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超声测量髂腰肌横截面积诊断老年2型糖尿病肌少症的临床价值

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临床超声医学杂志 2024年第6期26卷 475-479页

作者：应育娟易付良邓春颖查倩段议周媛黄奎四川省自贡市第四人民医院健康管理中心 643000 四川省自贡市第四人民医院内分泌科 643000

目的应用超声测量髂腰肌横截面积(CSA),探讨其在老年2型糖尿病(T2DM)肌少症诊断中的临床应用价值。方法选取我院确诊的老年T2DM患者133例,其中肌少症组38例、无肌少症组95例。使用生物电阻抗分析法测量四肢骨骼肌质量(ASM),手持式握力... 详细信息

目的应用超声测量髂腰肌横截面积(CSA),探讨其在老年2型糖尿病(T2DM)肌少症诊断中的临床应用价值。方法选取我院确诊的老年T2DM患者133例,其中肌少症组38例、无肌少症组95例。使用生物电阻抗分析法测量四肢骨骼肌质量(ASM),手持式握力测量仪测量握力(HgS);应用常规超声测量髂腰肌CSA,DFY软件测量髂腰肌平均灰阶值和分贝值,比较两组一般资料及髂腰肌CSA、平均灰阶值和分贝值的差异;分析髂腰肌CSA与ASM、HgS的相关性。采用多因素Logistic回归分析筛选老年T2DM患者肌少症的独立影响因素,并构建诊断模型。绘制受试者工作特征(ROC)曲线、校准曲线及临床决策曲线分别评估模型的区分度、校准度、临床收益。结果肌少症组患者体质量指数(BMI)和髂腰肌CSA均低于非肌少症组,差异均有统计学意义(均PgS均呈正相关(r=0.55、0.53,均PgS均呈正相关(r=0.30、0.40,均PgS均呈正相关(r=0.50、0.30,均Pgistic回归分析显示BMI、髂腰肌CSA均为老年T2DM患者肌少症的独立影响因素(OR=0.852、0.593,P=0.036、0.001);建立诊断模型为:Logit(P)=-0.160×BMI-0.522×髂腰肌CSA+5.881。ROC曲线分析显示,模型诊断老年T2DM患者肌少症的灵敏度、特异度、准确率分别为62.4%、81.2%、75.9%,曲线下面积为0.753;校准曲线显示实际概率与预测概率之间校准度良好;决策曲线显示根据该模型对肌少症患者进行干预可获得较高的临床收益。结论超声测量髂腰肌CSA在诊断老年T2DM肌少症中具有较高的临床应用价值。

关键词：超声检查髂腰肌 2型糖尿病,老年肌少症

Identification of MBF2 family genes in Bombyx mori and their expression in different tissues and stages and in response to Bacillus bombysepticus infection and starvation

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Insect Science 2016年第4期23卷 502-512页

作者： Chun-Yan Zhou Xing-Fu zha Chun Liu Min-Jin Han Li-ying zha.g Pan-Pan Shi He Wang Ren-Wen Zheng Qing-You Xia State Key Laboratory of Silkworm genome Biology Southwest University Chongqing China

The Multiprotein bridge factor 2 （MBF2） gene was first identified as a coactivator involved in BmFTZ-F 1-mediated activation of the Fushi tarazu gene. Herein, nine homologous genes of MBF2 gene are identified. Evolutionary analysis showed that this gene family is insect-specific and that the family members are closely related to response to pathogens （REPAT） genes. Tissue distribution analysis revealed that these genes could be expressed in a tissue-specific manner. Developmental profiles analysis showed that the MBF2 gene family members were highly expressed in the different stages. Analysis of the expression patterns of nine MBF2 family genes showed that Bacillus bombysepticus treatment induced the up-regulation of several MBF2 family genes, including MBF2-4, -7, -9, -8. Furthermore, we found the MBF2 family genes were modulated by starvation and the expression of these genes recovered upon re-feeding, except for MBF2-5, -9. These findings suggested roles for these proteins in insect defense against pathogens and nutrient metabolism, which has an important guiding significance for designing pest control strategies.

关键词： immunity nutrient metabolism physiology whole-genome scanning

Comparing the accuracy of Demirjian and Nolla methods and establishing a new method for dental age estimation in northeastern Chinese children

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Forensic Sciences Research 2022年第4期7卷 685-693页

作者： Dan Wen Zhiyu Ding Zhikai Tian Wenshuang Wu Weifeng Qu Wei He Chudong Wang Jienan Li Lagabaiyila zha ying Liu Department of Forensic Medicine School of Basic Medical SciencesCentral South UniversityChangshaChina Department of Orthopaedics The Third Xiangya Hospital of Central South UniversityChangshaChina Department of Oral Implantology Xiangya Stomatological HospitalCentral South UniversityChangshaChina Clinical Laboratory of Xiangya Stomatological Hospital Central South UniversityChangshaChina

Dental age estimation plays an important role in the field of clinic medicine and forensic *** Demirjian and Nolla methods are common scoring methods for dental age estimation but there was no research about the comparison of accuracy of these two methods in northeastern Chinese ***,in this study,we compared the accuracy of these two methods to explore more suitable method for our studied *** collected 535 orthopantomograms from northern Chinese children aged from 6 to 15 years and divided them into training dataset and testing dataset according to the ratio of 7:*** dental age of training dataset were estimated using Demirjian and Nolla methods,*** results suggested that the mean differences of these two methods were 0.24 and−0.40 years,and mean absolute difference were 0.65 and 0.59 *** to further improve the accuracy of dental age assessment,the new improved formulas and dental age conversion tables were established after analyzing the relationship between the sum scores based on Nolla method and chronology age in training *** to the new method used in testing dataset,the minimum value of mean difference(0.00)and mean absolute difference(0.49)were obtained,which are largely smaller than that of Demirjian and Nolla *** new developed method and dental age conversion scales may be more suitable dental age estimation method for northeastern Chinese children.

关键词： Forensic science forensic odontology dental age estimation Demirjian method Nolla method northeastern Chinese children

Validation of the chinese version of the EORTC QLQ-CR29 in patients with colorectal cancer

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World Journal of gastroenterology 2017年第10期23卷 1891-1898页

作者： Jin-bo Lin Lei zha.g Dong-Wen Wu Zhou-Huan xi xue-Jun Wang Yun-Shou Lin Wakana Fujiwara Jing-Ru Tian Min Wang Peng Peng Ai guo Zhen Yang Le Luo Ling-Ya Jiang qia.qia.Li xue-ying zha.g Yun-Feng zha.g Hou-Wei xu bing Yang xun-Lin Li Yi-xiong Lei School of Public Health Guangzhou Medical University Longgang Central Hospital of Shenzhen Department of Thoracic Surgery Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjin Lung Cancer Center Xiangya School of Medicine Central South University Department of gastrointestinal Surgery Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjin Lung Cancer Center Tianjin Medical University School of Medicine Georgetown University Department of Radiation Oncology Tumor HospitalXiangya School of Medicine of Central South University Longgang District Peoples Hospital of Shenzhen1 Cancer Center of guangzhou Medical University

AIM To assess the validity and reliability of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Colorectal Cancer 29 (EORTC QLQ-CR29) in Chinese patients with colorectal cancer (CRC). METHODS From March 2014 to January 2015, 356 patients with CRC from four different hospitals in China were enrolled in the study, and all patients self-administered the EORTC QLQ-CR29 and the quality of life core questionnaire (EORTC QLQ-C30). Evaluation of the scores was based on the Karnofsky Performance Scale (KPS). The reliability and validity of the questionnaires were assessed by Cronbach's proportional to coefficient, the Spearman correlation test and Wilcoxon rank sum test. RESULTS The EORTC QLQ-CR29 showed satisfactory reliability (proportional to > 0.7), although the urinary frequency and blood and mucus in stool dimensions had only moderate reliability (proportional to = 0.608). The multitrait scaling analyses showed good convergent (r > 0.4) and discriminant validity. Significant differences were obtained for each item in the different KPS subgroups (KPS 80). Body image and most single- item dimensions showed statistically significant differences in patients with a stoma compared with the rest of the patients. CONCLUSION The EORTC QLQ-CR29 exhibits high validity and reliability in Chinese patients with CRC, and can therefore be recommended as a valuable tool for the assessment of quality of life in these patients.

关键词： Colorectal cancer Health-related quality of life EORTC QLQ-CR29 China's Mainland

Fullerenol can improve the behavior of lead poisoning rats

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Fullerenol can improve the behavior of lead poisoning rats

Attention network function of insomniacs improved by manual acupuncture: Evidence from Attention Network Task

中国神经科学学会第十二届全国学术会议

作者： ying-ying zha Jin ge Cell Electrophysiology Laboratory Wannan Medical College

Objective Several reviews have been published about available applications of fullerenol, detailing the effects of fullerenol in manifold aspects,including drug delivery, reactive oxygen species quenching, targeted imaging, antiviral action, and antitumor therapy, even neuroprotection and *** primary purpose of this paper is to describe the effect of fullerenol on repairing brain damage caused by lead poisoning, showing how fullerenol might change the ability of learning and memory in lead-exposed animal models through cognitive and behavioral tests. Methods Transmission Electron Microscopy Imaging, Open Field Test, Step-Down Test and Blood Analysis had been used to test some changes in lead poisoning rats. Results（1） In Anxiety Determination study, there were obvious differences in the trace distance between the control group and the two experimental groups.（2） In Passive Avoidance study, during the retention test,Latencies for rats receiving lead solution were remarkablely decreased compared with the control group, while fullerenol had not altered the step-down latencies *** analysis of the effect of fullerenol on lead-induced impairment reveal a significant difference compared with the lead-exposed group, p＜0.001.（3） In Hematology study, some parameters（WBC and PLT） obtained from the lead-treated group presented similar trends with those from non-treated control group, while other factors（RBC, HgB, HCT, MCV and MCHC）, as the important hematology markers of anemia, presented significantly different. Conclusion Our own experience provides direct evidence suggesting the repairing effect of fullerenol on brain damages caused by lead, through behavior test.

关键词： fullerenol lead poisoning rats behavior test

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World Journal of Acupuncture-Moxibustion 2019年第2期29卷 91-96页

作者： Fei-yi zhaO Hong XU Yu-fang HONg ying-xia zhaO Haixia YAN qia.yi MA Xing MINg Jing HU Yan XU Nursing Department Shanghai Sanda University Shanghai 201209 China Shanghai Municipal Hospital of TCM affiliated to Shanghai TCM University Shanghai 200071 China College of Basic Medicine Shanghai University of TCM Shanghai 201203 China Shanghai Tianshan Hospital of TCM Shanghai 200051 China

Objective:To investigate if manual acupuncture can improve the primary insomnia-induced impairments of attention network function and its ***:Totally 64 eligible participants were enrolled in a randomized controlled trial,with 32 cases allocated to the treatment group and 32 cases allocated to the control group,*** participants in the treatment group received real-acupuncture therapy[acupuncture at 'Five Spirits Acupoints' including Shéntíng(神庭 gV 24),Běnshén(本神 gB 13),Sìshéncōng(四神聪 EX-HN 1),Shéndào(神道 gV11)and Shénmén(神门 HT 7)]whereas participants in control group received sham-acupuncture therapy with Streitberger placebo-needle and same *** were offered every two days and three times a week for total 8 *** Pittsburgh sleep quality index(PSQI)and Attention Network Task(ANT)were employed to assess the changes of sleep quality and attention network function at pretreatment and post-treatment,***,adverse effects were monitored and ***:(1)After 8-week treatment,the total score of PSQI in the treatment group decreased from14.22±3.46 to 8.19±3.34(Pgroup decreased from12.84±3.90 to 11.41±3.90(Pgroup was more significant than that in the control group(Pg efficiency of both groups increased,the treatment group increased from 40.44±5.62 to 56.44±5.37(Pgroup increased from 39.50±6.39 to 40.06±6.14(Pgroup was more significant than that in the control group(Pgroups decreased,the treatment group decreased from 574.94±10.1 to 548.34±15.05(Pgroup decreased from578.25±13.26 to 576.78±12.15(Pgroup was more significant than that in the control group(Pge in orienting efficiency was observed in

关键词： Insomnia Attention network function Acupuncture

Role of cell adhesion signal molecules in hepatocellular carcinoma cell apoptosis

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World Journal of gastroenterology 2005年第30期11卷 4667-4673页

作者： Jian-Min Su Li-ying Wang Yu-Long Liang Xi-Liang zha Department of Chemistry Fudan University Shanghai 200032 China Department of Biochemistry and Molecular Biology Shanghai Medical College of Fudan University Shanghai 200032 China

AIM： Cell adhesion molecules and their signal molecules play a very important role in carcinogenesis. The aim of this study is to elucidate the role of these molecules and the signal molecules of integrins and E-cadherins, such as （focal adhesion kinase） FAK, （integrin linked kinase） ILK, and β-catenin in hepatocellular carcinoma cell apoptosis. METHODS： We first synthesized the small molecular compound, S-（1,2-dichlorovinyl）-L-cysteine （DCVC）, and identified it, by element analysis and ^1H NMR. To establish the apoptosis model of the SMMC-7721 hepatocellular carcinoma cell, we treated cells with DCVC in EBSS for different concentrations or for various length times in the presence of 20 μmol/L N,N-cliphenyl-p-phenylenediamine, which blocks necrotic cell death and identified this model by flow cytometry and DNA ladder. Then we studied the changes of FAK, ILK, β-catenin, and PKB in this apoptotic model by Western blot. RESULTS： We found that the loss or decrease of cell adhesion signal molecules is an important reason in apoptosis of SMMC-7721 hepatocellular carcinoma cell and the apoptosis of SMMC-7721 cell was preceded by the loss or decrease of FAK, ILK, PKB, and β-catenin or the damage of cell-matrix and cell-cell adhesion. CONCLUSION： Our results suggested that the decrease of adhesion signal molecules, FAK, ILK, PKB, and β-catenin, could induce hepatocellular carcinoma cell apoptosis.

关键词： Cell adhesion signal molecule Hepatocellular carcinoma Cell apoptosis

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高校本科生特别培养学院组织文化研究

河北学刊 2009年第4期29卷 216-218页

作者：查颖浙江师范大学初阳学院浙江金华321004

本科生特别培养学院是中国高等教育大众化背景下,以培养拔尖创新的卓越人才为目标的荣誉学院,而优秀的组织文化是其顺利实施英才教育的基础。本文在对英才教育、大学组织文化和培育组织文化的意义进行理论思考的基础上,从特别培养学院... 详细信息

本科生特别培养学院是中国高等教育大众化背景下,以培养拔尖创新的卓越人才为目标的荣誉学院,而优秀的组织文化是其顺利实施英才教育的基础。本文在对英才教育、大学组织文化和培育组织文化的意义进行理论思考的基础上,从特别培养学院是学习型、责任型、混合型和宽容型组织四个角度提炼并阐述了其组织文化的特质,并提出了特别培养学院的组织文化理念和实践载体。

关键词：本科生特别培养学院英才教育组织文化

文科大学生阅读问卷调查分析——对浙江省1004名大学生的调查

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中国高教研究 2016年第11期 65-69页

作者：查颖华东师范大学高等教育研究所博士生上海200062 浙江师范大学副教授浙江金华321004

以问卷形式通过对浙江省五所高校文科大学生的阅读认知、阅读内容、阅读数量、阅读方式、阅读环境、阅读互动调查显示:大学生对阅读的重要性高度认同,大学生的经典阅读十分匮乏,阅读数量明显偏少,更倾向纸质阅读方式,大学的阅读环境不... 详细信息

以问卷形式通过对浙江省五所高校文科大学生的阅读认知、阅读内容、阅读数量、阅读方式、阅读环境、阅读互动调查显示:大学生对阅读的重要性高度认同,大学生的经典阅读十分匮乏,阅读数量明显偏少,更倾向纸质阅读方式,大学的阅读环境不够浓厚,阅读互动频次不高。

关键词：大学生阅读调查