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Synthesis,Self-assembly and Electrode Application of Mussel-inspired Alternating Copolymers

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Chinese Journal of Polymer Science 2018年第8期36卷 897-897,898-904页

作者： ying-lin zhang Chuan-Long Li Tahir Rasheed Ping Huang Yong-Feng Zhou School of Chemistry and Chemical Engineering Shanghai Key Laboratory of Electrical Insulation and Thermal AgeingShanghai Jiao Tong University State Key Laboratory of Metal Matrix Composites Shanghai Jiao Tong University

We reported the first mussel-inspired alternating copolymer with a high amount of catechol groups （50% molar ratio） through a facile epoxy-amino click reaction between 9,9-bis（4-（2-glycidyloxyethyl）phenyl fluorene （BGEPF） and dopamine （DA）. The obtained copolymers were used to prepare carbon/nitrogen-doped α-Fe2O3 nanoparticles through self-assembly, coordination and calcination, which displayed excellent electrochemical performance as anode materials for Li-ion batteries.

关键词： Alternating copolymer Catechol groups Self-assembly Li-ion batteries

Dynamic Properties of Two-Dimensional Polydisperse Granular Gases

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Communications in Theoretical Physics 2007年第2X期48卷 343-347页

作者： LI Rui zhang Duan-Ming HUANG Ming-Tao SU Xiang-ying CHEN Zhi-Yuan ZHU Hong-ying zhang lin Department of Physics Huazhong University of Science and Technology Wuhan 430074 China

We propose a two-dimensional model of polydisperse granular mixtures with a power-law size distribution in the presence of stochastic driving. A fractal dimension D is introduced as a measurement of the inhomogeneity of the size distribution of particles. We define the global and partial granular temperatures of the multi-component mixture. By direct simulation Monte Carlo, we investigate how the inhomogeneity of the size distribution influences the dynamic properties of the mixture, focusing on the granular temperature, dissipated energy, velocity distribution, spatial clusterization, and collision time. We get the following results： a single granular temperature does not characterize a multi-component mixture and each species attains its own ＂granular temperature＂; The velocity deviation from Gaussian distribution becomes more and more pronounced and the partial density of the assembly is more inhomogeneous with the increasing value of the fractal dimension D; The global granular temperature decreases and average dissipated energy per particle increases as the value olD augments.

关键词： fractal fractal dimension polydisperse mixture

A 12-year cohort study on the efficacy of plasmaderived hepatitis B vaccine in rural newborns

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World Journal of Gastroenterology 2000年第3期6卷 381-383页

作者： Hong Bin Liu Zong Da Meng Jing Chen Ma Chang Quan Han ying lin zhang Zhan Chun Xing Yu Wei zhang Yu Zhong Liu Hui lin Cao Virology Department of Hebei Provincial Sanitary and Anti-Epidemic Station Baoding 071000Hebei ProvinceChina Department of Hepatitis Zhengding county Sanitary and Anti-Epidemic StationZhengding 070800ShijiazhuangHebei ProvinceChina Department of Hepatitis Institute of VirologyChinese Academy of Preventive MedicineBeijing 100052China

AIM To understand the anti-HBs persistenceand the long-term preventive efficacy in ruralnewborns after vaccination with plasma-derivedhepatitis B *** In the time of expanded program onimmunization(EPI),the newborns werevaccinated with 10μg×3 doses of hepatitis Bvaccine and 762 newborns who were HBsAgnegative after primary immunization wereselected for cohort observation from 1986 *** serum samples were detectedqualitatively and quantitatively for hepatitis Binfecting markers,including HBsAg,anti-HBsand anti-HBc by SPRIA *** annual HBsAgpositive conversion rate was counted by life-table ***①The anti-HBs positive rate was94.44% for the babies born to HBsAg negativemothers and 84.21% for those born to HBsAgpositive mothers in the 1st year afterimmunization,and dropped to 51.31% and52.50% in the 12th year *** valuewas dropped from 31.62 to 3.13 and 23.99 to 3.65in the 2nd to the 12th year *** a marked drop in GMT at the 3rd to the 5thyear,and in anti-HBs positive rate at the 9th tothe 10th year.②In the period of 12 yearsobservation,the person-year HBsAg positive conversion rates were 0.12%(5/4150.0)innewborns born to HBsAg negative mothers and0.20%(1/508.0)in those born to HBsAgpositive mothers,and none of the HBsAgpositive converted children became HBsAgchronic *** with the baselinebefore immunization,the protective rates were97.19% and 95.32% *** The protective efficacy ofplasma-derived hepatitis B vaccine persisted atleast 12 years,and a booster dose seems notnecessary within at least 12 years after theprimary three-doses immunization to newbornsborn to HBsAg negative mothers.

关键词： hepatitis B vaccine HBsAg vaccination rural newborn cohort study

PLASMA RESISTIN LEVELS AND SINGLE-NUCLEOTIDE POLYMORPHISMS IN RESISTIN GENE 5 FLANKING REGION IN PATIENTS WITH STROKE

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Chinese Medical Sciences Journal 2007年第1期22卷 27-32页

作者： Xing-jian lin ying-dong zhang Qing-shan Guan Qing Di Jing-ping Shi Wei-guo Liu Department of Neurology Nanjing Brain Hospital Nanjing Medical University Nanjing 210029

Objective To analyze the role of resistin in insulin resistance (IR) through investigating the variation of plasma resistin levels and single-nucleotide polymorphisms (SNPs) in resistin gene 5’ flanking region in stroke *** In 103 atherothrombotic cerebral infarction (ACI) patients, 85 lacunar infarction (LI) patients, 70 intracerebral hemorrhage (ICH) patients, and 86 healthy controls, plasma resistin and insulin levels were measured by ELISA , SNPs in resistin gene 5’ flanking region were detected by PCR and direct DNA sequencing. The subjects’ body height and weight, the body mass index, quantitative insulin sensitivity check index (QUICKI), blood pressure, and the concentration of fasting plasma glucose, triglyceride, total cholesterol, creatinine, low-density lipoprotein, and high-density lipoprotein were also determined. Results QUICKI was significantly lower in the ACI and ICH patients (0.316±0.037 and 0.309±0.032, respectively) than that in the controls (0.342±0.043, PG and -537A>C SNPs were not significantly different among the different groups, and those SNPs were not correlated with other clinical and biochemical *** Plasma resistin is associated with stroke by participating in the development of IR. The SNPs in resistin gene 5’ flanking region has no impact on the plasma resistin level.

关键词： resistin insulin resistance single-nucleotide polymorphisms stroke

Effect and mechanism of β-L-D4A on DNA polymerase α

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World Journal of Gastroenterology 2007年第46期13卷 6243-6248页

作者： Yan Li Ju-Sheng lin ying-Hui zhang Xiao-Yan Wang ying Chang Xing-Xing He Institute of Liver Diseases Tongji MedicalCollege Huazhong University of Science and Technology 1095Jiefang Street Wuhan 430030 Hubei Province China

AIM： To investigate the safety of β-L-D4A on DNA polymerase α.METHODS： Ion exchange chromatography was used to separate DNA polymerase cc from crude extract of human Hela cells. Detailed kinetic parameters were determined for β-L-D4A against DNA polymeraseα . RESULTS： DNA polymerase was purified with 4% yield and 31000 units/mg specific activity. The Michaelis constant （Km = 3.22 i^mol/L）, 50% inhibition concentration （IC50 = 178.49 μmol/L） and inhibition constant （Ki = 126 mol/L） of β-L-D4A were determined by kinetic analysis. CONCLUSION： β-L-D4A is a more safe nucleoside for hepatitis B virus （HBV） infection with a lower host toxicity.

关键词： Nucleoside β-L-D4A DNA polymeraseα Kinetic study Side effect Hepatitis B virus

Collagen proportionate area of liver tissue determined by digital image analysis in patients with HBV-related decompensated cirrhosis

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Hepatobiliary & Pancreatic Diseases International 2011年第5期10卷 497-501页

作者： Shi-Bin Xie, Chao Ma, Chao-Shuang lin,ying zhang, Jian-Yun Zhu and Wei-Min Ke Department of Infectious Disease, Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510630, China Department of Infectious Disease Third Affiliated Hospital Sun Yat-Sen University Guangzhou 510630 China

BACKGROUND: The accurate assessment of the degree of hepatic fibrosis plays a critical role in guiding the diagnosis, treatment and prognostic assessment of chronic liver diseases. Liver biopsy is currently the most reliable method to evaluate the severity of hepatic fibrosis. However, liver biopsy is an invasive procedure associated with morbidity and mortality, and has several limitations in patients with decompensated cirrhosis. There is no report on the collagen proportionate area (CPA) of liver tissue in the decompensated stage of cirrhosis. This study aimed to determine the CPA of resected liver tissue samples from patients with HBV-related decompensated cirrhosis using digital image analysis, and to analyze the relationship between the CPA and liver functional reserve. METHODS: Fifty-three resected liver tissue samples from liver transplant patients with chronic hepatitis B-induced decompensated cirrhosis were stained with Masson’s trichrome, and the CPA in these samples was quantitatively determined using digital image analysis. The values of relevant liver function just before liver transplantation, the CPA in liver tissue, and their correlation were analyzed. RESULTS: The mean CPA at the decompensated stage of cirrhosis was 35.93±14.42% (11.24%-63.41%). The correlation coefficients of the CPA with a model for end-stage liver disease score, serum total bilirubin and international standard ratio of prothrombin B were 0.553, 0.519 and 0.533, respectively (P<0.001). With increasing CPA values, the three indices reflecting liver functional reserve also changed ***: The degree of fibrosis may be correlated with the functional reserve. With the advancement of fibrosis, the liver functional reserve is attenuated accordingly.

关键词： collagen proportionate area digital image analysis decompensated cirrhosis chronic hepatitis B

清末及民国期间舆情观念的变迁初探——以《大公报》为例

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编辑之友 2018年第10期 88-94,112页

作者：林荧章广西师范学院新闻传播学院广西南宁530001

当前,有关清末及民国期间舆情观念的研究有所缺失,对其认知也出现误解和偏差。文章以《大公报》文本为样本,对这一阶段的舆情观念进行梳理和分析,研究发现,这一时期是中国舆情观念发展史上的过渡期与转折期,其时的舆情观念一方面承接了... 详细信息

当前,有关清末及民国期间舆情观念的研究有所缺失,对其认知也出现误解和偏差。文章以《大公报》文本为样本,对这一阶段的舆情观念进行梳理和分析,研究发现,这一时期是中国舆情观念发展史上的过渡期与转折期,其时的舆情观念一方面承接了传统的舆情观念,另一方面又在不断发生转型与变革,开启了新的理路与方向,为今天的舆情工作与舆情研究奠定了最初的"样板"。

关键词：大公报舆情新闻史

NOX4 exacerbates Parkinson's disease pathology by promoting neuronal ferroptosis and neuroinflammation

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Neural Regeneration Research 2025年第7期20卷 2038-2052页

作者： Zhihao lin Changzhou ying Xiaoli Si Naijia Xue Yi Liu Ran Zheng ying Chen Jiali Pu Baorong zhang Department of Neurology The Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang ProvinceChina

Parkinson's disease is primarily caused by the loss of dopaminergic neurons in the substantia nigra ***,a novel form of regulated cell death characterized by iron accumulation and lipid peroxidation,plays a vital role in the death of dopaminergic ***,the molecular mechanisms underlying ferroptosis in dopaminergic neurons have not yet been completely *** oxidase 4 is related to oxidative stress,however,whether it regulates dopaminergic neuronal ferroptosis remains *** aim of this study was to determine whether NADPH oxidase 4 is involved in dopaminergic neuronal ferroptosis,and if so,by what *** found that the transcriptional regulator activating transcription factor 3 increased NADPH oxidase 4 expression in dopaminergic neurons and astrocytes in an 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine-induced Parkinson's disease *** oxidase 4 inhibition improved the behavioral impairments observed in the Parkinson's disease model animals and reduced the death of dopaminergic ***,NADPH oxidase 4 inhibition reduced lipid peroxidation and iron accumulation in the substantia nigra of the Parkinson's disease model ***,we found that NADPH oxidase 4 interacted with activated protein kinase Cαto prevent ferroptosis of dopaminergic ***,by lowering the astrocytic lipocalin-2 expression,NADPH oxidase 4 inhibition reduced 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine-induced *** findings demonstrate that NADPH oxidase 4 promotes ferroptosis of dopaminergic neurons and neuroinflammation,which contribute to dopaminergic neuron death,suggesting that NADPH oxidase 4 is a possible therapeutic target for Parkinson's disease.

关键词： dopaminergic neuron ferroptosis NADPH oxidase 4(NOX4) neuroinflammation Parkinson's disease

Islet transplantation for diabetic rats through the spleen

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Hepatobiliary & Pancreatic Diseases International 2005年第2期4卷 203-206页

作者： ying Cheng, Jia-lin zhang, Yong-Feng Liu, Tie-Min Li and Ning Zhao Shenyang, China Organ Transplant Unit, First Affiliated Hospital of China Medical University, Shenyang 110001, China Organ Transplant Unit First Affiliated Hospital of China Medical University Shenyang 110001 China. chengying75@***

BACKGROUND: Islet transplantation is considered a po- tentially curative treatment for diabetic mellitus. The aim of this study was to assess the feasibility of islet transplant through the spleen. METHODS: Both donor and recipient Wistar rats (BW150± 20 g) were provided by the Animal Center of China Medi- cal University, Shenyang, China. Islets were isolated and purified with the modified Minnesota program. 600-800IE graft islets were handpicked and transplanted through the spleen of diabetic recipients. Blood glucose and insulin were evaluated after operation every other day. IVGTT was performed 10 days after transplantation. RESULTS: 300-400IE islet was procured from one donor rat. Secretion index (SI) of the glucose stress was 5.59± 0.62, showing the graft functioning well. The diabetic rats restored normal blood glucose levels of 3.4-5.4 mmol/L (mean 4.8 mmol/L). Their insulin levels were as normal as 8.5-12.2 μIU/ml. The K value of IVGTT in the rats after transplantation was similar to the normal one. CONCLUSIONS: The islets can be transplanted successfully through the spleen, while avoiding the complications caused by traditional transplantation through the portal vein, such as bleeding and portal vein hypertension. The graft islets loss can be reduced because of less centrifugation and mechanic pressure. In conclusion, transplantation through the spleen is a simple and feasible method.

关键词： islet transplantation spleen diabetes mellitus