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Hexagonal boron nitride based slippery liquid infused porous surface with anti-corrosion, anti-contaminant and anti-icing properties for protecting magnesium alloy

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Chinese Chemical Letters 2024年第4期35卷 532-538页

作者： Wenhao Yan Shuaiya xue xuerui Zhao Wei zhang Jian Li Key Laboratory of Eco-Functional Polymer Materials of the Ministry of Education College of Chemistry and Chemical EngineeringNorthwest Normal UniversityLanzhou 730070China

In an era where the concept of green development is deeply rooted, magnesium(Mg) alloy as a light metal has a long-term development prospect in the process of energy saving, emission reduction and environmental improvement. However, anti-corrosion performance of Mg alloy is poor due to the high chemical activity and low equilibrium potential, which limits the development of Mg alloy ***, three-dimensional mesopore hollow polypyrrole spheres(MHPS) were prepared, and the MHPS was inserted into the middle of the stacked hexagon boron nitride(h-BN) lamellae, which allowed the hBN to be separated forming a further composite with abundant pore structure. Subsequently, the MHPS/hBN-OH composite was uniformly sprayed on the Mg alloy surface via simple spraying method to form the superhydrophobic surface(SHS). Finally, the slippery liquid infused porous surface(SLIPS) was successfully fabricated by applying drops of silicone lubricant on the superhydrophobic coating surface. After a series of characterization and testing, the results showed that the stacking of h-BN lamellae was significantly reduced after h-BN was successfully embedded by MHPS. In addition, the fabricated SLIPS have excellent self-cleaning, mechanical stability, anti-icing and anti-corrosion properties. Therefore, the method of embedding polymer microspheres not only offers a new strategy for h-BN exfoliation, but also the successful prepared SLIPS largely retards the corrosion of Mg alloy while providing new ideas for the development of SLIPS.

关键词： Anti-corrosion Mg alloy Hexagon boron nitride Polypyrrole SLIPS

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Local Torrential Rainfall Event within a Mei-Yu Season Mesoscale Convective System:Importance of Back-Building Processes

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Advances in Atmospheric Sciences 2024年第5期41卷 847-863页

作者： Honglei zhang Ming xue Hangfeng SHEN Xiaofan LI Guoqing ZHAI Zhejiang Institute of Meteorological Sciences Hangzhou 310017China Center for Analysis and Prediction of Storms and School of MeteorologyUniversity of OklahomaNormanOklahoma 73072USA Department of Atmospheric Science School of Earth SciencesZhejiang UniversityHangzhou 310027China Hangzhou Weather Bureau Hangzhou 310007China

An extreme rainfall event occurred over Hangzhou,China,during the afternoon hours on 24 June *** event occurred under suitable synoptic conditions and the maximum 4-h cumulative rainfall amount was over 150 *** rainfall event had two major *** was caused by a quasi-stationary convective line,and the other by a backbuilding convective line related to the interaction of the outflow boundary from the first rainband and an existing low-level mesoscale convergence line associated with a mei-yu frontal *** rainfall event lasted 4 h,while the back-building process occurred in 2 h when the extreme rainfall center *** far,few studies have examined the back-building processes in the mei-yu season that are caused by the interaction of a mesoscale convergence line and a convective cold *** two rainbands are successfully reproduced by the Weather Research and Forecasting(WRF)model with fourlevel,two-way interactive *** the model,new cells repeatedly occur at the west side of older cells,and the backbuilding process occurs in an environment with large CAPE,a low LFC,and plenty of water *** from older cells enhance the low-level convergence that forces new *** precipitation efficiency of the back-building training cells leads to accumulated precipitation of over 150 *** experiments without evaporation of rainwater show that the convective cold pool plays an important role in the organization of the back-building process in the current extreme precipitation case.

关键词： torrential rainfall back-building processes numerical simulation trigger mechanism convergence line convective cold pool

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Development of pharmacological immunoregulatory anticancer therapeutics:current mechanistic studies and clinical opportunities

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Signal Transduction and Targeted Therapy 2024年第6期9卷 2477-2526页

作者： Nanhao Yin Xintong Li Xuanwei zhang Shaolong xue Yu Cao Gabriele Niedermann You Lu Jianxin xue Division of Thoracic Tumor Multimodality Treatment Cancer Center&State Key Laboratory of Biotherapyand The National Clinical Research Center for GeriatricsWest China HospitalSichuan UniversityNo.37Guoxue LaneChengdu 610041 SichuanPR China Department of Gynecology and Obstetrics West China Second University HospitalSichuan UniversityNo.20Section 3South Renmin RoadChengdu 610041 SichuanPR China Department of Emergency Medicine Laboratory of Emergency MedicineWest China HospitalSichuan UniversityNo.37Guoxue LaneChengdu 610041 SichuanPR China Institute of Disaster Medicine&Institute of Emergency Medicine Sichuan UniversityNo.17Gaopeng AvenueChengdu 610041 SichuanPR China Department of Radiation Oncology Medical Center—University of FreiburgFaculty of MedicineUniversity of FreiburgGerman Cancer Consortium(DKTK)Partner Site DKTK-FreiburgRobert-Koch-Strasse 379106 FreiburgGermany Laboratory of Clinical Cell Therapy West China HospitalSichuan UniversityNo.2222Xinchuan RoadChengdu 610041 SichuanPR China

Immunotherapy represented by anti-PD-(L)1 and anti-CTLA-4 inhibitors has revolutionized cancer treatment,but challenges related to resistance and toxicity still *** to the advancement of immuno-oncology,an increasing number of novel immunoregulatory targets and mechanisms are being revealed,with relevant therapies promising to improve clinical immunotherapy in the foreseeable ***,comprehending the larger picture is *** this review,we analyze and summarize the current landscape of preclinical and translational mechanistic research,drug development,and clinical trials that brought about next-generation pharmacological immunoregulatory anti-cancer agents and drug candidates beyond classical immune checkpoint *** with further clarification of cancer immunobiology and advances in antibody engineering,agents targeting additional inhibitory immune checkpoints,including LAG-3,TIM-3,TIGIT,CD47,and B7 family members are becoming an important part of cancer immunotherapy research and discovery,as are structurally and functionally optimized novel anti-PD-(L)1 and anti-CTLA-4 agents and agonists of co-stimulatory molecules of T *** by bispecific T cell engagers,newly emerging bi-specific and multi-specific antibodies targeting immunoregulatory molecules can provide considerable clinical ***-generation agents also include immune epigenetic drugs and cytokine-based *** therapies,cancer vaccines,and oncolytic viruses are not covered in this *** comprehensive review might aid in further development and the fastest possible clinical adoption of effective immuno-oncology modalities for the benefit of patients.

关键词： clinical immuno landscape

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Characteristic Study of Self-Powered Sensors Based on Native Protein Composite Film

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Energy & Environmental Materials 2024年第1期7卷 222-228页

作者： Jiehui xue Huijing Xiang Yanrong zhang Jun Yang Xia Cao Zhonglin Wang Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of SciencesBeijing 101400China School of Resources Environment and MaterialsSchool of PhysicsScience and TechnologyCenter on Nanoenergy ResearchGuangxi UniversityNanning 530004China Center for Green Innovation School of Mathematics and PhysicsUniversity of Science and Technology BeijingBeijing 100083China Research Centre of Information Technology Shenzhen Institute of Information TechnologyShenzhen 518172China School of Chemistry and Biological Engineering University of Science and Technology BeijingBeijing 100083China School of Materials Science and Engineering Georgia Institute of TechnologyAtlanta GA 30332-0245USA

Flexible electronic sensors composed of flexible film and conductive materials play an increasingly important role in wearable and internet information *** has received more and more attention and made some progress over the ***,it is still a great challenge to prepare biocompatible and highly transparent conductive *** white is a pure natural protein-rich *** cellulose has a good compatibility and high transparency,which is an ideal material for flexible ***,we overcome the problem of poor mechanical flexibility and electrical conductivity of protein,and develop a high transparency and good flexibility hydroxypropylmethyl cellulose/egg white protein composite membrane-based triboelectric nanogenerator('X'-TENG).The experimental results show that the flexible pressure sensor based on'X'-TENG has a high sensitivity,fast response speed,and low detection *** can even be used as a touch/pressure sensing artificial electronic *** can also be made into an intelligent waffle keyboard for recording and tracking users of the *** strategy may provide a new way to easily build flexible electronic sensors and move toward practical applications.

关键词： flexible sensors intelligent sensing natural protein-rich material triboelectric nanogenerators

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Guanine-derived F,N co-doped carbon-shell encapsulated iron carbide nanoparticles for enhanced CO_(2)electroreduction activity

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Nano Research 2024年第6期17卷 4744-4752页

作者： Shuo Chen Lishun Pei ying Peng xuefei zhang Zailai Xie Key Laboratory of Advanced Carbon-Based Functional Materials(Fujian Province University) Fuzhou UniversityFuzhou 350016China

The development of highly selective,cost-effective,and energy-efficient electrocatalysts is critical for carbon dioxide reduction reaction(CO_(2)RR)to produce high-value ***,we propose a facile strategy to obtain F,N co-doped carbon-coated iron carbide(Fe3C)nanoparticles by using biomolecule guanine and hexadecafluorophthalocyanine iron as raw ***,this method involves only one-step pyrolysis and does not require any guiding agent or sacrificial *** from the advantageous surface microenvironment adjustments achieved through graphitic N(GN)and F co-doping,Fe3C@NF-G-1000 demonstrates exceptional efficacy in the electroreduction of CO_(2)to carbon monoxide(CO)with an impressive Faradic efficiency(FEco)up to 98%at the potential of−0.55 V(*** hydrogen electrode(RHE)).Furthermore,it delivers a remarkable current density of up to−43 mA·cm^(−2)and exhibits virtually no current attenuation over a span of 20 h within the flow *** from density functional theory(DFT)calculations reveal that the composite structure of GN and F co-doped graphitic layer and Fe3C exhibits different electron density distributions from that of iron carbide *** is attributed to the synergistic effect of the composite structure leading to the enrichment of electrons in the graphite layer on the surface,which contributes to the stability of the key reaction intermediate*COOH,thus,resulting in an enhanced catalytic activity and ***,this work introduces a new and promising approach to the design of green and low-cost carbon-coated metal materials for CO_(2)reduction reactions.

关键词： guanine F,N co-doped carbon dioxide reduction reaction(CO_(2)RR) Fe-based catalyst

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Reinforcement of High Impact Polystyrene by Aramid Nanoparticle Fillers Prepared via an In situ Bottom-up Approach

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Chinese Journal of Polymer Science 2024年第8期42卷 1167-1176页

作者： Xiang-Jun Gong Zhi-Ping Zhao Chang-Mei Sun ying zhang Rong-Jun Qu ying Wang School of Chemistry and Materials Science Ludong UniversityYantai 264025China

In this work,aramid nanoparticles(ANPs)were prepared in dimethyl formamide(DMF)solution containing high impact polystyrene(HIPS)via a bottom-up *** electron microscopy(TEM)images showed that the obtained ANPs were evenly distributed in the HIPS matrix without any *** composition of the ANPs,i.e.,poly(p-phenyl-p-phenylenediamine)(PPTA),was confirmed by Fourier transform infrared spectroscopy(FTIR),X-ray photoelectron spectroscopy(XPS)and X-ray diffractometer(XRD).The ANP/HIPS composites,obtained after ethanol precipitation,were added to neat HIPS as fillers to fabricate ANP/HIPS composite *** surface roughness and the glass transition temperature(T_g)of the sheets were characterized by atomic force microscope(AFM)and differential scanning calorimetry(DSC),*** with neat HIPS,the mechanical properties of the composite sheet were significantly improved,and the Young's modulus increased from 246.55 MPa to 2025.12 MPa,the tensile strength increased from 3.07 MPa to 29.76 MPa,and the toughness increased from 0.32 N/mm^2 to 3.92 N/mm^2,with an increase rate of 721%,869%and 1125%,***,the thermal stability of the composites improved with the increase in ANP content.

关键词： High impact polystyrene PPTA nanoparticle Reinforce Mechanical property

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High-throughput calculation-based rational design of Fe-doped MoS_(2) nanosheets for electrocatalytic p H-universal overall water splitting

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Journal of Energy Chemistry 2024年第4期91卷 194-202页

作者： Guangtong Hai Xiangdong xue Zhenyu Wu Canyang zhang Xin Liu Xiubing Huang Institute of Zhejiang University-Quzhou Zhejiang UniversityQuzhou 324000ZhejiangChina Beijing Key Laboratory of Membrane Materials and Engineering Department of Chemical EngineeringTsinghua UniversityBeijing 100084China Beijing Advanced Innovation Center for Materials Genome Engineering Beijing Key Laboratory of Function Materials for Molecule&Structure ConstructionSchool of Materials Science and EngineeringUniversity of Science and TechnologyBeijing 100083China CentreÉnergie Matériaux et Télécommunications(EMT) Institut national de la recherche scientifique(INRS)Varennes J3X1P7QuébecCanada

Electrocatalytic water splitting is crucial for H2generation via hydrogen evolution reaction(HER)but subject to the sluggish dynamics of oxygen evolution reaction(OER).In this work,single Fe atomdoped MoS_(2)nanosheets(SFe-DMNs)were prepared based on the high-throughput density functional theory(DFT)calculation *** to the synergistic effect between Fe atom and MoS_(2)and optimized intermediate binding energy,the SFe-DMNs could deliver outstanding activity for both HER and *** assembled into a two-electrode electrolytic cell,the SFe-DMNs could achieve the current density of 50 mA cm^(-2)at a low cell voltage of 1.55 V under neutral *** results not only confirmed the effectiveness of high-throughput screening,but also revealed the excellent activity and thus the potential applications in fuel cells of SFe-DMNs.

关键词： High-throughput calculation Overall water splitting Single atom doped catalyst Molybdenum disulfide nanosheet

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Aggregation of CeAlO_(3) inclusions in heavy ingot of a steel containing 0.007% aluminum

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Journal of Iron and Steel Research International 2024年第8期31卷 1960-1972页

作者： Qiu-yue Zhou Jun-tao Ba Lun zhang Wei Chen ying Ren Li-feng zhang School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China School of Mechanical Engineering Yanshan UniversityQinhuangdao 066004HebeiChina School of Mechanical and Materials Engineering North China University of TechnologyBeijing 100144China

The distribution of inclusions at the bottom of a Ce-treated heavy steel ingot was detected and *** three-dimensional morphology and spatial distribution of CeAlOs clusters were characterized using the electrolytic extraction and Micro-CT detection.A model of inclusion collision to predict the aggregation of CeAlO_(3) inclusions in the ingot was established and validated by measured *** were mainly CeAlO_(3) and a small amount of Ce_(2)O_(2)S in the tundish after cerium *** collision and aggregation of inclusions led to the formation of large clusters in the ingot during the solidification *** slag entrainment inclusions,large CeAO_(3) clusters and small CeAlO_(3) particles were observed from the center to the edge of the ingot *** inclusions were mainly concentrated at the *** number density of inclusions larger than 200μm was 0.21 mm^(-3).The maximum diameter of CeA1O_(3) clusters was 1340μ*** the edge to the radial center and from the bottom to the top,the average diameter of inclusions gradually increased due to the longer solidification time of the ingot.

关键词： Inclusion Heavy ingot Cerium treatment Collision

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Design and validation of a variable camber wing structure

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Chinese Journal of Aeronautics 2024年第2期37卷 1-11页

作者： Xiasheng SUN Jingfeng xue Jin ZHOU Zhigang WANG Wenjuan WANG Mengjie zhang Chinese Aeronautical Establishment Beijing 100012China School of Aeronautic Science and Engineering Beihang UniversityBeijing 100191China Aircraft Strength Research Institute of China Xi’an 710065China Graduate School of Chinese Aeronautical Establishment Yangzhou 225002China

Variable camber wing technology is one of the important development trends of green aviation at *** smooth,seamless,continuous and adaptive change of wing camber,the aerodynamic performance is improved in achieving increase in lift and reduction in resistance and *** on the aerodynamic validation model CAE-AVM,Chinese Aeronautical Establishment(CAE)has carried out the design and validation of a variable camber wing,proposed an aerodynamic deformation matrix for the leading and trailing edges of aircraft wings in takeoff,landing and cruise *** structures and driving schemes are compared,and several key technology problems of leading and trailing edge deformation are solved.A full-size leading edge wind tunnel test piece with a span of 2.7 m and a trailing edge ground function test piece are *** deformation and shape maintenance capabilities of the leading edge is verified under real wind load conditions,and the load bearing and deformation capabilities of the trailing edge is verified under simulated follow-on *** results indicate that the leading and trailing edges of the variable camber wing can achieve the required deformation angle and have a certain load-bearing *** study can provide some insights into the application of variable camber wing technology for civil aircraft.

关键词： Variable camber wing Leading edge Trailing edge Structure Measurement and control Test

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Synaptotagmins family affect glucose transport in retinal pigment epithelial cells through their ubiquitination-mediated degradation and glucose transporter-1 regulation

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World Journal of Diabetes 2024年第5期15卷 958-976页

作者： Hong Xu Li-Bo zhang Yi-Yi Luo Ling Wang Ye-Pin zhang Pei-Qi Chen xue-ying Ba Jian Han Heng Luo Department of Ophthalmology The People’s Hospital of Chuxiong Yi Autonomous Prefecture&The Fourth Affiliated Hospital of Dali UniversityChuxiong Yi Autonomous Prefecture 675000Yunnan ProvinceChina Precision Medicine Center of Chuxiong Yi Autonomous Prefecture The People’s Hospital of Chuxiong Yi Autonomous Prefecture&The Fourth Affiliated Hospital of Dali UniversityChuxiong Yi Autonomous Prefecture 675000Yunnan ProvinceChina Department of Endocrinology The People’s Hospital of Chuxiong Yi Autonomous Prefecture&The Fourth Affiliated Hospital of Dali UniversityChuxiong Yi Autonomous Prefecture 675000Yunnan ProvinceChina Department of Pathology The People’s Hospital of Chuxiong Yi Autonomous Prefecture&The Fourth Affiliated Hospital of Dali UniversityChuxiong Yi Autonomous Prefecture 675000Yunnan ProvinceChina

BACKGROUND Synaptotagmins(SYTs)are a family of 17 membrane transporters that function as calcium ion sensors during the release of Ca2+-dependent neurotransmitters and ***,few studies have reported whether members of the SYT family play a role in glucose uptake in diabetic retinopathy(DR)through Ca2+/glucose transporter-1(GLUT1)and the possible regulatory mechanism of *** To elucidate the role of the SYT family in the regulation of glucose transport in retinal pigment epithelial cells and explore its potential as a therapeutic target for the clinical management of *** DR was induced by streptozotocin in C57BL/6J mice and by high glucose medium in human retinal pigment epithelial cells(ARPE-19).Bioinformatics analysis,reverse transcriptase-polymerase chain reaction,Western blot,flow cytometry,ELISA,HE staining,and TUNEL staining were used for *** Six differentially expressed proteins(SYT2,SYT3,SYT4,SYT7,SYT11,and SYT13)were found between the DR and control groups,and SYT4 was highly *** induces SYT4 overexpression,manipulates Ca2+influx to induce GLUT1 fusion with the plasma membrane,promotes abnormal expression of the glucose transporter GLUT1 and excessive glucose uptake,induces ARPE-19 cell apoptosis,and promotes DR *** deficiency inhibits the proteasomal degradation of SYT4 in DR,resulting in SYT4 accumulation and enhanced GLUT1 fusion with the plasma membrane,and these effects were blocked by oe-Parkin ***,dysregulation of the myelin transcription factor 1(Myt1)-induced transcription of SYT4 in DR further activated the SYT4-mediated stimulus-secretion coupling process,and this process was inhibited in the oe-MYT1-treated *** Our study reveals the key role of SYT4 in regulating glucose transport in retinal pigment epithelial cells during the pathogenesis of DR and the underlying mechanism and suggests potential therapeutic targets for clinical DR.

关键词： Diabetic retinopathy Glucose transporter-1 Synaptotagmin 4 Parkin Myelin transcription factor 1

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