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整合素α6靶向自组装促凋亡纳米多肽对中枢神经系统急性淋巴细胞白血病的靶向治疗

Engineering 2024年第4期35卷 226-240页

作者： Jia-Cong Ye Wan-Qiong li Mei-ling Chen Qian-Kun Shi Hua Wang Xin-ling li ying-he li Jie Yang Qiao-li Wang Fang Hu Yan-Feng Gao Shu-Wen liu Mu-Sheng Zeng Guo-Kai Feng Guangdong Provincial Key Laboratory of New Drug Screening&NMPA Key Laboratory of Drug Metabolism Research and Evaluation School of Pharmaceutical SciencesSouthern Medical UniversityGuangzhou 510515China State Key Laboratory of Oncology in South China&Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy Guangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhou 510060China School of Pharmaceutical Sciences(Shenzhen) Shenzhen Campus of Sun Yat-sen UniversityShenzhen 518107China Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering Biomaterials Research CenterSchool of Biomedical EngineeringSouthern Medical UniversityGuangzhou 510515China State Key Laboratory of Organ Failure Research Guangdong Provincial Institute of NephrologySouthern Medical UniversityGuangzhou 510515China

There is currently no effective targeted therapeutic strategy for the treatment of central nervous system acute lymphoblastic leukemia(CNS-ALL).Integrinα6 is considered a potential target for CNS-ALL diagnosis and therapy because of its role in promoting CNS-ALL disease *** targeted peptide D(RWYD)(abbreviated RD),with nanomolar affinity to integrinα6 was identified by peptide scanning techniques such as alanine scanning,truncation,and ***,we developed a therapeutic nanoparticle based on the integrinα6-targeted peptide for treating *** self-assembled proapoptotic nanopeptide_(D)(RWYD)-_(D)(KLAKLAK)_(2)-G_(D)(FFY)(abbreviated RD-KLA-Gffy)contains the integrinα6-targeted peptide RD,the well-known proapoptotic peptide_(D)(KLAKLAK)_(2)(abbreviated KLA),and the self-assembling tetrapeptide GD(FFY)(abbreviated Gffy).The functional mechanism of RD-KLA-Gffy is clarified using different *** results demonstrate that RD-KLA-Gffy is highly enriched in CNS-ALL lesions and induces tumor cell apoptosis,thus reducing CNS-ALL disease burden and prolonging the survival of CNS-ALL mice without obvious ***,the combined use of RD-KLA-Gffy and methotrexate(MTX)shows a potent antitumor effect in treating CNS-ALL,indicating that RD-KLA-Gffy plays an important role in suppressing CNS-ALL progression either as a single agent or in combination with MTX,which shows promise for application in CNS-ALL therapy.

关键词： Central nervous system acute lymphoblastic leukemia Integrinα6 Targeted peptide Proapoptotic Nanopeptide

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Integrin α6:a potential target for cancer molecular imaging and targeting therapy

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Malignancy Spectrum 2024年第1期1卷 30-45页

作者： Xin-ling li Zhuo-Lun Shen Qiao-li Wang Jia-Cong Ye Wen-Biao Zhang ying-he li Guo-Kai Feng Mu-Sheng Zeng State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineGuangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapySun Yat-sen University Cancer CenterGuangzhouGuangdongChina

As a major kind of cell surface adhesion molecules with signal transduction function,integrins play a major role in tumorigenesis and tumor *** role of integrins in tumor cells and the tumor microenvironment has been extensively *** the integrin family,integrinαvβ3 is the most studied integrin in the past 20 *** of preclinical and clinical studies have been conducted,which showed clinical benefits of targeting integrinαvβ3 in tumor imaging and ***,the focus of interest is gradually shifting from integrinαvβ3 toward other integrin ***α6 is expressed in many malignant tumors,such as colorectal cancer,head and neck squamous cell carcinoma,breast cancer,pancreatic cancer,and liver cancer,and its expression is correlated with poor survival of the *** studies have shown that tumor molecular imaging agents and therapeutic drugs targeting integrinα6 have excellent safety and efficacy in preclinical mouse models,encouraging clinical translation of this promising *** this review,we briefly overview the physiological and pathological function of integrinα6 and highlight the recent advances in integrinα6-targeted imaging and therapeutics in tumors.

关键词： tumor imaging tumor therapy tumor microenvironment molecular imaging integrin

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绿色创业导向对农民专业合作社绩效的影响研究

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农业现代化研究 2024年第2期45卷 270-281页

作者：贺迎黎莫经梅张社梅四川农业大学管理学院四川成都611130

激发合作社绿色创业的内生动力对于在大面上推进我国农业绿色转型具有重要意义。本研究构建了绿色创业导向影响合作社绩效的理论分析框架,采用多元OLS模型和中介效应模型,实证分析绿色创业导向对合作社绩效的影响效应及作用机制。研究... 详细信息

激发合作社绿色创业的内生动力对于在大面上推进我国农业绿色转型具有重要意义。本研究构建了绿色创业导向影响合作社绩效的理论分析框架,采用多元OLS模型和中介效应模型,实证分析绿色创业导向对合作社绩效的影响效应及作用机制。研究结果表明,实施绿色创业导向战略会显著影响合作社的绩效,其中,绿色先动性和绿色创新性更有助于合作社绩效水平的提升;机制分析表明,绿色创业导向通过影响绿色资源行动进而对合作社绩效产生影响;异质性分析发现,绿色创业导向对内部设置激励机制、示范等级较高的合作社影响作用更大。因此,政府应高度重视合作社在农业绿色转型发展中的平台作用,鼓励合作社积极推进绿色创业导向战略;针对性开展合作社农业绿色风险投资培训,着力加强合作社领导人绿色风险投资认知能力;建立合作社绿色资源行动考评制度,促进合作社绿色行动的产生;鼓励合作社建立激励机制,重点引导示范社积极探索多元化激励措施。

关键词：绿色创业导向绿色技术采纳绿色示范基地建设合作社绩效农业绿色发展

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Relationship between clinical features and intestinal microbiota in Chinese patients with ulcerative colitis

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World Journal of Gastroenterology 2021年第28期27卷 4722-4737页

作者： Xu-Xia he ying-he li Peng-Guang Yan Xiang-Chen Meng Chu-Yan Chen Ke-Min li Jing-Nan li Department of Gastroenterology Peking Union Medical College HospitalPeking Union Medical College and Chinese Academy of Medical ScienceBeijing 100730China

BACKGROUND Dysbacteriosis may be a crucial environmental factor for ulcerative colitis(UC).Further study is required on microbiota alterations in the gastrointestinal tract of patients with UC for better clinical management and *** To analyze the relationship between different clinical features and the intestinal microbiota,including bacteria and fungi,in Chinese patients with *** Eligible inpatients were enrolled from January 1,2018 to June 30,2019,and stool and mucosa samples were *** was diagnosed by endoscopy,pathology,Mayo Score,and Montreal *** amplicon sequencing of 16S rRNA gene and fungal internal transcribed spacer gene was used to detect the intestinal microbiota *** diversity,principal component analysis,similarity analysis,and Metastats analysis were employed to evaluate differences among *** A total of 89 patients with UC and 33 non-inflammatory bowel disease(IBD)controls were *** bacterial analysis,72 stool and 48 mucosa samples were obtained from patients with UC and 21 stool and 12 mucosa samples were obtained from the *** fungal analysis,stool samples were obtained from 43 patients with UC and 15 controls.A significant difference existed between the fecal and mucosal bacteria of patients with ***α-diversity of intestinal bacteria and the relative abundance of some families,such as Lachnospiraceae and Ruminococcaceae,decreased with the increasing severity of bowel inflammation,while Escherichia-Shigella showed the opposite *** intermicrobial correlations in UC in remission than in active patients were *** bacteriafungi correlations became single and uneven in patients with *** The intestinal bacteria flora of patients with UC differs significantly in terms of various sample types and disease *** intermicrobial correlations change in patients with UC compared with non-IBD controls.

关键词： Ulcerative colitis Intestinal microbiota Intermicrobial correlation Bacteria Fungi Chinese

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Solidification crack characteristics and sensitivity of peritectic steel

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Journal of Iron and Steel Research International 2024年第7期31卷 1668-1679页

作者： Ya-qiang li Jian-hua liu Zi-ming Wang ying-ying li Yang he Xiao-wei li Department of Automotive Engineering Hebei Vocational University of Technology and EngineeringXingtai 054000HebeiChina hebei Special Vehicle Modification Technology Innovation Center Hebei Vocational University of Technology and EngineeringXingtai 054000HebeiChina Institute of Engineering Technology University of Science and Technology BeijingBeijing 100083China School of Petroleum and Natural Gas Engineering Changzhou UniversityChangzhou 213164JiangsuChina

The characteristics and sensitivity of solidification cracks in peritectic steels were investigated using directional solidifi-cation *** cracks were observed in both hypoperitectic steels(12CrlMoV,15CrMo)and hyper-peritectic steel(20CrMo)during solidification at growth velocities of 15,50,and 80 pm/*** the dendritic boundaries,sulphide precipitates were found,promoting crack *** on the statistical analysis of interdendritic cracks in peritectic steels,the area ratio(RA)of interdendritic cracks in a directional solidification structure was proposed to evaluate the crack sensitivity of peritectic ***,the crack sensitivities of peritectic steels(12CrlMoV,15CrMo,and 20CrMo)were tested,evaluated,and compared with the surface crack rates of three types of steels produced from a steel *** results demonstrated that RA was in good agreement with that of the steel plant,and the crack sensitivity of 12CrlMoV steel was the strongest,followed by that of 15CrMo and 20CrMo ***,RA can be used to evaluate the crack sensitivity of peritectic steel.

关键词： Peritectic steel-Directional solidification Growth velocity Dendritic structure Solidification crack Crack sensitivity

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Protein lipidation in health and disease:molecular basis,physiological function and pathological implication

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1423-1465页

作者： Yuan Yuan Peiyuan li jianghui li Qiu Zhao ying Chang Xingxing he Department of Gastroenterology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Department of Gastroenterology Zhongnan Hospital of Wuhan UniversityWuhanChina Hubei Clinical Center and Key Laboratory of Intestinal and Colorectal Diseases WuhanChina

Posttranslational modifications increase the complexity and functional diversity of proteins in response to complex external stimuli and internal *** these,protein lipidations which refer to lipid attachment to proteins are prominent,which primarily encompassing five types including S-palmitoylation,N-myristoylation,S-prenylation,glycosylphosphatidylinositol(GPl)anchor and *** attachment to proteins plays an essential role in the regulation of protein trafficking,localisation,stability,conformation,interactions and signal transduction by enhancing *** evidence from genetic,structural,and biomedical studies has consistently shown that protein lipidation is pivotal in the regulation of broad physiological functions and is inextricably linked to a variety of *** of dedicated research have driven the development of a wide range of drugs targeting protein lipidation,and several agents have been developed and tested in preclinical and clinical studies,some of which,such as asciminib and lonafarnib are FDA-approved for therapeutic use,indicating that targeting protein lipidations represents a promising therapeutic ***,we comprehensively review the known regulatory enzymes and catalytic mechanisms of various protein lipidation types,outline the impact of protein lipidations on physiology and disease,and highlight potential therapeutic targets and clinical research progress,aiming to provide a comprehensive reference for future protein lipidation research.

关键词： lipid ation primarily

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Flotation separation of scheelite from calcite using luteolin as a novel depressant

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International Journal of Minerals,Metallurgy and Materials 2024年第3期31卷 462-472页

作者： Xiaokang li ying Zhang Haiyang he Yu Wu Danyu Wu Zhenhao Guan Faculty of Land and Resources Engineering Kunming University of Science and TechnologyKunming 650093China State Key Laboratory of Clean Utilization of Complex Non-Ferrous Metal Resources Kunming University of Science and TechnologyKunming 650093China

This paper proposes luteolin(LUT)as a novel depressant for the flotation-based separation of scheelite and calcite in a sodium oleate(NaOL)*** suitability of LUT as a calcite depressant is confirmed through micro-flotation *** pH=9,with LUT concentration of 50 mg·L^(-1) and NaOL concentration of 50 mg·L^(-1),scheelite recovery reaches 80.3%.Calcite,on the other hand,exhibits a recovery rate of 17.6%,indicating a significant difference in floatability between the two ***,the surface modifica-tions of scheelite and calcite following LUT treatment are characterized using adsorption capacity testing,Zeta potential analysis,Fourier transform infrared spectroscopy(FT-IR),X-ray photoelectron spectroscopy(XPS),and atomic force microscopy(AFM).The study in-vestigates the selective depressant mechanism of LUT on *** capacity testing and Zeta potential analysis demonstrate sub-stantial absorption of LUT on the surface of calcite,impeding the further adsorption of sodium oleate,while its impact on scheelite is ***-IR and XPS analyses reveal the selective adsorption of LUT onto the surface of calcite,forming strong chemisorption bonds between the hydroxyl group and calcium ions *** directly illustrates the distinct adsorption densities of LUT on the two miner-al ***,LUT can effectively serve as a depressant for calcite,enabling the successful separation of scheelite and calcite.

关键词： scheelite calcite luteolin flotation depressant separation

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Two-photon polymerization-based 4D printing and its applications

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International Journal of Extreme Manufacturing 2024年第1期6卷 1-25页

作者： Bingcong Jian Honggeng li Xiangnan he Rong Wang Hui ying Yang Qi Ge Shenzhen Key Laboratory of Soft Mechanics&Smart Manufacturing Southern University of Science and TechnologyShenzhen 518055People’s Republic of China Department of Mechanical and Energy Engineering Southern University of Science and TechnologyShenzhen 518055People’s Republic of China Pillar of Engineering Product Development Singapore University of Technology and Design8 Somapah RoadSingapore 487372Singapore

Two-photon polymerization(TPP)is a cutting-edge micro/nanoscale three-dimensional(3D)printing technology based on the principle of two-photon *** surpasses the diffraction limit in achieving feature sizes and excels in fabricating intricate 3D micro/nanostructures with exceptional *** concept of 4D entails the fabrication of structures utilizing smart materials capable of undergoing shape,property,or functional changes in response to external stimuli over *** integration of TPP and 4D printing introduces the possibility of producing responsive structures with micro/nanoscale accuracy,thereby enhancing the capabilities and potential applications of both *** paper comprehensively reviews TPP-based 4D printing technology and its diverse ***,the working principles of TPP and its recent advancements are ***,the optional4D printing materials suitable for fabrication with TPP are ***,this review paper highlights several noteworthy applications of TPP-based 4D printing,including domains such as biomedical microrobots,bioinspired microactuators,autonomous mobile microrobots,transformable devices and robots,as well as anti-counterfeiting *** conclusion,this paper provides valuable insights into the current status and future prospects of TPP-based4D printing technology,thereby serving as a guide for researchers and practitioners.

关键词： two-photonpolymerization 4D printing nano/micro fabrication microrobot

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晨交班教学模式在本科生传染病学临床实践的应用

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教育教学论坛 2024年第32期 22-25页

作者：闫涛涛任丹凤何英利刘锦锋西安交通大学第一附属医院感染性疾病科陕西西安710061

调查晨交班教学模式在本科生传染病学临床实践教学中的效果和教学质量反馈,为进一步提升临床实践教学质量提供数据支持。设计关于晨交班教学模式相关的调查问卷,随机抽取105名医学生完成问卷调查,进行数据统计及分析。在被调查的医学生... 详细信息

调查晨交班教学模式在本科生传染病学临床实践教学中的效果和教学质量反馈,为进一步提升临床实践教学质量提供数据支持。设计关于晨交班教学模式相关的调查问卷,随机抽取105名医学生完成问卷调查,进行数据统计及分析。在被调查的医学生中,超过99.0%的医学生表示晨交班教学模式对提高临床实践能力,尤其是临床思维能力有帮助;98.1%的医学生表示晨交班教学模式提升了自身的总结概括能力;98.1%的医学生建议对该教学模式进行推广。由此可知,晨交班教学模式可显著提高医学生的学习主观能动性,且有助于提高医学生的临床思维能力和实践能力。

关键词：医学生晨交班教学模式临床实践能力临床思维能力

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Conditions for the enrichment of karst hydrothermal resources in Bohai Bay Basin

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Energy Geoscience 2024年第1期5卷 172-183页

作者： Pengwei li Zhiliang he Zongquan Hu ying Zhang Jianyun Feng Petroleum Exploration and Production Research Institute SINOPECBeijing100083China SINOPEC Beijing100728China

Drilling for karst hydrothermal resources in eastern China has posed challenges,including disparities between the temperature and yield of geothermal *** is evident that relying solely on geothermal anomalies or indications of karst reservoirs is inadequate for the exploration of karst hydrothermal *** study seeks to elucidate the cause of geothermal sweet spots by analyzing the interplay between geothermal anomalies and karst reservoirs and the underlying geological conditions for karst hydrothermal *** findings include:(1)the Bohai Bay Basin has been geologically favorable for the development of karst hydrothermal resources since the Mesozoic era;(2)the karst hydrothermal enrichment varies significantly between the basin’s margin and its *** the basin margin,the enrichment is largely driven by groundwater activity and faults,particularly where faults facilitate the upwelling of geothermal *** contrast,within the basin’s interior,karst hydrothermal resources are predominantly influenced by buried hills and are especially enriched in areas facilitating the discharge of deep geothermal waters.

关键词： Buried hill Karst hydrothermal resources Enrichment regularity Bohai bay basin

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