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Integrated Network Pharmacology and Antioxidant Activity?Guided Screen System to Exploring Antioxidants and Quality Markers of Shunaoxin Pills against Chronic Cerebral Ischemia

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World Journal of Traditional Chinese Medicine 2019年第1期5卷 1-8页

作者： Nian-Wei Chang Dan-Dan Cheng Jia-Nan Ni ying-ying guo Guang-Cui Chu Unchol Kim Min Jiang Gang Bai Graduate School Tianjin University of Traditional Chinese Medicine Department of Genetic Engineering State Academy of SciencePyongyang Democratic People's Republic of Korea College of Pharmacy State Key Laboratory of Medicinal Chemical Biology Tianjin Key Laboratory of Molecular Drug Research Nankai University

Objective: The main objective of the study is to screen the quality markers(Q-markers) for relieving oxidative stress damage and against chronic cerebral ischemia in Shunaoxin pills(SNX). Methods: The benefit effect of SNX was evaluated by a rat chronic cerebral ischemia model. The main ingredients of SNX were identified by ultra-performance liquid chromatography-quadrupole time-of-flight, whereas its core targets and pathways around antioxidative stress were predicted by Pharm Mapper and kyoto encyclopedia of genes and genomes(KEGG) analysis. Moreover, the antioxidants were screened by high-performance liquid chromatography with postcolumn derivatization system and then representative ingredients were verified by cell experiments. Results: SNX could increase expression of catalase and superoxide dismutase(SOD) as well as antagonize oxidative damage in the brain. The effects may be related to three types of antioxidant pathways, including nitrogen metabolism, arachidonic acid metabolism, and the cyclic guanosine monophosphate-dependent protein kinase(c GMP-PKG) signaling pathway by multiple active components regulate targets. Among them, ferulic acid and ligustilide were shown the key scavenging ability for reactive oxygen free radicals and significantly increased the contents of nitric oxide(NO), NO synthase, and SOD as well as decreased malonaldehyde. Conclusion: The oxidation resistances of biological and chemical processes in SNX to protect against cerebral oxidative stress injury were preliminary revealed by an integrated network pharmacology and antioxidant activity-guided screen system. Ferulic acid and ligustilide played a major antioxidant role that could be used as Q-markers to control the quality of SNX.

关键词： Antioxidant chronic cerebral ischemia network pharmacology Q-markers Shunaoxin pills

Botany,Traditional Uses,and Pharmacology of Polygonati Rhizoma

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Chinese Medicine and Culture 2021年第4期4卷 251-259页

作者： Xiao-Jing Chen Ju-Feng Duan Kai-Qi Liu ying-ying guo Dong-Peng Wang Ming Liu Dan Zhao Bei Li Hong-Liang Li Xuan-Bin Wang Laboratory of Chinese Herbal Pharmacology Oncology CenterRenmin HospitalHubei Key Laboratory of Wudang Local Chinese Medicine ResearchSchool of PharmacyHubei University of MedicineShiyan 442000HubeiChina Biomedical Research Institute School of Basic MedicineHubei University of MedicineShiyan 442000HubeiChina

Huang Jing (黄精 Polygonati Rhizoma, PR) was first documented as a herbal medicine in Ming Yi Bie Lu (《名医别录》 Miscellaneous Records of Famous Physicians) in China. However, there was no comprehensive review on the botany, traditional uses, and pharmacological effects of PR till now. In this study, the botany, traditional uses including Taoist medicine, and pharmacological effects of PR were reviewed and summarized to provide insights on drug development of PR. In Taoist medicine, PR maintains agerasia and helps prolong human life-span, and is used for fasting (Bigu). In the Zhong guo Yao Dian (《中国药典》Chinese Pharmacopeia) version 2020, PR exerts replenishing qi and nourishing yin, invigorating the spleen, moistening the lung, and strengthening the kidney. Pharmacological studies show that PR has effects of anti-oxidation, anti-diabetes, anti-osteoporosis, anti-cancer, anti-hyperlipidemia, cardiomyocyte protection, immunomodulatory, and thus can be used for treatment of infertility, anti-microorganisms, and improving sleep and memory. In conclusion, PR may play a potential role for chronic disease management and health preservation and this very role deserves a more in-depth research.

关键词： Botany pharmacology Polygonati Rhizoma materia medica

Taurine-mediated browning of white adipose tissue is involved in its protective role against obesity in mice

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Taurine-mediated browning of white adipose tissue is involve...

Lateral distribution of EAS muons measured for the primary cosmic ray energy around 100 TeV

中国生物化学与分子生物学会2019年全国学术会议暨学会成立四十周年

作者： ying-ying guo Liang guo Qi-Qun Tang Key Laboratory of Metabolism and Molecular Medicine of the Ministry of Education Department of Biochemistry and Molecular Biology of School of Basic Medical Sciences and Department of Endocrinology and Metabolism of Zhongshan Hospital Fudan University

Taurine, a nonprotein amino acid, is widely distributed in almost all animal tissues. Ingestion of taurine helps to improve obesity and its related metabolic disorders. However, the molecular mechanism underlying the protective role of taurine against obesity is not completely understood. In this study, it was found that intraperitoneal treatment of the mice with taurine alleviated high-fat diet(HFD)-induced obesity, improved insulin sensitivity, and increased energy expenditure and adaptive thermogenesis of the mice. Meanwhile, administration of the mice with taurine markedly induced the browning of inguinal white adipose tissue(iWAT), with significantly elevated expression of PGC1α, UCP1 and other thermogenic genes in iWAT. In vitro studies indicated that taurine also induced the development of brown-like adipocytes in C3H10T1/2 white adipocytes. Knockdown of PGC1α blunted the role of taurine in promoting the brown-like adipocytes phenotype in C3H10T1/2 cells. Moreover, taurine treatment enhanced AMPK phosphorylation in vitro and in vivo, and knockdown of AMPKα1 prevented taurine-mediated induction of PGC1α in C3H10T1/2 cells. Consistently, specific knockdown of PGC1α in iWAT of the HFDfed mice inhibited taurine-induced browning of iWAT, with the role of taurine in the enhancement of adaptive thermogenesis, the prevention of obesity and the improvement of insulin sensitivity being partially impaired. These results reveal a functional role of taurine in facilitating the browning of white adipose tissue, which is dependent on the induction of PGC1α. Our studies also suggest a potential mechanism for the protective role of taurine against obesity which involves taurine-mediated browning of white adipose tissue.

关键词： Taurine White adipose tissue(WAT) browning Obesity Energy expenditure Adaptive thermogenesis PGC1α AMPK

来源： cnki会议评论

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Chinese Physics C 2019年第7期43卷 97-102页

作者： You-Liang Feng Yi Zhang Tian-Lu Chen Yi-Qing guo Hong-Bo Hu Cheng Liu Guang-Guang Xin Yu-Hua Yao Zhen Wang DANZENGLUOBU Qi Gao Mao-Yuan Liu Shi-Ping Zhao Bing-Qiang Qiao ying-ying guo Hui Cai Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China Physics Department of Science School Tibet UniversityLhasa 850000China School of Physics and Technology Wuhan UniversityWuhan 430072China College of Physical Science and Technology Sichuan UniversityChengduSichuan 610064China Key Laboratory of Dark Matter and Space Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210034China School of Nuclear Science and Technology Lanzhou UniversityLanzhou 730000China

The muonic component of the extensive air showers (EAS) is of great importance for the astroparticle physics. It carries the information about the properties of primary cosmic ray (CR) particles, such as their mass, and electromagnetic and hadronic nature. It provides a sensitive test for the hadronic interaction models, which are inevitable for describing the cascade shower development of cosmic rays in EAS experiments. The YangBaJing Hybrid Array (YBJ-HA) experiment has been in operation since the end of 2016. Surface detectors are used for the measurements of primary energy, angular direction and core position of a shower event, while underground muon detectors are used for measuring the density of muons at various locations. Using the data obtained by the YBJ-HA experiment,this work reports the first measurement of the lateral muon distribution for the primary cosmic ray energy in the 100TeV region. The punch-through effect is evaluated via MC simulation.

关键词： cosmic rays lateral distributions muon density YBJ-HA

基于专利文献的技术商业化潜力研究——以3D打印技术为例

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情报杂志 2016年第10期35卷 59-64,172页

作者：钱越黄颖郭颖孙甘露北京理工大学管理与经济学院北京100081

[目的/意义]技术只有经过商业化才能与经济、社会发展产生联系,并创造出实际价值。技术从研发到推广都具有不确定性,技术投入是否能带来预期的经济效益是目前技术转化研究的重点,通过构建客观的技术商业化潜力评价模型辅助决策者科学合... 详细信息

[目的/意义]技术只有经过商业化才能与经济、社会发展产生联系,并创造出实际价值。技术从研发到推广都具有不确定性,技术投入是否能带来预期的经济效益是目前技术转化研究的重点,通过构建客观的技术商业化潜力评价模型辅助决策者科学合理地选择技术投资方案。[方法/过程]基于专利数据和商业数据,构建了一个技术商业化潜力评价模型,从技术成熟度、技术机会和技术所处行业的竞争环境三方面科学、客观地评价3D打印技术的发展趋势和商业化潜力,并揭示了中国市场的重要影响。[结果/结论]研究结果表明当前3D打印行业正处于快速成长期,技术成熟度高;领域细化分支多、涵盖面广,环保节能材料研究成为新亮点;行业竞争激烈,大企业整合产业链,中小企业大批涌入,商业化潜力可观。验证了依据商业化过程提出的三个评价角度具有一致性和递进性。

关键词：专利分析 S曲线商业化潜力 3D打印

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多符号差分酉空时系统的低复杂度M算法设计

浙江大学学报（理学版） 2011年第1期38卷 50-54页

作者：金小萍应樱果金宁中国计量学院信息工程学院浙江杭州310018

为了解决多符号差分检测(MSDD)高计算复杂度的问题,已经提出了一系列低复杂度次优的检测算法,其中,M算法因其具有固定的复杂度和时延被广泛关注.当前,M算法在多符号差分检测中的运用大多假设每层的保留分支数M值是相同的,而这种方法在... 详细信息

为了解决多符号差分检测(MSDD)高计算复杂度的问题,已经提出了一系列低复杂度次优的检测算法,其中,M算法因其具有固定的复杂度和时延被广泛关注.当前,M算法在多符号差分检测中的运用大多假设每层的保留分支数M值是相同的,而这种方法在复杂度的角度来看并不是最佳的方法,鉴于此本文提出了一种动态M算法,即每层保留分支数设为不同的值,通过仿真分析得出该方法与恒定M值的方法比较不仅使扩展和更新的分支数减少,而且在高信噪比时其性能更优越.另外目前对M算法的研究主要集中在通过减少节点扩展分支数来降低复杂度,而对每层选取最佳M条路径的排序方法的研究几乎是空白,因此基于多符号差分检测系统对一种低复杂度的排序方法进行了研究.分析表明这种方法相比传统冒泡排序方法可以节约75.39%的比较交换次数.该方法的运用使得M算法更有利于在实际当中的运用.

关键词：多符号差分检测动态M算法复杂度排序

100 TeV diffuse γ-rays observation by YangBaJing Hybrid Array

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Radiation Detection Technology and Methods 2020年第3期4卷 392-398页

作者： Jian-Cheng He Yu-Hua Yao Zhen Wang Tian-Lu Chen Dan-Zeng-Luo-Bu Cun-Feng Feng Youliang Feng Qi Gao Yi-Qin guo ying-ying guo Hong-Bo Hu Xing-Tao Huang Cheng Liu Mao-Yuan Liu Yi-Bin Pan Bing-Qiang Qiao Guang-Guang Xin Xue-Yao Zhang Yi Zhang Shi-Ping Zhao Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of Sciences(CAS)Beijing 100049China University of Chinese Academy of Sciences(UCAS) Beijing 100049China College of Physics Sichuan UniversityChengdu 610064China Tsung-Dao Lee Institute Shanghai Jiao Tong UniversityShanghai 200240China Physics Department of Science School Tibet UniversityLhasa 850000China Institute of Frontier and Interdisciplinary Science Shandong UniversityJinan 250100China Key Laboratory of Dark Matter and Space Astronomy Purple Mountain ObservatoryChinese Academy of Sciences(CAS)Nanjing 210008China Department of Physics University of Wisconsin-Madison1150 University ave MadisonMadisonWI 53706USA School of Physics and Technology Wuhan UniversityWuhan 430072China

Purpose Cosmic rays up to PeV energy are believed to be generated in our galaxy.γ-rays at 100TeV energies are important probe to identify ***,γ-rays contain additional information on the propagation of the galactic cosmic *** Diffuseγ-rays originating from the Galactic plane from 20 to 200 TeV region are studied with early 160-day data collected by YangBaJing Hybrid Array(YBJ-HA),which is a hybrid array and consists of scintillation detectors and underground muon ***-distance equi-zenith angle and time-swapping methods are used to analyze the number ofγ-rays *** and conclusion Because of no significant observation onγ-ray emission,Helene's method is adopted to derive the 90%confidence level upper limits on the flux of diffuse galacticγ-*** the limit to the ratio of the flux ofγ-rays to CRs is obtained at the order of 10^(-4),which is the current best result at these energies.

关键词： Cosmic rays Diffuse y-rays YBJ-HA EAS

农民卫生服务利用与受益公平性分析——基于广西桂林的调查

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维普期刊数据库

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医学与哲学（A） 2017年第2期38卷 49-52页

作者：郭振友吴侃应国英姚伟桂林医学院人文与管理学院广西桂林541004

为分析广西桂林新农合参合农民卫生服务利用与受益的公平性,采取分层整群抽样的方法,利用集中指数和集中曲线对其卫生服务利用与受益的公平性进行评价。新农合参合农民门诊和住院服务利用的集中指数分别为0.178 5和0.198 9;补偿总费用... 详细信息

为分析广西桂林新农合参合农民卫生服务利用与受益的公平性,采取分层整群抽样的方法,利用集中指数和集中曲线对其卫生服务利用与受益的公平性进行评价。新农合参合农民门诊和住院服务利用的集中指数分别为0.178 5和0.198 9;补偿总费用的集中指数分别为0.404 5和0.161 6;门诊受益率和次均门诊补偿费用的集中指数分别为0.294 6和0.292 1;住院的集中指数分别为0.201 1和-0.018 8。新农合参合农民卫生服务利用与受益均存在不公平现象,门诊服务利用公平性好于住院服务,但门诊受益公平性较住院差,基层医疗机构的受益公平性好于市级及以上医疗机构。

关键词：新型农村合作医疗卫生服务利用公平性

Box-Behnken效应面法结合微遗传算法优化夏枯草的提取工艺

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中国实验方剂学杂志 2016年第20期22卷 14-17页

作者：曲永胜解盈盈郭威周倩王亮山东省中医药研究院济南250014 山东中医药大学药学院济南250355

目的:优化夏枯草中迷迭香酸的超声提取工艺,确定工艺参数的最优范围。方法:以乙醇体积分数、液固比、提取时间为考察因素,迷迭香酸提取率为评价指标,采用Box-Behnken效应面法进行试验设计并建立数学模型,采用微遗传算法对该模型进行优化... 详细信息

目的:优化夏枯草中迷迭香酸的超声提取工艺,确定工艺参数的最优范围。方法:以乙醇体积分数、液固比、提取时间为考察因素,迷迭香酸提取率为评价指标,采用Box-Behnken效应面法进行试验设计并建立数学模型,采用微遗传算法对该模型进行优化,得到提取工艺参数最优范围。结果:夏枯草中迷迭香酸的最佳提取工艺为超声功率200 W,超声频率53k Hz,乙醇体积分数(50.03±1.21)%,液固比(48.28±2.27)m L·g^(-1),提取时间(47.34±1.43)min。迷迭香酸提取率0.301%。结论:Box-Behnken效应面法和微遗传算法联用时优化的迷迭香酸工艺提取率高,能得到具有浮动范围且不影响提取率、容易在生产中实现的工艺参数,可为中药提取工艺的研究提供参考。

关键词：夏枯草工艺参数最优范围微遗传算法迷迭香酸超声提取法