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Construction and evaluation of a liver cancer risk prediction model based on machine learning

World Journal of gastrointestinal Oncology 2024年第9期16卷 3839-3850页

作者： ying-ying Wang Wan-Xia Yang qia.Jun Du Zhen-Hua Liu Ming-Hua Lu Chong-ge You Laboratory Medicine Center The Second Hospital&Clinical Medical SchoolLanzhou UniversityLanzhou 730030Gansu ProvinceChina

BACKgROUND Liver cancer is one of the most prevalent malignant tumors worldwide,and its early detection and treatment are crucial for enhancing patient survival rates and quality of ***,the early symptoms of liver cancer are often not obvious,resulting in a late-stage diagnosis in many patients,which significantly reduces the effectiveness of *** a highly targeted,widely applicable,and practical risk prediction model for liver cancer is crucial for enhancing the early diagnosis and long-term survival rates among affected *** To develop a liver cancer risk prediction model by employing machine learning techniques,and subsequently assess its *** In this study,a total of 550 patients were enrolled,with 190 hepatocellular carcinoma(HCC)and 195 cirrhosis patients serving as the training cohort,and 83 HCC and 82 cirrhosis patients forming the validation *** regression(LR),support vector machine(SVM),random forest(RF),and least absolute shrinkage and selection operator(LASSO)regression models were developed in the training *** performance was assessed in the validation ***,this study conducted a comparative evaluation of the diagnostic efficacy between the ASAP model and the model developed in this study using receiver operating characteristic curve,calibration curve,and decision curve analysis(DCA)to determine the optimal predictive model for assessing liver cancer *** Six variables including age,white blood cell,red blood cell,platelet counts,alpha-fetoprotein and protein induced by vitamin K absence or antagonist II levels were used to develop LR,SVM,RF,and LASSO regression *** RF model exhibited superior discrimination,and the area under curve of the training and validation sets was 0.969 and 0.858,*** values significantly surpassed those of the LR(0.850 and 0.827),SVM(0.860 and 0.803),LASSO regression(0.845 and 0.831),and ASAP(0.866 and 0.813)model

关键词： Hepatocellular carcinoma Cirrhosis Prediction model Machine learning Random forest

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Chiral transfer amidst one-dimensional linear polymers and twodimensional network covalent organic frameworks:Striking a fine balance between helicity and crystallinity

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Nano Research 2024年第6期17卷 5726-5734页

作者： Xinlin zha Mengjuan Zuo guilin Xu Zhong Yan Haining You Yi Xiong ying Liu yingying Li Liyan Yang Ke Liu Mufang Li Tao zhao Dong Wang College of Chemistry and Chemical Engineering Donghua UniversityShanghai 201620China Key Laboratory of Textile Fiber and Products Ministry of EducationWuhan Textile UniversityWuhan 430200China

The current landscape of chiral covalent organic frameworks(COFs)predominantly centered on constructing asymmetric molecular-scale chirality,often introducing an inherent contradiction to the COF symmetry and limiting ***,we overcome these challenges by achieving chiral transfer between one-dimensional(1D)imine linear polymers(LPs)and two-dimensional(2D)networkβ-ketoenamine COFs composed of achiral *** successfully synthesize several 1D imine LPs with mesoscopic helical chirality,comprising achiral C2-symmetric terephthalaldehyde and diamine linkers in a chiral supramolecular transcription *** the irreversible tautomerism mechanism within the linker replacement approach,terephthalaldehyde(TPA)units in these helical 1D LPs are substituted with C3-symmetric 1,3,5-triformylphloroglucinol(TP),yielding the corresponding 2D networkβ-ketoenamine *** and helicity of the resultantβ-ketoenamine COFs intimately hinge on reaction conditions,including the aldehyde stoichiometry of Tp and TPA,as well as the quantity and concentration of the catalyst *** optimized conditions,the nucleation and growth were precisely governed,achieving a harmonious equilibrium of crystallinity and helicity within the generated 2D networkβ-ketoenamine COFs,even with covalent bond rupture,recombination,and topological transition(from[C2+C2]to[C3+C2]).Impressively,the ground state chirality inherent to helical 1D LPs seamlessly transfers to helical 2D networkβ-ketoenamine *** study not only offers new perspectives on the development of chiral functional COFs,but also provides fresh insights into the precise control of COFs'microscopic morphology.

关键词： chiral covalent organic frameworks chiral transfer dimensional transformation helicity

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Novel PIKfyve/Tubulin Dual-target Inhibitor as a Promising Therapeutic Strategy for B-cell Acute Lymphoblastic Leukemia

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Current Medical Science 2024年第2期44卷 298-308页

作者： Zhen LU qia. LAI Zhi-feng LI Meng-ya ZHONg Yue-long JIANg Li-ying FENg Jie zha Jing-wei YAO Yin LI Xian-ming DENg Bing XU Department of Hematology The First Affiliated Hospital of Xiamen University and Institute of HematologySchool of MedicineXiamen UniversityXiamen361005China Key Laboratory of Xiamen for Diagnosis and Treatment of Hematological Malignancy Xiamen361005China Department of Oncology The First Affiliated Hospital of Jinan UniversityJinan UniversityGuangzhou510630China State Key Laboratory of Cellular Stress Biology Innovation Center for Cell Signaling NetworkSchool of Life SciencesXiamen UniversityXiamen361003China

Objective:In B-cell acute lymphoblastic leukemia(B-ALL),current intensive chemotherapies for adult patients fail to achieve durable responses in more than 50%of cases,underscoring the urgent need for new therapeutic regimens for this patient *** present study aimed to determine whether HZX-02-059,a novel dual-target inhibitor targeting both phosphatidylinositol-3-phosphate 5-kinase(PIKfyve)and tubulin,is lethal to B-ALL cells and is a potential therapeutic for B-ALL ***:Cell proliferation,vacuolization,apoptosis,cell cycle,and in-vivo tumor growth were *** addition,genome-wide RNA-sequencing studies were conducted to elucidate the mechanisms of action underlying the anti-leukemia activity of HZX-02-059 in ***:HZX-02-059 was found to inhibit cell proliferation,induce vacuolization,promote apoptosis,block the cell cycle,and reduce in-vivo tumor *** of the p53 pathway and suppression of the phosphoinositide 3-kinase(PI3K)/AKT pathway and the downstream transcription factors c-Myc and NF-κB were responsible for these ***:Overall,these findings suggest that HZX-02-059 is a promising agent for the treatment of B-ALL patients resistant to conventional therapies.

关键词： B-cell acute lymphoblastic leukemia dual-target inhibitor NF-kB c-Myc PI3K/AKT p53

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恒流充电有限柱体电极浓度分布及扩散诱导应力解析分析

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物理学报 2024年第15期73卷 225-234页

作者：彭颖吒张锴郑百林同济大学航空航天与力学学院上海200092

常见的柱状电极模型中,在轴向方向一般采用无限长假设广义平面应变分析方法,本文考虑恒流充电下有限柱形电极模型,基于力-化耦合一般方程,推导出位移与扩散诱导应力解析解.有限柱体电极中浓度分布由仅考虑径向扩散和仅考虑轴向扩散两部... 详细信息

常见的柱状电极模型中,在轴向方向一般采用无限长假设广义平面应变分析方法,本文考虑恒流充电下有限柱形电极模型,基于力-化耦合一般方程,推导出位移与扩散诱导应力解析解.有限柱体电极中浓度分布由仅考虑径向扩散和仅考虑轴向扩散两部分叠加求解.将浓度函数代入力学方程,使用Boussinesq-Papkovich函数得到应力分量解析解.计算了表面自由柱状电极中浓度和应力场,并将其结果与有限元软件计算的结果进行对比计算.结果表明,理论解和数值解中浓度分布一致,应力分量趋势一致数值相差较小,在荷电状态为17.9%时径向应力在中心处相对误差最大约为4%.本文分析了不同长径比柱状电极中径向和轴向单向扩散对应力场的影响,结果表明,随着长径比的增大,轴向扩散对浓度分布影响下降,径向扩散对应力场影响上升.

关键词：锂离子电池有限柱体电极扩散诱导应力 Boussinesq-Papkovich 函数

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Real-world effectiveness of early insulin therapy on the incidence of cardiovascular events in newly diagnosed type 2 diabetes

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Signal Transduction and Targeted Therapy 2024年第7期9卷 2953-2959页

作者： Sihui Luo Xueying Zheng Wei Bao Sheng Nie Yu Ding Tong Yue Yilun Zhou ying Hu Hua Li Qiongqiong Yang Qijun Wan Bicheng Liu Hong Xu guisen Li gang Xu Chunbo Chen Huafeng Liu Yongjun Shi Yan zha Yaozhong Kong guobin Su ying Tang Mengchun gong Linong Ji Fan Fan Hou Jianping Weng Department of Endocrinology First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHeifeiChina Institute of Public Health Sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiChina Division of Nephrology National Clinical Research Center for Kidney DiseaseState Key Laboratory of Organ Failure ResearchNanfang HospitalSouthern Medical UniversityGuangzhouChina Department of Nephrology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina The Second Affiliated Hospital of Zhejiang University School of Medicine HangzhouChina Sir Run Run Shaw Hospital Zhejiang University School of MedicineHangzhouChina Department of Nephrology Sun Yat-Sen Memorial HospitalSun Yat-Sen UniversityGuangzhouChina The Second People’s Hospital of Shenzhen Shenzhen UniversityShenzhenChina Institute of Nephrology Zhongda HospitalSoutheast University School of MedicineNanjingChina Children’s Hospital of Fudan University ShanghaiChina Renal Department and Institute of Nephrology Sichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaSichuan Clinical Research Center for Kidney DiseasesChengduChina Division of Nephrology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Department of Critical Care Medicine Maoming People’s HospitalMaomingChina Key Laboratory of Prevention and Management of Chronic Kidney Disease of zhanjiang City Institute of NephrologyAffiliated Hospital of Guangdong Medical UniversityZhanjiangChina Huizhou Central People’s Hospital Sun Yat-Sen UniversityHuizhouChina guizhou Provincial People’s Hospital Guizhou UniversityGuiyangChina Department of Nephrology the First People’s Hospital of FoshanFoshanChina Department of Nephrology Guangdong Provincial Hospital of Chinese Medicinethe Second Affiliated Hospitalthe Second Clinical CollegeGuangzhou University of Chinese Medicin

Early insulin therapy is capable to achieve glycemic control and restoreβ-cell function in newly diagnosed type 2 diabetes(T2D),but its effect on cardiovascular outcomes in these patients remains *** this nationwide real-world study,we analyzed electronic health record data from 19 medical centers across China between 1 January 2000,and 26 May *** included 5424 eligible patients(mean age 56 years,2176 women/3248 men)who were diagnosed T2D within six months and did not have prior cardiovascular *** Cox regression models were used to estimate the associations of early insulin therapy(defined as the first-line therapy for at least two weeks in newly diagnosed T2D patients)with the incidence of major cardiovascular events including coronary heart disease(CHD),stroke,and hospitalization for heart failure(HF).During 17,158 persons years of observation,we documented 834 incident CHD cases,719 stroke cases,and 230 hospitalized cases for *** diagnosed T2D patients who received early insulin therapy,compared with those who did not receive such treatment,had 31%lower risk of incident stroke,and 28%lower risk of hospitalization for *** significant difference in the risk of CHD was *** found similar results when repeating the aforesaid analysis in a propensity-score matched population of 4578 patients and with inverse probability of treatment weighting *** findings suggest that early insulin therapy in newly diagnosed T2D may have cardiovascular benefits by reducing the risk of incident stroke and hospitalization for HF.

关键词： cardiovascular treatment nationwide

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单纯前庭导水管扩大患儿人工耳蜗植入术后效果研究

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中华耳科学杂志 2024年第3期22卷 431-435页

作者：樊小勤林颖任寸寸查定军空军军医大学第一附属医院耳鼻咽喉头颈外科西安710032

目的探讨单纯前庭导水管扩大患儿在人工耳蜗(cochlear implant,CI)植入术后的听觉及言语能力效果,为术前咨询及术后效果预估提供参考依据。方法选取2017年8月至2021年4月空军军医大学第一附属医院耳鼻咽喉头颈外科收治的植入CI的59例... 详细信息

目的探讨单纯前庭导水管扩大患儿在人工耳蜗(cochlear implant,CI)植入术后的听觉及言语能力效果,为术前咨询及术后效果预估提供参考依据。方法选取2017年8月至2021年4月空军军医大学第一附属医院耳鼻咽喉头颈外科收治的植入CI的59例单纯大前庭导水管综合征(large veatibular aqueduct syndrome,LVAS)患儿为LVAS组,另选取CI植入时年龄、CI使用时长等临床资料相匹配的59例内耳结构正常的CI植入患儿为对照组。使用听觉行为分级标准(categories of auditory performance,CAP)、婴幼儿有意义听觉整合量表(infant-toddler meaningful auditory integration scale,IT-MAIS)或有意义听觉整合量表(meaningful auditory integration scale,MAIS)、言语可懂度分级标准(speech intelligibility rating,SIR)、有意义使用言语量表(meaningful use of speech scale,MUSS)对两组患儿进行CI植入术后的听觉及言语能力评估。结果 CI植入术后,LVAS组和对照组患儿CAP得分比较(4.06±1.42)分vs(3.66±1.34)分,IT-MAIS(或MAIS)得分比较(74.36±22.84)%vs(67.45±24.46)%,SIR得分比较(1.98±1.10)分vs(1.77±1.01)分,MUSS得分比较(28.55±23.70)%vs(23.26±20.97)%,差异均无统计学意义(P>0.05),但LVAS组患儿CAP和IT-MAIS(或MAIS)SIR和MUSS得分平均值均略高于内耳结构正常对照组患儿。结论单纯前庭导水管扩大患儿人工耳蜗植入术后听觉及言语效果与内耳结构正常的对照组患儿相似。

关键词：单纯前庭导水管扩大人工耳蜗听觉言语

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高通量测序分析褐飞虱circRNA表达谱及其潜在功能

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昆虫学报 2024年第3期67卷 431-442页

作者：于鑫滢赵哲奇闸雯俊湖北省农业科学院粮食作物研究所粮食作物种质创新与遗传改良湖北省重点实验室武汉430064 湖北洪山实验室武汉430070 武汉大学生命科学学院武汉430072 农业农村部作物分子育种重点实验室武汉430070

【目的】探究褐飞虱Nilaparvata lugens如何适应抗性水稻品种YHY15,并为研究环状RNA(circular RNA, circRNA)在褐飞虱对抗性水稻适应机制中的作用奠定基础。【方法】利用高通量测序技术鉴定生物型1和生物型Y(能致害抗性水稻YHY15的生物... 详细信息

【目的】探究褐飞虱Nilaparvata lugens如何适应抗性水稻品种YHY15,并为研究环状RNA(circular RNA, circRNA)在褐飞虱对抗性水稻适应机制中的作用奠定基础。【方法】利用高通量测序技术鉴定生物型1和生物型Y(能致害抗性水稻YHY15的生物型)褐飞虱的circRNA,并统计其类型和分布。分析生物型1和生物型Y褐飞虱间circRNA表达差异,并对circRNA来源基因进行gO功能注释和KEgg富集分析。【结果】生物型1和生物型Y褐飞虱共鉴定到19个circRNA,分布在9条染色体上,其中17个circRNA由剪接位点之间的外显子构成,2个circRNA由剪接位点之间的所有碱基构成,17个circRNA长度在200~800 bp。生物型Y褐飞虱的circRNA表达丰度与表达量比生物型1褐飞虱的更高。分析结果表明,在生物型1褐飞虱克服抗性水稻YHY15形成新的生物型Y的过程中,在自然选择压力下,circRNA的表达出现变化,推测这种变化影响了褐飞虱新生物型的形成。KEgg分析结果表明,鉴定到的生物型1和生物型Y褐飞虱circRNA来源基因主要富集到自噬相关通路上。【结论】褐飞虱长期取食抗性水稻,导致褐飞虱消化、解毒和代谢能力进化,能降解抗性水稻为抵御褐飞虱而产生的次生代谢物。鉴定到的生物型1和生物型Y褐飞虱的circRNA来源基因与细胞自噬相关,表明褐飞虱通过细胞自噬过程应答抗虫水稻,这种应答反应促进褐飞虱适应抗虫水稻,致害性增强和生物型形成。

关键词：褐飞虱 circRNA 细胞自噬抗虫水稻高通量测序

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一种构建参数化量子线路的区块环拓扑结构

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电子学报 2024年第8期52卷 2726-2736页

作者：刘文杰吴青山查颖王海彬南京信息工程大学软件学院江苏南京210044 南京信息工程大学江苏省大气环境与装备技术协同创新中心江苏南京210044 数字取证教育部工程研究中心江苏南京210044

在变分量子算法中,参数化量子线路拓扑结构的选择对算法性能具有重要意义.目前已有的拓扑结构存在一些问题,如全连接拓扑结构所需量子门数量较多,环型拓扑结构的表达能力与纠缠能力略有欠缺.为了解决以上问题,本文提出了一种新型的区块... 详细信息

在变分量子算法中,参数化量子线路拓扑结构的选择对算法性能具有重要意义.目前已有的拓扑结构存在一些问题,如全连接拓扑结构所需量子门数量较多,环型拓扑结构的表达能力与纠缠能力略有欠缺.为了解决以上问题,本文提出了一种新型的区块环(Block-Ring,BR)拓扑结构,在保障良好性能的同时减少参数规模(即量子门数量),降低线路复杂度.在BR拓扑中,n个量子比特被等分为多个区块,每个区块包含m个量子比特,区块内部所有量子比特两两连接,区块之间采用环型结构进行连接.为了构造BR拓扑结构的参数化量子线路,设计了一种多层线路生成算法,可自动生成由单量子比特门Rx、Rz和双量子比特门CRx或CRz构成的量子线路.IBM Q模拟实验表明,相较于环型拓扑结构,无论单层、双层以及三层BR拓扑结构的表达能力和纠缠能力均有不同程度的提升;相较于拥有最高表达能力与纠缠能力的全连接拓扑结构,BR拓扑结构呈现接近的性能指标,且线路复杂度显著降低,即参数数量与双量子比特门数量均从O(n^(2))降低为O(mn),线路深度从O(n^(2))降低为O(n/m+m^(2)).

关键词：参数化量子线路线路拓扑结构区块环拓扑表达能力纠缠能力线路复杂度

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几种主要水化学因素对典型重金属水生生物毒性的影响分析

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中国环境科学 2024年第7期44卷 4071-4083页

作者：王昕噶玛扎西石文卿程英豪许子寒郭伟王颖北京航空航天大学材料科学与工程学院北京100191 北京航空航天大学空间与环境学院北京100191 生态环境部核与辐射安全中心北京100082 北京师范大学水科学研究院北京100875 中国环境科学研究院环境基准与风险评估国家重点实验室北京100012 北京市水文总站北京100089

为阐明不同水化学条件对水体中重金属生物毒性的影响,本研究探究了pH值、硬度、温度和有机碳(OC)四个主要水化学因素对4种典型重金属引起不同类别水生生物急、慢性毒性的影响.结果表明,单一水化学因素对不同金属的水生生物毒性影响存在... 详细信息

为阐明不同水化学条件对水体中重金属生物毒性的影响,本研究探究了pH值、硬度、温度和有机碳(OC)四个主要水化学因素对4种典型重金属引起不同类别水生生物急、慢性毒性的影响.结果表明,单一水化学因素对不同金属的水生生物毒性影响存在较大差异;硬度和OC的升高会使得鱼类的水生生物毒性降低;温度的升高则会增加鱼类、昆虫的水生生物毒性.对不同类别的生物,单一水化学因素的毒性影响不同.考虑综合水化学因素的影响时,水生生物急性毒性和慢性毒性受到的影响效果显著不同;综合因素中OC可能是影响毒性的重要因子.

关键词：重金属水生生物水化学因素毒性影响

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高校图书馆员数据素养培育实践及启示——基于国外案例调查

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图书情报工作 2024年第7期68卷 46-56页

作者：罗靖琳刘倩秀查颖钟庆虹深圳大学图书馆深圳518061

[目的/意义]数据素养是高校图书馆员当前应必备的专业核心能力,国内外都在持续探索适合的馆员数据素养培育路径。我国在此方面尚处于起步阶段,调查和研究国外开展的高校图书馆员数据素养培育实践案例,归纳经验启示,有利于为我国馆员数... 详细信息

[目的/意义]数据素养是高校图书馆员当前应必备的专业核心能力,国内外都在持续探索适合的馆员数据素养培育路径。我国在此方面尚处于起步阶段,调查和研究国外开展的高校图书馆员数据素养培育实践案例,归纳经验启示,有利于为我国馆员数据素养培育提供借鉴,提升培育质量。[方法/过程]选取国外12个馆员数据素养培育案例,结合3P教育模型和传播学5W理论,从培育前提、过程、结果三个方面进行分析研究并总结启示。[结果/结论]构建普适性的馆员数据素养培育模型,基于此提出思考,从培育主体、对象、内容、方式、结果等方面提出具体建议。

关键词：数据素养高校图书馆员培育模型

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