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Kinesin family member 14 expression and its clinical implications in colorectal cancer

World Journal of Gastrointestinal Oncology 2025年第3期17卷 299-321页

作者： Kai Qin Jia-Yuan Luo Da-Tong Zeng Wan-ying Huang Bin Li Qi Li Yan-Ting Zhan Rong-Quan He Wei-Jian Huang Gang Chen zu-Yuan Chen Bang-Teng Chi Yu-Xing Tang Rui-Xue Tang Hui Li Department of Pathology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Pathology Redcross Hospital of Yulin CityYulin 537000Guangxi Zhuang Autonomous RegionChina Department of Medical Oncology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Pathology The First Affiliated Hospital of Shandong First Medical University&Shandong Provincial Qianfoshan HospitalJinan 250000Shandong ProvinceChina Department of Colorectal and Anal Surgery The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina

BACKGROUND Colorectal cancer(CRC)is the third most common cancer globally,causing over 900000 deaths *** factors include aging,diet,obesity,sedentary lifestyle,tobacco use,genetic predisposition,and inflammatory bowel *** current treatments,survival rates for advanced CRC remain low,highlighting the need for better therapeutic *** To evaluate both the clinical significance and the pathological implications of the Kinesin family member 14(KIF14)expression within CRC ***,this study aims to investigate the interaction between nitidine chloride(NC)and KIF14,considering their potential as therapeutic *** The expression of the KIF14 protein in CRC was analyzed using immunohistochemical *** integration of multicenter high-throughput data facilitated the calculation of the standardized mean difference(SMD)for KIF14 mRNA *** assessment of clinical and pathological impact was enhanced by analyzing combined receiver operating characteristic curves,along with measures of sensitivity,specificity,and likelihood ***,clustered regularly interspaced short palindromic repeats knockout screening for cell growth and single-cell sequencing were employed to validate the significance of KIF14 expression in *** analysis established the prognostic value of KIF14 in *** molecular mechanism of NC against CRC was elucidated through whole-genome sequencing and enrichment analysis,and molecular docking was utilized to explore the targeting affinity between NC and *** KIF14 was highly expressed in 208 CRC *** from 17 platforms involving 2436 CRC samples and 1320 noncancerous colorectal tissue controls indicated that KIF14 expression was significantly higher in CRC samples,with an SMD of 1.92(95%CI:1.49-2.35).The area under the curve was 0.94(95%CI:0.92-0.96),with a sensitivity of 0.85(95%CI:0.78-0.90)and a specificity of 0.90(95%CI:0.85-0.93).The positive and negative l

关键词： Colorectal cancer Kinesin family member 14 Nitidine chloride Molecular docking Standardized mean difference

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已公开个人信息在合理范围内处理的规范逻辑与实践因应

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行政法学研究 2025年第1期 146-159页

作者：赵祖斌中南财经政法大学刑事司法学院

我国对于已公开个人信息处理作了特别规定,由“已公开”“在合理范围内处理”“对个人权益有重大影响”“个人明确拒绝”等规范构成要件因素组成了特殊规则体系,“在合理范围内处理”被置于规范体系中较为突出的位置,通过平衡已公开个... 详细信息

我国对于已公开个人信息处理作了特别规定,由“已公开”“在合理范围内处理”“对个人权益有重大影响”“个人明确拒绝”等规范构成要件因素组成了特殊规则体系,“在合理范围内处理”被置于规范体系中较为突出的位置,通过平衡已公开个人信息附着利益、补充知情同意规则和具化“信赖”理念发挥着价值导向和规范指引功能。作为权义复合性法律规则,其与“合理使用”不同,具有阻却违法、设定义务、赋予权利等多重面向。当个人信息处理“在合理范围内”,符合其他规范构成要件因素便获得了合法性基础,信息处理者免于承担民事责任和刑事责任。因此,“在合理范围内处理”的判定尤为重要,立法却未对此作出明确规定,而其与必要等个人信息处理原则联系密切,天然地契合比例原则的要义,故可引入比例原则作为评判分析工具。为了保障已公开个人信息处理在合理范围内,需在建立数字信任的基础上强化已公开个人信息处理过程中的权利保障和义务履行。

关键词：已公开个人信息合理处理利益衡量比例原则

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抗战时期中国共产党人民族复兴话语的四种形态

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河北学刊 2025年第2期45卷 1-12页

作者：俞祖华浙江工商大学人文与传播学院中国化时代化马克思主义研究院

抗战时期,中国共产党人多元一体的复合型中华民族观定型,并阐释了民族解放、民族复兴思想。抗战时期中国共产党人的民族复兴话语可分为四种形态:政治话语方面,中国共产党建构了以多元一体的中华民族为叙事主体、以抗日救亡的民族解放为... 详细信息

抗战时期,中国共产党人多元一体的复合型中华民族观定型,并阐释了民族解放、民族复兴思想。抗战时期中国共产党人的民族复兴话语可分为四种形态:政治话语方面,中国共产党建构了以多元一体的中华民族为叙事主体、以抗日救亡的民族解放为核心术语、以反帝反封建为走向复兴的政治前提、以新民主主义的新中国为奋斗目标、以中共为实现民族解放之中流砥柱的中华民族复兴政治话语体系;媒介话语方面,各报刊作为思想观念的重要载体与传播介质,促进了“中华民族”“民族复兴”观念从政治语境引入大众传播,从而有力推动着各族人民国家认同、民族认同的建构;学术话语方面,理论工作者立足中华民族长远历史,着眼中华民族救亡大业,把马克思主义民族理论同中国具体实际、同中华优秀传统文化相结合,从史料体系、话语体系、理论体系等方面,为书写交融汇聚的中华民族发展史、为阐释多元一体的中华民族观念、为倡导救亡图强的民族解放思想,提供了坚实的学理支撑;艺术话语方面,包括诗文、电影、话剧、歌曲、绘画、书法等在内的文艺作品,在传播“中华民族”“民族复兴”话语、强化中华民族认同中发挥了不可替代的作用。

关键词：抗战时期中国共产党人中华民族民族复兴话语

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Precision storage lifetime measurements of highly charged heavy ions in the CSRe storage ring using a Schottky resonator

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Nuclear Science and Techniques 2025年第1期36卷 150-160页

作者： Qian Wang Xin-Liang Yan Guang-Yu Zhu Shahab Sanjari Li-Jun Mao He Zhao Yuri ALitvinov Rui-Jiu Chen Meng Wang Yu-Hu Zhang You-Jin Yuan Jun-Xia Wu Hong-Yang Jiao Yue Yu zu-Yi Chen Yin-Fang Luo Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China University of Chinese Academy of Sciences Beijing 100049China GSI Helmholtzzentrum für Schwerionenforschung Planckstrasse 164291 DarmstadtGermany FH Aachen University of Applied Sciences Heinrich-Mussmann-Str.152428 JülichGermany

Schottky mass spectrometry utilizing heavy-ion storage rings is a powerful technique for the precise mass and decay half-life measurements of highly charged *** to the nondestructive ion detection features of Schottky noise detectors,the number of stored ions in the ring is determined by the peak area in the measured revolution frequency *** of their intrinsic amplitude-frequency characteristic(AFC),Schottky detector systems exhibit varying sensitivities at different *** low-energy electron-cooled stored ions,a new method is developed to calibrate the AFC curve of the Schottky detector system of the Experimental Cooler Storage Ring(CSRe)storage ring located in Lanzhou,*** the amplitude-calibrated frequency spectrum,a notable refinement was observed in the precision of both the peak position and peak *** a result,the storage lifetimes of the electron-cooled fully ionized^(56)Fe^(26+)ions were determined with high precision at beam energies of 13.7 and 116.4 MeV/u,despite of frequency drifts during the *** electron cooling was turned off,the effective vacuum condition experienced by the 116.4 MeV/u^(56)Fe^(26+)ions was determined using amplitude-calibrated spectra,revealing a value of 2×10^(−10)mbar,which is consistent with vacuum gauge readings along the CSRe *** method reported herein will be adapted for the next-generation storage ring of the HIAF facility under construction in Huizhou,*** can also be adapted to other storage ring facilities worldwide to improve precision and enhance lifetime measurements using many ions in the ring.

关键词： Lifetime measurement Schottky mass spectrometry Sensitivity response Highly charged heavy ion Resonator UH vacuum Nondestructive diagnostics

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“地点”的湮灭:克里斯蒂安·佩措尔德导演的过渡空间及其隐喻

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当代电影 2025年第1期 69-77页

作者：路春艳祖岳北京师范大学艺术与传媒学院

克里斯蒂安·佩措尔德是当代德国影坛最重要的导演之一,他的作品观照社会现实,惯常表现面临诸多生存困境、漂泊于德国街头的边缘个体。在他的影像中,传统意义上的“地点”常常缺席,取而代之的是一个个充当过渡空间之用的“非地点”。这... 详细信息

克里斯蒂安·佩措尔德是当代德国影坛最重要的导演之一,他的作品观照社会现实,惯常表现面临诸多生存困境、漂泊于德国街头的边缘个体。在他的影像中,传统意义上的“地点”常常缺席,取而代之的是一个个充当过渡空间之用的“非地点”。这些“非地点”作为叙事空间具有丰富的意涵:一方面,佩措尔德导演通过它们回望德国战时对“地点”的湮灭;另一方面,战后德国的重建与现代化进程的加速导致大量“非地点”的涌现,这些空间隐喻了影片角色不稳定的生存处境及心理状态。随着现实语境的变化,佩措尔德导演近年来也通过“非地点”的影像呈现表达出对全球紧迫议题的关注。栖身“非地点”中的人们怀有对救赎的渴望,佩措尔德导演的一些作品表现出在“非地点”上进行重建的可能,带来了富有深意的人文关怀与视听想象。

关键词：克里斯蒂安·佩措尔德过渡空间 “非地点” “地点”

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FINITE ELEMENT NUMERICAL SIMULATION OF THREE-DIMENSIONAL SEEPAGE CONTROL FOR DEEP FOUNDATION PIT DEWATERING

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Journal of Hydrodynamics 2008年第5期20卷 596-602页

作者： LUO zu-jiang ZHANG ying-ying WU Yong-xia College of Civil Engineering Hohai University Nanjing 210098 China

For deep foundation pit dewatering in the Yangtze River Delta, it is easy to make a dramatic decrease of the underground water level surrounding the dewatering area and cause land subsidence and geologic disasters. In this work, a three-dimensional finite element simulation method was applied in the forth subway of Dongjiadu tunnel repair foundation pit dewatering in Shanghai. In order to control the decrease of the underground water level around the foundation pit, the foundation pit dewatering method was used to design the optimization project of dewatering ,which was simulated under these conditions that the aquifers deposited layer by layer, the bottom of the aquifers went deep to 144.45 m, the retaining wall of foundation pit shield went deep to 65 m, the filters of the extraction wells were located between 44 m to 59 m, the water level in the deep foundation pit was decreased by 34 m, and the maximum decrease of water level outside the foundation pit was 3 m. It is shown that the optimization project and the practical case are consistent with each other. Accordingly, the three-dimensional finite element numerical simulation is the basic theory of optimization design of engineering structures of dewatering in deep foundation pit in such areas.

关键词： Yangtze River Delta land subsidence deep foundation pit dewatering seepage control

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Uniqueness and Least Energy Property for Solutions to a Strongly Coupled Elliptic System

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Acta Mathematica Sinica,English Series 2017年第3期33卷 419-438页

作者： Shan ZHANG ling ZHOU zu Han LIU Department of Applied Mathematics Nanjing University of Finance & Economics Nanjing 210003 P. R. China School of Mathematical Science Yangzhou University Yangzhou 225002 P. R. China

For the strongly coupled system of M ≥ 3 competing species：-△[（di＋∑j=1^Mβijuj）ui]=（ai-bi）ui-kui∑j≠iui,i=1,…,M,we prove the uniqueness of the limiting configuration as k →∞ under suitable conditions. Moreover, we prove that the limiting configuration minimizes a variational problem associated to the strongly coupled system among the segregated states with the same boundary conditions.

关键词： Strongly coupled elliptic system uniqueness spatial segregation

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Effects of Time-Delay on Intracellular Ca^(2+) Concentration Oscillations

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Chinese Physics Letters 2001年第5期18卷 695-697页

作者： ying Yang-Jun HUANG zu-Qia Institute of Low Energy Nuclear Physics Beijing Normal UniversityBeijing 100875 Institute of Applied Physics and Computational Mathematics P.O.Box 8009Beijing 100088

Based on SS-model[Somogyi R and Stucki J W ***.266(1991)11068]for the generation of intracellular Ca^(2+)concentration oscillations,we consider a time-delay for the binding kinetics of the Ca^(2+)channel and find a significant phenomenon that the oscillation takes two quite different modes when a parameter of the system across a *** is a quick oscillation mode and the other is a slow oscillation *** are different from each other on oscillation frequencies for more than ten *** change of oscillation form with parameters and its critical behaviour are illustrated by numerical simulation results.

关键词： oscillation kinetics behaviour

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中外合作办学背景下高校图书馆国际化与本土化探索——以上海纽约大学图书馆为例

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大学图书馆学报 2025年第1期43卷 31-37页

作者：祖晓静黄煜上海纽约大学图书馆上海200124

在高等教育国际化进程下,国际教育项目和中外合作办学蓬勃发展。文章采用案例分析的方法,深入研究上海纽约大学图书馆在馆藏建设、人员配置和服务模式等方面的具体做法。通过对图书馆在不同发展阶段的策略选择和实施效果进行分析,总结... 详细信息

在高等教育国际化进程下,国际教育项目和中外合作办学蓬勃发展。文章采用案例分析的方法,深入研究上海纽约大学图书馆在馆藏建设、人员配置和服务模式等方面的具体做法。通过对图书馆在不同发展阶段的策略选择和实施效果进行分析,总结其在国际化与本土化融合方面的经验。研究表明,中外合作办学背景下的高校图书馆,应在充分利用国际资源的同时,注重本土化需求的满足。在构建多元文化团队,创新服务模式,以及灵活运用数字化工具等方面,在国际化与本土化之间找到平衡,从而更好地支持学校的教学和科研工作。

关键词：大学图书馆国际化本土化中外合作办学

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A Compensation Model of Continuous Temperature Measurement for Molten Steel in Tundish

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Journal of Iron and Steel Research International 2012年第7期19卷 6-11页

作者： zu ling-yu MENG Hong-ji XIE Zhi College of Information Science and Engineering Northeastern UniversityShenyang 110819LiaoningChina

A compensation model has been proposed to reduce errors caused by the immersion depth of the sensor and the time lag of continuous temperature measurement for molten steel in tundish, which is based on the limited data fitting method and data fusion technology. According to the heat *** of sensor, the thermal model has been bulit to determine the temperature variation function. The parameters of the compensation model are recognized by generic algorithm, which combines the determine function, the molten steel mass in the ladle and pouring time. The processing of error compensation is divided into three stages： tracking, holding and compensation. When the processing is stable, the measured temperature error is small, and the measured temperature is regarded as accurate val- ue and tracked. For the end of pouring stage of the ladle, the temperature error is caused by the immersion depth of the sensor, and the measured temperature before sharp decreasing is considered as real temperature and held. For the temperature increasing stage after ladle changed, the measured temperature is compensated online. The application results show that the error between the compensation temperatures and the actual ones have been decreased to ±2 ℃, and the time lag could be shortened from 3-5 min to 40 s by applying this model.

关键词： compensation temperature time lag genetic algorithm error

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