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Liver transplantation for liver failure in kidney transplantation recipients with hepatitis B virus infection

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Hepatobiliary & Pancreatic Diseases International 2021年第1期20卷 94-98页

作者： Peng-Peng Zhang Xing-Guo She Ke Cheng Hong Liu ying Niu ying-zi ming Transplantation Center Third Xiangya HospitalCentral South UniversityChangsha 410013China Engineering&Technology Research Center for Transplantation Medicine of National Ministry of Health Changsha 410013China

To the Editor:Worldwide,approximately 400 million patients have chronic hepatitis B virus(HBV)infection[1].Because of the high incidence of HBV in China,the incidence of HBV infection in uremia and kidney transplantation(KTx)patients is 2.5%and 2.7%,respectively[2].Since the first successful organ transplant conducted between twins in 1954,refined surgical techniques,improved immunosuppressive protocols,and improved perioperative management of transplant patients have resulted in improved patient and graft survivals following K Tx[3].However,the K Tx community is now challenged with liver failure due to the increased risk of HBV viral activation and replication induced by immunosuppressive *** et al.[4]highlighted that KTx recipients with HBV infection had lower 5-year survival(61%)than patients on dialysis(85%).Although these KTx recipients were treated with regular anti-HBV therapy,the incidence of liver failure was increased in KTx patients with HBV ***,isolated liver transplantation(LTx),sequential liver and kidney transplantation(SLKT),and combined liver and kidney transplantation(CLKT)are the optimal treatments for patients with liver failure and hepatorenal syndrome[5].However,the outcomes of KTx recipients following isolated LTx,SLKT or CLKT for HBV-associated liver failure remain to be ***,we report our experience in ten HBV-positive KTx recipients with liver failure undergoing LTx.

关键词： infection kidney liver

Severe and delayed immune-mediated hemolysis post-liver transplantation

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Hepatobiliary & Pancreatic Diseases International 2017年第6期16卷 665-668页

作者： Quan Zhuang Hong Liu Ke Cheng ying Niu Xing-Guo She ying-zi ming Transplantation Center of the Third Xiangya Hospital Central South University Changsha 410013 China

To the Editor:Hemolysis,which is caused by a variety of immune and non-immune mechanisms,is a well-recognized complication of solid organ transplantation.;Hemolysis post-liver transplantation can be induced by drug,in... 详细信息

关键词： RBC Severe and delayed immune-mediated hemolysis post-liver transplantation PLS DCD EBV

Detecting chimerism contributes to diagnosis of graft versus host disease after orthotopic liver transplantation

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Hepatobiliary & Pancreatic Diseases International 2018年第4期17卷 363-366页

作者： Bo Peng Hong Liu Quan Zhuang Ke Cheng ying-zi ming Transplantation Center of the Third Xiangya Hospital Central South UniversityChangsha 410013China Engineering Technology Research Center for Transplantation Medicine of National Ministry of Health Changsha 410013China

To the Editor:Graft versus host disease(GVHD)occurs when the immunocompetent cells from the donor mount an immune response against the tissues of the host[1].It is commonly seen in the patients who received hematopoie... 详细信息

关键词： OLT POD

Orthotopic liver transplantation from a donor with Schistosoma japonicum

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Hepatobiliary & Pancreatic Diseases International 2017年第3期16卷 326-328页

作者： Bo Peng Xing-Guo She Ke Cheng Hong Liu ying Niu ying-zi ming The Transplantation Center of the Third Xiangya Hospital Central South University Changsha 410013 China Engineering & Technology Research Center for Transplantation Medicine of National Ministry of Health Changsha 410013 China

To the Editor：Despite of the rapid increase of donation after cardiac death （DCD） in China, the shortage of organs continues to be a major problem. Every organ procured is so valuable that it should never be discarded easily, especially a liver that could save a patient＇s life in an emergency. This leads to the use of grafts from donors with unrecognized Here and unusual diseases, including schistosomiasis. we reported a case of orthotopic liver transplantation （OLT） from a donor with Schistosorna japonicurn to a patient with end-stage cirrhosis due to HBV infection.

关键词： from on is Orthotopic liver transplantation from a donor with Schistosoma japonicum with of

Hepatic veins anatomy and piggy-back liver transplantation

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Hepatobiliary & Pancreatic Diseases International 2012年第4期11卷 429-433页

作者： ying-zi ming,ying Niu,ming-Jie Shao,Xing-Guo She and Qi-Fa Ye Research Center of Chinese Health Ministry on Transplantation Medicine Engineering and Technology,The Third Xiangya Hospital,Central South University,Changsha 410013,China Research Center of Chinese Health Ministry on Transplantation Medicine Engineering and Technology The Third Xiangya Hospital Central South University Changsha 410013 China

BACKGROUND:The piggy-back caval anastomosis technique is widely used in orthotopic liver transplantation although it carries an increased risk of complications,including outflow obstruction and Budd-Chiari *** aim of this study is to clarify the anatomy and variations of hepatic veins(HVs) draining into the inferior vena cava(IVC),and to classify the surgical techniques of piggy-back liver transplantation(PBLT) based on the anatomy of HVs which can reduce the occurrence of ***:PBLT was performed in 248 consecutive cases at our hospital from January 2004 to August *** anatomy of recipients’ HVs was determined when removing the native diseased *** anatomy of HVs and short HVs draining into the IVC were *** data were collected and ***:We classified anatomic variations of HVs in the 248 livers into five types according to the way of drainage into the IVC:type I(trunk type of left and middle HVs),142(57.3%) patients;type II(trunk type of right and middle HVs),54(21.8%);type III(trunk type of left,middle and right HVs),14(5.6%);type IV(non-trunk type of left,middle and right HVs),of which,type IVa,16(6.5%),in the same horizontal plane;type IVb,18(7.3%),in different horizontal planes;and type V(segment type),4(1.6%).The patients whose HVs anatomy belonged to types I,II and III underwent classical piggy-back liver *** IVa patients had classical PBLT via HV venoplasty prior to piggy-back anastomosis,while type IVb patients and type V patients could only have modified ***:This study demonstrates that HVs can be classified according to the anatomy of their drainage into the IVC and we can use this classification to choose the best operative approach to PBLT.

关键词： hepatic vein classification piggy-back liver transplantation

Preoperative risk factor analysis in orthotopic liver transplantation with pretransplant artificial liver support therapy

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World Journal of Gastroenterology 2006年第31期12卷 5055-5059页

作者： Jin-Zhong Yuan Qi-Fa Ye Ling-Ling Zhao ying-zi ming Hong Sun Shai-Hong Zhu Zu-Fa Huang Min-Min Wang Blood Purification Center Xiangya Transplantation Institute Third Xiangya Hospital of Central South University Changsha 410013 Hunan Province China

AIM： To assess the value of pre-transplant artificial liver support in reducing the pre-operative risk factors relating to early mortality after orthotopic liver transplantation （OLT）. METHODS： Fifty adult patients with various stages and various etiologies undergoing OLT procedures were treated with molecular adsorbent recycling system （MARS） as preoperative liver support therapy. The study included two parts, the first one is to evaluate the medical effectiveness of single MARS treatment with some clinical and laboratory parameters, which were supposed to be the therapeutical pre-transplant risk factors, the second part is to study the patients undergoing OLT using the regression analysis on preoperative risk factors relating to early mortality （30 d） after OLT. RESULTS： In the 50 patients, the statistically significant improvement in the biochemical parameters was observed （pre-treatment and post-treatment）. Eight patients avoided the scheduled Ltx due to significant relief of clinical condition or recovery of failing liver function, 8 patients died, 34 patients were successfully bridged to Ltx, the immediate outcome of this 34 patients within 30d observation was： 28 kept alive and 6 patients died. CONCLUSION： Pre-operative SOFA, level of creatinine, INR, TNF-α, IL-10 are the main preoperative risk factors that cause early death after operation, MARS treatment before transplantion can relieve these factors significantly.

关键词： Liver transplantation Artificial liver Sequential Organ Failure Assessment Risk factors analysis

前列腺素E1后处理对大鼠移植肝缺血再灌注损伤的保护作用

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中国现代医学杂志 2017年第8期27卷 17-20页

作者：王玉柱明英姿郑州大学人民医院(河南省人民医院)肝胆胰腺外科河南郑州450003 中南大学湘雅移植医学研究院湖南长沙410013

目的探讨前列腺素E1(PGE1)后处理对大鼠移植肝缺血再灌注损伤(IRI)的保护作用及其机制。方法建立SD大鼠肝移植模型,随机分为3组:IRI组、PGE1后处理组(PGE1组)及假手术组(S组)。检测各组血清谷丙转氨酶(ALT)、谷草转氨酶(AST)、超氧化物... 详细信息

目的探讨前列腺素E1(PGE1)后处理对大鼠移植肝缺血再灌注损伤(IRI)的保护作用及其机制。方法建立SD大鼠肝移植模型,随机分为3组:IRI组、PGE1后处理组(PGE1组)及假手术组(S组)。检测各组血清谷丙转氨酶(ALT)、谷草转氨酶(AST)、超氧化物岐化酶(SOD)及丙二醛(MDA)的含量;采用逆转录聚合酶链式反应(RT-PCR)方法检测移植肝组织内肿瘤坏死因子(TNF-α)信使核糖核酸(mRNA)的表达水平;苏木精-伊红染色(HE)观察移植肝病理形态学变化。结果供肝再灌注后2及6 h,PGE1组的大鼠血清ALT、AST和MDA水平及TNF-αmRNA的表达低于IRI组(P<0.05),血清SOD水平高于IRI组(P<0.05),光镜下PGE1组肝组织损伤较IRI组轻。结论 PGE1后处理可通过提高肝组织的抗氧化能力,降低TNF-α来减轻大鼠移植肝IRI。

关键词：肝移植缺血再灌注损伤药物后处理前列腺素E1

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超导磁共振机房的磁干扰及屏蔽分析

中国医学装备 2018年第5期15卷 117-120页

作者：伍子英蔡名金广州医科大学附属第三医院总务科广东广州510150 广州医科大学附属第三医院放射科广东广州510150

目的:分析探讨磁共振成像(MRI)系统安装环境的磁干扰及屏蔽措施,以满足MRI系统的正常工作。方法:评估MRI系统安装前外部环境和动态干扰环境,分析磁体等中心磁场的磁力线而构成的影响。结果:在MRI系统机房选址时首先考虑磁干扰及其影响因... 详细信息

目的:分析探讨磁共振成像(MRI)系统安装环境的磁干扰及屏蔽措施,以满足MRI系统的正常工作。方法:评估MRI系统安装前外部环境和动态干扰环境,分析磁体等中心磁场的磁力线而构成的影响。结果:在MRI系统机房选址时首先考虑磁干扰及其影响因素,并予以屏蔽措施,根据实际的场地环境施以磁屏蔽及射频屏蔽措施,使超导MRI机房具备磁共振系统运行的基础条件。结论:对MRI系统安装环境磁干扰及屏蔽的评估,是顺利完成MRI系统安装工作的关键环节。

关键词：磁共振成像系统磁干扰屏蔽机房

Panax notoginseng saponins preconditioning protects rat liver grafts from ischemia/reper- fusion injury via an antiapoptotic pathway

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Hepatobiliary & Pancreatic Diseases International 2005年第2期4卷 207-212页

作者： Yi Zhang, Qi-Fa Ye, Li Lu, Xian-Lin Xu, ying-zi ming and Jian-Sheng Xiao Wuhan, China Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China Xiangya Transplantation Medical Academy, Third Xiangya Hospital, Xiangya Medi- cal College, Central South University, Changsha 410013, China Institute of Organ Transplantation Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China.

BACKGROUND: Ischemia/reperfusion (I/R) injury is a major cause of primary graft dysfunction and renders an al- lograft more immunogenic in orthotopic liver transplanta- tion (OLT). Panax notoginseng saponins (PNS) has been re- ported to exert protective effects against I/R injury to vari- ous organs. The objective of this study is to investigate whether PNS preconditioning protects rat liver grafts from I/R injury via an antiapoptotic pathway. METHODS: Male Sprague-Dawley rats were used as donors and recipients of orthotopic liver transplantation ( OLT) and were divided into PNS preconditioning group (group P) and normal saline control group (group N) randomly according to whether PNS (50 mg/kg) was injected intra- venously 1 hour before liver grafts harvesting, and sham group (group S). The animals were separately killed 2, 6 and 24 hours after reperfusion. Plasma samples were collect- ed for test of alanine amino-transferase (ALT) and aspartate aminotransferase (AST). Liver tissues were collected to de- tect histological changes, apoptosis and the expression of TNF-α, Bcl-2 and Caspase-3 mRNA. RESULTS: The serum levels of ALT and AST and the apop- tosis index (AI) of liver tissue in group P were lower than in group N significantly 2, 6 and 24 hours after reperfusion. Compared with group N, the expression of TNF-a and Caspase-3 mRNA was reduced significantly in group P 2 and 6 hours after reperfusion and the expression of Bcl-2 mRNA was enhanced significantly in group P 6 and 24 hours after reperfusion. CONCLUSIONS: PNS preconditioning protects liver grafts from I/R injury effectively in rat OLT via an antiapoptotic pathway. The antiapoptotic mechanisms of PNS may in- clude inhibiting the expression of TNF-a and Caspase-3 and enhancing the expression of Bcl-2.

关键词： Panax notoginseng saponins liver transplantation ischemia/reperfusion injury apoptosis