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Microstructure and property of the Ti-24Al-15Nb-1.5Mo/TC11 joint welded by electron beam welding

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International Journal of Minerals,Metallurgy and Materials 2009年第5期16卷 568-575页

作者： ying-ying liu Ze-kun Yao Hong-zhen Guo Hang-hang Yang College of Materials Science and Engineering Northwestern Polytechnical University Xi＇an 710072 China

The Ti-24Al-15Nb-1.5Mo alloy, in the as-forged and heat-treated states, was joined to the as-forged TC 11 titanium alloy by electron beam welding with the heat inputs of 135 and 150 kJ/m. Then the microstructure and property of the Ti-24Al-15Nb- 1.5Mo/TC 11 welding interface were investigated. The results show that the phase constitution of the weld is not related to the heat input, and is mainly composed of α＇ phase. Moreover, the intermetallic phases of TiEAlNb, MoNb, NbaAl, and TiAl3 are formed in the weld zone. Therefore, the microhardness value of the weld zone is higher than that of the other portions in the same sample. The profile of the weld is asymmetrically fimnel-like. The grain sizes of the weld and its heat-affected zones are increased with increasing heat input. There is an obvious difference in the element content of the welding interface; only the alloying elements in the fusion zone reach a new balance during solidification.

关键词： titanium alloys electron beam welding heat input microstructure property

Hepatoid adenocarcinoma of the extrahepatic duct

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World Journal of Gastroenterology 2013年第22期19卷 3524-3527页

作者： Yu Wang ying-ying liu Gui-Ping Han Department of Pathology the 2 nd Affiliated Hospital of Harbin Medical University

Hepatoid carcinoma is a unique type of extrahepatic tumor associated with hepatic differentiation and displays the morphological and functional features of hepatocellular carcinoma. Hepatoid carcinoma of the extrahepatic duct has rarely been reported in the literature. We report a 62-year-old man who presented with epigastric discomfort, xanthochromia, dull pain of the right shoulder, nausea and pruitus. Microscopic examination of the extrahepatic duct indicated that the tumor was primarily composed of "hepatoid cells", which were characterized by an eosinophilic cytoplasm, enlarged nucleus and prominent nucleoli. The cells were arranged in nests or proliferated in a trabecular pattern. Immunohistochemistry indicated that the tumor cells were positive for hepatocyte paraffin 1 and cytokeratins 8 and 18. Based on these findings, this case was diagnosed as hepatoid carcinoma of the extrahepatic duct.

关键词： Extrahepatic bile ducts Hepatocellular Adenocarcinoma Immunohistochemistry Surgical pathology Differential diagnosis

Tonifying Kidney, Lung, and Spleen Combined with Western Medicine for Stable Chronic Obstructive Pulmonary Disease: A Systematic Review

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World Journal of Traditional Chinese Medicine 2019年第4期5卷 202-213页

作者： ying-ying liu Zhen Gao Department of Integrative Medicine Huashan HospitalFudan UniversityShanghai National Clinical Research Base of Traditional Chinese Medicine Traditional Chinese Medicine Hospital Affiliated to Xinjiang Medical UniversityUrumqiChina

Introduction:This study aimed to evaluate the clinical effectiveness and safety of tonifying kidney,lung,and spleen(TKLS)combined with Western medicine for stable chronic obstructive pulmonary disease(COPD).Materials and Methods:Randomized controlled trials(RCTs)of TKLS for stable COPD were searched from four databases including Pub Med,the Cochrane Library,China Biology Medicine,and China National Knowledge Infrastructure from inception to December *** reviewers independently screened the literature,extracted the data,and assessed the risk of bias in the included *** Man5.3 software was used for ***:Fourteen RCTs involving 1339 patients with stable COPD were *** of the included articles described the specific method of randomization,1 of them was double-blind method research,and 1 of them was single-blind method *** with the conventional Western medicine(CWM)group,the use of TKLS,if combined with CWM demonstrated significantly improved effective rate(relative risk=1.25,95%confidence interval[CI]:1.18–1.33,P<0.00001),decreased traditional Chinese medicine syndrome score(mean difference[MD]-5.72,95%CI:-8.31 to-3.14,P<0.0001),Decreased St George's Respiratory Questionnaire total score(MD-7.39,95%CI:-10.46 to-4.31,P<0.00001),increased 6-min walk distance in meters(MD 78.46,95%CI:60.18–96.73,P<0.00001),increased forced expiratory volume 1%(MD 6.49,95%CI:3.64–9.33,P<0.00001),increased CD4(MD 9.84,95%CI:6.73–12.94,P<0.00001),CD8(MD-1.84,95%CI:-3.62 to-0.06,P=0.04)and CD4/CD8(MD 0.26,95%CI:0.20–0.32,P<0.0001),and increased immunoglobulin M(MD 0.15,95%CI:0.10–0.20 P<0.00001)..Conclusions:For stable COPD,TKLS combined with CWM is superior to CWM alone with regard to clinical effectiveness,symptoms,and quality of *** above conclusion needs to be validated by further well-designed,multicentric,large-scale,double-blinded RCTs.

关键词： Chronic obstructive pulmonary disease traditional Chinese medicine tonifying kidney lung and spleen systematic review meta-analysis randomized controlled trial

Yeast KEOPS complex regulates telomere length independently of its t6A modification function

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Journal of Genetics and Genomics 2018年第5期45卷 247-257页

作者： ying-ying liu Ming-Hong He Jia-Cheng liu Yi-Si Lu Jing Peng Jin-Qiu Zhou CAS Center for Excellence in Molecular Cell Science Shanghai Institute of Biochemistry and Cell BiologyChinese Academy of SciencesUniversity of Chinese Academy of SciencesShanghai 200031China School of Life Science and Technology.ShanghaiTech University Shanghai 201210China

In Saccharornyces cerevisiae, the highly conserved Sua5 and KEOPS complex （including five subunits Kael, Bud32, Cgi121, Pccl and Gon7） catalyze a universal tRNA modification, namely N6-threonylcarbamoy- ladenosine （t6A）, and regulate telomere replication and recombination. However, whether telomere regulation function of Sua5 and KEOPS complex depends on the t6A modification activity remains unclear. Here we show that Sua5 and KEOPS regulate telomere length in the same genetic pathway. Interestingly, the telomere length regulation by KEOPS is independent of its t6A biosynthesis activity. Cytoplasmic overexpression of Qri7, a functional counterpart of KEOPS in mitochondria, restores cytosolic tRNA t6A modification and cell growth, but is not sufficient to rescue telomere length in the KEOPS mutant kae1△ cells, indicating that a t6A modification-independent function is responsible for the telomere regulation. The results of our in vitro biochemical and in vivo genetic assays suggest that telomerase RNA TLC1 might not be modified by Sua5 and KEOPS. Moreover, deletion of KEOPS subunits results in a dramatic reduction of telomeric G-overhang, suggesting that KEOPS regulates telomere length by promoting G-overhang generation. These findings support a model in which KEOPS regulates telomere replication independently of its function on tRNA modification.

关键词： Telomere KEOPS complex Sua5 G-overhang t6A modification

Hsa-miR-202-3p,up-regulated in type 1 gastric neuroendocrine neoplasms,may target DUSP1

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World Journal of Gastroenterology 2018年第5期24卷 573-582页

作者： Dou Dou Yan-Fen Shi Qing liu Jie Luo Ji-Xi liu Meng liu ying-ying liu Yuan-Liang Li Xu-Dong Qiu Huang-ying Tan Department of Integrative Oncology China-Japan Friendship Hospital Beijing University of Chinese Medicine Beijing 100029China Department of Integrative Oncology China-Japan Friendship HospitalBeijing 100029China Department of Pathology China-Japan Friendship HospitalBeijing 100029China Department of Gastroenterology China-Japan Friendship HospitalBeijing 100029China Department of Integrative Oncology Luoyang Central Hospital Affiliated to Zhengzhou UniversityLuoyang 471009Henan ProvinceChina

AIM To detect abnormal micro RNA(miRNA) expression in type 1 gastric neuroendocrine neoplasms(g-NENs) and find potential target *** Tumour tissues from patients with type 1 g-NENs were used as experimental samples, and gastric mucosal tissues from the same patients obtained during gastroscopy review after several months were used as control samples. miRNA expression was examined with Agilent human miRNA chips and validated via RTPCR. Three types of target gene prediction software(TargetScan, PITA, and microRNAorg) were used to predict potential target genes of the differentially expressed miRNAs, and a dual-luciferase reporter assay system was used for verification. RESULTS Six miRNAs were significantly upregulated or downregulated in the tumours compared to the control samples. Among them, miR-202-3 p was extraordinarily upregulated. RT-PCR of seven sample sets confirmed that miR-202-3 p was upregulated in tumour tissues. In total, 215 target genes were predicted to be associated with miR-202-3 p. Among them, dual-specificity phosphatase 1(DUSP1) was reported to be closely related to tumour occurrence and development. The dual-luciferase reporter assay showed that miR-202-3 p directly regulated DUSP1 in 293 T cells. CONCLUSION miR-202-3 p is upregulated in type 1 g-NEN lesions and might play important roles in the pathogenesis of type 1 g-NENs by targeting DUSP1.

关键词： microRNA type 1 g-NEN neuroendocrine neoplasm recurrence

Traditional Chinese Medicine Pattern Classification and Herbal Medicine for COVID-19: A Comparative Study of Data from Different Sources

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World Journal of Traditional Chinese Medicine 2023年第1期9卷 81-93页

作者： Zhen Gao ying-ying liu Ye-Meng Chen Jing-Cheng Dong Department of Integrative Medicine Huashan HospitalFudan UniversityShanghaiChina Institute of Basic Theory and Application Institutes of Integrative MedicineFudan UniversityShanghaiChina Department of Geriatrics and Retired Cadre Putuo HospitalShanghai University of Traditional Chinese MedicineShanghaiChina Dean's Office New York College of Traditional Chinese MedicineMineolaNYUSA

Background: Traditional Chinese medicine(TCM) plays a crucial role in the prevention and control of coronavirus disease 2019(COVID-19). Objective: The study aimed to reveal the distribution characteristics of COVID-19 TCM syndrome types and syndrome elements and the law of TCM treatment and medication. Methods: The TCM diagnosis and treatment protocol for COVID-19 and clinical research data were obtained through network retrieval, and Revman 5.3 and SPSS 23.0 were employed to analyze the composition of TCM syndromes and the situation of TCMs in meta and frequency. Results: The top three TCM syndromes of COVID-19 included damp-heat accumulation in the lung pattern, damp abundance due to spleen deficiency, and epidemic toxin invading the lung pattern, while the syndrome elements were dampness, heat, and toxin. Gypsum fibrosum, Pogostemonis herba, and Armeniacae semen were identified as the commonly used drugs. Different syndrome elements were identified at lung disease location: Forsythiae fructus, Glycyrrhizae radix, and Armeniacae semen can be used for “wind;” Glycyrrhizae radix, Armeniacae semen, and Scutellariae radix can be used for “Heat;” Armeniacae semen, Sheng Gypsum fibrosum, and Ephedrae herba can be used for “Toxin;” Ephedrae herba, Armeniacae semen, and Atractylodis rhizome can be used for “Damp;” Magnoliae officinalis Cortex, Ephedrae herba, and Zingiberis Rhizoma recens can be used for “cold;” and Armeniacae semen, Gypsum fibrosum, Ephedrae herba, and Lepidii/Descurainiae semen can be used for “epidemic.” Conclusion: The establishment of a treatment scheme based on the classification of disease syndrome elements should be considered for sudden infectious diseases, such as COVID-19. Pogostemonis herba, Armeniacae semen, Gypsum fibrosum, and Glycyrrhizae radix should be considered as effective drugs from TCM for the treatment of COVID-19.

关键词： COVID-19 diagnosis and treatment protocol for COVID-19 syndrome syndrome element traditional Chinese medicine traditional Chinese medicine syndrome investigation

Study on the active sites of Cu-ZSM-5 in trichloroethylene catalytic combustion with air

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Chinese Chemical Letters 2008年第11期19卷 1387-1390页

作者： Cheng Hua Xu Chuan Qi liu Yan Zhong Xiu Zhou Yang Jian ying liu ying Chun Yang Zhi Xiang Ye Department of Environmental Engineering Chengdu University of Information Technology （CULT） Chengdu 610225 China

The catalytic activity of Cu-ZSM-5 in trichloroethylene （TCE） combustion increases with the increasing skeletal Cu amount and however decreases with the increase of surface amorphous CuO, which is detected by infrared spectroscopy （IR） and diffuse reflectance ultraviolet-visible spectroscopy （DRS-UV-vis）, therefore the skeletal Cu species are concluded to be the active sites for the TCE combustion.

关键词： Cu-ZSM-5 Active sites Trichloroethylene Catalytic combustion

Quantitative evaluation framework and application for regional water sustainability under local energy transition

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Advances in Climate Change Research 2023年第6期14卷 976-987页

作者： Lan-Tian ZHANG ying-ying liu Sha CHEN Han-Bing LI Su-Mei LI Ke-Jun JIANG Ji GAO College of Environmental Science and Engineering Key Laboratory of Beijing on Regional Air Pollution ControlBeijing University of TechnologyBeijing 100124China Energy Research Institute Chinese Academy of Macroeconomic ResearchBeijing 100038China Environmental Defense Fund Beijing 100007China

Quantitatively analysing the impacts on regional water sustainability under the energy transition is vital to regional water management and specific technology selection,which is also relevant to dealing with climate *** study proposed a new multi-indicator evaluation framework for regional water sustainability under local energy transition to quantitatively evaluate the water withdrawal and water environment during the energy transition from a lifecycle *** integrated regional energy-water evaluation model was also developed based on the Low Emissions Analysis Platform with a combination of lifecycle assessment and water footprint *** province in China was then taken as a case study,and the impacts of its energy transition on regional water environmental sustainability,including quantity and quality,were investigated under five *** showed that the large-scale application of carbon capture,utilisation and storage technology and bio-energy equipped with carbon capture and storage technology could have additional advantages regarding CO_(2) ***,such technologies exhibit a minimal effect on improving water environmental quality and reducing water demand for the first time due to the leakage of absorbents,CO_(2) and other risky substances during capture,transportation and storage from a lifecycle *** finding drives the innovation of related breakthrough technologies with the promotion of water and end-treatment technologies in the future.

关键词： Water sustainability Energy-water nexus Transition path Spatial and temporal analyses

Investigating the Potential Mechanism of Huazhi Rougan Granules Against Alcoholic Liver Disease by Network Pharmacology and Experiment

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World Journal of Traditional Chinese Medicine 2024年第2期10卷 191-203页

作者： ying-ying Tan ying-ying liu Yi-Yan Zhai Yi-Xuan Wang Zhi-Shan Wu Antony Stalin Guo-Liang Cheng Bing Li Chao Wu Zhi-Hong Huang Shan Lu Xiao-Tian Fan Zheng Zhao Jia-Rui Wu Department of Clinical Chinese Pharmacy School of Chinese Materia MedicaBeijing University of Chinese MedicineBeijingChina Department of Bioinformatics Institute of Fundamental and Frontier SciencesUniversity of Electronic Science and Technology of ChinaChengduChina Department of Traditional Chinese Medicine State Key Laboratory of Generic Manufacture Technology of Chinese Traditional MedicineLinyiChina Department of Clinical Medicine Beijing Zest Bridge Medical Technology Inc.BeijingChina

Objective: Huazhi Rougan granules(HRGs) are a promising drug to improve alcoholic liver disease(ALD), but its mechanism remains unclear. Materials and Methods: Network pharmacology, molecular docking, and animal experiments were used to reveal the potential mechanism of HRG against ALD. Results: A total of 245 potential targets of HRG against ALD were obtained. Functional enrichment analysis suggests that HRG could synergistically regulate various biological pathways to exert therapeutic effects on ALD. Molecular docking showed that the key targets exhibited the good binding ability with the key compounds. The in vivo experiments showed that HRG can effectively alleviate pathological changes in liver tissue, improve blood lipid levels, antioxidant stress ability, and liver function, and reduce the release of inflammatory cytokines in the liver. Conclusions: This study reflects that HRG is an effective strategy for treating ALD, providing a basis for revealing the prevention and treatment mechanisms of ALD.

关键词： Alcoholic liver disease Huazhi Rougan granules inflammatory response network pharmacology