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Chinese Medical Journal 2019年第7期132卷 860-864页

作者： Bing-Lei Zhang Jian Zhou Tian-Xi Lyu Rui-Rui Gui ying-ling zu Feng-Kuan Yu Hui-Fang Zhao Zhen Li Juan Wang Yan-Li Zhang Wen-Lin Zhang Yue-Wen Fu Xu-Dong Wei Bai-Jun Fang Yu-Fu Li Ke-Shu Zhou Yong-Ping Song Department of Hematology Tumor Hospital Affiliated to Zhengzhou UniversityHenan Cancer HospitalZhengzhouHenan 450003China

To the Editor:Leukemia is a malignant proliferative disease that has become the most common malignancy in children,accounting for 40.5%of malignant cancers children.[1]Although chemotherapy can effectively treat children,some patients with high-risk and relapsed acute lymphoblastic leukemia(ALL)and acute myelocytic leukemia(AML)failed to achieve long-term *** these patients,allogeneic hematopoietic stem cell transplantation(allo-HSCT)is the best ***,many factors may impact the efficacy of *** retrospectively analyzed the clinical data of 71 children with leukemia treated using allo-HSCT to observe the clinical efficacy and analyze the possible influencing factors.

关键词： allogeneic hematopoietic stem cell transplantation leukemia malignant cancers children

谱系1和8重组猪繁殖与呼吸综合征病毒的分离鉴定与遗传进化分析

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动物医学进展 2025年第1期46卷 29-37页

作者：邹舟黎颖韦莹莹刘惠僮韦祖樟广西大学动物科学技术学院动物传染病与分子免疫学实验室广西南宁530005 广西壮族自治区兽用生物制品工程研究中心广西南宁530005 广西畜禽繁育与疾病防控重点实验室广西南宁530004

2023年从广西疑似发生猪繁殖与呼吸综合征病毒(PRRSV)感染猪场的病猪肺脏组织中分离到1株PRRSV,将其命名为GXWZ20230831。采用RT-PCR扩增其全基因组序列并测序,分析遗传进化特点。结果显示,GXWZ20230831能够在Marc-145细胞上增殖,且产... 详细信息

2023年从广西疑似发生猪繁殖与呼吸综合征病毒(PRRSV)感染猪场的病猪肺脏组织中分离到1株PRRSV,将其命名为GXWZ20230831。采用RT-PCR扩增其全基因组序列并测序,分析遗传进化特点。结果显示,GXWZ20230831能够在Marc-145细胞上增殖,且产生明显的细胞病变;该毒株全基因组长度为15019个核苷酸(nt),与基因2型PRRSV谱系1 NADC30-like毒株的同源性最高,为94.0%,与基因1型PRRSV代表毒株Lelystad virus同源性最低,仅为60.0%;通过Nsp2氨基酸序列比对,结果发现GXWZ20230831存在NADC30-like典型的131(111+1+19)个氨基酸的不连续缺失模式;与美洲型代表株VR2332相比,GXWZ20230831的GP5蛋白在非中和抗原表位发生了V27A、V185A以及R191K 3处突变,同时在GP5蛋白中存在4个潜在的N-糖基化位点;构建的全基因组序列、nsp2基因、ORF5基因遗传进化树均显示该毒株处于谱系1的分支;重组分析表明,GXWZ20230831是1株以谱系1经典毒株NADC30为骨架,谱系8毒株提供重组片段的重组毒株,重组断点位于基因组的nsp1(458-1821 nt)和Nsp4(5405-8179 nt)中。研究结果可为掌握广西地区的PRRSV遗传变异规律提供参考,为制定防控措施提供科学依据。

关键词：猪繁殖与呼吸综合征病毒分离鉴定重组遗传进化分析

The compound(E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one alleviates neuroinflammation and cognitive impairment in a mouse model of Alzheimer's disease

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Neural Regeneration Research 2025年第11期20卷 3330-3344页

作者： Xueyan Liu Wei Wu Xuejuan Li Chengyan Wang Ke Chai Fanru Yuan Huijuan Zheng Yuxing Yao Chenlu Li zu-Cheng Ye Daijun Zha Department of Medicinal Chemistry School of PharmacyFujian Medical UniversityFuzhouFujian ProvinceChina Fujian Provincial Key Laboratory of Brain Aging and Neurodegenerative Diseases School of Basic Medical SciencesFujian Medical UniversityFuzhouFujian ProvinceChina Institute of Laboratory Animal Center Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Neurosurgery Neurosurgery Research InstituteThe First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvinceChina Department of Hyperbaric Oxygen National Regional Medical CenterBinhai Campus of the First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvinceChina

Previous studies have shown that the compound(E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one(D30),a pyromeconic acid derivative,possesses antioxidant and anti-inflammatory properties,inhibits amyloid-β aggregation,and alleviates scopolamine-induced cognitive impairment,similar to the phase Ⅲ clinical drug *** this study,we established a mouse model of Alzheimer's disease via intracerebroventricular injection of fibrillar amyloid-β to investigate the effect of D30 on fibrillar amyloid-β-induced *** results showed that D30 alleviated fibrillar amyloid-β-induced cognitive impairment,promoted fibrillar amyloid-β clearance from the hippocampus and cortex,suppressed oxidative stress,and inhibited activation of microglia and astrocytes.D30 also reversed the fibrillar amyloid-β-induced loss of dendritic spines and synaptic protein ***,we demonstrated that exogenous fibrillar amyloid-βintroduced by intracerebroventricular injection greatly increased galectin-3 expression levels in the brain,and this increase was blocked by *** the role of D30 in clearing amyloid-β,inhibiting neuroinflammation,protecting synapses,and improving cognition,this study highlights the potential of galectin-3 as a promising treatment target for patients with Alzheimer's disease.

关键词： Alzheimer's disease amyloid-β astrocyte cognitive impairment D30 dendritic spines galectin-3 microglia neuroinflammation neuron

FINITE ELEMENT NUMERICAL SIMULATION OF THREE-DIMENSIONAL SEEPAGE CONTROL FOR DEEP FOUNDATION PIT DEWATERING

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Journal of Hydrodynamics 2008年第5期20卷 596-602页

作者： LUO zu-jiang ZHANG ying-ying WU Yong-xia College of Civil Engineering Hohai University Nanjing 210098 China

For deep foundation pit dewatering in the Yangtze River Delta, it is easy to make a dramatic decrease of the underground water level surrounding the dewatering area and cause land subsidence and geologic disasters. In this work, a three-dimensional finite element simulation method was applied in the forth subway of Dongjiadu tunnel repair foundation pit dewatering in Shanghai. In order to control the decrease of the underground water level around the foundation pit, the foundation pit dewatering method was used to design the optimization project of dewatering ,which was simulated under these conditions that the aquifers deposited layer by layer, the bottom of the aquifers went deep to 144.45 m, the retaining wall of foundation pit shield went deep to 65 m, the filters of the extraction wells were located between 44 m to 59 m, the water level in the deep foundation pit was decreased by 34 m, and the maximum decrease of water level outside the foundation pit was 3 m. It is shown that the optimization project and the practical case are consistent with each other. Accordingly, the three-dimensional finite element numerical simulation is the basic theory of optimization design of engineering structures of dewatering in deep foundation pit in such areas.

关键词： Yangtze River Delta land subsidence deep foundation pit dewatering seepage control

Uniqueness and Least Energy Property for Solutions to a Strongly Coupled Elliptic System

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Acta Mathematica Sinica,English Series 2017年第3期33卷 419-438页

作者： Shan ZHANG ling ZHOU zu Han LIU Department of Applied Mathematics Nanjing University of Finance & Economics Nanjing 210003 P. R. China School of Mathematical Science Yangzhou University Yangzhou 225002 P. R. China

For the strongly coupled system of M ≥ 3 competing species：-△[（di＋∑j=1^Mβijuj）ui]=（ai-bi）ui-kui∑j≠iui,i=1,…,M,we prove the uniqueness of the limiting configuration as k →∞ under suitable conditions. Moreover, we prove that the limiting configuration minimizes a variational problem associated to the strongly coupled system among the segregated states with the same boundary conditions.

关键词： Strongly coupled elliptic system uniqueness spatial segregation

Effects of Time-Delay on Intracellular Ca^(2+) Concentration Oscillations

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Chinese Physics Letters 2001年第5期18卷 695-697页

作者： ying Yang-Jun HUANG zu-Qia Institute of Low Energy Nuclear Physics Beijing Normal UniversityBeijing 100875 Institute of Applied Physics and Computational Mathematics P.O.Box 8009Beijing 100088

Based on SS-model[Somogyi R and Stucki J W ***.266(1991)11068]for the generation of intracellular Ca^(2+)concentration oscillations,we consider a time-delay for the binding kinetics of the Ca^(2+)channel and find a significant phenomenon that the oscillation takes two quite different modes when a parameter of the system across a *** is a quick oscillation mode and the other is a slow oscillation *** are different from each other on oscillation frequencies for more than ten *** change of oscillation form with parameters and its critical behaviour are illustrated by numerical simulation results.

关键词： oscillation kinetics behaviour

A Compensation Model of Continuous Temperature Measurement for Molten Steel in Tundish

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Journal of Iron and Steel Research International 2012年第7期19卷 6-11页

作者： zu ling-yu MENG Hong-ji XIE Zhi College of Information Science and Engineering Northeastern UniversityShenyang 110819LiaoningChina

A compensation model has been proposed to reduce errors caused by the immersion depth of the sensor and the time lag of continuous temperature measurement for molten steel in tundish, which is based on the limited data fitting method and data fusion technology. According to the heat *** of sensor, the thermal model has been bulit to determine the temperature variation function. The parameters of the compensation model are recognized by generic algorithm, which combines the determine function, the molten steel mass in the ladle and pouring time. The processing of error compensation is divided into three stages： tracking, holding and compensation. When the processing is stable, the measured temperature error is small, and the measured temperature is regarded as accurate val- ue and tracked. For the end of pouring stage of the ladle, the temperature error is caused by the immersion depth of the sensor, and the measured temperature before sharp decreasing is considered as real temperature and held. For the temperature increasing stage after ladle changed, the measured temperature is compensated online. The application results show that the error between the compensation temperatures and the actual ones have been decreased to ±2 ℃, and the time lag could be shortened from 3-5 min to 40 s by applying this model.

关键词： compensation temperature time lag genetic algorithm error

Optimization of time-delayed feedback control of seismically excited building structures

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2008年第3期9卷 330-337页

作者： Xue-ping LI Wei-qiu ZHU zu-guang ying Department of Mechanics School of Aeronautics and Astronautics State Key Laboratory of Fluid Power Transmission and Control Zhejiang University Hangzhou 310027 China

An optimization method for time-delayed feedback control of partially observable linear building structures subjected to seismic excitation is proposed. A time-delayed control problem of partially observable linear building structure under horizontal ground acceleration excitation is formulated and converted into that of completely observable linear structure by using separation principle. The time-delayed control forces are approximately expressed in terms of control forces without time delay. The control system is then governed by Itoe stochastic differential equations for the conditional means of system states and then transformed into those for the conditional means of modal energies by using the stochastic averaging method for quasi-Hamiltonian systems. The control law is assumed to be modal velocity feedback control with time delay and the unknown control gains are determined by the modal performance indices. A three-storey building structure is taken as example to illustrate the proposal method and the numerical results are confirmed by using Monte Carlo simulation.

关键词： Time-delayed feedback control Stochastic averaging method Hamiltonian Earthquake

A Unified Algebraic Dynamical Solution to General Two-Photon Algebra Systems

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Chinese Physics Letters 1999年第12期16卷 861-863页

作者： ying zu-jian WANG Shun-jin Department of Modern Physics Lanzhou UniversityLanzhou 730000 Institute of Modern Physics Southwest Jiaotong UniversityChengdu 610031

We use squeezing and displacement operators and apply algebraic dynamics to develop a unified solution of general time-dependent two-photon algebra systems. A set of orthogonal-and-normalized solutions are derived wit... 详细信息

关键词： state operators algebra

Multiparty Quantum Secret Sharing Using Quantum Fourier Transform

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Communications in Theoretical Physics 2009年第2期51卷 221-226页

作者： HUANG Da-zu CHEN Zhi-Gang GUO ying School of Information Science Engineering Central South University Changsha 410083 China Department of Information Management Hunan College of Finance and Economics Changsha 410205 China

A （n, n）-threshold scheme of multiparty quantum secret sharing of classical or quantum message is proposed based on the discrete quantum Fourier transform. In our proposed scheme, the secret message, which is encoded by using the forward quantum Fourier transform and decoded by using the reverse, is split and shared in such a way that it can be reconstructed among them only if all the participants work in concert. Fhrthermore, we also discuss how this protocol must be carefully designed for correcting errors and checking eavesdropping or a dishonest participant. Security analysis shows that our scheme is secure. Also, this scheme has an advantage that it is completely compatible with quantum computation and easier to realize in the distributed quantum secure computation.

关键词： quantum secret sharing quantum Fourier transform quantum error correction code