检索结果-南通市图书馆

Metabolic disorders in prediabetes:From mechanisms to therapeutic management

在线全文

学校读者我要写书评

暂无评论

World Journal of Diabetes 2024年第3期15卷 361-377页

作者： Wen-Xin Ping Shan Hu Jing-qian Su Song-ying Ouyang Biomedical Research Center of South China College of Life SciencesFujian Normal UniversityFuzhou 350117Fujian ProvinceChina

Diabetes,one of the world's top ten diseases,is known for its high mortality and complication rates and low cure *** precedes the onset of diabetes,during which effective treatment can reduce diabetes *** risk factors include high-calorie and high-fat diets,sedentary lifestyles,and *** may include considerable damage to vital organs,including the retina,liver,and *** for treating prediabetes include a healthy lifestyle diet and pharmacological ***,while these options are effective in the short term,they may fail due to the difficulty of long-term *** may also be used to treat *** review examines prediabetic treatments,particularly metformin,glucagon-like peptide-1 receptor agonists,sodium glucose cotransporter 2 inhibitors,vitamin D,and herbal *** the remarkable impact of prediabetes on the progression of diabetes mellitus,it is crucial to intervene promptly and effectively to regulate ***,the current body of research on prediabetes is limited,and there is considerable confusion surrounding clinically relevant *** paper aims to provide a comprehensive summary of the pathogenesis of prediabetes mellitus and its associated therapeutic *** ultimate goal is to facilitate the clinical utilization of medications and achieve efficient and timely control of diabetes mellitus.

关键词： Prediabetes Glucagon-like peptide agonists Sodium–glucose cotransporter 2 inhibitors Vitamin D Chinese herbal medicines

Interpenetrating network-reinforced gel polymer electrolyte for ultra-stable lithium−iodine batteries

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Carbon Energy 2024年第6期6卷 234-247页

作者： ying Jiang peng Huang Minman Tong Bingxin Qi Tao Sun Zhongyun Xian Wen Yan Chao Lai School of Chemistry and Materials Science Jiangsu Normal UniversityXuzhouJiangsuChina

Li-I_(2) batteries have attracted much interest due to their high capacity,exceptional rate performance,and low *** so,the problems of unstable Li anode/electrolyte interface and severe polyiodide shuttle in Li-I_(2) batteries need to be ***,the interfacial reactions on the Li anode and I_(2) cathode have been effectively optimized by employing a well-designed gel polymer electrolyte strengthened by cross-linked Ti-O/Si-O(GPETS).The interpenetrating network-reinforced GPETS with high ionic conductivity(1.88×10^(-3)S cm^(-1)at 25℃)and high mechanical strength endows uniform Li deposition/stripping over 1800 h(at 1.0mA cm^(-2),with a plating capacity of 3.0mAh cm^(-2)).Moreover,the GPETS abundant in surface hydroxyls is capable of capturing soluble polyiodides at the interface and accelerating their conversion kinetics,thus synergistically mitigating the shuttle *** from these properties,the use of GPETS results in a high capacity of 207 mAh g^(-1)(1 C)and an ultra-low fading rate of 0.013%per cycle over 2000 cycles(5 C).The current study provides new insights into advanced electrolytes for Li-I_(2) batteries.

关键词： electrode/electrolyte interface gel polymer electrolytes lithium dendrites lithium−iodine batteries polyiodide shuttle

Studies of an event-building algorithm of the readout system for the twin TPCs in HFRS

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nuclear Science and Techniques 2024年第4期35卷 82-95页

作者： Jing Tian Zhi-peng Sun Song-Bo Chang Yi qian Hong-Yun Zhao Zheng-Guo Hu Xi-Meng Chen Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China School of Nuclear Science and Technology University of LanzhouLanzhou 730000China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China Advanced Energy Science and Technology Guangdong LaboratoryHuizhou 516000China

The High-energy Fragment Separator(HFRS),which is currently under construction,is a leading international radioactive beam *** sets of position-sensitive twin time projection chamber(TPC)detectors are distributed on HFRS for particle identification and beam *** twin TPCs'readout electronics system operates in a trigger-less mode due to its high counting rate,leading to a challenge of handling large amounts of *** address this problem,we introduced an event-building *** algorithm employs a hierarchical processing strategy to compress data during transmission and *** addition,it reconstructs twin TPCs'events online and stores only the reconstructed particle information,which significantly reduces the burden on data transmission and storage *** studies demonstrated that the algorithm accurately matches twin TPCs'events and reduces more than 98%of the data volume at a counting rate of 500 kHz/channel.

关键词： High counting rate Twin TPCs Trigger-less Readout electronics Event building Hierarchical data processing

Revealing the role of CCoAOMT1: fine-tuning bHLH transcription factors for optimal anther development

在线全文

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2024年第3期67卷 565-578页

作者： Zesen Lai Jianzheng Wang ying Fu Menghan Wang Hong Ma Shiqing peng Fang Chang State Key Laboratory of Genetic Engineering Ministry of Education Key Laboratory of Biodiversity Sciences and Ecological Engineering and Institute of Biodiversity SciencesInstitute of Plant BiologySchool of Life SciencesFudan UniversityShanghai 200438China School of Tropical Agriculture and Forestry Agriculture-Rural Affairs and Rural RevitalizationHainan UniversityHaikou 570228China Key Laboratory of Biology and Genetic Resources of Tropical Crops Ministry of AgricultureInstitute of Tropical Bioscience and BiotechnologyChinese Academy of Tropical Agricultural SciencesHaikou 571101China Department of Biology Huck Institutes of the Life SciencesPennsylvania State UniversityUniversity ParkPA 16802USA

The tapetum,a crucial innermost layer encompassing male reproductive cells within the anther wall,plays a pivotal role in normal pollen *** transcription factors (TFs) bHLH010/089/091 redundantly facilitate the rapid nuclear accumulation of DYSFUNCTIONAL TAPETUM 1,a gatekeeper TF in the ***,the regulatory mechanisms governing the activity of bHLH010/089/091 remain *** this study,we reveal that caffeoyl coenzyme A O-methyltransferase 1 (CCoAOMT1) is a negative regulator affecting the nuclear localization and function of bHLH010 and bHLH089,probably through their K259 *** findings underscore that CCoAOMT1 promotes the nuclear export and degradation of bHLH010 and ***,elevated CCoAOMT1 expression resulted in defective pollen development,mirroring the phenotype observed in bhlh010 bhlh089 ***,our investigation revealed that the K259A mutation in the bHLH089 protein disrupted its translocation from the nucleus to the cytosol and impeded its degradation induced by ***,transgenic plants with the probHLH089::bHLH089^(K259A)construct failed to rescue proper pollen development or gene expression in bhlh010 bhlh089 ***,these findings emphasize the need to maintain balanced TF homeostasis for male *** firmly establish CCoAOMT1 as a pivotal regulator that is instrumental in achieving equilibrium between the induction of the tapetum transcriptional network and ensuring appropriate anther development.

关键词： anther development nuclear localization bHLH O-methyltransferase transcription factor homeostasis

A stepwise-responsive editor integrated with three copper ions for the treatment of oral squamous cell carcinoma

在线全文

学校读者我要写书评

暂无评论

Nano Research 2024年第6期17卷 5424-5434页

作者： Jinna Ren Jingying Hu Fan Dong Yan Xu Yang peng Yuping qian Guanmeng Zhang Min Wang Yuguang Wang Department of Prosthodontics Hospital of StomatologyJilin UniversityChangchun 130021China Department of General Dentistry II Peking University School and Hospital of Stomatology&National Center for Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Research Center of Oral Biomaterials and Digital Medical DevicesBeijing 100081China Center of Digital Dentistry Peking University School and Hospital of Stomatology&National Center for Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Research Center of Oral Biomaterials and Digital Medical DevicesBeijing 100081China Department of Nursing Peking University School and Hospital of Stomatology&National Center for Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Research Center of Oral Biomaterials and Digital Medical DevicesBeijing 100081China The VIP Department School and Hospital of StomatologyChina Medical UniversityLiaoning Provincial Key Laboratory of Oral DiseasesShenyang 110002China

Cuprotosis,a new type of cell death,provides great opportunities for the treatment of oral squamous cell carcinoma,as nanocarriers of copper ions can induce cuprotosis and immunogenic ***,we studied an editor that enables production of a nanoparticle“storm”in oral squamous cell carcinoma,maximizing the toxic effect of these particles and reprogramming the tumor microenvironment;as a result,T cells and natural killer(NK)cells can infiltrate the tumor microenvironment to activate an antitumor immune *** this basis,the editor can be combined with optical therapy to improve patient *** this study,the metal ratio was regulated in response to the nanocarrier of acid response ***,in the presence of a specific copper ion content,the nanocarrier could change the permeability of the tumor cell *** on these results,the nanoparticles were cracked in an acidic environment and then released copper ***,the nanoparticles contributed to cuprotosis and immunogenic *** addition,the editor could inhibit murine oral cancer 1(MOC1)tumors in C57BL/6 without *** rate of tumor growth inhibition was as high as approximately 80%.This strategy provides a new idea for ***,it can improve the interaction between immunotherapy and the copper-induced death of oral squamous cell *** all,this study will provide a new opportunity for the effective treatment of oral squamous cell carcinoma.

关键词： cuprotosis immunogenic death photothermal therapy tumor microenvironment immunotherapy

Mesenchymal stem cells-extracellular vesicles alleviate pulmonary fibrosis by regulating immunomodulators

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Stem Cells 2024年第6期16卷 670-689页

作者： ying Gao Mei-Fang Liu Yang Li Xi Liu Yu-Jie Cao qian-Fa Long Jun Yu Jian-ying Li Department of Respiratory and Critical Care Medicine Shaanxi Provincial Rehabilitation HospitalXi’an 710000Shaanxi ProvinceChina Department of Respiratory and Critical Care Medicine Second Affiliated Hospital of Ningxia Medical University(The First People’s Hospital of Yinchuan)Yinchuan 750001Ningxia Hui Autonomous RegionChina School of Clinical Medicine Xi’an Medical UniversityXi’an 710021Shaanxi ProvinceChina Department of Respiratory and Critical Care Medicine Xi’an Central HospitalXi’an 710000Shaanxi ProvinceChina Department of Neurosurgery Xi’an Central HospitalXi’an 710000Shaanxi ProvinceChina Department of Emergency Xi’an Central HospitalXi’an 710000Shaanxi ProvinceChina

BACKGROUND Pulmonary fibrosis(PF)is a chronic interstitial lung disease characterized by fibroblast proliferation and extracellular matrix formation,causing structural damage and lung *** cell therapy and mesenchymal stem cells-extracellular vesicles(MSC-EVs)offer new hope for PF *** To investigate the therapeutic potential of MSC-EVs in alleviating fibrosis,oxidative stress,and immune inflammation in A549 cells and bleomycin(BLM)-induced mouse *** The effect of MSC-EVs on A549 cells was assessed by fibrosis markers[collagen I andα-smooth muscle actin(α-SMA),oxidative stress regulators[nuclear factor E2-related factor 2(Nrf2)and heme oxygenase-1(HO-1),and inflammatory regu-lators[nuclear factor-kappaB(NF-κB)p65,interleukin(IL)-1β,and IL-2].Similarly,they were assessed in the lungs of mice where PF was induced by BLM after MSC-EV ***-EVs ion PF mice were detected by pathological staining and western ***-cell RNA sequencing was performed to investigate the effects of the MSC-EVs on gene expression profiles of macrophages after modeling in *** Transforming growth factor(TGF)-β1 enhanced fibrosis in A549 cells,significantly increasing collagen I andα-SMA ***,treatment with MSC-EVs demonstrated a remarkable alleviation of these ***,the expression of oxidative stress regulators,such as Nrf2 and HO-1,along with inflammatory regulators,including NF-κB p65 and IL-1β,were mitigated by MSC-EV ***,in a parallel manner,MSC-EVs exhibited a downregulatory impact on collagen deposition,oxidative stress injuries,and inflammatory-related cytokines in the lungs of mice with ***,the mRNA sequencing results suggested that BLM may induce PF in mice by upregulating pulmonary collagen fiber deposition and triggering an immune inflammatory *** findings collectively highlight the potential therapeutic efficacy of MSC-EVs in ameliorating fibrotic processes,oxidative stres

关键词： Mesenchymal stem cells Extracellular vesicles Pulmonary fibrosis Oxidative stress response Epithelial-mesenchymal transition

Mobile genetic elements facilitate the transmission of antibiotic resistance genes in multidrug-resistant Enterobacteriaceae from duck farms

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Food Science and Human Wellness 2024年第2期13卷 729-735页

作者： Xin’er Zheng Dingting Xu Jinchang Yan Min qian peng Wang Davood Zaeim Jianzhong Han Daofeng Qu School of Food Science and Biotechnology Zhejiang Gongshang UniversityHangzhou 310035China The Second Affiliated Hospital School of MedicineZhejiang UniversityHangzhou 311100China Agricultural and rural Bureau of Wangdian Town Xiuzhou DistrictJiaxing 314011China

Multidrug-resistant(MDR)Enterobacteriaceae critically threaten duck farming and public *** phenotypes,genotypes,and associated mobile genetic elements(MGEs)of MDR Enterobacteriaceae isolated from 6 duck farms in Zhejiang Province,China,were investigated.A total of 215 isolates were identified as Escherichia coli(64.65%),Klebsiella pneumoniae(12.09%),Proteus mirabilis(10.23%),Salmonella(8.84%),and Enterobacter cloacae(4.19%).Meanwhile,all isolates were resistant to at least two *** isolates carried tet(A)(85.12%),blaTEM(78.60%)and sul1(67.44%)resistance *** co-occurrence analysis showed that the resistance genes were associated with IS26 and integrons.A conjugative IncFII plasmid pSDM004 containing all the above MGEs was detected in Proteus mirabilis isolate *** isolate was resistant to 18 antibiotics and carried the blaNDM-5 ***,especially plasmids,are the primary antibiotic resistance gene transmission route in duck *** findings provide a theoretical basis for the rational use of antibiotics in farms which are substantial for evaluating public health and food safety.

关键词： Duck farm Mobile genetic element Antibiotic resistance gene Plasmid Food safety

In vivo imaging reveals a synchronized correlation among neurotransmitter dynamics during propofol and sevoflurane anesthesia

在线全文

学校读者我要写书评

暂无评论

Zoological Research 2024年第3期45卷 679-690页

作者： Gao-Lin Qiu Li-Jun peng peng Wang Zhi-Lai Yang Ji-qian Zhang Hu Liu Xiao-Na Zhu Jin Rao Xue-Sheng Liu Department of Anesthesiology First Affiliated Hospital of Anhui Medical UniversityHefeiAnhui 230022China School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China

General anesthesia is widely applied in clinical ***,the precise mechanism of loss of consciousness induced by general anesthetics remains ***,we measured the dynamics of five neurotransmitters,includingγ-aminobutyric acid,glutamate,norepinephrine,acetylcholine,and dopamine,in the medial prefrontal cortex and primary visual cortex of C57BL/6 mice through in vivo fiber photometry and genetically encoded neurotransmitter sensors under anesthesia to reveal the mechanism of general anesthesia from a neurotransmitter *** revealed that the concentrations of γ-aminobutyric acid,glutamate,norepinephrine,and acetylcholine increased in the cortex during propofol-induced loss of *** levels did not change following the hypnotic dose of propofol but increased significantly following surgical doses of propofol ***,the concentrations of the five neurotransmitters generally decreased during sevoflurane-induced loss of ***,the neurotransmitter dynamic networks were not synchronized in the non-anesthesia groups but were highly synchronized in the anesthetic *** findings suggest that neurotransmitter dynamic network synchronization may cause anesthetic-induced loss of consciousness.

关键词： General anesthesia Loss of consciousness In vivo neurotransmitter imaging Medial prefrontal cortex Primary visual cortex

Identification of anti-gastric cancer effects and molecular mechanisms of resveratrol: From network pharmacology and bioinformatics to experimental validation

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2024年第2期16卷 493-513页

作者： ying-qian Ma Ming Zhang Zhen-Hua Sun Hong-Yue Tang ying Wang Jiang-Xue Liu Zhan-Xue Zhang Chao Wang Department of Oncology Hebei General HospitalShijiazhuang 050051Hebei ProvinceChina School of Graduate Studies Hebei Medical UniversityShijiazhuang 050017Hebei ProvinceChina Clinical Medical Research Center Hebei General HospitalShijiazhuang 050051Hebei ProvinceChina Department of Gastrointestinal Surgery Second Hospital of Hebei Medical UniversityShijiazhuang 050000Hebei ProvinceChina

BACKGROUND Gastric cancer(GC)is one of the most aggressive malignancies with limited therapeutic options and a poor ***,a non-flavonoid poly-phenolic compound found in a variety of Chinese medicinal materials,has shown excellent anti-GC ***,its exact mechanisms of action in GC have not been *** To identify the effects of resveratrol on GC progression and explore the related molecular *** Action targets of resveratrol and GC-related targets were screened from public *** overlapping targets between the two were confirmed using a Venn diagram,and a“Resveratrol-Target-GC”network was constructed using Cyto-scape software version *** protein-protein interaction(PPI)network was constructed using STRING database and core targets were identified by PPI network *** Database for Annotation,Visualization and Integrated A total of 378 resveratrol action targets and 2154 GC disease targets were obtained from public databases,and 181 intersection targets between the two were screened by Venn *** top 20 core targets were identified by PPI network analysis of the overlapping *** function analysis mainly involved protein binding,identical protein binding,cytoplasm,nucleus,negative regulation of apoptotic process and response to xenobiotic *** enrichment analysis suggested that the involved signaling pathways mainly included PI3K-AKT signaling pathway,MAPK signaling pathway,IL-17 signaling pathway,TNF signaling pathway,ErbB signaling pathway,*** murine osteosarcoma viral oncogene homolog(FOS)and matrix metallopeptidase 9(MMP9)were selected by differential expression analysis,and they were closely associated with immune *** docking results showed that resveratrol docked well with these two *** treatment arrested the cell cycle at the S phase,induced apoptosis,and weakened viability,migration and invasion in a dose-dependent ***,re

关键词： Resveratrol Gastric cancer Network pharmacology Bioinformatics Molecular docking