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High dimensional proteomic mapping of bone marrow immune characteristics in immune thrombocytopenia

Science China(Life Sciences) 2024年第8期67卷 1635-1647页

作者： Feng-Qi Liu Qing-Yuan Qu ying Lei Qi Chen Yu-Xiu Chen Meng-Lin Li Xue-Yan Sun Ye-Jun Wu Qiu-Sha Huang Hai-xia Fu Yuan Kong Yue-ying Li Qian-Fei wang xiao-Jun Huang xiao-Hui Zhang Peking University People’s Hospital Peking University Institute of HematologyBeijing 100044China Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Beijing 100044China National Clinical Research Center for Hematologic Disease Beijing 100044China Collaborative Innovation Centre of Hematology Peking UniversityBeijing 100044China CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesPeking UniversityBeijing 100074China State Key Laboratory of Natural and Biomimetic Drugs Peking UniversityBeijing 100191China

To investigate the role of co-stimulatory and co-inhibitory molecules on immune tolerance in immune thrombocytopenia(ITP),this study mapped the immune cell heterogeneity in the bone marrow of ITP at the single-cell level using Cytometry by Time of Flight(CyTOF).Thirtysix patients with ITP and nine healthy volunteers were enrolled in the *** soluble immunomodulatory molecules,more sCD25 and sGalectin-9 were detected in ITP *** the cell surface,co-stimulatory molecules like ICOS and HVEM were observed to be upregulated in mainly central memory and effector T *** contrast,co-inhibitory molecules such as CTLA-4 were significantly reduced in Th1 and Th17 cell *** a platelet count of 30×10^(9)L^(−1)as the cutoff value,ITP patients with high and low platelet counts showed different T cell immune ***-presenting cells such as monocytes and B cells may regulate the activation of T cells through CTLA-4/CD86 and HVEM/BTLA interactions,respectively,and participate in the pathogenesis of *** conclusion,the proteomic and soluble molecular profiles brought insight into the interaction and modulation of immune cells in the bone marrow of *** may offer novel targets to develop personalized immunotherapies.

关键词： immune thrombocytopenia autoimmune diseases co-stimulatory co-inhibitory immune checkpoint CTLA4 Cytometry by Time of Flight bone marrow

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Individualised evaluation based on pathophysiology for moyamoya vasculopathy:application in surgical revascularisation

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Stroke & Vascular Neurology 2024年第3期9卷 268-278,I0241-I0246页

作者： Xin Zhang Yu Lei Jiabin Su Chao Gao Yanjiang Li Rui Feng Ding xia Peng Gao Yuxiang Gu ying Mao Department of Neurosurgery Huashan Hospital Fudan UniversityShanghaiChina Department of Radiology Huashan Hospital Fudan UniversityShanghaiChina

Background Although bypass surgery is an effective treatment for moyamoya vasculopathy(MMV),the incidence of postoperative complications is still *** study aims to introduce a novel evaluating system based on individualised pathophysiology of MMV,and to assess its clinical *** This multicentre,prospective study enrolled adult patients with MMV from Huashan Hospital,Fudan University and National Center for Neurological Disorders,China between March 2021 and February *** neuroimages containing structural and functional information were used to evaluate personalised disease severity and fused to localise the surgical field,avoid invalid regions and propose alternative recipient *** recipient artery was further selected intraoperatively by assessing regional haemodynamic and electrophysiological *** preanastomosis and postanastomosis data were compared with assist with the postoperative *** who received such tailored revascularisations were included in the novel group and the others were included in the traditional *** 30-day surgical outcomes and intermediate long-term follow-up were *** Totally 375 patients(145 patients in the novel group and 230 patients in the traditional group)were *** overall complication rate was significantly lower in the novel group(p˂0.001).In detail,both the rates of postoperative infarction(p=0.009)and hyperperfusion syndrome(p=0.010)were significantly *** functional outcomes trended to be more favourable in the novel group,though not significantly(p=0.260).Notably,the proportion of good functional status was higher in the novel group(p=0.009).Interestingly,the preoperative statuses of perfusion and metabolism around the bypass area were significantly correlated with the occurrence of postoperative complications(P˂0.0001).Conclusions This novel evaluating system helps to identify appropriate surgical field and recipient arteries during b

关键词： surgical bypass metabolism

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Metal complexes of bipyridine-functionalized covalent organic frameworks as efficient electrocatalysts for oxygen evolution reaction

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Rare Metals 2024年第7期43卷 3096-3106页

作者： Zhuang-Zhuang Wu Tian xia ying Liang Yong-Peng Li Zhu-Yin Sui Li-Juan Feng Dao-Xiong Wu Xin-Long Tian Qi Chen State Key Laboratory of Marine Resource Utilization in South China Sea School of Marine Science and EngineeringHainan UniversityHaikou 570228China School of Chemistry and Chemical Engineering Yantai UniversityZhuhai519041China School of Bioengineering Zhuhai Campus of Zunyi Medical UniversityZhuhai519041China

Electrocatalytic water splitting is considered a clean and practic al method for producing *** this study,COF-Bpy,a bipyridine-functionalized covalent organic framework(COF),was prepared via post-synthetic modification,after which electrocatalysts for the oxygen evolution reactions(OER)were formed through coordination to single-or double-transition metals(Fe,Co,Ni,FeCo,FeNi or CoNi).COF-Bpy@FeNi delivered the best OER performance among the studied electrocatalysts,with an overpotential of 399 mV at 10 mA·cm^(-2)in an alkaline electrolyte(1.0 mol·L^(-1)KOH aqueous).Notably,the electrocatalytic performance of COF-Bpy@FeNi showed slight degradation during durability testing,which is ascribable to its irreversible benzoquinoline structure and strong metal *** expected,COF-Bpy@FeNi exhibited a low overpotential of 347 mV at a turnover frequency(TOF)of 0.1 s^(-1),which suggests that COF-Bpy@FeNi possesses excellent intrinsic electroc atalytic OER ***,density functional theory(DFT)calculations reveal that the Ni site plays a major role,while the Fe site adjusts the electronic structure of the Ni ions,which rationalizes the excellent OER properties of COF-Bpy@*** study not only provides a simple and efficient method for complexing COFs with transition metals,but also offers a novel strategy for designing porous organic polymer electrocatalysts.

关键词： Covalent organic framework Oxygen evolution reactions(OER)electrocatalyst Nickel-iron synergy Water splitting

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低噪声控制阀优化设计及试验验证

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船舶力学 2017年第5期21卷 642-650页

作者：何涛郝夏影王锁泉吴有生中国船舶科学研究中心船舶振动噪声重点实验室江苏无锡214082 江苏省绿色船舶技术重点实验室江苏无锡214082

控制阀在舰船管路系统中运行时受流体激励产生振动噪声,抑制阀门节流口空化及降低阀内流动脉动是低噪声控制阀设计的关键。该文基于计算流体动力学方法,以某型分层迷宫式控制阀为对象,进行了低噪声的优化设计。优化设计方案采取了一系... 详细信息

控制阀在舰船管路系统中运行时受流体激励产生振动噪声,抑制阀门节流口空化及降低阀内流动脉动是低噪声控制阀设计的关键。该文基于计算流体动力学方法,以某型分层迷宫式控制阀为对象,进行了低噪声的优化设计。优化设计方案采取了一系列有利于抑制空化、均匀流场并降低流动脉动措施,包括应用双层渐变开孔阀套、入流整流装置、阀芯吸振装置、出流导流装置等。优化设计方案的流动计算分析结果表明,优化设计方案有利于降低振动噪声源。通过对普通控制阀、分层迷宫式控制阀和新型低噪声控制阀台架试验对比结果表明,相同水力状态下新型低噪声控制阀水动力噪声、振动响应和空气噪声皆显著降低,优化设计方案得到了试验验证。

关键词：控制阀流体动力学振动噪声优化设计试验验证

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Efficient micrometer-scale thick-film perovskite solar cells with superior stability

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Rare Metals 2024年第4期43卷 1647-1657页

作者： Jian-Fei Hu Gang Chen Shun-Zhang Yu Yue-Xin Lin Kai-Yu wang Zong-Wei Li Guo-Dong Zhang Teng-Fei Pan Ya-Jing Li Ming-Jie Li ying-Dong xia Yi-Fan Lv Yong-Hua Chen Key Laboratory of Flexible Electronics(KLoFE)and Institute of Advanced Materials(IAM) School of Flexible Electronics(Future Technologies)Nanjing Tech University(NanjingTech)Nanjing211816China Department of Applied Physics The Hong Kong Polytechnic UniversityHong Kong999077China Shenzhen Research Institute The Hong Kong Polytechnic UniversityShenzhen518057China Optics Valley Laboratory Hubei430074China

It is essential to enhance the thickness of the absorber layer for perovskite solar cells(PSCs)to improve device performance and reduce industry ***,thick perovskite films(>1μm)are difficult to be fabricated by employing traditional solvents,such as N,N-dimethylformamide(DMF),dimethyl sulfoxide(DMSO).Besides,it is a challenge to fabricate thick-film perovskite owing to the deteriorated surface morphology and serious defect ***,a simple method was reported to deposit uniform pinhole-free perovskite films with a thickness of more than 2μm utilizing the methylamine acetate(MAAc)ionic liquid as the *** with methylammonium chloride(MACl)as an additive,thick-film perovskite with~2μm in grain size and few grain boundaries(GBs)was prepared,which dramatically improved the perovskite crystal quality and enhanced carrier transport *** final PSCs exhibited a power conversion efficiency(PCE)of 20.16%.The device showed improved stability with 95%of its initial efficiency in a nitrogen environment over 5000 *** work provides an alternative strategy to produce extremely efficient and stable thick-film *** can be believed that this device has great potential in the application of large areas and laminated PSCs.

关键词： Perovskite solar cells Thick-film Stability Ionic liquid

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N-glycan biosignatures as a potential diagnostic biomarker for earlystage pancreatic cancer

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 659-669页

作者： Yan-Rong Wen xia-Wen Lin Yu-Wen Zhou Lei Xu Jun-Li Zhang Cui-ying Chen Jian He Department of Nuclear Medicine Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjing 210008Jiangsu ProvinceChina Department of Research and Development Sysdiagno(Nanjing)Biotech Co.LtdNanjing 210008Jiangsu ProvinceChina

BACKGROUND Pancreatic ductal adenocarcinoma(PDAC)has a poor prognosis,with a 5-year survival rate of less than 10%,owing to its late-stage *** detection of pancreatic cancer(PC)can significantly increase survival *** To identify the serum biomarker signatures associated with early-stage PDAC by serum N-glycan *** An extensive patient cohort was used to determine a biomarker signature,in-cluding patients with PDAC that was well-defined at an early stage(stages I and II).The biomarker signature was derived from a case-control study using a case-cohort design consisting of 29 patients with stage I,22 with stage II,4 with stage III,16 with stage IV PDAC,and 88 *** used multiparametric analysis to identify early-stage PDAC N-glycan signatures and developed an N-glycan sig-nature-based diagnosis model called the“Glyco-model”.RESULTS The biomarker signature was created to discriminate samples derived from patients with PC from those of controls,with a receiver operating characteristic area under the curve of *** addition,the biomarker signature combined with cancer antigen 19-9 could discriminate patients with PDAC from controls,with a receiver operating characteristic area under the curve of ***-model demonstrated favorable diagnostic performance in all stages of *** diagnostic sensitivity for stage I PDAC was 89.66%.Core Tip:This study employed a patient cohort to investigate the N-glycan signature of early-stage pancreatic cancer(PC).Serum N-glycans analysis was conducted to identify the serum biomarker signature associated with early-stage pancreatic ductal adenocarcinoma(PDAC),resulting in the identification of nine early-stage PDAC N-glycan ***,utilizing these biosignatures,a diagnostic model named the“Glyco-model”was developed,demonstrating promising diagnostic performance across all stages of *** study revealed that the diagnostic sensitivity for stage I PDAC was determined to be 89.66%.Co

关键词： Glycomics N-glycans Biomarkers Pancreatic cancer Predictive modeling

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Two-dimensional Sb net generated nontrivial topological states in SmAgSb_(2) probed by quantum oscillations

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Chinese Physics B 2024年第7期33卷 51-58页

作者：袁健石贤彪杜红李田郗传英王霞夏威王保田钟瑞丹郭艳峰 School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Tsung-Dao Lee Institute Shanghai Jiao Tong UniversityShanghai 200240China Xingzhi College Zhejiang Normal UniversityJinhua 321100China Anhui Province Key Laboratory of Condensed Matter Physics at Extreme Conditions High Magnetic Field Laboratory of the Chinese Academy of SciencesHefei 230031China ShanghaiTech Laboratory for Topological Physics ShanghaiTech UniversityShanghai 201210China

The REAgSb_(2)(RE = rare earth and Y) family has drawn considerable research interest because the two-dimensional Sb net in their crystal structures hosts topological fermions and hence rich topological properties. We report herein the magnetization and magnetotransport measurements of SmAgSb_(2) single crystal, which unveil very large magnetoresistance and high carrier mobility up to 6.2 × 10^(3)% and 5.58 × 10^(3)cm^(2)·V^(-1)·s^(-1), respectively. The analysis of both Shubnikov–de Haas and de Haas–van Alphen quantum oscillations indicates nontrivial Berry phases in the paramagnetic state while trivial Berry curvature in the antiferromagnetic state, indicating a topological phase transition induced by the antiferromagnetic order. It is also supported by the first-principles calculations. The results not only provide a new interesting topological material but also offer valuable insights into the correlation between magnetism and nontrivial topological states.

关键词： large magnetoresistance quantum oscillations topological phase transition

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Mucosa color and size may indicate malignant transformation of chicken skin mucosa-positive colorectal neoplastic polyps

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 750-760页

作者： ying-Jie Zhang Meng-xia Yuan Wu Wen Fan Li Yi Jian Chuan-Ming Zhang Ye Yang Feng-Lin Chen Department of Digestive Diseases Chengdu Second People’s HospitalChengdu 610000Sichuan ProvinceChina Graduate School Chengdu Medical CollegeChengdu 610000Sichuan ProvinceChina

BACKGROUND Lipid metabolism reprogramming is suspected to exist in pre-cancerous lesions,including colorectal *** colonoscopy frequently reveals chicken skin mucosa(CSM;white or yellow-white speckled mucosa)surrounding colo-rectal polyps,caused by macrophages engulfing and accumulating the lipids decomposed by colon cells or adjacent ***-positive colorectal polyps are associated with various diseases;however,their prognosis varies *** snare polypectomy is commonly used to resect lesions up to 10 to 15 mm in diameter without signs of submucosal invasion but is controversial for CSM-positive colorectal *** imaging is required to diagnose and treat CSM-positive colorectal *** This retrospective cohort study included 177 patients with CSM-positive colorectal polyps diagnosed using *** patient-related information was extracted from the Goldisc soft-clinic DICOM system or electronic medical record *** on the pathological results,patients were classified as non-neoplastic polyps(five juvenile polyps),neoplastic polyps,non-invasive high-grade neoplasia(NHGN),or submucosal invasive carcinoma(SM stage cancer).We analyzed and compared the clinical features,suspected risk factors for malignant transformation of neoplastic polyps,and early infiltration of sub-mucosal *** The diameters of NHGN and SM polyps were much smaller than those of neoplastic *** NHGN polyps had a deeper red mucosal *** logistic regression analyses,diameter and deeper red mucosal color were independent risk factors for malignant transformation of neoplastic *** 1 CSM was more common in high-grade intraepithelial neoplasia and SM;type 2 CSM was more common in neoplastic *** regression analyses revealed no significant differences in the malignant transformation of neoplastic polyps or early submucosal invasion of CSM-positive colorectal *** in the CSM mucosa surrounding neoplastic

关键词： Chicken skin mucosa Colorectal cancer Colorectal polyps Endoscopic resection Malignant transformation White light endoscopy

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1例肾移植术后严重根霉菌感染患者复杂药物治疗的药学服务

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中国药学杂志 2017年第2期52卷 162-166页

作者：彭怀东刘英冯霞王若伦广州医科大学附属第二医院药学部广州510260 益阳市中心医院药剂科湖南益阳413000

目的介绍临床药师对1例肾移植术后严重根霉菌感染患者开展药学服务,达到较好的效果。方法临床药师参与1例肾移植术后严重根霉菌感染患者的药物治疗工作,从抗微生物治疗的角度和对移植肾的保护角度推荐患者使用泊沙康唑治疗,同时结合该... 详细信息

目的介绍临床药师对1例肾移植术后严重根霉菌感染患者开展药学服务,达到较好的效果。方法临床药师参与1例肾移植术后严重根霉菌感染患者的药物治疗工作,从抗微生物治疗的角度和对移植肾的保护角度推荐患者使用泊沙康唑治疗,同时结合该药的药动学特点、药物相互作用和患者的病情等因素,对药物治疗方案进行优化。结果使用泊沙康唑口服混悬液200 mg qid,与肠内营养液混合给药,患者根霉菌感染得到控制;根据泊沙康唑与他克莫司药物相互作用特点和患者CYP3A5基因型检测结果调整他克莫司用量,整个治疗期间,患者他克莫司血药浓度绝大部分时间控制在4.8~6.7μg·L^(-1)之间,保证了移植肾的安全;同时,通过调整泊沙康唑服药方法、减少麦考酚钠的剂量和补充微生态制剂等措施减轻了患者的腹泻。结论肾移植术后发生严重感染的患者,药物治疗一般比较复杂。临床药师可对此类特殊人群开展药学服务,通过治疗药物监测及药动学知识分析,发挥专业特长,促进此类患者获得最佳的药物治疗。

关键词：临床药师药学服务肾移植根霉菌感染泊沙康唑

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Relationship of inflammatory indices with left atrial appendage thrombus or spontaneous echo contrast in patients with atrial fibrillation

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World Journal of Clinical Cases 2024年第21期12卷 4550-4557页

作者： Zhao wang Bin-Hao wang xiao-Lei Yang Yun-Long xia Sheng-Min Zhang ying Che Department of Ultrasonography First Affiliated Hospital of Dalian Medical UniversityDalian 116000Liaoning ProvinceChina Arrhythmia Center First Affiliated Hospital of Ningbo UniversityNingbo 315000Zhejiang ProvinceChina Department of Cardiology First Affiliated Hospital of Dalian Medical UniversityDalian 116000Liaoning ProvinceChina Department of Ultrasonography First Affiliated Hospital of Ningbo UniversityNingbo 315000Zhejiang ProvinceChina

BACKGROUND Inflammatory indices derived from complete blood tests have been reported to be associated with poor outcomes in patients with atrial fibrillation(AF).The data about the relationship between inflammatory indices and left atrial appendage thrombus(LAAT)or dense spontaneous echo contrast(SEC)are *** To explore the value of inflammatory indices for predicting the presence of LAAT or dense SEC in nonvalvular AF *** A total of 406 patients with nonvalvular AF who underwent transesophageal echocardiography were included and divided into two groups based on the presence(study group)or absence(control group)of LAAT or dense *** indices,including the neutrophil-to-lymphocyte ratio(NLR),platelet–tolymphocyte ratio(PLR),and lymphocyte-to-monocyte ratio(LMR),were calculated from complete blood *** associations of inflammatory indices RESULTS LAAT and dense SEC were detected in 11(2.7%)and 42(10.3%)patients,*** PLR only showed an association with LAAT/dense SEC in the univariate *** NLR(odds ratio[OR]=1.48,95%confidence interval[CI]:1.11-1.98,P=0.007)and reduced LMR(OR=0.59,95%CI:0.41-0.83,P=0.003)were found to be independent risk factors for the presence of LAAT/dense *** areas under the NLR and LMR curves for predicting LAAT/dense SEC were 0.73(95%CI:0.66-0.80,P<0.001)and 0.73(95%CI:0.65-0.81,P<0.001),respectively,while the cutoff values were 2.8(sensitivity:69.8%;specificity:64.0%)and 2.4(sensitivity:71.7%;specificity:60.6%),*** Increased NLR and decreased LMR may predict LAAT/dense SEC in patients with nonvalvular AF.

关键词： Nonvalvular atrial fibrillation Left atrial appendage thrombus Spontaneous echo contrast Neutrophil–lymphocyte ratio Lymphocyte–monocyte ratio

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