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我国区域研发效率及其影响因素研究

华东经济管理 2016年第6期30卷 68-71页

作者：姜彩楼查颖南京信息工程大学中国制造业发展研究院江苏南京210044 南京大学经济学院江苏南京210093

文章基于创新价值链对研发活动进行划分,并采用随机前沿函数测算了我国29个省级单位的区域研发效率。结果表明:三个阶段研发效率均呈现逐年上升趋势,其中知识创新效率最高,发明型专利的研发效率最低,反映出我国优质资源长期向基础研究... 详细信息

文章基于创新价值链对研发活动进行划分,并采用随机前沿函数测算了我国29个省级单位的区域研发效率。结果表明:三个阶段研发效率均呈现逐年上升趋势,其中知识创新效率最高,发明型专利的研发效率最低,反映出我国优质资源长期向基础研究领域倾斜,而对研发的市场化重视不够。在空间跨度上,我国区域研发效率呈现东部、中部和西部地区递减的趋势。我国应该完善产学研转化机制,加大高素质人才培养,为研发活动创造良好的经济环境。

关键词：研发效率三阶段产出随机前沿函数环境变量

Atrial natriuretic peptide attenuates inflammatory responses on oleic acid-induced acute lung injury model in rats

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Chinese Medical Journal 2013年第4期126卷 747-750页

作者： ZHU Yao-bin zha.g Yan-bo LIU Dong-hai LI Xiao-feng LIU Ai-jun FAN Xiang-ming qia. Chen-hui LINg Feng LIU ying-long Department of Pediatric Heart Center Beijing Anzhen Hospital Capital Medical University Beijing 100029 China Department of Pediatric Heart Center State Key Laboratory of Cardiovascular Disease Fuwai Hospital National Center for Cardiovascular Disease Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100037 China Department of Cardiovascular Surgery First Affiliated Hospital of Zhengzhou University Zhengzhou Henan 450052 China Department of Cardiothoracic Surgery Second Affiliated Hospital of Kunming Medical University Kunming Yunnan 650101 China

Background An inflammatory response leading to organ dysfunction and failure continues to be a major problem after injury in many clinical conditions such as sepsis, severe burns, and trauma. It is increasingly recognized that atrial natriuretic peptide （ANP） possesses a broad range of biological activities, including effects on endothelial function and inflammation. A recent study has revealed that ANP exerts anti-inflammatory effects. In this study we tested the effects of human ANP （hANP） on lung injury in a model of oleic acid （OA）-induced acute lung injury （ALl） in rats. Methods Rats were randomly assigned to three groups （n=6 in each group）. Rats in the control group received a 0.9% solution of NaCI （1 ml-kg-l.h1） by continuous intravenous infusion, after 30 minutes a 0.9% solution of NaCI （1 ml/kg） was injected intravenously, and then the 0.9% NaCI infusion was restarted. Rats in the ALl group received a 0.9% NaCI solution （1 ml-kgl-h-~） intravenous infusion, after 30 minutes OA was injected intravenously （0.1 ml/kg）, and then the 0.9% NaCI infusion was restarted. Rats in the hANP-treated ALl group received a hANP （0.1 ***-Lmin~） infusion, after 30 minutes OA was injected intravenously （0.1 ml/kg）, and then the hANP infusion was restarted. The anti-inflammation effects of hANP were evaluated by histological examination and determination of serum cytokine levels. Results Serum interleukin （IL）-113, IL-6, IL-10 and tumor necrosis factor （TNF） a were increased in the ALl group at six hours. The levels of all factors were significantly lower in the hANP treated rats （P 〈0.005）. Similarly, levels of IL-113, IL-6, IL-10 and TNF-a were higher in the lung tissue in the ALl group at six hours, hANP treatment significantly reduced the levels of these factors in the lungs （P 〈0.005）. Histological examination revealed marked reduction in interstitial congestion, edema, and inflammation. Conclusion hANP can attenuate inflammation in OA-induced lung injury in rat model.

关键词： acute respiratory distress syndrome atrial natriuretic peptide inflammatory response cytokine rats

Trigger and noise filtering algorithms for the LHAASO water Cherenkov detector array

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Radiation Detection Technology and Methods 2017年第2期1卷 37-50页

作者： Xiao-Jie Wang Zhi-guo Yao Min zha Ming-Jun Chen Bo gao De-Zhi Huang Hui-Cai Li Jin-Yan Liu Wen-ying Liao Han-Rong Wu For the LHAASO collaboration Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China Nankai University Tianjin 300071China 不详

Introduction The Large High Altitude Air Shower Observatory(LHAASO)will be constructed at ***,Sichuan Province,*** several detector components of the LHAASO,the Water Cherenkov Detector Array(WCDA)is of great importance for gamma-ray astronomy from 100 geV to 30 *** single-channel counting rate of a photo-multiplier tube can reach as high as 30-35 kHz,most of them are background noise hits from the low energy cosmic ray showers,bringing a big challenge on data transferring,data storage and event *** In this paper,a dedicated trigger scheme and a fast noise filtering method aiming to deal with these high rate background noise hits are *** methods are tested with some Monte Carlo simulation data,showing a fair efficiency in filtering background noise hits,while most of the real shower signals are *** This method is proposed to be applied in a stage of the online processing just after the data are acquired in LHAASO-WCDA.

关键词： LHAASO-WCDA High level soft trigger Background noise filtering

Down-regulation of PTEN expression due to loss of promoter activity in human hepatocellular carcinoma cell lines

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World Journal of gastroenterology 2005年第29期11卷 4472-4477页

作者： Dong-Zhu Ma Zhen Xu Yu-Long Liang Jian-Ming Su Zeng-Xia Li Wen zha.g Li-ying Wang Xi-Liang zha Ministry of Health Key Laboratory of glycocojugate Research Department of Biochemistry and Molecular Biology Shanghai Medical College Fudan University Shanghai 200032 China

AIM: To investigate the regulation of phosphatase and tensin homolog deleted on chromosome ten (PTEN) gene expression in human hepatocellular carcinoma (HCC) cell ***: The mRNA and protein levels of PTEN were detected by Northern blot and Western blot in HCC cell lines, respectively. Plasmids containing different fragments of PTEN promoter with Luciferase reporter were constructed and transiently transfected into HCC cell lines to study the promoter activity. DNA analysis and RT-PCR were performed to detect the mutation of PTEN promoter and PTEN ***: Either protein or mRNA levels of PTEN in L02 cells (as a control) were significantly higher than that in HCC cell lines. The profile of PTEN promoter activity in 8 cell lines was closely correlated with levels of PTEN mRNA and PTEN protein. Furthermore, the sequence analysis of 8 cells lines showed no mutation in the region of PTEN promoter and ***: PTEN expression is down-regulated in HCC cell lines probably due to loss of activity of PTEN promoter.

关键词： Phosphatase Tensin homolog Hepatocellular carcinoma

Clinical analysis and risk stratification of ventricular septal rupture following acute myocardial infarction

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Chinese Medical Journal 2013年第21期126卷 4105-4108页

作者： Hu Xiao-ying Qiu Hong qia.Shu-bin Kang Lian-ming Song Lei zha.g Jun Tan Xiao-yan Wu Yuan Yang Yue-jin gao Run-lin Chen Zai-jia Chinese Acad Med Sci Fu Wai Hosp Natl Ctr Cardiovasc Dis Coronary Heart Dis Ctr Beijing 100037 Peoples R China Peking Union Med Coll Beijing 100037 Peoples R China

Background Ventricular septal rupture （VSR） remains an infrequent but devastating complication of acute myocardial infarction （AMI）. The best time to undergo surgical repair is controversial and there is currently no risk stratification for patients with VSR to guide treatment. The purpose of this study was to review the clinical outcomes of 70 patients with VSR, to analyze the short-term prognosis factors of VSR following AMI, and to make a risk stratification for patients with VSR.

关键词： myocardial infarction ventricular septal rupture clinical analysis risk stratification

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计及风电最优置信度的机组组合优化方法

电网技术 2017年第3期41卷 808-815页

作者：王颖周刚韩红卫李婷丁恰张凯锋复杂工程系统测量与控制教育部重点实验室(东南大学) 江苏省南京市210096 宁夏电力调度中心宁夏回族自治区银川市750001 智能电网保护和运行控制国家重点实验室(国电南瑞科技股份有限公司) 江苏省南京市210061

对于计及风电不确定性的机组组合问题,需要选择合适的风电置信度。随着风电置信度增减,机组组合经济成本与风险成本呈现此消彼长的关系,理应存在最优风电置信度,使机组组合经济性与风险性达到平衡。建立了包含风电置信度的机组组合优化... 详细信息

对于计及风电不确定性的机组组合问题,需要选择合适的风电置信度。随着风电置信度增减,机组组合经济成本与风险成本呈现此消彼长的关系,理应存在最优风电置信度,使机组组合经济性与风险性达到平衡。建立了包含风电置信度的机组组合优化模型,以机组组合经济性与风险性综合成本达到最小为优化目标,求解最优风电置信度。对风险成本进行离散线性化处理,将该问题转化为混合整数规划问题。对含风电场的6节点和IEEE 118节点系统进行仿真,验证了所提方法的有效性。

关键词：风电置信度机组组合调度计划风电概率预测

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金属薄膜裂纹扩展的分子动力学研究

东北大学学报（自然科学版） 2013年第9期34卷 1319-1321,1326页

作者：姜文全杜广煜巴德纯查英英东北大学机械工程及自动化学院辽宁沈阳110819

研究了冲击载荷作用下金属薄膜表面裂纹扩展的微观机制,采用分子动力学方法对Cu薄膜进行模拟计算,求得冲击载荷作用下带有表面裂纹模型的系统动能、应力、应变及微观结构变化图.当系统从压应力转变为拉应力状态时,裂纹上的原子获得较大... 详细信息

研究了冲击载荷作用下金属薄膜表面裂纹扩展的微观机制,采用分子动力学方法对Cu薄膜进行模拟计算,求得冲击载荷作用下带有表面裂纹模型的系统动能、应力、应变及微观结构变化图.当系统从压应力转变为拉应力状态时,裂纹上的原子获得较大动能,裂纹尖端原子开始发生溅射,继而晶格内部出现空位.当拉应力达到3643.85 MPa时,空位扩大形成裂尖钝劈现象,裂纹发生扩展.结果表明:在高速冲击载荷作用下,金属薄膜裂纹扩展主要原因是系统能量和应力的变化使得微裂纹尖端出现钝劈损伤.

关键词：冲击载荷金属薄膜裂纹扩展分子动力学钝劈损伤

不同绿肥品种、种植时间对烤烟农艺性状、产质量及植烟土壤化学成分的影响

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江西农业学报 2024年第2期36卷 1-6页

作者：查宏波赵芳桂龙凤陈华高顺波朱勋田刘武波高华磊王楠李应玥马诗曼杨武云南省烟草公司昭通市公司云南昭通657000 云南农业大学烟草学院云南昆明650201

为探索不同绿肥品种与种植时间对植烟土壤化学成分及烤烟产质量的影响,分别在昭阳区布嘎回族乡、苏家院镇开展了小面积同田对比试验,共设置9个处理:种植光叶紫花苕同田冬闲对照(g_(CK))、8月5日播种光叶紫花苕(g_(0))、8月20日播种光叶... 详细信息

为探索不同绿肥品种与种植时间对植烟土壤化学成分及烤烟产质量的影响,分别在昭阳区布嘎回族乡、苏家院镇开展了小面积同田对比试验,共设置9个处理:种植光叶紫花苕同田冬闲对照(g_(CK))、8月5日播种光叶紫花苕(g_(0))、8月20日播种光叶紫花苕(g_(15))、种植黑麦草同田冬闲对照(H_(CK))、8月5日播种黑麦草(H_(0))、8月20日播种黑麦草(H_(15))、种植肥田萝卜同田冬闲对照(F_(CK))、8月5日播种肥田萝卜(F_(0))、8月20日播种肥田萝卜(F_(15))。结果表明:种植光叶紫花苕、黑麦草和肥田萝卜3种绿肥品种并翻压还田均对烤烟田间农艺性状和经济性状具有较好的改善作用,对植烟土壤的化学成分也具有一定的调控作用;光叶紫花苕和黑麦草在当地8月中旬末播种,下茬烤烟移栽前90 d内全部翻压还田对烤烟经济性状的提升效果较好,肥田萝卜在当地8月初播种,下茬烤烟移栽前90 d内全部翻压还田对烤烟经济性状的提升效果较好。

关键词：烤烟绿肥农艺性状产质量植烟土壤

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外生批发价下的两级供应链生产与定价问题

系统管理学报 2009年第1期18卷 34-39页

作者：查迎春吴杰安徽大学经济学院合肥230039 中国科学技术大学管理学院合肥230026

分析了带2次销售机会的两级供应链生产与销售定价问题。制造商在第1阶段期末根据市场状况以批发价的形式将剩余库存卖给零售商,制造商与零售商之间关系分为一体化与分散化决策两种情形。研究结果表明,在期末产品剩余价值、缺货惩罚成本... 详细信息

分析了带2次销售机会的两级供应链生产与销售定价问题。制造商在第1阶段期末根据市场状况以批发价的形式将剩余库存卖给零售商,制造商与零售商之间关系分为一体化与分散化决策两种情形。研究结果表明,在期末产品剩余价值、缺货惩罚成本为零以及市场批发价格外生的条件下,一体化决策使得供应链的整体利润最大;而分散化决策只能在特定的批发价合同下才能使得供应链达到一体化下的结果。分散化决策将导致更少的第2阶段销量,更低的第1阶段销售价格以及制造商的生产量。

关键词：批发价生产与定价供应链协调