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Hepatocellular carcinoma with concomitant hepatic angiomyolipoma and cavernous hemangioma in one patient

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World Journal of Gastroenterology 2015年第11期21卷 3414-3419页

作者： Xiao-Wen Ge Hai-ying Zeng Akesu Su-Jie Min Du Yuan Ji Yun-Shan Tan ying-yong hou Jian-Fang Xu Department of Pathology Zhongshan HospitalFudan University

The risk of developing hepatocellular carcinoma(HCC) is strongly associated with hepatitis B virus *** angiomyolipoma(AML),a rare benign tumor,is composed of a heterogeneous mixture of adipose cells,smooth muscle cells and blood ***,we report the case of a 44-year-old man who developed HCC with a concomitant hepatic AML and a cavernous hemangioma,in the absence of *** our knowledge,based on an extensive literature search using the *** website,this is the first report of an HCC case with both concomitant AML and cavernous hemangioma at the same position in the *** presence of the hepatitis B surface antigen was detected,but the liver function was *** and pathological data were collected before and during the *** AML was diagnosed based on the typical histological characteristics and immunohistochemical staining,which revealed,a positive staining with a melanocytic cell-specific monoclonal *** was no evidence of tuberous sclerosis complex in this *** the HCC was poor- to moderately-differentiated,the characteristics of the AML and the cavernous hemangioma in this patient did not match any criteria for *** followed by transarterial chemoembolization treatment were effective therapeutic methods for the adjacent lesions in this *** case is an interesting coincidence.

关键词： Angiomyolipoma Hepatocellular carcinoma Cavernous

Familial gastrointestinal stromal tumors with KIT germline mutation in a Chinese family:A case report

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World Journal of Clinical Cases 2022年第15期10卷 4878-4885页

作者： Wei Yuan Wen Huang Lei Ren Chen Xu Li-Juan Luan Jie Huang An-Wei Xue yong Fang Xiao-Dong Gao Kun-Tang Shen Jing-Huan Lv ying-yong hou Department of Pathology Zhongshan HospitalFudan UniversityShanghai 200032China Department of General Surgery Zhongshan HospitalFudan UniversityShanghai 200032China Department of Pathology the Affiliated Suzhou Hospital of Nanjing Medical UniversitySuzhou 215002Jiangsu ProvinceChina

BACKGROUND Familial gastrointestinal stromal tumors(GISTs)is a rare autosomal dominant disorder characterized by an array of clinical *** 35 kindreds with germline KIT mutations and six with germline PDGFRA mutations have been reported so *** is often characterized by a series of manifestations,such as multiple lesions and ***,the effect of imatinib treatment in these patients is still *** SUMMARY Here,we report two patients(father and daughter)in a Chinese family(for the first time)with germline KIT mutation,and described their pathology,genetics and clinical manifestations.A 25-year-old Chinese woman went to hospital because of abdominal pain,and computed tomography showed multiple tumors in the small *** pigmented spots appeared on the skin within a few months after *** father also had multiple pigmented spots and a history of multifocal *** GISTs associated with diffuse interstitial Cajal cells(ICCs)hyperplasia were positive for CD117 and *** sequencing revealed a germline mutation at codon 560 of exon 11(p.V560G)of KIT gene in these two *** therapy showed the long-lasting disease stability after ***,the hypopigmentation of the skin could also be *** germline KIT mutation has not been identified yet in the 3-year-old daughter of the female *** Diagnosis of familial GISTs depends on combination of diffuse ICCs hyperplasia,germline KIT/PDGFRA mutation,hyperpigmentation and family history.

关键词： Familial gastrointestinal stromal tumor Germline KIT mutation Cutaneous hyperpigmentation Imatinib therapy Case report

Imatinib mesylate neoadjuvant treatment for rectal malignant gastrointestinal stromal tumor

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World Journal of Gastroenterology 2009年第15期15卷 1910-1913页

作者： ying-yong hou Yang Zhou Shao-Hua Lu Wei-Dong Qi Cheng Xu Jun hou Yun-Shan Tan Department of Pathology Zhongshan Hospital Fudan University 180 FenglinRoad Shanghai 200032 China

Surgical treatments including radical resection and local excision remain the main treatment for primary rectal gastrointestinal stromal tumors(GISTs). However,since patients with high-grade rectal GISTs have a higher risk of tumor recurrence and a shorter life expectancy,neoadjuvant treatment is necessary. In this case report,the efficacy of imatinib mesylate (IM)as a neoadjuvant therapy was assessed in an old man with malignant rectal *** patient received IM preoperative treatment for a short period of one and a half months;at the end of the IM treatment, computed tomography scanning showed a markedly reduced tumor size and cystic changes of the tissue. At that time,a function sphincter-sparing surgery was *** histological examination of the resected specimen detected no tumor cells,but residual blood vessels and scattered inflammatory *** surgery,the patient has been followed up without additional IM treatment and remained disease-free for 57 *** case indicates that IM neoadjuvant therapy can dramatically improve the prognosis of rectal malignant GIST.

关键词： Gastrointestinal stromal tumor Imatinibmesylate Neoadjuvant

Long-term outcomes of endoscopic submucosal dissection for high-grade dysplasia and early-stage carcinoma in the colorectum

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Cancer Communications 2018年第1期38卷 42-49页

作者： Tao Chen Wen-Zheng Qin Li-Qing Yao Yun-Shi Zhong Yi-Qun Zhang Wei-Feng Chen Jian-Wei Hu Marie Ooi Ling-Li Chen ying-yong hou Mei-Dong Xu Ping-Hong Zhou Endoscopy Center Zhongshan Hospital and Endoscopy Research InstituteFudan University180 Fenglin RoadShanghai 200032P.R.China Department of Pathology Zhongshan HospitalFudan UniversityShanghai 200032P.R.China

Background:Colorectal carcinomas(CRCs)arise from premalignant precursors in an adenoma-carcinoma sequence,in which adenoma with high-grade dysplasia(HGD)and early-stage carcinoma are defined as advanced neoplasia.A limited number of studies have evaluated the long-term outcomes of endoscopic submucosal dissection(ESD)for advanced colorectal *** study aimed to assess the efficacy and safety of ESD for advanced colorectal neoplasia as well as the long-term outcomes,including local recurrence and ***:We analyzed data collected from 610 consecutive patients with 616 advanced colorectal neoplasia lesions treated with ESD between January 2007 and December ***,endoscopic,and histological data were col-lected over a median follow-up period of 58 months to determine tumor stage and type,resection status,complica-tions,tumor recurrence,and distant ***:The overall rates of en bloc resection,histological complete resection,and major complications were 94.3%,89.4%,and 2.3%,*** ESD was an independent factor of piecemeal *** location in the colon was associated with increased risk of ESD-related *** the follow-up period,all patients remained free of ***,local recurrence occurred in 4 patients(0.8%);piecemeal resection was a risk ***:ESD is effective and safe for resection of advanced colorectal neoplasia,with a high en bloc resection rate and favorable long-term *** is indicated for the treatment of HGD and early-stage CRC to obtain cura-tive resection and reduce local recurrence rate.

关键词： Early-stage carcinoma High-grade dysplasia Colorectum Endoscopic submucosal resection

Assessment of T staging and mesorectal fascia status using high-resolution MRI in rectal cancer with rectal distention

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World Journal of Gastroenterology 2007年第30期13卷 4141-4146页

作者： Sheng-Xiang Rao Meng-Su Zeng Jian-Ming Xu Xin-Yu Qin Cai-Zhong Chen Ren-Chen Li ying-yong hou Department of Radiology Zhongshan Hospital Fudan University and Shanghai Medical Imaging Institute Shanghai 200032 China Department of General Surgery Zhongshan Hospital Fudan University Shanghai 200032 China Department of Pathology Zhongshan Hospital Fudan University Shanghai 200032 China

AIM： To determine the accuracy of high-resolution magnetic resonance imaging （MRI） using phasedarray coil for preoperative assessment of T staging and mesorectal fascia infiltration in rectal cancer with rectal distention.METHODS： In a prospective study of 67 patients with primary rectal cancer, high-resolution magnetic resonance imaging （in-plane resolution, 0.66 × 0.56） with phased-array coil were performed for T-staging and measurement of distance between the tumor and the mesorectal fascia. The assessment of MRI was compared with postoperative histopathologic findings. Sensitivity, specificity, accuracy, positive predictive value, and negative predictive value were evaluated.RESULTS： The overall magnetic resonance accuracy was 85.1% for Tstaging and 88% for predicting mesorectal fascia involvement. Magnetic resonance sensitivity, specificity, accuracy, positive predictive value, and negative predictive value was 70%, 97.9%, 89.6%, 93.3% and 88.5% for ≤ T2 tumors, 90.5% , 76% , 85.1%, 86.4% and 82.6% for T3 tumors, 100%, 95.2%, 95.5% , 62.5% and 100% for T4 tumors, and 80% , 90.4%, 88%, 70.6% and 9d% for predicting mesorectal fascia involvement, respectively.CONCLUSION： High-resolution MRI enables accurate preoperative assessment for T staging and mesorectal fascia infiltration in rectal cancer with rectal distention.

关键词： Magnetic resonance imaging Rectum Neoplasm Staging Mesorectal fascia

Expression profile of microRNAs in gastrointestinal stromal tumors revealed by high throughput quantitative RT-PCR microarray

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World Journal of Gastroenterology 2015年第19期21卷 5843-5855页

作者： Han-Xing Tong Yu-Hong Zhou ying-yong hou yong Zhang Yuan Huang Bin Xie Jiong-Yuan Wang Quan Jiang Jun-Yi He Ye-Bo Shao Wu-Mei Han Ruo-ying Tan Jun Zhu Wei-Qi Lu Department of General Surgery Zhongshan Hospital Fudan University Department of Oncology Zhongshan HospitalFudan University Department of Pathology Zhongshan HospitalFudan University The Center of Endoscopy Zhongshan HospitalFudan University Department of Surgery The Central Hospital of Zaozhuang Mining Group Biovue Technology Ltd

AIM: To investigate the microRNA(miRNA) expression profile in gastrointestinal stromal tumor(GIST) tissues that could serve as a novel diagnostic biomarker for GIST ***: We performed a quantitative real-time quantitative reverse transcriptase polymerase chain reaction assay to analyze the expression of 1888 miRNAs in a sample set that included 54 GIST tissue ***: We found that dysregulation of several miRNAs may be related to the malignant potential of GISTs. Six of these miRNAs, hsa-let-7c, miR-218,miR-488#, miR-4683, miR-34c-5p and miR-4773, were selected as the final list of biomarkers to separate the malignant GISTs(M group) from the benign GISTs(B group). In addition, MiR-29b-2#, hsa-let-7c, miR-891 b, miR-218, miR-204, miR-204-3p, miR-628-5p,miR-744, miR-29c#, miR-625 and miR-196 a were used to distinguish between the borderline(BO group) and M groups. There were 11 common miRNAs selected to separate the benign and borderline(BB) group from the M group, including hsa-let-7c, miR-218, miR-628-5p,miR-204-3p, miR-204, miR-891 b, miR-488#, miR-145,miR-891 a, miR-34c-5p and miR-196 ***: The identified miRNAs appear tobe novel biomarkers to distinguish malignant from benign GISTs, which may be helpful to understand the mechanisms of GIST oncogenesis and progression,and to further elucidate the characteristics of GIST subtypes.

关键词： Gastrointestinal stromal tumors microRNAs Microarray analysis Real-time polymerase chainreaction Diagnosis

Viscosity and structure relationship with equimolar substitution of CaO with MgO in the CaO–MgO–Al_(2)O_(3)–SiO_(2)slag melts

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 70-79页

作者： yong hou Shuo Zhang Jie Dang Jia Guo Hanghang Zhou Xuewei Lü College of Materials Science and Engineering Chongqing UniversityChongqing 400044China Chongqing Key Laboratory of Vanadium-Titanium Metallurgy and New Materials Chongqing UniversityChongqing 400044China

Currently,the Al_(2)O_(3)content in the high-alumina slag systems within blast furnaces is generally limited to 16wt%–18.5wt%,making it challenging to overcome this *** most studies that concentrated on managing the MgO/Al_(2)O_(3)ratio or basicity,this paper explored the effect of equimolar substitution of MgO for CaO on the viscosity and structure of a high-alumina CaO-MgO-Al_(2)O_(3)-SiO_(2)slag system,providing theoretical guidance and data to facilitate the application of high-alumina *** results revealed that the viscosity first decreased and then increased with higher MgO substitution,reaching a minimum at 15mol%MgO *** transform infrared spectroscopy(FTIR)results found that the depths of the troughs representing[SiO_(4)]tetrahedra,[AlO_(4)]tetrahedra,and Si-O-Al bending became progressively deeper with increased MgO *** of the Raman spectra showed that the average number of bridging oxygens per Si atom and the X_(Q^(3))/X_(Q^(2))(X_(Q^(i))is the molar fraction of Q^(i) unit,and i is the number of bridging oxygens in a[SiO_(4)]tetrahedral unit)ratio increased from 2.30 and 1.02 to 2.52 and 2.14,respectively,indicating a progressive polymerization of the silicate structure.X-ray photoelectron spectroscopy(XPS)results highlighted that non-bridging oxygen content decreased from 77.97mol% to 63.41mol% with increasing MgO concentration,whereas bridging oxygen and free oxygen contents *** analysis demonstrated a gradual increase in the polymerization degree of the tetrahedral structure with the increase in MgO ***,bond strength is another important factor affecting the slag *** occurrence of a viscosity minimum can be attributed to the complex evolution of bond strengths of non-bridging oxygens generated during depolymerization of the[SiO_(4)]and[AlO_(4)]tetrahedral structures by CaO and MgO.

关键词： aluminosilicate viscosity structure spectroscopy

Unraveling the mechanism of action of Shangxia Liangji formula for treating insomnia:a metabolomics and network pharmacology approach

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Traditional Medicine Research 2025年第2期10卷 16-29页

作者： Xia-Jie Quan Hao Liang yong-Hong Tang Li Jiang Xiong-ying Ji Feng-ying Zhang Ping Zhang Bo Ouyang Department of Information The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Neurology The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Gastroscopy The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Traditional Chinese Medicine The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China

Background:Insomnia is a prevalent clinical condition and Shangxia Liangji formula(SXLJF)is a well-established method of ***,the specific mechanism of action of SXLJF remains ***:The mouse model of insomnia was established by intraperitoneal injection of ***-two mice were randomly divided into a negative control group,model group,SXLJF group(18.72 g/kg/day),and positive control group(diazepam,2 mg/kg)and treated with the corresponding drugs for 7 consecutive *** open field test and pentobarbital-induced sleeping test were ***-MS-based untargeted metabolomics and network pharmacology were applied to explore the potential targets of SXLJF for treating ***,key targets were validated using ***:Behavioral tests demonstrated that SXLJF reduced the total distance,average velocity,central distance,and sleep latency,and prolonged sleep *** and network pharmacology revealed potential targets,signaling pathways,metabolic pathways,and metabolites associated with the anti-insomnia effects of ***,tyrosine hydroxylase(TH)and tyrosine metabolism emerged as crucial metabolic pathways and targets,***-qPCR results supported the role of TH in the mechanism of SXLJF in treating ***:In conclusion,TH and tyrosine metabolism may represent significant targets and pathways for SXLJF in treating insomnia.

关键词： Shangxia Liangji formula insomnia metabolomics network pharmacology tyrosine hydroxylase tyrosine metabolism

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河北省蚤目新种的记述及讨论

昆虫学报 1974年第2期17卷 219-223页

作者：柳支英吴厚永常凤嶓

从河北省的一批蚤类标本中,经过鉴定和研究,获得两个新种和一种国内新记录,兹分别记述如下。新种记述狭板猬形蚤 Hystrichopsylla (Hystroceras)stenosterna新种鉴别特征新种较近田鼠猬形蚤(Hystrickopsylla microti Scalon,1950),... 详细信息

从河北省的一批蚤类标本中,经过鉴定和研究,获得两个新种和一种国内新记录,兹分别记述如下。新种记述狭板猬形蚤 Hystrichopsylla (Hystroceras)stenosterna新种鉴别特征新种较近田鼠猬形蚤(Hystrickopsylla microti Scalon,1950),两种在颊栉的刺数、臀前鬃序的长度比较、性抱器和早性Ⅶ腹板后缘的形状以及大地区分布都比较相似。但是新种体型较大,前胸栉刺数较多,Ⅷ腹板后段显较狭长,Ⅸ腹板后臂端部平直,♀Ⅶ腹板鬃数较多,主要宿主是草原黄鼠(Citellus dauricus),生境是冀北温带丘陵干草原;而田鼠猬形蚤体型较小(3.2—3.5,♀4.0毫米左右),前胸栉刺数较少

关键词：指名亚种蚤属大林姬鼠腹节鉴别特征前胸栉后胸后侧片蚤目阳茎端草原黄鼠达乌尔黄鼠腹板模式标本河北省