检索结果-南通市图书馆

Interfacial mechanism of hydrogel with controllable thickness for stable drag reduction

在线全文

学校读者我要写书评

暂无评论

Friction 2024年第2期12卷 231-244页

作者： Xiaotong WU ying LIU Yunlei ZHANG Xingwei wang Wufang YANG lang JIANG Shuanhong MA Meirong CAI Feng ZHOU School of Advanced Manufacturing Nanchang UniversityNanchang 330031China State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000China Yantai Zhongke Research Institute of Advanced Materials and Green Chemical Engineering Shandong Laboratory of Yantai Advanced Materials and Green ManufactureYantai 264006China

Surface wettability plays a significant role in reducing solid–liquid frictional resistance,especially the superhydrophilic/hydrophilic interface because of its excellent thermodynamic *** this work,poly(acrylic acid)-poly(acrylamide)(PAA–PAM)hydrogel coatings with different thicknesses were prepared in situ by polydopamine(PDA)-UV assisted surface catalytically initiated radical *** drag reduction performance of hydrogel surface was measured using a rotational rheometer by the plate–plate *** experimental results showed that the average drag reduction of hydrogel surface could reach up to about 56%in Couette flow,which was mainly due to the interfacial polymerization phenomenon that enhanced the ability of hydration layer to delay the momentum dissipation between fluid layers and the diffusion behavior of *** proposed drag reduction mechanism of hydrogel surface was expected to shed new light on hydrogel–liquid interface interaction and provide a new way for the development of steady-state drag reduction methods.

关键词： steady state drag reduction hydrogel interface hydration hydrophilic

Dynamic Analysis of Incentive Policy Impacts on Recycling of Retired Batteries for Electric Vehicles

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Systems Science and Information 2024年第4期12卷 491-514页

作者： Cuixia wang lang WEI School of Information Management Jiangxi University of Finance and EconomicsNanchang 330032China School of Economics and Management Hunan College of InformationChangsha 410200China

Electric Vehicles(EVs),as a low-carbon means of transportation,have promptly become popular worldwide in the past *** the lifespan of batteries is limited,massive of Electric Vehicle Batteries(EVBs)are being retired,resulting in a rapid increase in the demand for the recycling of retired EVBs in recent ***,due to high recycling costs and immature recycling technologies,EV manufacturers are facing significant challenges in recycling retired ***,as the country with the largest number of EV users in the world,is exploring effective incentive policies for the recycling of retired *** this context,we developed a system dynamics model to analyze the impact of incentive polices such as,recycling subsidies,technological progress,and carbon trading on the retired EVBs *** show that:1)recycling subsidies can improve the recycling ratios quickly in the short term,and dynamic subsidies are more efficient than static subsidies;2)the policy of technological advancement can reduce the recovery and cascade utilization cost,thus having a positive impact on battery recycling,but the policy effect has a time-delay;3)the carbon trading policy is unable to promote efficient recycling due to the current low carbon prices;4)dynamic subsidy and technological advancement policies complement each other,therefore,the combination of these two policies is the best way to promote the recycling of retired EVBs and reduce carbon *** is hoped that this study will contribute to the ongoing debate on policies for the industrialization of retired EVBs recycling.

关键词： electric vehicles retired battery recycling policy impact system dynamics

Genetically programmable cell membrane-camouflaged nanoparticles for targeted combination therapy of colorectal cancer

在线全文

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2024年第7期9卷 2999-3014页

作者： Yun Yang Qingya Liu Meng wang lang Li Yan Yu Meng Pan Danrong Hu Bingyang Chu ying Qu Zhiyong Qian Department of Biotherapy Cancer Center and State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041China

Cell membrane-camouflaged nanoparticles possess inherent advantages derived from their membrane structure and surface antigens,including prolonged circulation in the bloodstream,specific cell recognition and targeting capabilities,and potential for ***,we introduce a cell membrane biomimetic nanodrug platform termed MPB-3BP@CM *** microporous Prussian blue nanoparticles(MPB NPs)serving as both a photothermal sensitizer and carrier for 3-bromopyruvate(3BP),these nanoparticles are cloaked in a genetically programmable cell membrane displaying variants of signal regulatory proteinα(SIRPα)with enhanced affinity to *** a result,MPB-3BP@CM NPs inherit the characteristics of the original cell membrane,exhibiting an extended circulation time in the bloodstream and effectively targeting CD47 on the cytomembrane of colorectal cancer(CRC)***,blocking CD47 with MPB-3BP@CM NPs enhances the phagocytosis of CRC cells by ***,3BP,an inhibitor of hexokinase II(HK2),suppresses glycolysis,leading to a reduction in adenosine triphosphate(ATP)levels and lactate ***,it promotes the polarization of tumor-associated macrophages(TAMs)towards an anti-tumor M1 ***,integration with MPB NPs-mediated photothermal therapy(PTT)enhances the therapeutic efficacy against *** advantages make MPB-3BP@CM NPs an attractive platform for the future development of innovative therapeutic approaches for ***,it introduces a universal approach for engineering disease-tailored cell membranes for tumor therapy.

关键词： CD47 colorectal cancer

Targeted drug approvals in 2023:breakthroughs by the FDA and NMPA

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2024年第3期9卷 813-821页

作者： lang Zheng Wenjing wang Qiu Sun Department of Biotherapy Cancer Center and State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041China West China Medical Publishers West China HospitalSichuan UniversityChengdu 610041China

According to the official website of China’s National Medicines and Pharmaceutical Administration(NMPA),a total of 87 novel drugs were approved in China in 2023,with targeted drugs accounting for 67.8%of the total,amounting to 59 drugs(Fig.1a;Table 1)[https://***/yaopin/ypjgdt/***].Notably,domestic innovation is flourishing,with five first-in-class drugs,including Glumetinib,a c-Met inhibitor from Haihe Biopharma;Leritrelvir,a 3CL protease inhibitor from Raynovent;Anaprazole,a proton pump inhibitor from Xuanzhu Biopharm;Pegol-Sihematide,an EPO drug from Hansoh Pharma;and Zuberitamab from BioRay Biopharmaceutical Co.,***,the world’s first allosteric inhibitor targeting TYK2,Sotyktu(deucravacitinib),has been approved for the treatment of psoriasis and Selumetinib,a MEK inhibitor co-developed by AstraZeneca and Merck Sharp&Dohme(MSD),became the first approved drug in China for the treatment of neurofibromatosis type I(NF1).Beyond these drugs,the approval of novel drug types such as CAR-T cell products,siRNA,monoclonal antibodies,dual antibodies,and ADCs in China is a significant development in the country’s pharmaceutical industry(Fig.1a).

关键词： drugs Merck approval

Surface modification by ligand growth strategy for dense copper bismuth film as photocathode to enhance hydrogen production activity

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers in Energy 2024年第1期18卷 89-100页

作者： Zhouzhou wang Qingwei WU Jieming wang ying YU Institute of Nanoscience and Nanotechnology College of Physical Science and TechnologyCentral China Normal UniversityWuhan 430079China

Hydrogen production from photoelectrochemical(PEC)water splitting has been regarded as a promising way to utilize renewable and endless solar ***,semiconductor film grown on photoelectrode suffers from numerous challenges,leading to the poor PEC ***,a straightforward sol-gel method with the ligand-induced growth strategy was employed to obtain dense and homogeneous copper bismuthate photocathodes for PEC hydrogen evolution *** various characterizations,it was found that the nucleation and surface growth of CuBi_(2)O_(4)layer induced by 2-methoxyethanol ligand(2-CuBi_(2)O_(4))demonstrated a decent crystallinity and coverage,as well as a large grain size and a low oxygen vacancy concentration,leading to the good ability of light absorption and carrier ***,under simulated sunlight irradiation(AM1.5G,100 mW/cm^(2)),the 2-CuBi_(2)O_(4)photocathode achieved an enhanced photocurrent density of−1.34 mA·cm^(−2)at 0.4 V versus the reversible hydrogen electrode and a promising applied bias photon-to-current efficiency of 0.586%.This surface modification by ligand growth strategy will shed light on the future design of advanced photoelectrodes for PEC water splitting.

关键词： copper bismuthate photocathode ligand growth strategy dense film PEC

Theoretical insights of the pharmaceutical compound fluoxetine in water:Role in direct photolysis and indirect photolysis by free radicals

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2024年第8期142卷 269-278页

作者： ying Lu Se wang Yifan Shen School of Environmental Science and Engineering Collaborative Innovation Center of Atmospheric Environment and Equipment TechnologyJiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution ControlNanjing University of Information Science and TechnologyNanjing 210044China

The frequent detection of pharmaceutical compounds in the environment has led to a growing awareness,which may pose a major threat to the aquatic *** this study,photodegradation(direct and indirect photolysis)of two different dissociation states of fluoxetine(FLU)was investigated in water,mainly including the determination of photolytic transition states and products,and the mechanisms of indirect photodegradation with·OH,CO_(3)^(*-)and NO_(3)^(*).The main direct photolysis pathways are defluorination and C–C bond *** addition,the indirect photodegradation of FLU in water is mainly through the reactions with·OH and NO_(3)^(*),and the photodegradation reaction with CO_(3)^(*-)is relatively difficult to occur in the water *** results provide a theoretical basis for understanding the phototransformation process of FLU in the water environment and assessing its potential risk.

关键词： Fluoxetine Photochemical mechanism Direct photolysis Free radical reaction DFT

Robust-augmentation nonlinear dynamic inversion control of over-actuated coaxial high-speed helicopter in transition mode

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Aeronautics 2024年第8期37卷 404-420页

作者： Yuqing QIU Yan LI Jinxi lang Yuxian LIU Zhong wang School of Automation Northwestern Polytechnical UniversityXi’an 710129China

As the elevator and rudder can be used actively for control,in addition to the rotors,Coaxial High-speed Helicopters(CHHs)have the problems of control redundancy and changing control authority in the transition *** paper presents a robust-augmentation transitioning flight control design for a CHH under the adverse conditions of parametric uncertainties and external ***,based on control characteristic analysis,an Adaptive Filtered Nonlinear Dynamic Inversion(AFNDI)controller is proposed for the angular rate to handle the effect of unknown unstructured uncertainties and external *** analysis proves that the presented angular rate controller can guarantee steady-state and transient ***,the attitude angle and velocity controllers are also ***,an Incremental-based Nonlinear Prioritizing Control Allocation(INPCA)method is designed to take into account control surface transition and changing control authority,which efficiently distributes the required moments between coaxial rotors and aero-surfaces,and avoids the control reversal problem of the yaw *** the proposed control architecture,the low-pass filter is introduced to alleviate the adverse influence of time delay and measurement ***,the effectiveness of the proposed controller is demonstrated through nonlinear numerical simulations,and is compared with existing *** results show that the proposed control law can improve both capabilities of disturbance rejection and fast response,and works satisfactorily for the CHH transitioning control characteristic.

关键词： Coaxial high-speed helicopter Transition mode Attitude control Control allocation Robust adaptive control

Tensile strength behavior of cement-stabilized dredged sediment reinforced by polypropylene fiber

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers of Structural and Civil Engineering 2024年第3期18卷 380-392页

作者： Lei lang Jiangshan LI Xin CHEN Lijun HAN Ping wang State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicChinese Academy of SciencesWuhan 430071China Hubei Provincial Key Laboratory of Contaminated Sludge and Soil Science and Engineering Wuhan 430071China University of Chinese Academy of Sciences Beijing 100049China

This study evaluated the feasibility of using polypropylene fiber(PF)as reinforcement in improving tensile strength behavior of cement-stabilized dredged sediment(CDS).The effects of cement content,water content,PF content and length on the tensile strength and stress–strain behavioral evolutions were evaluated by conducting splitting tensile strength ***,the micro-mechanisms characterizing the tensile strength behavior inside PF-reinforced CDS(CPFDS)were clarified via analyzing macro failure and microstructure *** results indicate that the highest tensile strengths of 7,28,60,and 90 d CPFDS were reached at PF contents of 0.6%,1.0%,1.0%,and 1.0%,exhibiting values 5.96%,65.16%,34.10%,and 35.83%higher than those of CDS,***,3 mm,PF of showed the best reinforcement *** CPFDS exhibited obvious tensile strain-hardening characteristic,and also had better ductility than *** mix factor(C_(C)^(a)/C_(w)^(b))and time parameter(q_(t0)(t))of CDS,and the reinforcement index(k_(t-PF))of CPFDS were used to establish the tensile strength prediction models of CDS and CPFDS,considering multiple *** PF“bridge effect”and associated cementation-reinforcement coupling actions inside CPFDS were mainly responsible for tensile strength behavior *** key findings contribute to the use of CPFDS as recycled engineering soils.

关键词： dredged sediment chemical stabilization fiber reinforcement splitting tensile strength micro-mechanisms

Stall Evolution Mechanism of a Centrifugal Compressor with a Wide-Long Vaneless Diffuser

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Thermal Science 2024年第3期33卷 899-913页

作者： ZHANG Lei KANG Jiacheng lang Jinhua AN Guangyao ZHANG Qian wang Longyao wang Qifang Department of Power Engineering North China Electric Power UniversityBaoding071003China Hebei Key Laboratory of Low Carbon and High Efficiency Power Generation Technology North China Electric Power UniversityBaoding071003China

The rotating stall mechanism is of high importance for the stability of centrifugal compressors and thermal power *** majority of research concerning this topic has concentrated on the initial stall ***,the evolution of stall cells in wide-long diffusers has not been comprehensively *** this paper,the causes of rotating stall in the wide-long diffuser and the three-dimensional evolution mechanism of stall cells during the stall process were thoroughly *** the stall induction phase,an annulus vortex structure was found in the reverse-flow zone near the hub side of the diffuser outlet,which was the initial form of stall *** whole evolution process of stall cells was divided into three phases as the flow rate *** the initial stall phase,the dynamic equilibrium was built under effects of the impeller wake and the adverse pressure *** a result,the number of stall cells was kept at seven and the size of stall cells remained *** the transition phase,the flow in the diffuser became *** cells extended to the impeller outlet,and the effect of the wake flow was strengthened *** cells started integrating and separating *** a result,the number and propagation speed of stall cells varied periodically at a constant mass flow *** the deep stall phase,the size of stall cells remained unchanged,and the number of stall cells kept at *** study has important practical guidance and engineering value for the high-efficiency design and safe operation of centrifugal compressors.

关键词： centrifugal compressor wide-long vaneless diffuser stall evolution mechanism wake flow