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Negative efficacy of antidepressants in pharmacotherapy of child and adolescent depression

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World Journal of Psychiatry 2025年第1期15卷 32-36页

作者： Min Xu Hai-ying jin Feng-Li Sun Wei-Dong jin Department of Psychiatry Zhejiang Chinese Medical UniversityHangzhou 310053Zhejiang ProvinceChina Department of Psychiatry Tongde Hospital of Zhejiang ProvinceHangzhou 310012Zhejiang ProvinceChina Department of Psychiatry Zhejiang Provincial Mental Health CenterHangzhou 311122Zhejiang ProvinceChina

Antidepressants are the main drugs used to treat depression,but they have not been shown to be effective in the treatment of child and adolescent ***,many adolescent depression treatment guidelines still recommend the use of antidepressants,especially specific serotonin re-uptake *** studies have suggested that antidepressants have little therapeutic effect but many side effects,such as switching to mania,suicide,and non-suicidal self injury(NSSI),in the treatment of child and adolescent *** the process of developing guidelines,drug recommendations should not only focus on impro-ving symptoms,but they should also consider potential side *** review discusses the serious side effects of antidepressants,including switching to mania,suicide,and NSSI.

关键词： Child depression Adolescent depression Antidepressant Switch Suicide Non-suicidal self injury

Stimuli-Responsive Interconversion between Poly-NHC-Based Organometallic Assemblies and Their Self-Aggregated Dimers

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Chinese Journal of Chemistry 2024年第22期42卷 2840-2844页

作者： Guang-Feng jin ying-Feng Han Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education Xi'an Key Laboratory of Functional Supramolecular Structureand MaterialsCollege of Chemistry and Materials ScienceNorthwest UniversityXi'anShaanxi 710127China

Comprehensive Summary Poly-NHC-based organometallic assemblies 3-PF6,3-SbF6 and 3-OTf were obtained and verified by NMR spectroscopy,ESI mass spectrometry and single-crystal X-ray diffraction *** structural interconversion was observed between the poly-NHC-based organometallic assemblies and their self-aggregated dimers in solution affected by concentration,solvent and metal ion.1H NMR spectra of assembly 3-PF6 in CD3CN at different concentrations demonstrated controllable structural interconversion,and 19F NMR spectrum of assembly 3-PF6 at high concentration further evidenced the presence of the free hexafluorophosphate anion and encapsulated hexafluorophosphate anion for its two sets of *** addition,single-crystal X-ray diffraction analysis provided clear evidence that in the solid state,two assemblies 3-PF6 were vertically stuck,forming a self-aggregated dimer with an encapsulated hexafluorophosphate *** the reversible structural interconversion is beneficial for revealing the intrinsic nature on the atom level and paving the way to design the stimuli-responsive functional system.

关键词： N-Heterocyclic carbene Organometallic assemblies Self-aggregated dimer Stimuli-responsive Structural interconversion Concentrationl Solvent Metalion

Regulating the oxygen-atom configuration of carbon anode enabling extremely fast-charging potassium-ion hybrid capacitors

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Nano Research 2025年第1期18卷 373-381页

作者： Daping Qiu Yuehui Wang Lulu Zhang Hang Lei Haizhou ying jin Niu Min Li Xuelin Yang Feng Wang Ru Yang Hubei Provincial Collaborative Innovation Center for New Energy Microgrid College of Electrical Engineering and New EnergyChina Three Gorges UniversityYichang 443002China State Key Laboratory of Chemical Resource Engineering Laboratory of Electrochemical Process and Technology for MaterialsBeijing University of Chemical TechnologyBeijing 100029China College of Materials and Chemical Engineering China Three Gorges UniversityYichang 443002China

Metal-ion hybrid capacitors,such as potassium-ion hybrid capacitors(PIHCs),are regarded as promising fast-charging energy storage ***,the kinetics mismatch between the battery anode and the capacitive cathode restricts their fastcharging *** constructing carbon anodes with enhanced kinetics is an innovative approach to address this ***,using epigallocatechin gallate with high oxygen content as the precursor,oxygen-enriched carbon materials(OEC)with tunable C=O content are successfully ***,the C=O content of OEC is regulated by adjusting the pyrolysis *** as an anode for PIHCs,OEC-600 with the highest C=O content exhibits an attractive fast-charging specific capacity of 135.2 mAh·g^(-1)at 20 A·g^(-1),along with a superior fast-charging cycling *** theoretical calculations,comprehensive kinetics analysis and in-situ Raman,the positive effects of C=O on the potassium storage capability and reversibility of OEC-600 are ***,PIHCs assembled based on an OEC-600 anode deliver impressive energy/power density of 145.1 Wh·kg^(-1)/45.9 kW·kg^(-1)and superior fast-charging cycling stability with 87.5%of capacity retention over 20,000 cycles at 5 A·g^(-1).This work is anticipated to provide an optional design concept toward the carbon anode for fast-charging PIHCs.

关键词： carbon anode oxygen epigallocatechin gallate potassium-ion hybrid capacitor

Vertical distribution of nonylphenol and nonylphenol ethoxylates in sedimentary core from the Beipaiming Channel, North China

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Journal of Environmental Sciences 2007年第3期19卷 353-357页

作者： jin Fen HU Jian-ying YANG Min State Key Lab of Environmental Aquatic Chemistry Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100085 China College of Environmental Science Peking University Beijing 100871 China

The vertical profiles of nonylphenol （NP） and nonylphenol ethoxylates （NPEOs） were investigated in a sediment core from the Beipaiming Channel, North China using high sensitive LC-MS and GC-MS metthods In this core, relatively high concentrations of NP and NPEOs occurred in the surface sediment （≤40 cm）, with the maximum value of NP and NPEOs reaching 3539 and 12735 mg/g, respectively, whereas, no NP or NPEOs were detected in deeper sediments （〉40 cm）. The high concentrations of NP and NPEOs in the surface layers suggested recent inputs in this area. NPEOs with short ethoxy chains （NPnEO, n=0-3） were dominant in the NPEO mixture with percentages from 54% to 78%, which were similar to the distribution of homolog NPEO in effluents from nearby sewage treatment plants （STPs）, indicating that the channel received the effluents from these STPs. The sewage treatment ratio was quite similar to that found in North America before the 1980s. Finally, the concentrations of NP and NPEOs were related to the total organic carbon （TOC）（p〈0.001）, suggesting that TOC was an important factor for vertical distribution of NPEOs and NP from the Beipaiming Channel.

关键词： nonylphenol nonylphenol ethoxylates sediment core Bohai Bay

Recent advancements in single-cell metabolic analysis for pharmacological research

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Journal of Pharmaceutical Analysis 2023年第10期13卷 1102-1116页

作者： ying Hou Hongren Yao jin-Ming Lin Beijing Key Laboratory of Microanalytical Methods and Instrumentation Key Laboratory of Bioorganic Phosphorus Chemistry&Chemical Biology(Ministry of Education)Department of ChemistryTsinghua UniversityBeijing100084China

Cellular heterogeneity is crucial for understanding tissue biology and disease *** research is being advanced by single-cell metabolic analysis,which offers a technique to identify variations in RNA,proteins,metabolites,and drug molecules in *** this review,the recent advancement of single-cell metabolic analysis techniques and their applications in drug metabolism and drug response are ***-precision and controlled single-cell isolation and manipulation are provided by microfluidics-based methods,such as droplet microfluidics,microchamber,open microfluidic probe,and digital *** are used in tandem with variety of detection techniques,including optical imaging,Raman spectroscopy,electrochemical detection,RNA sequencing,and mass spectrometry,to evaluate single-cell metabolic changes in response to drug *** advantages and disadvantages of different techniques are discussed along with the challenges and future directions for single-cell *** techniques are employed in pharmaceutical analysis for studying drug response and resistance pathway,therapeutic targets discovery,and in vitro disease model evaluation.

关键词： Single-cell Metabolism Pharmacology Drug response Microfluidics

Polyethylene Oxide-Coated Electrospun Polyimide Fibrous Seperator for High-Performance Lithium-Ion Battery

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Journal of Materials Science & Technology 2016年第3期32卷 200-206页

作者： Xingxing Liang ying Yang Xin jin Jie Cheng Department of Electrical Engineering Tsinghua University Beijing 100084 China Beijing Smart China Energy Internet Research Institute Beijing 100176 China State Key Lab. of Power System Tsinghua University Beijing 100084 China Zhangjiagang Smartgrid Research Institute Zhangjiagang 215600 China Research Institute of Chemical Defense Beijing 100191 China

A polyethylene oxide （PEO）-coated polyimide （PI） membrane was prepared by electrospinning method followed by a dip-coating and drying process for high-performance lithium-ion batteries （LIB）. 8emicrystal PEO was covered on the surface of the fibers and partially enmeshed in PI matrix, which formed unique porous structures. The pores with an average size of 4.1 μm and a porosity of 90% served as ion transport channels. Compared with the cell with Celgard 2400 membrane, the half-cell using PEO-coated P1 membrane as a separator exhibits excellent electrochemical performance both at room temperature and at low temperature. The electrolyte uptaking rate of PEO-coated PI membrane was 170% and the ionic conductivity was 3.83 × 10^-3 S cm^-1. PEO-coated PI membrane possessed 5.3 V electrochemical window. The electrode-electrolyte interfacial resistance was 62.4 Ω. The capacity retention ratios with PEO- coated PI membrane were 86.4% at 5 C and 73.5% at 10 C at 25 ℃ and 75% at 5 C at 0 ℃. Furthermore, the cell using the separator demonstrates excellent capacity retention over cycling. These advanced characteristics would boost the application of the PEO-coated PI membrane for high-power lithium ion battery.

关键词： Lithium-ion batteries Electrospinning Polyimide Polyethylene oxide Low temperature

Fluid Pump Using a Bar-shaped Piezoelectric Transducer

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Chinese Journal of Mechanical Engineering 2011年第6期24卷 1130-1135页

作者： jin Jiamei WANG Yin YANG ying ZHANG Jianhui State Key Laboratory of Mechanics and Control of Mechanical Structures Nanjing University of Aeronautics and AstronauticsNanjing 210016China

There are two kinds of piezoelectric pumps:check valve pumps and valve-less *** to use a check valve or not depends upon the application *** achieve large backpressure for higher flow rates,the pump with check valve is ***,adding check valves implies more complex structure and higher probability of valve blocking,*** order to solve the problem,effective driving and transport mechanics with compact construction and reliable service are being *** this paper,using the second-order longitudinal vibration mode of a bar-shaped piezoelectric vibrator for driving fluid,a piezoelectric pump is successfully *** proposed piezoelectric pump consists of coaxial cylindrical shells and a bar-shaped piezoelectric vibrator,which has a disk part and a cone *** lead zirconium titanate ceramic rings fixed in the vibrator are polarized along the thickness *** the second-order longitudinal vibration of the vibrator along its axis is excited,the disk part of the vibrator changes periodically the volume of the chamber and the cone part acts as a pin valve,driving the fluid from the inlet port to the outlet *** elements analysis on the proposed pump model is carried out to verify its operation principle and design by the commercial FEM software *** of the piezoelectric pump were manufactured,assembled,and tested for flow rate and backpressure to validate the concepts of the proposed pump and confirm the simulation results of modal and harmonic *** test results show that the performance of the proposed piezoelectric pump is about 910 mL/min in flow rate with a highest pressure level of 1.5 kPa under 400 V peak-to-peak voltage and 51.7 kHz operating *** is confirmed that this bar-shaped piezoelectric transducer can be effectively applied in fluid transferring mechanism of pump through this research.

关键词： piezoelectric pump check valve longitudinal vibration mode FEM simulation bar-shaped transducer

Synthesis,Crystal Structure,and Spectral Properties of a Novel Co(II) Complex Containing Imidazole Derivative

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Chinese Journal of Structural Chemistry 2006年第11期25卷 1303-1308页

作者： jin Feng HAO Fu-ying MA Ji-Long WU Jie-ying TIAN Yu-Peng Department of Chemistry Fuyang Normal College Fuyang 236041 China Department of Chemistry Anhui University Hefei 230039 China State Key Laboratory of Coordination Chemistry Nanjing University Nanjing 210093 China

A novel imidazole derivative with functional group and π-conjugated system, 1- [trans-4-（4-diethylaminostyryl）phenyl]imidazole （abbreviated as L）, and its Con complex （COCl2L4）2 （Co2C168H184N24Cl4, Mr = 2799.05 ） have been synthesized and the crystal structure of the latter was determined by X-ray diffraction. The crystal is of triclinic, space group PI with a = 8.823（3）, b = 18.799（7）, c =23.065（9） A, α = 77.349（6）, β = 83.128（7）, ）, γ= 80.942（3）°, V = 3671.5（12） A^3, Z = 1, Dc = 1.266 g/cm^3,/z = 0.361 mm^-1 F（000） = 1482, the final R = 0.0587 and wR = 0.1284 for 6562 observed reflections with I 〉 2σ（I）. In the molecular structure of （COCl2L4）2, there are two crystallographically unique units. The Co^Ⅱ atoms are six-coordinated by four N atoms from four imidazole ligands （L） and two Cl atoms to form a distorted octahedral geometry. The optical properties of complex （COCl2L4）2 have been experimentally studied.

关键词： imidazole derivative n-conjugated system Co complex crystal structure optical property

Mobile CRISPR-Cas9 based anti-phage system in E. coli

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Frontiers of Chemical Science and Engineering 2022年第8期16卷 1281-1289页

作者： Zhou Cao Yuxin Ma Bin Jia ying-jin Yuan Frontier Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering(Ministry of Education) Tianjin UniversityTianjin 300072China Collaborative Innovation Center of Chemical Science and Engineering(Tianjin) School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300072China

Escherichia coli is one of the most important microbial cell factories,but infection by bacteriophages in the environment may have a huge impact on its application in industrial ***,we developed a mobile CRISPR-Cas9 based anti-phage system for bacteriophages defense in *** conjugative plasmids pGM1(phosphoglucomutase 1)and pGM2 carrying one and two guide RNAs,respectively,were designed to defend against a filamentous *** results showed that the pGM1 and pGM2 could decrease the phage infection rate to 1.6%and 0.2%respectively in infected *** preventing phage infection in ***,the pGM2 decreased the phage infection rate to 0.1%,while pGM1 failed to block phage *** verification revealed that point mutations in protospacer or protospacer adjacent motif sequences of the phage genome caused loss of the defense *** results support the potential application of MCBAS in *** cell factories to defend against phage infections.

关键词： phage infections anti-phage CRISPR-Cas9,conjugative transfer synthetic biology