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World Journal of Clinical Cases 2022年第21期10卷 7599-7608页

作者： Yan Tao Qiong Nan Zi lei ying-lei miao Jun-Kun Niu Department of Gastroenterology The First Affiliated Hospital of Kunming Medical UniversityYunnan Province Clinical Research Center for Digestive DiseasesKunming 650032Yunnan ProvinceChina Department of Pathology The First Affiliated Hospital of Kunming Medical UniversityKunming 650032Yunnan ProvinceChina

BACKGROUND Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue(MALT lymphoma)occurs in approximately 9%of non-Hodgkin B-cell lymphomas.The gastrointestinal tract is the most commonly affected site of the extranodal forms of primary non-Hodgkin’s lymphomas.However,it rarely occurs within the rectum,and at present,there is no consensus on its diagnosis and treatment at this site.CASE SUMMARY We report a rare laterally spreading tumour-like rectal MALT lymphoma case in which the diagnosis and the depth of infiltration were determined by magnifying endoscopy and ultrasonic endoscopy.Then,the lesion was en bloc resected by endoscopic submucosal dissection(ESD)alone.The lesion was confirmed as MALT lymphoma by haematoxylin and eosin staining,immunohistochemical staining and gene arrangement analysis.Surveillance exams have indicated a 2-year disease-free survival for this patient.CONCLUSION We report a rare primary rectal MALT lymphoma that was curable with resection by ESD.ESD is a safe and effective therapeutic option for rectal MALT lymphoma.

关键词： Rectum Mucosa-associated lymphoid tissue lymphoma Endoscopic submucosal dissection En bloc resection Case report

Thalidomide combined with endoscopy in the treatment of Cronkhite-Canada syndrome:A case report

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World Journal of Clinical Cases 2022年第28期10卷 10366-10374页

作者： Jia-Mei Rong Meng-Lin Shi Jun-Kun Niu Juan Luo ying-lei miao Department of Gastroenterology The First Affiliated Hospital of Kunming Medical UniversityKunming 650032Yunnan ProvinceChina

BACKGROUND Cronkhite-Canada syndrome(CCS)is a rare non-hereditary disease with a poor prognosis and a mortality rate of up to 55%.Currently,there is no standard treatment for CCS.The department of gastroenterology of our hospital admitted a patient with CCS whose symptoms improved significantly after treatment with thalidomide combined with endoscopy,and there was no obvious adverse reaction during the 2-year follow-up.CASE SUMMARY A 47-year-old Chinese man presented with diarrhea for more than 4 mo,accompanied by loss of taste,fatigue,and weight loss.Physical examination demonstrated that the patient’s skin and hands were hyperpigmented,the front edges of the nails of both hands were notably thickened and yellow,and the nails were partially atrophied.Gastrointestinal endoscopy identified a diffuse polypoid bulge,and the patient bore an albumin level of 27.3 g/L.The level of the calcium correction amount was(2.164 m M)which allowed for a comprehensive diagnosis of Cronkhite-Canada syndrome,combined with hypoalbuminemia and hypocalcemia.Thalidomide of 150 mg per day was administered to regulate immunity,and the symptoms were relieved after 1 wk.During the follow-up period,polyps were still found that had not been resolved by thalidomide treatment,and endoscopic therapy was performed.This resulted in further improvement of his condition and no particular discomfort during the 2 years of follow-up.CONCLUSION The patient’s symptoms were significantly relieved by thalidomide 2 years after treatment,proposing it as a potential treatment for CCS.

关键词： Cronkhite-Canada syndrome Diarrhea Polyp Thalidomide Endoscopic therapy Case report

Anaplastic lymphoma kinase-negative anaplastic large cell lymphoma masquerading as Behcet’s disease: A case report and review of literature

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World Journal of Clinical Cases 2019年第20期7卷 3377-3383页

作者： Juan Luo ying-Han Jiang Zi lei ying-lei miao Department of Gastroenterology the First Affiliated Hospital of Kunming Medical UniversityInstitute of Digestive DiseaseKunming 650000Yunnan ProvinceChina Department of Pathology the First People’s Hospital of Yunnan ProvinceKunming 650000Yunnan ProvinceChina Department of Pathology the First Affiliated Hospital of Kunming Medical UniversityKunming 650000Yunnan ProvinceChina

BACKGROUND Anaplastic large cell lymphoma(ALCL)is a CD30-positive T cell lymphoma,a rare type of non-Hodgkin lymphoma.The current World Health Organization classification system divides ALCLs into anaplastic lymphoma kinase(ALK)-positive and ALK-negative groups.ALCL rarely presents in the gastrointestinal tract.CASE SUMMARY A 54-year-old male was admitted to the department of gastroenterology for abdominal pain.He presented with lower abdominal pain,diarrhea and recurrent oral and penile ulcers.He was misdiagnosed with Behcet's disease and treated with prednisone.But after one month,he was hospitalized in another hospital for reexamination.This time,the lesion on the penis was biopsied for histological examination.The final pathological diagnosis was ALCL,ALKnegative.The patient was treated with cyclophosphamide,doxorubicin,vincristine,prednisolone chemotherapy.However,he died within one month.CONCLUSION Gastrointestinal ALCL needs to be considered in the differential diagnosis to avoid delaying treatment.Repeated biopsy is the most important for early diagnosis and treatment.

关键词： Anaplastic large cell lymphoma Anaplastic lymphoma kinase Behcet's disease Colon ulcer Penis ulcer Case report

Awareness and attitude of fecal microbiota transplantation through transendoscopic enteral tubing among inflammatory bowel disease patients

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World Journal of Clinical Cases 2020年第17期8卷 3786-3796页

作者： Min Zhong Yang Sun Hong-Gang Wang Cicilia Marcella Bo-Ta Cui ying-lei miao Fa-Ming Zhang Medical Center for Digestive Diseases The Second Affiliated Hospital of Nanjing Medical UniversityNanjing 210011Jiangsu ProvinceChina Key Lab of Holistic Integrative Enterology Nanjing Medical UniversityNanjing 210011Jiangsu ProvinceChina Department of Gastroenterology The First Affiliated Hospital of Kunming Medical UniversityYunnan Institute of Digestive DiseaseKunming 650032YunnanChina Medical Center for Digestive Diseases The Affiliated Huaian No.1 People’s Hospital of Nanjing Medical UniversityHuaian 223300Jiangsu ProvinceChina

BACKGROUND Transendoscopic enteral tubing(TET)has been used in China as a novel delivery route for fecal microbiota transplantation(FMT)into the whole colon with a high degree of patient satisfaction among adults.AIM To explore the recognition and attitudes of FMT through TET in patients with inflammatory bowel disease(IBD).METHODS An anonymous questionnaire,evaluating their awareness and attitudes toward FMT and TET was distributed among IBD patients in two provinces of Eastern and Southwestern China.Question formats included single-choice questions,multiple-choice questions and sorting questions.Patients who had not undergone FMT were mainly investigated for their cognition and acceptance of FMT and TET.Patients who had experience of FMT,the way they underwent FMT and acceptance of TET were the main interest.Then all the patients were asked whether they would recommend FMT and TET.This study also analyzed the preference of FMT delivery in IBD patients and the patient-related factors associated with it.RESULTS A total of 620 eligible questionnaires were included in the analysis.The survey showed that 44.6%(228/511)of patients did not know that FMT is a therapeutic option in IBD,and 80.6%(412/511)of them did not know the concept of TET.More than half(63.2%,323/511)of the participants stated that they would agree to undergo FMT through TET.Of the patients who underwent FMT via TET[62.4%(68/109)],the majority[95.6%(65/68)]of them were satisfied with TET.Patients who had undergone FMT and TET were more likely to recommend FMT than patients who had not(94.5%vs 86.3%,P=0.018 and 98.5%vs 87.8%,P=0.017).Patients’choice for the delivery way of FMT would be affected by the type of disease and whether the patient had the experience of FMT.When compared to patients without experience of FMT,Crohn’s disease and ulcerative colitis patients who had experience of FMT preferred mid-gut TET(P<0.001)and colonic TET(P<0.001),respectively.CONCLUSION Patients’experience of FMT through TET lead them to maintain a positive attitude tow

关键词： Recognition Fecal microbiota transplant Washed microbiota transplantation Transendoscopic enteral tubing Attitude

Gene expression profiles in peripheral blood mononuclear cells of ulcerative colitis patients

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World Journal of Gastroenterology 2013年第21期19卷 3339-3346页

作者： ying-lei miao Yu-Liang Xiao Yan Du Li-Ping Duan Department of Gastroenterology The First Affiliated Hospital of Kunming Medical University Department of Gastroenterology The Second People's Hospital of Yunnan Province Department of Clinical Laboratory The First Affiliated Hospital of Kunming Medical University

AIM: To identify peripheral blood mononuclear cell (PBMC) gene expression profiles of ulcerative colitis (UC) patients, using oligonucleotide microarrays, to gain insights into UC molecular mechanisms. METHODS: The Human OneArray microarrays were used for a complete genome-wide transcript profiling of PBMCs from 12 UC patients and 6 controls. Differential analysis per gene was performed with a random variance model; t test and P values were adjusted to control the false discovery rate (5%). Gene ontology (GO) was deployed to analyze differentially expressed genes at significant levels between patients and controls to identify the biological processes involved in UC. RESULTS: Comparative analysis revealed that 4438 probes (4188 genes) were differentially expressed between the two groups, of which 3689 probes (3590 genes) were down-regulated whereas 749 probes (598 genes) were up-regulated. Many disregulated genes in our data have been reported by previous microarray studies carried out on intestinal mucosa samples, such as S100A8 , CEACAM1 and S100A9 . GO enrichment analysis revealed 67 high enrichment up-regulated categories and one significant down-regulated category. The up-regulated genes were mainly involved in immune and inflammatory response, cell cycle and proliferation, DNA metabolism and repair. CONCLUSION: Gene expression profiling of PBMCs from patients with UC has highlighted several novel gene categories that could contribute to the pathogenesis of UC.

关键词： Ulcerative colitis Microarray Gene ontology Peripheral blood mononuclear cells

Thalidomide and thalidomide analogues in treatment of patients with inflammatory bowel disease:Meta-analysis

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World Journal of Meta-Analysis 2017年第5期5卷 124-131页

作者： Khan Rana Sami Ullah Yu-Lin Xiong ying-lei miao Saeed Ummair Wei Dai Department of Gastroenterology First Affiliated Hospital of Kunming Medical UniversityYunnan Institute of Digestive Disease Library of Kunming Medical University Department of Dermatology First Affiliated Hospital of Kunming Medical University

AIM To examine the efficacy and safety of thalidomide and thalidomide analogues in induction and maintenance of remission in patients with inflammatory bowel disease(IBD).METHODS A literature search was performed in the following databases: PubM ed, EMBASE, Web of Science, Ovid and the Cochrane Library, and Chinese databases such as the China National Knowledge Infrastructure, China Science and Technology Journal Database(VIP), Wanfang Data. The randomized controlled analysis was performed to assess the effects of thalidomide therapy on inflammatory bowel disease for patients who did show good response with other therapies. RESULTS Three studies(n = 212) met the inclusion criteria were used in this Meta-analysis. No difference was found between thalidomide/thalidomide analogues and placebo in the induction of remission(RR = 1.36, 95%CI: 0.83-2.22, P = 0.22), the induction of clinical response(RR = 1.14, 95%CI: 0.75-1.72, P = 0.54) and the induction of adverse events(RR = 1.41, 95%CI: 0.99-2.02, P = 0.06).CONCLUSION Currently, there is not enough evidence to support use of thalidomide or its analogue for the treatment in patients of any age with IBD. However, it warrants a reanalysis when more data become available.

关键词： Inflammatory bowel disease Thalidomide Thalidomide analogues Treatment Efficacy Safety Meta-analysis

Establishment and validation of a computer-assisted colonic polyp localization system based on deep learning

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World Journal of Gastroenterology 2021年第31期27卷 5232-5246页

作者： Sheng-Bing Zhao Wei Yang Shu-Ling Wang Peng Pan Run-Dong Wang Xin Chang Zhong-Qian Sun Xing-Hui Fu Hong Shang Jian-Rong Wu Li-Zhu Chen Jia Chang Pu Song ying-lei miao Shui-Xiang He Lin miao Hui-Qing Jiang Wen Wang Xia Yang Yuan-Hang Dong Han Lin Yan Chen Jie Gao Qian-Qian Meng Zhen-Dong Jin Zhao-Shen Li Yu Bai Changhai Hospital Second Military Medical University/Naval Medical UniversityShanghai 200433China Tencent AI Lab National Open Innovation Platform for Next Generation Artificial Intelligence on Medical ImagingShenzhen 518063Guangdong ProvinceChina Department of Gastroenterology Changhai HospitalSecond Military Medical University/Naval Medical UniversityShanghai 200433China Tencent Healthcare(Shenzhen)Co.LTD. Shenzhen 518063Guangdong ProvinceChina Department of Gastroenterology The First Affiliated Hospital of Kunming Medical UniversityKunming 650000Yunnan ProvinceChina Department of Gastroenterology The First Affiliated Hospital of Xi'an Jiaotong UniversityXi'an 710061Shaanxi ProvinceChina Institute of Digestive Endoscopy and Medical Center for Digestive Disease The Second Affiliated Hospital of Nanjing Medical UniversityNanjing 210011Jiangsu ProvinceChina Department of Gastroenterology The Second Hospital of Hebei Medical UniversityHebei Key Laboratory of GastroenterologyHebei Institute of GastroenterologyShijiazhuang 050000Hebei ProvinceChina Department of Gastroenterology 900th Hospital of Joint Logistics Support ForceFuzhou 350025Fujian ProvinceChina Department of Gastroenterology No.905 Hospital of The Chinese People's Liberation ArmyShanghai 200050China

BACKGROUND Artificial intelligence in colonoscopy is an emerging field,and its application may help colonoscopists improve inspection quality and reduce the rate of missed polyps and adenomas.Several deep learning-based computer-assisted detection(CADe)techniques were established from small single-center datasets,and unrepresentative learning materials might confine their application and generalization in wide practice.Although CADes have been reported to identify polyps in colonoscopic images and videos in real time,their diagnostic performance deserves to be further validated in clinical practice.AIM To train and test a CADe based on multicenter high-quality images of polyps and preliminarily validate it in clinical colonoscopies.METHODS With high-quality screening and labeling from 55 qualified colonoscopists,a dataset consisting of over 71000 images from 20 centers was used to train and test a deep learning-based CADe.In addition,the real-time diagnostic performance of CADe was tested frame by frame in 47 unaltered full-ranged videos that contained 86 histologically confirmed polyps.Finally,we conducted a selfcontrolled observational study to validate the diagnostic performance of CADe in real-world colonoscopy with the main outcome measure of polyps per colonoscopy in Changhai Hospital.RESULTS The CADe was able to identify polyps in the test dataset with 95.0%sensitivity and 99.1%specificity.For colonoscopy videos,all 86 polyps were detected with 92.2%sensitivity and 93.6%specificity in frame-by-frame analysis.In the prospective validation,the sensitivity of CAD in identifying polyps was 98.4%(185/188).Folds,reflections of light and fecal fluid were the main causes of false positives in both the test dataset and clinical colonoscopies.Colonoscopists can detect more polyps(0.90 vs 0.82,P<0.001)and adenomas(0.32 vs 0.30,P=0.045)with the aid of CADe,particularly polyps<5 mm and flat polyps(0.65 vs 0.57,P<0.001;0.74 vs 0.67,P=0.001,respectively).However,high efficacy is not realized in colonoscopies with inadequ

关键词： Computer-assisted detection Artificial intelligence Deep learning Colonoscopy Clinical validation Colorectal polyp

Enhancing thermoelectric performance in P-type Mg_(3)Sb_(2)-based Zintls through optimization of band gap structure and nanostructuring

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Journal of Materials Science & Technology 2024年第3期170卷 25-32页

作者： Yi-bo Zhang Ji-Sheng Liang Chengyan Liu Qi Zhou Zhe Xu Hong-bo Chen Fu-cong Li ying Peng lei miao Guangxi Key Laboratory of Information Material Engineering Research Center of Electronic Information Materials and DevicesMinistry of EducationSchool of Material Science and EngineeringGuilin University of Electronic TechnologyGuilin 541004China Guangxi Key Laboratory for Relativity Astrophysics Center on Nanoenergy ResearchGuangxi Key Laboratory of Processing for Nonferrous Metal and Featured MaterialsSchool of Physical Science&TechnologyGuangxi UniversityNanning 530004China Guangxi Key Laboratory of Precision Navigation Technology and Application Guilin University of Electronic TechnologySchool of Information and CommunicationGuilin 541004China

P-type Mg_(3)Sb_(2)-based Zintls have attracted considerable interest in the thermoelectric(TE)field due to their environmental friendliness and low cost.However,compared to their n-type counterparts,they show relatively low TE performance,limiting their application in TE devices.In this work,we simultaneously introduce Bi alloying at Sb sites and Ag doping at Mg sites into the Mg_(3)Sb_(2)to coopera-tively optimize the electrical and thermal properties for the first time,acquiring the highest ZT value of∼0.85 at 723 K and a high average ZT of 0.39 in the temperature range of 323-723 K in sample Mg_(2.94)Ag_(0.06)Sb_(1.9)Bi_(0.1).The first-principle calculations show that the codoping of Ag and Bi can shift the Fermi level into the valence band and narrow the band gap,resulting in the increased carrier concentration from 3.50×10^(17)cm^(-3)in the reference Mg 3 Sb 0.9 Bi 0.1 to∼7.88×10^(19)cm^(-3)in sample Mg 2.94 Ag 0.06 Sb 0.9 Bi 0.1.As a result,a remarkable power factor of∼778.9μW m^(-1)K^(-2)at 723 K is achieved in sample Mg 2.94 Ag 0.06 Sb 0.9 Bi 0.1.Meanwhile,a low lattice thermal conductivity of∼0.48 W m^(-1)K^(-1)at 723 K is also obtained with the help of phonon scattering at the distorted lattice,point defects,and nano-precipitates in sample Mg 2.94 Ag 0.06 Sb 0.9 Bi 0.1.The synergistic effect of using the multi-element co-doping/-alloying to optimize electrical properties in Mg_(3)Sb_(2)holds promise for further improving the TE performance of Zintl phase materials or even others.

关键词： Thermoelectric materials Band engineering Nanostructuring P-type Mg_(3)Sb_(2) Ag and Bi Co-doping

Progress and prospect of Pt-based catalysts for electrocatalytic hydrogen oxidation reactions

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Nano Research 2024年第3期17卷 960-981页

作者： Xu Zhang ying Xie lei Wang Key Laboratory of Functional Inorganic Material Chemistry Ministry of Education of the People’s Republic of ChinaHeilongjiang UniversityHarbin 150080China

To achieve the goals of the peak carbon dioxide emissions and carbon neutral,the development and utilization of sustainable clean energy are extremely important.Hydrogen fuel cells are an important system for converting hydrogen energy into electrical energy.However,the slow hydrogen oxidation reaction(HOR)kinetics under alkaline conditions has limited its development.Therefore,elucidating the catalytic mechanism of HOR in acidic and alkaline media is of great significance for the construction of highly active and stable catalysts.In terms of practicality,Pt is still the primary choice for commercialization of fuel cells.On the above basis,we first introduced the hydrogen binding energy theory and bifunctional theory used to describe the HOR activity,as well as the pH dependence.After that,the rational design strategies of Pt-based HOR catalysts were systematically classified and summarized from the perspective of activity descriptors.In addition,we further emphasized the importance of theoretical simulations and in situ characterization in revealing the HOR mechanism,which is crucial for the rational design of catalysts.Moreover,the practical application of Pt-based HOR catalysts in fuel cells was also presented.In closing,the current challenges and future development directions of HOR catalysts were discussed.This review will provide a deep understanding for exploring the mechanism of highly efficient HOR catalysts and the development of fuel cells.

关键词： Pt-based catalysts hydrogen oxidation reaction(HOR) electrocatalytic mechanism hydrogen binding energy theory bifunctional theory

A study on carbon emission calculation in operation stage of residential buildings based on micro electricity usage behavior:Three case studies in China

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Building Simulation 2024年第1期17卷 147-164页

作者： Menghan Niu ying Ji miao Zhao Jiefan Gu Aonan Li Beijing Key Laboratory of Green Built Environment and Energy Efficient Technology Beijing University of TechnologyBeijing 100124China College of Architecture and Urban Planning Tongji UniversityShanghai 201804China The Bartlett School of Architecture University College LondonWC1E 6BTUK

Along with the improvement of social productivity and living standard,residential buildings generate a growing portion of carbon emissions,especially during the operation stage.However,energy use behaviors are usually ignored in carbon emission calculation.This study focuses on calculating carbon emissions during the operation stage for residential buildings based on the characteristics of energy use behaviors in different regions.Firstly,we investigated energy use behaviors in dwellings across three cities in China:Xi'an,Shanghai and Fuzhou.Then,we established calibrated carbon emission models and optimization models with different green building measures for residential buildings.The results of this research reveal a significant disparity between the energy usage habits of residents in different climate regions.The carbon emissions of residential electricity bills in Xi'an,Shanghai and Fuzhou are 13.6 kgCO_(2)/(m^(2)·a)(excluding central heating),29.3 kgCO_(2)/(m^(2)·a)and 17.2 kgCO_(2)/(m^(2)·a),respectively.Equipment carbon emissions account for 32.2%-64.1% of the total.In comparison to the model based on internal standard setting,the accuracy of the models using actual internal has improved by 25.9%-37.4%.The three-star green building methods have the highest carbon reduction rate among different star buildings,the emission reduction rates are around 30%.This study's findings are useful for carbon emission calculation and green building design of residential buildings in the future.

关键词： residential building energy usage behavior energy simulation carbon emissions