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A Baseline Correction Algorithm for FAST

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Research in Astronomy and Astrophysics 2022年第8期22卷 1-5页

作者： De-Jian liu Ye Xu ying-jie li Ze-Hao lin Shuai-Bo Bian Chao-jie Hao Purple Mountain Observatory Chinese Academy of SciencesNanjing 210008China School of Astronomy and Space Science University of Science and Technology of ChinaHefei 230026China

The Five-hundred-meter Aperture Spherical radio Telescope(FAST)is the most sensitive ground-based,singledish radio telescope on ***,the original HⅠspectra produced by FAST are affected by standing *** maximize the power of FAST for high-sensitivity observations,we proposed an algorithm that combines fast Fourier transforms and extreme envelope curves to automatically correct the baselines of FAST HⅠspectra and remove standing waves from the *** algorithm can reduce the amplified noise level caused by standing waves to a near-ideal level without losing signals or introducing false *** root mean square of the average baseline reaches~8 mK,approaching the theoretical sensitivity of an HⅠspectrum produced by FAST for an integration time of 335 minutes,i.e.,~6 m K.

关键词： methods:observational techniques:spectroscopic telescopes

Laparoscopy-assisted transanal total mesorectal excision for lower rectal cancer:A feasible and innovative technique

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World Journal of Gastrointestinal Oncology 2021年第1期13卷 12-23页

作者： ying-jie li lin Wang Ting-Ting Sun Ai-Wen Wu Gastrointestinal Cancer Center Unit III Beijing Cancer Hospital and Beijing Institute for Cancer ResearchBeijing 100142China Department of Gastrointestinal Surgery Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education)Beijing Cancer Hospital and Beijing Institute for Cancer ResearchBeijing 100142China

BACKGROUND Transanal total mesorectal excision(taTME)is a new technique with many potential technical ***-assisted taTME is a combination of transabdominal taTME and transluminal endoscopic surgery ***-assisted taTME is a combination of techniques such as minimally invasive surgery,intersphincter-assisted resection,natural orifice extraction,ta minimally invasive surgery,and ultralow-level preservation of the *** To verify the feasibility and safety of an innovative technique of taTME for treatment of cancer located in the lower *** From January 2016 to March 2018,we attempted to perform laparoscopy-assisted taTME surgery in 24 patients with lower rectal *** The new technique of laparoscopy-assisted taTME was successfully performed in all 24 *** operating time was 310.0 min and mean intraoperative blood loss was 69.1 *** mean time to passing of first flatus was 3.1 d,and mean postoperative hospital stay was 9.2 *** patients were given postoperative analgesics due to anal ***-three patients were able to walk in first 2 d,and five patients had postoperative *** Laparoscopy-assisted taTME is suitable for selected patients with lower rectal cancer,and this technique is worthy of further recommendation.

关键词： Laparoscopy-assisted Total mesorectal excision Technique Lower rectal cancer Trans-abdominal Trans-anus

Non-monotonic influence of a magnetic field on the electrochemical behavior of Fe_(78)Si_9B_(13) glassy alloy in NaOH and NaCl solutions

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International Journal of Minerals,Metallurgy and Materials 2014年第10期21卷 1009-1018页

作者： Hong-di Zhang Xiao-yu li Jing Pang li-juan Yin Hai-jian Ma ying-jie li Yan liu Wei-min Wang Key Laboratory for liquid-Solid Structural Evolution and Processing of Materials (Ministry of Education) Shandong University Qingdao Yunlu Energy Technology Co. Ltd. School of Mechanical and Electrical Engineering Weifang University

The corrosion behavior and microstructure of Fe78Si9B13 glassy alloy in NaOH and NaCl solutions under a 0.02-T magnetic field were investigated through electrochemical testing and scanning electron microscopy （SEM）. The current-density prepeak （PP） in the anodic polarization curves in low-concentration NaOH solutions （classified as type I） tends to disappear when the NaOH concentration is increased to 0.4 mol/L and the magnetic field is applied. Under the magnetic field, the height of the second current-density peak is increased in low-concentration NaOH solutions （type I） but decreased in high-concentration NaOH solutions （type Ⅱ）. The non-monotonic effect of the magnetic field was similarly observed in the case of polarization curves of samples measured in NaCl solutions, Ring-like corroded patterns and round pits are easily formed under the magnetic field in NaOH and NaC1 solutions. These experimental results were discussed in terms of the magnetohydrodynamic （MHD） effect.

关键词： amorphous alloys electrochemical behavior magnetic field anodic polarization micrographs

linking anisotropy with Fe_3C distribution in AISI 1045 steel

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International Journal of Minerals,Metallurgy and Materials 2015年第12期22卷 1293-1303页

作者： Ke-chang Shen Gui-hua li Yi-min Sun Yong-gang Wang ying-jie li Guang-hui Cao Wei-min Wang Key Laboratory for liquid-Solid Structural Evolution and Processing of Materials (Ministry of Education) Shandong University Shandong Institute of Metrology School of Materials Science and Engineering Shanghai University

The anisotropy of the microstructure, thermal expansion behavior, corrosion resistance and magnetic properties of AISI 1045 steel was investigated. The distribution of Fe3C lameUae in the investigation plane parallel to the radial directions of molds was observed to differ from that in the investigation plane perpendicular to the radial directions by transmission electron microscopy. The lattice constants a0 of α-Fe deduced from the XRD patterns of samples prepared using a sand （S）-mold and cut parallel to the radial direction of the mold （S//） and using a metal （M）-mold and cut parallel to the radial direction （M//）, the corrosion resistance measured using an electrochemical work- station, and the magnetic permeability obtained by vibrating sample magnetometry also indicated the existence of anisotropy in the tested samples. The anisotropic change of corrosion potential （Eeorr）, pitting potential （Epit） and magnetic permeability （μ） of the samples was observed to depend on the orientation factorF200 of α-Fe in the measured samples, which is controlled by the distribution of Fe3C lamellae in the eutectoid structure.

关键词： carbon steel microstructure anisotropy lattice constants

Effect of proppant pumping schedule on the proppant placement for supercritical CO_(2) fracturing

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Petroleum Science 2022年第2期19卷 629-638页

作者： Yong Zheng Hai-Zhu Wang ying-jie li Gang-Hua Tian Bing Yang Cheng-Ming Zhao Ming-Sheng liu State Key Laboratory of Petroleum Resources and Prospecting China University of Petroleum(Beijing)Beijing102249China CNPC Offshore Engineering Co.Ltd. Beijing100028China

Supercritical CO_(2)fracturing is a potential waterless fracturing technique which shows great merits in eliminating reservoir damage,improving shale gas recovery and storing CO_(2)*** insight into the proppant-transport behavior of CO_(2)is required to better apply this technique in the engineering *** the present paper,we adopted a coupled Computational Fluid Dynamics and Discrete Element Method(CFD-DEM)approach to simulate the proppant transport in a fracking fracture with multiple perforation *** experiments were first simulated to benchmark the CFD-EDM approach,and then various pumping schedules and injection parameters(injection location,multi-concentration injection order,multi-density injection order and injection temperature)were investigated to determine the placement characteristics of *** indicate that the swirling vortex below the injection tunnels dominates the proppant diffusion in the *** velocity of fluid flow across the proppant bank surface in multi-concentration injection shows a positive correlation with the proppant *** high-density proppant first can promote the transportation of low-density proppant injected later in the fracture to a certain *** the initial injection temperature of supercritical CO_(2)slurry helps enhance the particle-driving effect of fluid and improve the performance of supercritical CO_(2)in carrying proppant.

关键词： Supercritical CO_(2)fracturing Proppant placement CFD-DEM Unconventional natural gas CO_(2)utilization

HLA Class I Expressions on Peripheral Blood Mononuclear Cells in Colorectal Cancer Patients

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Chinese Journal of Cancer Research 2012年第1期24卷 77-82页

作者： Zhi-mian Zhang Xiao Guan ying-jie li Ming-chen Zhu Xiao-jing Yang Xiong Zou Department of Health Examination Center Qilu HospitalShandong UniversityJinan 250012China Department of Clinical Laboratory Medicine Qilu HospitalShandong UniversityJinan 250012China

Objective： To investigate the expression change of human leukocyte antigen （HLA） class I on human peripheral blood mononuclear ceils （PBMCs） at both mRNA and protein levels, and to evaluate its roles in the development of colorectal cancer （CRC）. Methods： In the present study, 50 patients with CRC, 35 patients with benign colorectal lesion and 42 healthy volunteers were enrolled. Expression levels of HLA class I mRNA and protein were determined using real-time quantitative reverse transcription PCR （RT-PCR） and flow cytometry analysis, respectively. Results： The expression levels of HLA class I mRNA and proteins were not influenced by age and gender. The relative ratios of HLA class I mRNA were 0.99±0.27 in healthy controls, 0.76±0.19 in benign patients, and 0.48±0.21 in CRC patients. Mean fluorescence intensities of HLA class I were 145.58±38.14 in healthy controls, 102.05±35.98 in benign patients and 87.44±34.01 in CRC patients. HLA class I on PBMCs was significantly down-regulated at both mRNA and protein levels in patients with stage III and IV CRC. CRC patients with lymph node metastasis also showed a decreased HLA class I expression at protein level. Conclusion： HLA class I expressions on PBMCs are associated with staging of CRC and lymph node metastasis. Monitoring the expression of HLA class I on PBMCs may provide useful information for diagnosis and metastasis judgement of CRC.

关键词： HLA class I Peripheral blood mononuclear cells RT-PCR Flow cytometry Colorectal cancer

A 95 GHz methanol emission survey toward eight small supernova remnants

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Research in Astronomy and Astrophysics 2017年第12期17卷 65-76页

作者： ying-jie li Ye Xu Xi Chen Deng-Rong Lu Yan Sun Xin-Yu Du Zhi-Qiang Shen Purple Mountain Observatory Chinese Academy of SciencesNanjing 210008China University of Science and Technology of China Chinese Academy of SciencesHefei 230026China Center for Astrophysics Guangzhou UniversityGuangzhou 51006China Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030China University of the Chinese Academy of Sciences Beijing 100049China

We report on a 95 GHz（80-71A＋） methanol（CH3OH） emission survey with the Purple Mountain Observatory Delingha 13.7 m telescope. Eight supernova remnants（SNRs） with angular size〈10′ were observed, but emission was only detected in three SNRs near the Galactic center（Sgr A East,G 0.1–0.1 and G 359.92–0.09）. CH3OH emission mainly surrounds the SNRs and can be decomposed into nine spatial peaks with the velocity range of eight peaks being（-30, 70） km s-1, and the other is（70, 120） km s-1. They are probably excited by interaction with these SNRs and adjacent molecular gas in the central molecular zone（CMZ）, although star formation may play an important role in exciting CH3OH emission in some regions of CMZ. We infer that tidal action is unlikely to be an excitation source for CH3OH emission.

关键词： ISM:molecules ISM:supernova remnants Galaxy:center ISM:kinematics and dynamics ISM:clouds

Network pharmacology and molecular docking-based analyses to predict the potential mechanism of Huangqin decoction in treating colorectal cancer

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World Journal of Clinical Cases 2023年第19期11卷 4553-4566页

作者： ying-jie li Dong-Xin Tang Hong-Ting Yan Bing Yang Zhu Yang Feng-Xi Long Guizhou University of Traditional Chinese Medicine Guizhou University of Traditional Chinese MedicineGuiyang 550005Guizhou ProvinceChina Digestive Department The First Affiliated Hospital of Guizhou University of Traditional Chinese MedicineGuiyang 550001Guizhou ProvinceChina Guizhou University of Traditional Chinese Medicine Guizhou University of Traditional Chinese MedicineGuiyang 550001Guizhou ProvinceChina Guizhou University of Traditional Chinese Medicine Guizhou University of Traditional Chinese MedicineGui Yang 550001Guizhou ProvinceChina

BACKGROUND To analyze the potential action mechanism of Huangqin decoction(HQD)in colorectal cancer(CRC)treatment on the basis of network pharmacology and molecular *** To investigate the molecular mechanisms of HQD for CRC treatment by using network pharmacology and molecular *** All HQD active ingredients were searched using the Systematic Pharmacology and Traditional Chinese Medicine Systems Pharmacology databases and the Bioinformatics Analysis Tool for Molecular Mechanisms in traditional Chinese ***,the targets of the active ingredients were *** abbreviations of protein targets were obtained from the UniProt database.A“drug–compound–target”network was constructed to screen for some main active *** targets related to the therapeutic effect of CRC were obtained from the GeneCards,DisGeNET,Therapeutic Target Database,and Online Mendelian Inheritance in Man *** intersection of targets of Chinese herbs and CRC was taken.A Venn diagram was drawn to construct the intersection target interactions network by referring to the STRING *** analysis of the protein interaction network was performed using Cytoscape 3.7.2 software to screen the core HQD targets for *** core targets were imported into the DAVID 6.8 analysis website for gene ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses and ***,molecular docking was performed using AutoDockTool and PyMOL for *** In total,280 potential drug-active ingredients were present in HQD,including 1474 targets of the drug-active *** main active ingredients identified were betulin,tetrahydropalmatine,and *** total,10249 CRC-related targets and 1014 drug-disease intersecting targets were identified,including 28 core targets of action such as Jun proto-oncogene,AP-1 transcription factor subunit,signal transducer and activator of transcription 3,tumor protein p53,vascular endothelia

关键词： Huangqin decoction Colorectal cancer Network pharmacology

Autophagy and multidrug resistance in cancer

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Chinese Journal of Cancer 2017年第8期36卷 342-351页

作者： ying-jie li Yu-He Lei Nan Yao Chen-Ran Wang Nan Hu Wen-Cai Ye Dong-Mei Zhang Zhe-Sheng Chen Institute of Traditional Chinese Medicine & Natural Products College of Pharmacy Jinan University Department of Pharmaceutical Sciences College of Pharmacy and Health SciencesSt.John's University

Multidrug resistance(MDR) occurs frequently after long-term chemotherapy, resulting in refractory cancer and tumor ***, combatting MDR is an important issue. Autophagy, a self-degradative system, universally arises during the treatment of sensitive and MDR cancer. Autophagy can be a double-edged sword for MDR tumors: it participates in the development of MDR and protects cancer cells from chemotherapeutics but can also kill MDR cancer cells in which apoptosis pathways are inactive. Autophagy induced by anticancer drugs could also activate apoptosis signaling pathways in MDR cells, facilitating MDR reversal. Therefore, research on the regulation of autophagy to combat MDR is expanding and is becoming increasingly important. We summarize advanced studies of autophagy in MDR tumors, including the variable role of autophagy in MDR cancer cells.

关键词： Autophagy Drug resistance Neoplasms Cell survival Cell death