2期33卷 564-577页

作者： WANG Zhibin li Zilong JIA lisi DING bin CHEN ying School of Materials and Energy Guangdong University of TechnologyGuangzhou510006China Guangdong Provincial Key Laboratory of Functional Soft Condensed Matter Guangzhou510006China College of New Energy China University of Petroleum(East China)Qingdao266580China

Microencapsulation phase change material slurry(MEPCMS) becomes a potential working fluid for cooling high energy density miniaturized components,thanks to the latent heat absorption of particles in the heat transfer *** this work,the Discrete Phase Model(DPM) based on the Euler-Lagrangian method is used to numerically investigate the convective heat transfer characteristics of MEPCMS flowing through a rectangular minichannel with constant heat *** results show that particles of MEPCMS are mainly subjected to drag force during the *** so,they can migrate from the high-temperature region to the low-temperature region driven by the thermophoretic force,affecting the particle distribution and phase change ***,the Nux of the MEPCMS fluctuates due to particle phase change with varying specific heat ***,the value increases first,then decreases,and eventually increases again until it approaches the fully developed value of the pure base fluid as the particles gradually ***,the heat transfer performance of the MEPCMS is influenced by the combination of fluid inlet temperature fluid inlet velocity(v),and mass concentration(c_(m)) of MEPCM *** result shows that the maximum reduction of the maximum bottom wall temperature difference(ΔT_(w)) is 23.98% at T_(in)=293.15 K,v=0.15 m·s^(-1),c_(m)=10%.

关键词： Microencapsulated Phase Change Material Slurry(MPCMS) Discrete Phase Model(DPM) particle-fluid interaction force minichannel heat sink thermophoresis

Effect of genistein on voltage-gated potassium channels in guinea pig proximal colon smooth muscle cells

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World Journal of Gastroenterology 2006年第3期12卷 420-425页

作者： Shi-ying li bin-bin Huang Shou Ouyang Xiamen Institute of Medicine Xiamen 361003 Fujian Province China

AIM： To investigate the action of genistein （GST）, a broad spectrum tyrosine kinase inhibitor, on voltagegated potassium channels in guinea pig proximal colon smooth muscle cells. METHODS： Smooth muscle cells in guinea pig proximal colon were enzymatically isolated. Nystatin-perforated whole cell patch clamp technique was used to record potassium currents including fast transient outward current （Ikto） and delayed rectifier current （Ikdr）, tWO of which were isolated pharmacologically with 10 mmol/L tetraethylammonium or 5 mmol/L 4-aminopyridine. Contamination of calcium-dependent potassium currents was minimized with no caldum and 0.2 mmol/L CdCl2 in an external solution. RESULTS： GST （10-100 μmol/L） reversibly and dosedependently reduced the peak amplitude of Ikto with an IC50 value of 22.0±6.9 μmol/L. To a lesser extent, Ikdr, was also inhibited in both peak current and sustained current. GST could not totally block the outward potassium current as a fraction of the outWard potassium current, which was insensitive to GST. GST had no effect on the steady-state activation （n =6） and inactivation kinetics （n =6） of Ikto. Sodium orthovanadate （1 retool/L）, a potent inhibitor of tyrosine phosphatase, significantly inhibited GST-induced inhibition （P〈 0.05）. CONCLUSION： GST can dose-dependently and reversibly block voltage-gated potassium channels in guinea pig proximal colon smooth muscle cells.

关键词： Protein tyrosine kinase Patch-clamptechnique Genistein Voltage-gated potassium channel Colon Smooth muscle cells

Well-dispersed Sb particles embedded on N-doped carbon nanofibers toward high-performance li-ion battery

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Rare Metals 2024年第7期43卷 2994-3006页

作者： ying li Yi-Han Zhao Lu-Lu Zhao Peng-Fei Wang ying Xie Ting-Feng Yi School of Materials Science and Engineering Northeastern UniversityShenyang 110819China Key Laboratory of Dielectric and Electrolyte Functional Material Hebei Province School of Resources and MaterialsNortheastern University at QinhuangdaoQinhuangdao 066004China Key Laboratory of Functional Inorganic Material Chemistry Ministry of EducationSchool of Chemistry and Materials ScienceHeilongjiang UniversityHarbin 150080China

The alloy-type material Sb is widely used in the anode materials of lithium-ion batteries(liBs)due to its high theoretical specific ***,its serious volume expansion problem during alloying/dealloying of li~+limits its practical *** this work,C-Sb composite was constructed as anode material of liBs by electrospinning route for the first time,Sb was introduced into the polyacrylonitrile-based hard carbon and coal tar pitch-based soft carbon composite amorphous carbon fiber with a diameter of 300-600 nm,which realized high cycling *** C-Sb-2(the mass ratio of polyacrylonitrile to Sb source is 1:2)electrode displayed charge capacities of 1098.5,930.3,841.7,753.5,643.9 and 545.8 mAh·g^(-1)at 0.1,0.2,0.3,0.5,1 and 2 A·g^(-1),*** when the current density returned to 0.1 A·g^(-1),the charge capacity was 939.3 mAh·g^(-1),revealing good stability and *** introduction of Sb into the amorphous carbon improved its conductivity and addressed the volume expansion issue of high specific capacity Sb during charge/***-situ XRD analysis confirmed the high reversibility of the C-Sb-2 during charging and *** functional theory(DFT)calculations revealed the gradual enhancement of the interface interaction between Sb_(x)li_(y) and amorphous carbon(AMC)with increasing lithium content,contributing to the anchoring of alloy nanoparticles on the AMC surface and buffering the volume change of the ***,the gradual lithiation of Sb facilitated the electron transfer from Sb_(x)li_(y) to *** findings hold promise for designing lithium storage materials with exceptional performance,highlighting the potential of C-Sb composites as anode materials for efficient next-generation lithium storage.

关键词： li-ion battery Metallic Sb Carbon Electrospinning Cycling stability

Wideband spectrum sensing using step-sampling based on the multipath nyquist folding receiver

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Defence Technology（防务技术） 2024年第1期31卷 523-536页

作者： Kai-lun Tian Kai-li Jiang Sen Cao Jian Gao ying Xiong bin Tang Xu-ying Zhang Yan-fei li University of Electronic Science and Technology of China Chengdu611731China China Electronics Technology Group Corporation 29th Research Institute Chengdu610036China

Wideband spectrum sensing with a high-speed analog-digital converter(ADC) presents a challenge for practical *** Nyquist folding receiver(NYFR) is a promising scheme for achieving cost-effective real-time spectrum sensing,which is subject to the complexity of processing the modulated *** this case,a multipath NYFR architecture with a step-sampling rate for the different paths is *** different numbers of digital channels for each path are designed based on the Chinese remainder theorem(CRT).Then,the detectable frequency range is divided into multiple frequency grids,and the Nyquist zone(NZ) of the input can be obtained by sensing these ***,high-precision parameter estimation is performed by utilizing the NYFR *** with the existing methods,the scheme proposed in this paper overcomes the challenge of NZ estimation,information damage,many computations,low accuracy,and high false alarm *** simulation experiments verify the effectiveness of the proposed architecture in this paper.

关键词： Wideband spectrum sensing Sub-Nyquist sampling Step-sampling Nyquist folding receiver(NYFR) Multisignal processing

Mars exploration——In situ K-Ar dating of jarosite

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Science China Earth Sciences 2024年第3期67卷 641-656页

作者： Jing YANG Dewen ZHENG ying WU Hong CHEN li YANG bin ZHANG Key Laboratory of Active Tectonics and Geological Safety Ministry of Natural ResourcesInstitute of GeomechanicsChinese Academy of Geological SciencesBeijing 100081China State Key Laboratory of Earthquake Dynamics Institute of GeologyChina Earthquake AdministrationBeijing 100029China Institute of Earth Sciences China University of GeosciencesBeijing 100083China Key Laboratory of Cenozoic Geology and Environment Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029Chin

To accurately determine the chronological framework of climatic variations recorded by various Martian terrains, the absolute ages of Martian events and cratering rate need to be constrained by either in situ dating or returned samples. In situ K-Ar dating is currently a more plausible dating technique as compared with sample return. Jarosite(KFe_(3)[SO_(4)]_(2)[OH]_(6)) is the only confirmed K sulfate mineral that is widely present on Mars, as indicated by in situ detection, orbital remote sensing, and meteorite studies. Jarosite can be used for precise K-Ar and (40)Ar/(39)Ar dating. The preservation of jarosite on Mars provides information about the nature and duration of aqueous processes on the Martian surface. Different ages of Martian jarosite represent the key to constraining the transition from Martian surface water activity to arid climatic conditions. This paper summarizes recent advances in our knowledge of the spatial distribution of Martian jarosite, its mineralogical properties and stability on Mars, the Ar diffusion kinetics of jarosite, and the current status of in situ K-Ar dating. Moreover, we examine the key scientific issues to be addressed for in situ K-Ar dating of jarosite and Martian sample return missions, and discuss future research directions.

关键词： Mars Jarosite In situ K-Ar dating Ar diffusion Stability