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Chinese Physics Letters 2017年第10期34卷 56-59页

作者： Zhao-Wen Ren Hui Xie ying-ying zhou School of Materials and Chemical Engineering Xi＇an Technological University Xi＇an 710021 School of Materials Engineering Xi ＇ an Aeronautical University Xi ＇ an 710077 State Key Laboratory of Solidification Processing Northwestern Polytechnical University Xi＇an 710072

Silica-coated carbonyl iron particles （CIPs） are fabricated with the Stober method to improve their heat-resistance and wave-aSsorption properties. The morphology, heat-resistance, electromagnetic properties and microwave absorption of raw-CIPs and silica-coated CIPs are investigated using a scanning electron microscope, an energy dispersive spectrometer, a thermal-gravimetric analyzer, and a network analyzer. The results show that the heat-resistance of silica-coated CIPs is better than that of raw CIFs. The reflection losses exceeding -lOdB of silica-coated CIPs are obtained in the frequency range 9.5-12.4 GHz for the absorber thickness of 2.3 mm, and the same reflection losses of uncoated CIPs reach the data in the lower frequency range for the same thickness. The enhanced microwave absorption of silica-coated CIPs can be ascribed to the combination of proper electromagnetic impedance match and the decrease of dielectric permittivity.

关键词： ab Enhancement of Heat-Resistance of Carbonyl Iron Particles by Coating with Silica and Consequent Changes in Electromagnetic Properties Figure

Application of NIR spectroscopy for firmness evaluation of peaches

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2008年第7期9卷 552-557页

作者： Xia-ping FU Yi-bin ying ying zhou Li-juan XIE Hui-rong XU College of Biosystems Engineering and Food Science Zhejiang University Hangzhou 310029 China

The use of near infrared （NIR） spectroscopy was proved to be a useful tool for quality analysis of fruits. A bifurcated fiber type NIR spectrometer, with a detection range of 800-2500 nm by InGaAs detector, was used to evaluate the firmness of peaches. Anisotropy of NIR spectra and firmness of peaches in relation to detecting positions of different parts （including three latitudes and three longitudes） were investigated. Both spectra absorbency and firmness of peach were influenced by longitudes （i, ii, iii） and latitudes （A, B, C）. For modeling, two thirds of the samples were used as the calibration set and the remaining one third were used as the validation or prediction set. Partial least square regression （PLSR） models for different longitude and latitude spectra and for the whole fruit show that collecting several NIR spectra from different longitudes and latitudes of a fruit for NIR calibration modeling can improve the modeling performance. In addition, proper spectra pretreatments like scattering correction or derivative also can enhance the modeling performance. The best results obtained in this study were from the holistic model with multiplicative scattering correction （MSC） pretreatment, with correlation coefficient of cross-validation γcv=0.864, root mean square error of cross-validation RMSECV=6.71 N, correlation coefficient of calibration r=0.948, root mean square error of calibration RMSEC=4.21 N and root mean square error of prediction RMSEP=5.42 N. The results of this study are useful for further research and application that when applying NIR spectroscopy for objectives with anisotropic differences, spectra and quality indices are necessarily measured from several parts of each object to improve the modeling performance.

关键词： Near infrared (NIR) Anisotropy Peach Firmness Partial least square regression (PLSR)

A chaos genetic algorithm for optimizing an artificial neural network of predicting silicon content in hot metal

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Journal of University of Science and Technology Beijing 2003年第2期10卷 68-71页

作者： Deling Zheng, Ruixin Liang, ying zhou, and ying WangInformation Engineering School, University of Science and Technology Beijing, Beijing 100083, China Information Engineering School University of Science and Technology Beijing Beijing 100083 China

A genetic algorithm based on the nested intervals chaos search (NICGA) hasbeen given. Because the nested intervals chaos search is introduced into the NICGA to initialize thepopulation and to lead the evolution of the population, the NICGA has the advantages of decreasingthe population size, enhancing the local search ability, and improving the computational efficiencyand optimization precision. In a multi4ayer feed forward neural network model for predicting thesilicon content in hot metal, the NICGA was used to optimize the connection weights and thresholdvalues of the neural network to improve the prediction precision. The application results show thatthe precision of predicting the silicon content has been increased.

关键词： blast furnace optimization chaos genetic algorithm neural network silicon content prediction

Edge detection of range images using genetic neural networks

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重庆邮电大学学报（自然科学版） 2009年第2期21卷 272-275页

作者： FAN Jian-ying DU ying zhou Yang WANG Yang Department of Measurement-Control Technology ＆ Instrument Harbin University of Science ＆ TechnologyHarbin 150080 P. R. China

Due to the complexity and asymmetrical illumination, the images of object are difficult to be effectively segmented by some routine method. In this paper, a kind of edge detection method based on image features and genetic algorithms neural network for range images was proposed. Fully considering the essential difference between an edge point and a noise point, some characteristic parameters were extracted from range maps as the input nodes of the network in the algorithm. Firstly, a genetic neural network was designed and implemented. The neural network is trained by genetic algorithm, and then genetic neural network algorithm is combined with the virtue of global optimization of genetic algorithm and the virtue of parallel computation of neural network, so that this algorithm is of good global property. The experimental results show that this method can get much faster and more accurate detection results than the classical differential algorithm, and has better anti-noise performance.

关键词：遗传神经网络基于图像检测范围遗传算法边缘检测方法神经网络训练神经网络算法参数提取

Efficacy and safety of intravenous itraconazole followed by oral itraconazole solution in the treatment of invasive pulmonary mycosis

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Chinese Medical Journal 2011年第20期124卷 3415-3419页

作者： ZHANG ying-ying zhou Xin Department of Respiratory Medicine Shanghai First People＇sHospital Affiliated to Shanghai Jiao Tong University Shanghai200080 China

Background Invasive pulmonary mycosis is the most common type of invasive fungal infection. It is often severe and difficult to treat, and is accompanied by high mortality. In this study, we aimed to evaluate the efficacy and safety of intravenous itraconazole followed by oral itraconazole solution in the treatment of invasive pulmonary mycosis and to determine the distribution of different fungi species. Methods This was a multi-center, open-label study which enrolled 71 patients who were diagnosed as invasive pulmonary mycosis between July 2007 and January 2009. All patients received intravenous itraconazole therapy followed by oral itraconazole solution with a total treatment duration of 6 weeks. Intravenous itraconazole was given at a dose of 200 mg bid （intravenous infusion every 12 hours） for the first two days, 200 mg qd for the subsequent 12 days. Sequential oral itraconazole solution was given at a dose of 100 mg bid for 4 weeks. Efficacy and safety were assessed according to clinical as well as microbiological criteria. Results Seventy one patients participated in this study. Of the 60 patients in the full analysis dataset, the clinical response rate was 61.7% and the mycological eradication rate was 66.7%. The overall response rate was 66.7%. Drug-related adverse events occurred in 18.0% of patients： hypokalemia, liver function impairment and mild gastrointestinal side effects were the most common. One patient suffered from severe adverse event, with limb and facial swelling. Conclusion This study showed that in patients with invasive pulmonary mycosis, intravenous itraconazole followed by oral itraconazole solution therapy was safe and effective.

关键词： itraconazole invasive pulmonary mycosis sequential therapy

All-trans-retinoic acid generation is an antidotal clearance pathway for all-trans-retinal in the retina

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2019年第12期20卷 960-971页

作者： Qing-qing XIA Ling-min ZHANG ying-ying zhou Ya-lin WU Jie LI Central Laboratory Department of Laboratory MedicineHuangyan Hospital of Wenzhou Medical UniversityTaizhou First People rs HospitalTaizhou 318020China Eye Institute of Xiamen University Fujian Provincial Key Laboratory of Ophthalmology and Visual ScienceSchool of MedicineXiamen UniversityXiamen 361102China

The present study was designed to analyze the metabolites of all-trans-retinal(atRal) and compare the cytotoxicity of atRal versus its derivative all-trans-retinoic acid(atRA) in human retinal pigment epithelial(RPE) cells. We confirmed that atRA was produced in normal pig neural retina and RPE. The amount of all-trans-retinol(atROL) converted from atRal was about 2.7 times that of atRal-derived atRA after incubating RPE cells with 10 μmol/L atRal for 24 h, whereas atRA in medium supernatant is more plentiful(91 vs. 29 pmol/mL), suggesting that atRA conversion ? facilitates elimination of excess atRal in the retina. Moreover, we found that mRNA expression of retinoic acid-specific hydroxylase CYP26 b1 was dose-dependently up-regulated by atRal exposure in RPE cells, indicating that atRA inactivation may be also initiated in atRal-accumulated RPE cells. Our data show that atRA-caused viability inhibition was evidently reduced compared with the equal concentration of its precursor atRal. Excess accumulation of atRal provoked intracellular reactive oxygen species(ROS) overproduction, heme oxygenase-1(HO-1) expression, and increased cleaved poly(ADP-ribose) polymerase 1(PARP1) expression in RPE cells. In contrast, comparable dosage of atRA-induced oxidative stress was much weaker, and it could not activate apoptosis in RPE cells. These results suggest that atRA generation is an antidotal metabolism pathway for atRal in the retina. Moreover, we found that in the eyes of ABCA4-/-RDH8-/-mice, a mouse model with atRal accumulation in the retina, the atRA content was almost the same as that in the wild type. It is possible that atRal accumulation simultaneously and equally promotes atRA synthesis and clearance in eyes of ABCA4-/-RDH8-/-mice, thus inhibiting the further increase of atRA in the retina. Our present study provides further insights into atRal clearance in the retina.

关键词： All-trans-retinal All-trans-retinoic acid Antidotal pathway Human retinal pigment epithelial cell Oxidative stress

Effect of genetic variants in KCNJ11, ABCC8, PPARG and HNF4A loci on the susceptibility of type 2 diabetes in Chinese Han population

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Chinese Medical Journal 2009年第20期122卷 2477-2482页

作者： WANG Fang HAN Xue-yao REN Qian ZHANG Xiu-ying HAN Ling-chuan LUO ying-ying zhou Xiang-hai JI Li-nong Department of Endocrinology and Metabolism Peking University People's Hospital Beijing 100044 China

Background KCNJ11, ABCC8, PPARG, and HNF4A have been found to be associated with type 2 diabetes in populations with different genetic backgrounds. The aim of this study was to test, in a Chinese Han population from Beijing, whether the genetic variants in these four genes were associated with genetic predisposition to type 2 diabetes. Methods We studied the association of four representative SNPs in KCNJ11, ABCC8, PPARG, and HNF4A by genotyping them using ABI SNaPshot Multiplex System in 400 unrelated type 2 diabetic patients and 400 unrelated normoglycaemic subjects. Results rs5219（E23K） in KCNJ11 was associated with genetic susceptibility to type 2 diabetes （OR=1.400 with 95% CI 1.117 1.755, P=0.004 under an additive model, 0R=1.652 with 95% CI 1.086 2.513, P=0.019 under a recessive model, and OR=1.521 with 95% Cl 1.089 2.123, P=0.014 under a dominant model） after adjusting for sex and body mass index （BMI）. We did not find evidence of association for ABCC8 rs1799854, PPARG rs1801282 （Pro12Ala） and HNF4A rs2144908. Genotype-phenotype correlation analysis revealed that rs1799854 in ABCC8 was associated with 2-hour postprandial insulin secretion （P=0.005） after adjusting for sex, age and BMI. Although no interactions between the four variants on the risk of type 2 diabetes were detected, the multiplicative interaction between PPARG Pro12Ala and HNF4A rs2144908 was found to be associated with 2-hour postprandial insulin （P=-0.004 under an additive model for rs2144908; and P=0.001 under a dominant model for rs2144908） after adjusting for age, sex and BMI, assuming a dominant model for PPARG Pro12Ala. Conclusions Our study replicated the association of rs5219 in KCNJ11 with type 2 diabetes in Chinese Han population in Beijing. And we also observed that ABCC8 as well as the interaction between PPARG and HNF4A may contribute to post-challenge insulin secretion.

关键词： type 2 diabetes KCNJ11 ABCC8 PPARG HNF4A

Tangled but ordered human mitochondrial tRNA maturation

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Science China Life Sciences 2025年

作者： Shi-ying Yao Xiao-Long zhou Key Laboratory of RNA Innovation Science and Engineering CAS Center for Excellence in Molecular Cell Science Shanghai Institute of Biochemistry and Cell Biology Chinese Academy of Sciences University of Chinese Academy of Sciences Key Laboratory of Systems Health Science of Zhejiang Province School of Life Science Hangzhou Institute for Advanced Study University of Chinese Academy of Sciences

Mitochondria are cellular organelles that originate from an endosymbiotic bacterial ancestor and are primarily responsible for ATP generation via oxidative phosphorylation (OXPHOS). OXPHOS is conducted by five mitochondrial respiratory complexes in the inner mitochondrial membrane. Human mitochondria possess a distinct genome, a small, circular, doublestranded DNA (mtDNA) of 16,569 base pairs.

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近距离绳系卫星动力学与释放方法研究

系统仿真学报 2008年第20期20卷 5642-5645页

作者：刘莹莹周军西北工业大学精确制导与控制研究所陕西西安710072

针对绳系子星近距离快速释放问题,研究了短系绳释放过程的动力学特性,分析了适当的释放方式。考虑子星姿态,建立了绳系卫星系统运动学与动力学模型,探索了适合于近距离系绳释放的方式。提出以一定初始速度释放子星,并通过减速释放保证... 详细信息

针对绳系子星近距离快速释放问题,研究了短系绳释放过程的动力学特性,分析了适当的释放方式。考虑子星姿态,建立了绳系卫星系统运动学与动力学模型,探索了适合于近距离系绳释放的方式。提出以一定初始速度释放子星,并通过减速释放保证系绳张紧的释放方法。通过数学仿真,分析了释放过程中系绳与子星姿态的运动特性。表明这种方法能够实现绳系子星任意方向的释放,满足快速释放的要求。减速释放过程中系绳轨道面内角度以轨道角速度发生偏移,子星姿态小幅振动,系绳保持张紧。这些动力学特性为以后近距离绳系卫星的释放与的控制提供了重要依据。

关键词：绳系卫星近距离释放动力学子星姿态

Nanostructured ZnO/BiVO_(4)I-scheme heterojunctions for piezocatalytic degradation of organic dyes via harvesting ultrasonic vibration energy

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 488-497页

作者： Yiling Li Xiaoyao Yu yingjie zhou Yao Lin ying Wu Key Laboratory of the Ministry of Education for Advanced Catalysis Materials College of Chemistry and Materials ScienceZhejiang Normal UniversityJinhua 321004China

BiVO_(4)porous spheres modified by ZnO were designed and synthesized using a facile two-step *** resulting ZnO/BiVO_(4)composite catalysts have shown remarkable efficiency as piezoelectric catalysts for degrading Rhodamine B(RhB)unde mechanical vibrations,they exhibit superior activity compared to pure *** 40wt%ZnO/BiVO_(4)heterojunction composite displayed the highest activity,along with good stability and *** enhanced piezoelectric catalytic activity can be attributed to the form ation of an I-scheme heterojunction structure,which can effectively inhibit the electron-hole ***,hole(h+)and superoxide radical(·O_(2)^(-))are proved to be the primary active ***,ZnO/BiVO_(4)stands as an efficient and stable piezoelectric catalyst with broad potential application in the field of environmental water pollution treatment.

关键词： piezoelectric catalytic heterojunction dye degradation ultrasonic vibration