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Classification of congenital cataracts based on multidimensional phenotypes and its association with visual outcomes

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International Journal of Ophthalmology(English edition) 2024年第3期17卷 473-479页

作者： Yuan Tan ying-shi zou ying-Lin Yu Le-Yi Hu Ting Zhang Hui Chen Ling Jin Duo-Ru Lin Yi-Zhi Liu Hao-Tian Lin Zhen-Zhen Liu State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangdong Provincial Key Laboratory of Ophthalmology and Visual ScienceGuangdong Provincial Clinical Research Center for Ocular DiseasesGuangzhou 510060Guangdong ProvinceChina

●AIM:To establish a classification for congenital cataracts that can facilitate individualized treatment and help identify individuals with a high likelihood of different visual outcomes.●METHODS:Consecutive patients diagnosed with congenital cataracts and undergoing surgery between January 2005 and November 2021 were *** on visual outcomes and the phenotypic characteristics of ocular biometry and the anterior and posterior segments were extracted from the patients’medical records.A hierarchical cluster analysis was *** main outcome measure was the identification of distinct clusters of eyes with congenital cataracts.●RESULTS:A total of 164 children(299 eyes)were divided into two clusters based on their ocular *** 1(96 eyes)had a shorter axial length(mean±SD,19.44±1.68 mm),a low prevalence of macular abnormalities(1.04%),and no retinal abnormalities or posterior *** 2(203 eyes)had a greater axial length(mean±SD,20.42±2.10 mm)and a higher prevalence of macular abnormalities(8.37%),retinal abnormalities(98.52%),and posterior cataracts(4.93%).Compared with the eyes in Cluster 2(57.14%),those in Cluster 1(71.88%)had a 2.2 times higher chance of good best-corrected visual acuity[<0.7 logMAR;OR(95%CI),2.20(1.25–3.81);P=0.006].●CONCLUSION:This retrospective study categorizes congenital cataracts into two distinct clusters,each associated with a different likelihood of visual *** innovative classification may enable the personalization and prioritization of early interventions for patients who may gain the greatest benefit,thereby making strides toward precision medicine in the field of congenital cataracts.

关键词： classification congenital cataract phenotype visual acuity cluster analysis

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Hotspots and frontiers of genetic research on pediatric cataracts from 2013 to 2022:a scientometric analysis

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国际眼科杂志:英文版 2023年第10期16卷 1682-1691页

作者： Yuan Tan Wei Jiang Le-Yi Hu Yan-Yu Shen Hui Chen ying-shi zou Li-Xia Luo Guang-Ming Jin Zhen-Zhen Liu State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangdong Provincial Key Laboratory of Ophthalmology and Visual ScienceGuangdong Provincial Clinical Research Center for Ocular DiseasesGuangzhou 510060Guangdong ProvinceChina Zhongshan Medical School Sun Yat-sen UniversityGuangzhou 510060Guangdong ProvinceChina

AIM:To explore the hotspots and frontiers of genetic research on pediatric ***:Global publications from 2013 to 2022 related to genes in pediatric cataracts were extracted from the Web of Science Core Collection,and were analyzed in terms of the publication counts,countries,journals,authors,keywords,cited references,subject categories,and the underlying hotspots and ***:Totally 699 publications were included in the final *** predominant actors were identified,with China(n=240)and PLoS One(n=33)being the most productive country and journal *** research hotspots extracted from keywords were crystallin gene mutations,pathogenicity evaluation,phenotypes of ocular and neurodevelopmental abnormalities,genes encoding membrane proteins,and diagnosis of multisystemic *** co-cited articles formed 10 clusters of research topics,including FYCO1(56 items),mutation screening(43 items),gap junction(29 items),the Warburg Micro syndrome(29 items),ephrin-A5(28 items),novel mutation(24 items),eye development and function(22 items),cholestanol(7 items),OCRL(6 items),and pathogenicity prediction(3 items).The research frontiers were FYCO1,ephrin-A5,and *** biology showed the strongest bridging effects among different disciplines in the field(betweenness centrality=0.44).CONCLUSION:With the progress in next-generation sequencing and multidisciplinary collaboration,genetic research on pediatric cataracts broadens the knowledge scope of the crystalline lens,as well as other organs and systems,shedding light on the molecular mechanisms of systemic *** biology may integrate multidisciplinary content to address cutting-edge issues in the field.

关键词： gene pediatric cataract next generation sequencing genotype phenotype association

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103 GHz germanium-on-silicon photodiode enabled by an optimized U-shaped electrode

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Photonics Research 2024年第1期12卷 1-6页

作者： Yang shi Xiang Li Mingjie zou Yu Yu Xinliang Zhang Wuhan National Laboratory for Optoelectronics&School of Optical and Electronic Information Huazhong University of Science and TechnologyWuhan 430074China School of Mechanical Engineering and Electronic Information China University of GeosciencesWuhan 430074China Optics Valley Laboratory Wuhan 430074China Xidian University Xi’an 710126China

High-performance germanium photodiodes are crucial components in silicon photonic integrated circuits for large-capacity data ***,the bandwidths of most germanium photodiodes are limited by the intractable resistance–capacitance parasitic ***,we introduce a unique U-shaped electrode to alleviate this issue,reducing the parasitic effect by 36%without compromising any other ***,a large bandwidth of 103 GHz,an optical responsivity of 0.95 A/W at 1550 nm,and a dark current as low as 1.3 nA are achieved,leading to a record high specific *** is the first breakthrough to 100 GHz bandwidth among all vertical germanium photodiodes,to the best of our *** eye diagrams of 120 Gb/s on-off keying and 200 Gb/s four-level pulse amplitude signals are well *** work provides a promising solution for chip-based ultra-fast photodetection.

关键词： Gb/s shaped electrode

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Identification of human microRNA-disease association via low-rank approximation-based link propagation and multiple kernel learning

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Frontiers of Computer Science 2024年第2期18卷 217-229页

作者： Yizheng WANG Xin ZHANG ying JU Qing LIU Quan zou Yazhou ZHANG Yijie DING ying ZHANG Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaChengdu 610054China Yangtze Delta Region Institute(Quzhou) University of Electronic Science and Technology of ChinaQuzhou 324000China Beidahuang Industry Group General Hospital Harbin 150088China School of Informatics Xiamen UniversityXiamen 361005China Department of Anesthesiology Hospital(T.C.M)Affiliated to Southwest Medical UniversityLuzhou 646000China Software Engineering College Zhengzhou University of Light IndustryZhengzhou 450002China

Numerous studies have demonstrated that human microRNAs(miRNAs)and diseases are associated and studies on the microRNA-disease association(MDA)have been *** developed a model using a low-rank approximation-based link propagation algorithm with Hilbert–Schmidt independence criterion-based multiple kernel learning(HSIC-MKL)to solve the problem of the large time commitment and cost of traditional biological experiments involving miRNAs and diseases,and improve the model *** constructed three kernels in miRNA and disease space and conducted kernel fusion using *** propagation uses matrix factorization and matrix approximation to effectively reduce computation and time *** results of the experiment show that the approach we proposed has a good effect,and,in some respects,exceeds what existing models can do.

关键词： human miRNA-disease association multiple kernel learning link propagation miRNA similarity disease similarity

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Reduction behavior of iron ore powder by high-volatile coal in thermogravimetric-gas chromatographic and kinetic analysis

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Journal of Iron and Steel Research(International) 2024年第1期31卷 92-107页

作者： Rui-meng shi Qi-yuan Mi Bin Li Xiao shi Chong zou Jing Guo Han-jie Guo School of Metallurgical Engineering Xi’an University of Architecture and TechnologyXi’an710055ShaanxiChina China International Engineering Consulting Corporation Beijing100048China School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing100083China

The reduction behavior of iron ore powder by high-volatile coal was investigated,and its kinetic mechanism was *** effect of volatiles in coal on the reduction reaction of iron ore was compared by utilizing a Xinjiang lignite with a high volatile content and its pyrolysis carbon produced by high-temperature pyrolysis to remove volatiles,serving as a *** mass loss and gas composition of the samples during the reduction process were detected using thermo-gravimetric analysis and gas chromatography,and the morphological changes of iron ore powder were observed through scanning electron *** kinetic parameters of the iron oxide reduction reaction were calculated by the Flynn-Ozawa-Wall method,and the kinetic mechanism of volatile participation in the iron oxide reduction reaction was determined through the Coats-Redfern *** results indicate that the coupling effect between the high-volatile coal pyrolysis and reduction reactions occurs during the second stage of the entire coupling process,which corresponds to the late stage of coal pyrolysis with a substantial release of H_(2)and *** volatiles in coal actively participated in the reduction reaction,reducing the initiation temperature of the reaction by around 200℃.The reduction of iron oxides by high-volatile coal was jointly promoted by the"hydrogen cycle"and"carbon cycle",resulting in a higher reduction extent and metallization rate at the end of the *** high-volatile coal was used as the reductant,the average activation energy for the entire process was 76.5 kJ/mol,a significant decrease compared to the employment of pyrolysis carbon without volatiles as the reductant(1167 kJ/mol).

关键词： Direct reduction High-volatile coal Volatile Kinetics Reduction mechanism

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Phylogenetic study on Scenedesmacae with the description of a new genus Coccoidesmus gen. nov. (Chlorophyceae, Chlorophyta) and chloroplast genome analyses

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JOURNAL OF OCEANOLOGY AND LIMNOLOGY 2024年第4期42卷 1-14页

作者： Wang, Qinghua Hou, ying Li, Yanhui shi, ying Liu, Guoxiang Taiyuan Normal Univ Coll Biol Sci & Technol Jinzhong 030619 Shanxi Peoples R China Shanxi Vocat Univ Engn Sci & Technol Jinzhong 030619 Peoples R China Chinese Acad Sci Inst Hydrobiol Key Lab Algal Biol Wuhan 430072 Hubei Peoples R China

Members of the family Scenedesmaceae are some of the most common algal taxa in inland ecosystems, and they are widely distributed in freshwaters, aerial, and sub-aerial habitats. With the continuous updating of methods, the classic morphological taxonomy of this family needs to be revised. In recent years, many genera of Scenedesmaceae have been established via the use of molecular methods. The phylogenetic relationships within Scenedesmaceae were analyzed using different molecular markers and morphological data, and the new freshwater genus Coccoidesmus Wang, Hou et Liu gen. nov. was described. Two new species in this genus were also described. Phylogenetic analysis based on tufA genes revealed that the new genus formed an independent clade closely related to Comasiella. However, these two genera are characterized by significant morphological differences in colony arrangement and cell shape. The chloroplast genome of the type species was assembled and annotated, and analyses of genome structure and sequences were conducted. More genome data could help clarify the phylogenetic relationships within this family.

关键词： phylogenetic Scenedesmaceae Coccoidesmus morphology chloroplast genome TREBOUXIOPHYCEAE ALGAE CHODATODESMUS OOCYSTACEAE ALIGNMENT POSITION

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Method of fabricating artificial rock specimens based on extrusion free forming(EFF)3D printing

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第4期16卷 1455-1466页

作者： Xiaomeng shi Tingbang Deng Sen Lin Chunjiang zou Baoguo Liu Key Laboratory for Urban Underground Engineering of the Ministry of Education Beijing Jiaotong UniversityBeijing100044China School of Civil Engineering Beijing Jiaotong UniversityBeijing100044China Department of Civil Engineering Monash UniversityMelbourne3800Australia

Three-dimensional(3D)printing technology has been widely used to create artificial rock samples in rock *** 3D printing can create complex fractures,the material still lacks sufficient similarity to natural *** free forming(EFF)is a 3D printing technique that uses clay as the printing material and cures the specimens through high-temperature *** this study,we attempted to use the EFF technology to fabricate artificial rock *** results show the physico-mechanical properties of the specimens are significantly affected by the sintering temperature,while the nozzle diameter and layer thickness also have a certain *** specimens are primarily composed of SiO_(2),with mineral compositions similar to that of natural *** density,uniaxial compressive strength(UCS),elastic modulus,and tensile strength of the printed specimens fall in the range of 1.65–2.54 g/cm3,16.46–50.49 MPa,2.17–13.35 GPa,and 0.82–17.18 MPa,*** is capable of simulating different types of rocks,especially mudstone,sandstone,limestone,and ***,the simulation of hard rocks with UCS exceeding 50 MPa still requires validation.

关键词： Artificial rock 3D printing Extrusion free forming(EFF) Similarity analysis Mechanical properties

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Vortex identification based on the Liutex method and its effect on fish passage upstream

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Journal of Hydrodynamics 2024年第1期36卷 130-141页

作者： Chun-ying Shen Rui-guo Yang Xiao-tao shi Ming-ming Wang shi-hua He Faculty of Electrical Power Engineering Kunming University of Science and TechnologyKunming650500China Hubei International Science and Technology Cooperation Base of Fish Passage China Three Gorges UniversityYichang443002China Shanghai Investigation Design and Research Institute Co.LtShanghai200434China

Fishway research is important for mitigating the fragmentation of river habitats caused by hydraulic *** vertical slit fishway is a broadly used fishway type because of its high efficiency and adaptability to water ***,the resulting vortex current disrupts the fish passage hence directly affecting fish *** study aims to accurately capture the vortex structure in the fishway and analyze the effect of vortex elements(vortex structure,vortex intensity,etc.)on *** conducted an analysis of the 3-D current flow field in the fishway through the utilization of an experimental model and the large eddy simulation(LES)***,we captured the vortex information in the fishway at different flow rates using the Liutex vortex identification method and investigated the effect of the vortex on fish *** results revealed that the structures inside the fishway pool occupy most of the room,however,the areas with higher vortex strength were primarily located in the vortex near the vertical seam and the mainstream,the vortex strength inside the fishway gradually increases with increasing flow,suppressing fish *** experienced significantly increased resistance when encountering strong *** suggests that the vortex may act as a physical barrier to fish *** findings highlight the potential negative effects of vortex on fish movement and reiterate the importance of understanding vortex dynamics for aquatic environmental *** an effective tool for identifying vortices in fluid flow,the Liutex method demonstrates features of vortex within the fishway,thereby providing important insights into the interaction between fluid dynamics and aquatic organisms.

关键词： Vertical slit fishway vortex identification method Liutex large eddy simulation(LES) fish experiment computational fluid dynamics

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Glucose-sensitive Membrane with PBA-based Contraction-type Linear Polymer as Chemical Valves Prepared by Surface Grafting

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CHINESE JOURNAL OF POLYMER SCIENCE 2024年第8期42卷 1067-1076页

作者： Zhang, Chun-Peng Gao, Si-Jia Luo, ying zou, Lei Zhang, Yong-Jun Tiangong Univ Sch Mat Sci & Engn State Key Lab Separat Membranes & Membrane Proc Tianjin 300387 Peoples R China Tiangong Univ Sch Pharmaceut Sci State Key Lab Separat Membranes & Membrane Proc Tianjin 300387 Peoples R China Tiangong Univ Cangzhou Inst Cangzhou 061000 Peoples R China Nankai Univ Inst Hepatobiliary Dis Tianjin Key Lab Extracorporeal Life Support Crit D Affiliated Ctr Hosp 3 Tianjin 300170 Peoples R China

Glucose-sensitive membrane has potential application in self-regulating insulin release. Phenylboronic acid (PBA) is a well-known glucose reporter. Unfortunately, most PBA-based glucose-sensitive materials are expansion-type, which are not suitable as chemical valves in membrane pores for self-regulating insulin release. According to a new glucose-sensitive mechanism, we synthesized PBA-based contraction-type glucose-sensitive liner polymer and microgels. Herein, a glucose-sensitive membrane was prepared by grafting PBA-based contraction-type glucose-sensitive linear polymer on the membrane surface. Through adjusting the chain length and chain density, the glucose-sensitivity of the membrane was optimized. The membrane can reversibly regulate insulin release at physiologically relevant glucose concentrations in simulates body fluids and fetal bovine serum. The membrane also has good stability, anti-fouling and biocompatibility. It has potential application in self-regulating insulin release.

关键词： Phenylboronic acid Glucose-sensitive Membrane Surface grafting Insulin PHENYLBORONIC ACID BRUSHES DENSITY CHAINS LENGTH FILM

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Research on intelligent search-and-secure technology in accelerator hazardous areas based on machine vision

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Nuclear Science and Techniques 2024年第4期35卷 96-107页

作者： ying-Lin Ma Yao Wang Hong-Mei shi Hui-Jie Zhang School of Traffic and Transportation Beijing Jiaotong UniversityBeijing 100044China School of Mechanical Electronic and Control EngineeringBeijing Jiaotong UniversityBeijing 100044China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China

Prompt radiation emitted during accelerator operation poses a significant health risk,necessitating a thorough search and securing of hazardous areas prior to ***,manual sweep methods are ***,the limitations of manual sweeps have become increasingly evident with the implementation of large-scale *** leveraging advancements in machine vision technology,the automatic identification of stranded personnel in controlled areas through camera imagery presents a viable solution for efficient search and *** the criticality of personal safety for stranded individuals,search and security processes must be sufficiently *** ensure comprehensive coverage,180°camera groups were strategically positioned on both sides of the accelerator tunnel to eliminate blind spots within the monitoring *** YOLOV8 network model was modified to enable the detection of small targets,such as hands and feet,as well as larger targets formed by individuals near the ***,the system incorporates a pedestrian recognition model that detects human body parts,and an information fusion strategy is used to integrate the detected head,hands,and feet with the identified pedestrians as a cohesive *** strategy enhanced the capability of the model to identify pedestrians obstructed by equipment,resulting in a notable improvement in the recall ***,recall rates of 0.915 and 0.82were obtained for Datasets 1 and 2,*** there was a slight decrease in accuracy,it aligned with the intended purpose of the search-and-secure software *** tests conducted within an accelerator tunnel demonstrated the effectiveness of this approach in achieving reliable recognition outcomes.

关键词： Search and secure Machine vision Camera Human body parts recognition Particle accelerator Hazardous area

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