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Hepatic metastases in ovarian cancer

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Hepatobiliary Surgery and Nutrition 2022年第6期11卷 924-926页

作者： ying shan ying Jin Lingya Pan Department of Obstetrics and Gynecology National Clinical Research Center for Obstetric&Gynecologic DiseasesPeking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijingChina

Ovarian cancer is the most lethal disease among gynecologic malignancies(1);about 1/4 of ovarian cancer patients are in stage IV when *** ovarian epithelial cancer patients with stage IV disease,the mean overall survival(OS)is around 20 months,and the 5 year-OS is about 20%.About 1 in 5 patients with advanced-stage ovarian cancer have hepatobiliary involvement.

关键词： cancer involvement patients

Effect of bastnaesite as reductant on hematite reduction during in-situ suspension magnetization roasting of refractory iron ore under neutral atmosphere

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International Journal of Mining Science and Technology 2022年第4期32卷 877-886页

作者： Wenbo Li Jijia Chen Wentao Zhou Yuexin han Yan shan School of Resources and Civil Engineering Northeastern UniversityShenyang 110819China National-Local Joint Engineering Research Center of High-Efficient Exploitation Technology for Refractory Iron Ore Resources Shenyang 110819China

The iron tailings of Bayan Obo mines are solid waste,which occupies land area and also causes environmental pollution;however,this waste can be *** this study,based on the characteristics of iron minerals and fluorocarbonate contained in Bayan Obo iron tailings,clean magnetization roasting of iron minerals by bastnaesite from iron tailings during in-situ suspension magnetization roasting in a neutral atmosphere was *** results show that for iron tailings with a mass of 12 g,a N_(2) gas flow rate of 600 mL/min,and roasting for 5 min at 800℃,iron concentrate with a 60.44%iron grade at an iron recovery of 76.04%could be obtained.X-ray diffraction analysis showed that the weak magnetic hematite was reduced to strong magnetic magnetite in the neutral atmosphere,without additional *** kinetics of the magnetization roasting of mineral mixtures(bastnaesite and hematite)in a neutral atmosphere showed that the optimal reaction mechanism function was the three-dimensional diffusion model with activation energy of 161.8838 kJ·mol^(-1);this indicates that the reaction was a heterogeneous,diffusion-controlled solid-state reaction.

关键词： Bayan Obo iron tailings In-situ suspension roasting Clean recovery Phase magnetic transformation Kinetics mechanism

Revisiting the X-ray emission of the asynchronous polar V1432 Aql

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Research in Astronomy and Astrophysics 2021年第12期21卷 499-508页

作者： Qi-shan Wang Sheng-Bang Qian Li-ying Zhu Yunnan Observatories Chinese Academy of SciencesKunming 650216China Key Laboratory of the Structure and Evolution of Celestial Objects Chinese Academy of SciencesKunming 650216China University of Chinese Academy of Sciences Beijing 100049China Center for Astronomical Mega-Science Chinese Academy of SciencesBeijing 100101China

As the only eclipsing asynchronous polar,V1432 Aql provides an excellent laboratory to study the interaction between the accreted matter and the magnetic ***,we report an analysis of the X-ray data from the contemporaneous NuSTAR and Swift-XRT *** X-ray data present a profile with a low-intensity state for almost half an orbital period,a dip at 0.6 phase,and a peak at 0.75 phase,which suggests that there was only one accretion region during the observation and the claim is supported by the spectral *** comparison with the previous data indicates that the X-ray data have an orbital modulation,as the case in BeppoSAX,rather than a spin one observed in *** attribute the orbit and spin modulations to the different accretion geometries at *** spectral analysis of the wide-band data presents a significant reflection effect,a commonly observed soft X-ray temperature,and the energy balance in V1432 ***,we obtained a low total accretion rate of 1.3×10~(-10)M yr~(-1)and a high specific accretion rate of 3.8 g cm~(-2)s~(-1)which explains the strong reflection from the surface of the white ***,due to its complex emission,a more physical understanding of its accretion geometry is still outstanding.

关键词： stars:individual(V1432 Aql) cataclysmic variables:asynchronous polars

Cutaneous metastases of pancreatic carcinoma to the labia majora: A case report and review of literature

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World Journal of Gastrointestinal Oncology 2020年第11期12卷 1372-1380页

作者： ying Shi shan-shan Li Dan-Yan Liu Yan Yu Department of Dermatology First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina Department of Dermatology and Venereology First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina Department of Radiology First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina

BACKGROUND Cutaneous metastases originating from pancreatic cancer are relatively rare. The most common reported site of metastasis is the umbilicus, and this manifestation is known as the Sister Mary Joseph's nodule. Non-umbilical cutaneous metastases are far less common, with only a few cases reported in the literature. Our case is the first case report, to our knowledge, on metastasis involving the labia majora and flat *** SUMMARY A 49-year-old Chinese female patient presented with a number of red, swollen papules on the vulva for 2 mo. Histological examination of the labia majora lesion revealed metastatic adenocarcinoma. The serum levels of tumor biomarkers CA199, CA242, and CA125 were significantly elevated. B-mode ultrasoundguided needle biopsy of the pancreas demonstrated moderately and poorly differentiated adenocarcinoma. The patient finally declined treatment for financial reasons and died 3 mo *** Metastatic cutaneous lesions could indicate pancreatic cancer. Serum levels of tumor biomarkers may aid in diagnosing metastatic pancreatic adenocarcinoma.

关键词： Pancreatic cancer Cutaneous Metastasis Non-umbilical Biomarker Case report

A Level Set Method for the Inverse Problem of Wave Equation in the Fluid-Saturated Porous Media

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Communications in Computational Physics 2009年第9期6卷 793-803页

作者： ying He Bo han Department of Mathematics Harbin Institute of TechnologyHarbin150001China School of Mathematical Sciences Heilongjiang UniversityHarbin150080China

In this paper,a level set method is applied to the inverse problem of 2-D wave equation in the fluid-saturated *** only consider the situation that the parameter to be recovered takes two different values,which leads to a shape reconstruction problem.A level set function is used to present the discontinuous parameter,and a regularization functional is applied to the level set function for the ill-posed *** the resulting inverse problem with respect to the level set function is solved by using the damped Gauss-Newton *** experiments show that the method can recover parameter with complicated geometry and the noise in the observation data.

关键词： Level set method fluid-saturated porous media parameterrecovery damped GaussNewton method

Balancing free and confined metallic Ni for an active and stable catalyst——A case study of CO methanation over Ni/Ni–Al2O3

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Journal of Energy Chemistry 2020年第11期29卷 73-84页

作者： Yong-shan Xiao Yong-Hong Song Chang Liu Xian-ying Shi han-Qing Ge Min-Li Zhu Zhao-Tie Liu Zhong-Wen Liu Key Laboratory of Syngas Conversion of Shaanxi Province School of Chemistry&Chemical EngineeringShaanxi Normal UniversityXi'an 710119ShaanxiChina

We propose a new strategy to make an active and stable Ni-based catalyst which can be operated in a wide range of reaction temperatures. The ordered mesoporous alumina(OMA) with confined Ni in the pore wall(Ni-OMA) was prepared via the one-pot evaporation induced self-assembly method. By using the incipient impregnation method, different amounts of free Ni were loaded over Ni-OMA(Ni/NiOMA) at a fixed total NiO content of 15 wt%. Characterization results confirmed the formation of wellstructured Ni-OMA, and the ordered structure was still well preserved even after impregnating NiO at a content of as high as 12 wt%. The catalysts were evaluated for the CO methanation as a model reaction under varied conditions. Importantly, the activity and stability of Ni/Ni-OMA for the titled reaction were significantly regulated by simply changing the ratio of the confined to free Ni. Over the optimum catalyst of NiO(2 wt%)/NiO(13 wt%)-OMA, the high activity at a temperature of as low as 300 ℃ was achieved with the space-time yield of methane over 7.6 g gcat-1 h-1 while a long-term stability for a time-onstream of 400 h was confirmed without an observable deactivation under the conditions of 600 ℃ and an extremely high gas hourly space velocity of 120,000 mL g-1 h-1. The results were well explained as the integrated merits of the free Ni for a high dispersion and the confined Ni in OMA for the anti-sintering property.

关键词： CO methanation Ni Ordered mesoporous alumina Evaporation induced self-assembly Ni-support interactions

Meroterpenoids Possessing Diverse Rearranged Skeletons with Anti-inflammatory Activity from the Mangrove-Derived Fungus Penicillium sp. HLLG-122

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Chinese Journal of Chemistry 2023年第19期41卷 2507-2517页

作者： Yu-Yue Qin Wan-shan Li Xuan Zhang Zhang-Xin Yu Xiao-Bao Li han-Yi Chen Yan-Ru Lv Chang-Ri han Guang-ying Chen Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education and Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province College of Chemistry and Chemical EngineeringHainan Normal UniversityHaikouHainan571158 China Key Laboratory of Medicinal and Edible Plants Resources of Hainan Province Hainan Vocational University of Science and TechnologyHaikouHainan571126 China

Fifteen new meroterpenoids, littoreanoids A—O (1—15), including three rearranged skeleton meroterpenoids (1—3), were isolated from the mangrove-derived fungus Penicillium sp. HLLG-122. Compound 1 was a novel berkeleyacetal-derived meroterpenoid featuring an unusual spirocyclic 2-oxaspiro[5.5]undeca-4,7-dien-3-one moiety. Compound 2 possessed an unusual 6/6/6/6/6 pentacyclic system with a novel 1-hydroxy-7,7-dimethyl-2-oxabicyclo[2.2.2]octan-5-yl acetate moiety. Compound 3 was an unusual 6/7/6/5/6/5/4 polycyclic systems containing a β-lactone ring. The structures and absolute configurations of new compounds were elucidated by HRESIMS, NMR spectroscopy, single crystal X-ray diffraction analysis, and electronic circular dichroism calculations. The plausible biosynthetic pathways of 1—3 were also proposed. Compounds 6 and 11 exhibited anti-inflammatory effects with IC_(50) values of 30.41 and 19.02 μmol/L, respectively. The bioactive compound 11 was selected for the investigation of preliminary mechanism using molecular docking and Western blotting experiments. Compound 11 could suppress the levels of TNF-α and IL-6, and down-regulate the protein expression of iNOS and COX-2 in RAW 264.7 cells.

关键词： Penicillium sp Terpenoids Structural elucidation Anti-inflammatory activities Conformation analysis Natural products

CFAR Block-Sparse Bayesian Learning Algorithm for the Off-grid DOA Estimation with Coprime Array

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Chinese Journal of Electronics 2019年第4期28卷 863-870页

作者： han Jun HE Minghao FENG Mingyue JIANG ying Air Force Early Warning Academy

Constant false-alarm rate Block-sparse Bayesian learning(CFAR-BSBL) algorithm is proposed to reduce the computational complexity and improve Direction of arrival(DOA) estimation accuracy of offgrid signals with coprime array. Firstly, a signal model with normalized noise is built to avoid the learning procedure of noise parameter. Secondly, a block sparse Bayesian framework is built with the introduction of a temporary correlation matrix in order to use t he temporal structure of incident signals. Then the algorithm uses CFAR detection to detect the grids close to the real DOA and relieve the dependence on the number of signals. Finally,an off-grid process based on the closest grids is adopted to deal with the off-grid problem. The proposed CFAR-BSBL algorithm can obtain high accuracy and low complexity DOA estimation of off-grid signals with coprime array.

关键词： Off-grid direction-of-arrival estimation Block sparse Bayesian learning(BSBL) Coprime array CFAR detection Low complexity

Microstructure and properties of Ti64.51Fe26.40Zr5.86Sn2.93Y0.30 biomedical alloy fabricated by laser additive manufacturing

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Transactions of Nonferrous Metals Society of China 2020年第12期30卷 3274-3286页

作者： Li-ying han Cun-shan WANG School of Materials and Metallurgy University of Science and Technology LiaoningAnshan 114051China Key Laboratory of Materials Modification by Laser Ion and Electron Beams of Ministry of EducationDalian University of TechnologyDalian 116024China

From the perspective of biomechanics and forming technology,Ti−Fe−Zr−Sn−Y eutectic alloy was designed using a“cluster-plus-glue-atom”model,and then the alloy was prepared by laser additive manufacturing(LAM)on pure titanium *** mechanical properties of the alloy were evaluated using micro-hardness and compression tester,and the elastic modulus was measured by *** results show that the alloy exhibits a high hardness of HV(788±10),a high strength of 2229 MPa,a failure strain of 14%,and a low elastic modulus of 87.5 *** alloy also has good tribological,chemical,forming,and biological *** comprehensive performances of the Ti64.51Fe26.40Zr5.86Sn2.93Y0.30 alloy are superior to those of the Ti70.5Fe29.5 eutectic alloy and commercial Ti−6Al−4V *** the above-mentioned qualities make the alloy a promising candidate as LAM biomaterial.

关键词： laser additive manufacturing composition design biomedical titanium alloy microstructure property