检索结果-南通市图书馆

Enhancing immunotherapy efficacy against MHC-I deficient triple-negative breast cancer using LCL161-loaded macrophage membranedecorated nanoparticles

引用

Acta Pharmaceutica Sinica B 2024年第7期14卷 3218-3231页

作者： Wen Zhang Yihui Zhai ying Cai Xiang Gong Yunxuan Jiang Rong Rong Chao Zheng Binyu Zhu Helen He Zhu hao Wang Yaping Li Pengcheng Zhang China State Institute of Pharmaceutical Industry Shanghai 201203China State Key Laboratory of Drug Research&Center of Pharmaceutics Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China School of Biomedical Engineering&State Key Laboratory of Advanced Medical Materials and Devices ShanghaiTech UniversityShanghai 201210China School of Chinese Materia Medica Nanjing University of Chinese MedicineNanjing 210023China Yantai Institute of Materia Medica Shandong 264000China State Key Laboratory of Oncogenes and Related Genes Renji-Med-X Stem Cell Research CenterDepartment of UrologyRen Ji HospitalSchool of Medicine and School of Biomedical EngineeringShanghai Jiao Tong UniversityShanghai 200127China University of Chinese Academy of Sciences Beijing 100049China

Current cytotoxic T lymphocyte(CTL)activating immunotherapy requires a major histocompatibility complex I(MHC-I)-mediated presentation of tumor-associated antigens,which malfunctions in around half of patients with triple-negative breast cancer(TNBC).Here,we create a LCL161-loaded macrophage membrane decorated nanoparticle(LMN)for immunotherapy of MHC-I-deficient *** on the macrophage membrane helps LMNs recognize CD47-expressing cancer cells for targeted delivery of LCL161,which induces the release of high mobility group protein 1 and proinflammatory cytokines from cancer *** released cytokines and high mobility group protein 1 activate antitumor immunity by increasing the intratumoral density of the phagocytic macrophage subtype by 15 times and elevating the intratumoral concentration of CTL lymphotoxin by 4.6 *** also block CD47-mediated phagocytosis *** inhibit the growth of MHC-I-deficient TNBC tumors,as well as those resistant to combined therapy of anti-PDL1 antibody and albumin-bound paclitaxel,and prolong the survival of animals,during which process CTLs also play important *** macrophage membrane-decorated nanoparticle presents a generalizable platform for increasing macrophagemediated antitumor immunity for effective immunotherapy of MHC-I-deficient cancers.

关键词： MHC-I deficiency Macrophage CD47 Immunotherapy Triple-negative breast cancer Phagocytosis Immune checkpoint Innate immunity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Recent advances,challenges,and perspectives on carbon capture

引用

Frontiers of Environmental Science & Engineering 2024年第6期18卷 75-104页

作者： Shihan Zhang Yao shen Chenghang Zheng Qianqian Xu Yifang Sun Min Huang Lu Li Xiongwei Yang hao Zhou Heliang Ma Zhendong Li Yuanhang Zhang Wenqing Liu Xiang Gao Institute of Energy and Sustainable Development Zhejiang University of TechnologyHangzhou 310014China College of Environment Zhejiang University of TechnologyHangzhou 310014China Baima Lake Laboratory Hangzhou 310051China Institute of Carbon Neutrality College of Energy EngineeringZhejiang UniversityHangzhou 310027China State Key Joint Laboratory of Environmental Simulation and Pollution Control College of Environmental Sciences and EngineeringPeking UniversityBeijing 100871China Key Laboratory of Environmental Optics and Technology Anhui Institute of Optics and Fine MechanicsHFIPSChinese Academy of SciencesHefei 230031China

Carbon capture,utilization and storage(CCUS)technologies play an essential role in achieving Net Zero Emissions *** the lack of timely reviews on the recent advancements in promising CCUS technologies,it is crucial to provide a prompt review of the CCUS advances to understand the current research gaps pertained to its industrial *** that end,this review first summarized the developmental history of CCUS technologies and the current large-scale ***,based on a visually bibliometric analysis,the carbon capture remains a hotspot in the CCUS *** that the materials applied in the carbon capture process determines its *** a result,the state-of-the-art carbon capture materials and emerging capture technologies were comprehensively summarized and *** between state-of-art carbon capture process and its ideal counterpart are analyzed,and insights into the research needs such as material design,process optimization,environmental impact,and technical and economic assessments are provided.

关键词： Carbon capture,utilization and storage Visualization analysis Research hotspots and trends CO_(2)capture technology

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A survey for light field super-resolution

引用

High-Confidence Computing 2024年第1期4卷 118-129页

作者： Mingyuan Zhao hao sheng Da Yang Sizhe Wang Ruixuan Cong Zhenglong Cui Rongshan Chen Tun Wang Shuai Wang Yang Huang Jiahao shen State Key Laboratory of Virtual Reality Technology and Systems School of Computer Science and EngineeringBeihang UniversityBeijing 100191China Key Laboratory of Data Science and Intelligent Computing International Innovation InstituteBeihang UniversityHangzhou 311115China State Key Laboratory of Software Development Environment School of Computer Science and EngineeringBeihang UniversityBeijing 100191China

Compared to 2D imaging data,the 4D light field(LF)data retains richer scene’s structure information,which can significantly improve the computer’s perception capability,including depth estimation,semantic segmentation,and LF ***,there is a contradiction between spatial and angular resolution during the LF image acquisition *** overcome the above problem,researchers have gradually focused on the light field super-resolution(LFSR).In the traditional solutions,researchers achieved the LFSR based on various optimization frameworks,such as Bayesian and Gaussian *** learning-based methods are more popular than conventional methods because they have better performance and more robust generalization *** this paper,the present approach can mainly divided into conventional methods and deep learning-based *** discuss these two branches in light field spatial super-resolution(LFSSR),light field angular super-resolution(LFASR),and light field spatial and angular super-resolution(LFSASR),***,this paper also introduces the primary public datasets and analyzes the performance of the prevalent approaches on these ***,we discuss the potential innovations of the LFSR to propose the progress of our research field.

关键词： Light field super-resolution Convolutional neural network Transformer Sub-aperture image Epipolar-plane image

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Establishment and application of a surrogate model for human Ebola virus disease in BSL-2 laboratory

引用

Virologica Sinica 2024年第3期39卷 434-446页

作者： Wanying Yang Wujian Li Wujie Zhou shen Wang Weiqi Wang Zhenshan Wang Na Feng Tiecheng Wang ying Xie Yongkun Zhao Feihu Yan Xianzhu Xia Hebei Key Lab of Laboratory Animal Science Department of Laboratory Animal ScienceHebei Medical UniversityShijiazhuang050017China Key Laboratory of Jilin Province for Zoonosis Prevention and Control Changchun Veterinary Research InstituteChinese Academy of Agricultural SciencesChangchun130122China College of Veterinary Medicine Jilin UniversityChangchun130062China College of Veterinary Medicine Jilin Agricultural UniversityChangchun130118China

The Ebola virus(EBOV)is a member of the Orthoebolavirus genus,Filoviridae family,which causes severe hemorrhagic diseases in humans and non-human primates(NHPs),with a case fatality rate of up to 90%.The development of countermeasures against EBOV has been hindered by the lack of ideal animal models,as EBOV requires handling in biosafety level(BSL)-4 ***,accessible and convenient animal models are urgently needed to promote prophylactic and therapeutic approaches against *** this study,a recombinant vesicular stomatitis virus expressing Ebola virus glycoprotein(VSV-EBOV/GP)was constructed and applied as a surrogate virus,establishing a lethal infection in *** infection with VSV-EBOV/GP,3-week-old female Syrian hamsters exhibited disease signs such as weight loss,multi-organ failure,severe uveitis,high viral loads,and developed severe systemic diseases similar to those observed in human EBOV *** animals succumbed at 2–3 days post-infection(dpi).Histopathological changes indicated that VSV-EBOV/GP targeted liver cells,suggesting that the tissue tropism of VSV-EBOV/GP was comparable to wild-type EBOV(WT EBOV).Notably,the pathogenicity of the VSV-EBOV/GP was found to be species-specific,age-related,gender-associated,and challenge ***,equine anti-EBOV immunoglobulins and a subunit vaccine were validated using this ***,this surrogate model represents a safe,effective,and economical tool for rapid preclinical evaluation of medical countermeasures against EBOV under BSL-2 conditions,which would accelerate technological advances and breakthroughs in confronting Ebola virus disease.

关键词： Ebola virus(EBOV) Recombinant vesicular stomatitis virus Pathogenicity Syrian hamster Surrogate models Vaccine evaluation and drug screening

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Design of high-performance and sustainable Co-free Ni-rich cathodes for next-generation lithium-ion batteries

引用

SusMat 2024年第1期4卷 48-71页

作者： hao Ge Zhiwen shen Yanhong Wang Zhijia Sun Xiaoman Cao Chaoyue Wang Xinyue Fan Jinsong Bai Rundong Li Tianhua Yang Gang Wu School of Energy and Environment Shenyang Aerospace UniversityShenyangP.R.China shenyang Aircraft Airworthiness Certification Center of CAAC ShenyangP.R.China College of Chemistry and Materials Engineering Bohai UniversityJinzhouP.R.China Liaoning General Aviation Academy ShenyangP.R.China Department of Chemical and Biological Engineering University at BuffaloState University of New YorkBuffaloNew YorkUSA

Great attention has been given to high-performance and inexpensive lithiumion batteries(LIBs)in response to the ever-increasing demand for the explosive growth of electric vehicles(EVs).High-performance and low-cost Co-freeNi-rich layered cathodes are considered one of the most favorable candidates for nextgeneration LIBs because the current supply chain of EVs relies heavily on scarce and expensive ***,we review the recent research progress on Co-free Nirich layered cathodes,emphasizing on analyzing the necessity of replacing Co and the popular improvment *** current advancements in the design strategies of Co-free Ni-rich layered cathodes are summarized in *** considerable improvements achieved so far,the main technical challenges contributing to the deterioration of Co-free Ni-rich cathodes such as detrimental phase transitions,crack formation,and severe interfacial side reactions,are difficult to resolve by a single *** cooperation of multiple modification strategies is expected to accelerate the industrialization of Co-free Ni-rich layered cathodes,and the corresponding synergistic mechanisms urgently need to be *** effects will be aroused to explore high-performance Co-free Ni-rich layered cathodes to promote the sustainable development of LIBs.

关键词： Co-free cathodes electrochemical performance lithium-ion batteries modification strategies Ni-rich layered cathodes

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Suppression of intervalley scattering and enhanced phonon anharmonic interactions in 2D Bi_(2)TeSe_(2):Crystal-field symmetry and band convergence

引用

Journal of Materiomics 2024年第2期10卷 386-395页

作者： Lei Peng Ao Wu Yujie Xia haotian Zhang Yuting Yang Hezhu Shao ying Chen Juan Zhang Le Shu Heyuan Zhu Yuxiang Zheng hao Zhang School of Information Science and Technology Department of Optical Science and EngineeringFudan UniversityShanghai 200433China College of Electrical and Electronic Engineering Wenzhou UniversityWenzhou 325035China Department of Light Sources and Illuminating Engineering Fudan UniversityShanghai 200433China Yiwu Research Institute of Fudan University Yiwu 322000China

The electron-phonon(el-ph)and phonon-phonon interactions play a key role in determining electronic and thermal transport properties,respectively,in promising two-dimensional(2D)semiconductor *** this study,we investigated el-ph interactions using Wannier-Fourier interpolation method and renormalized phonon scattering considering finite-temperature effects in Bi_(2)TeSe_(2)*** re-sults show that the optical phonon modes dominate the carrier scattering,where level repulsion induced by crystal field splitting and spin-orbit coupling(SOC)effect effectively suppresses intervalley scattering,leading to high hole ***,the strong anharmonicity in Bi_(2)TeSe_(2)monolayer results in the temperature-dependent softening of its optical phonons,along with a corresponding variation in interatomic force constants(IFCs).As a result,the lattice thermal conductivity is remarkably low and exhibits weak temperature ***,the predicted dimensionless thermoelectric figure of merit exceeds unity in the range of 200-800 K,indicating the potential of Bi_(2)TeSe_(2)monolayer for thermoelectric *** work provides new insights into the elimination of intervalley scat-tering by crystal field splitting and SOC effects,and paves the way for the evaluation of thermoelectric properties of materials with complex scattering mechanisms and strong anharmonicity.

关键词： El-ph interactions Crystal field splitting Spin-orbit coupling Intervalley scattering Renormalized phonon scattering

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Upregulated lncRNA PRNT promotes progression and oxaliplatin resistance of colorectal cancer cells by regulating HIPK2 transcription

引用

World Journal of Gastrointestinal Oncology 2024年第4期16卷 1564-1577页

作者： Sai-Nan Li Shan Yang hao-Qi Wang Tian-Li Hui Meng Cheng Xi Zhang Bao-Kun Li Gui-ying Wang The First Department of Surgery The Fourth Hospital of Hebei Medical UniversityShijiazhuang 050011Hebei ProvinceChina The Second Department of Surgery The Fourth Hospital of Hebei Medical UniversityShijiazhuang 050011Hebei ProvinceChina Department of General Surgery The Second Hospital of Hebei Medical UniversityShijiazhuang 050000Hebei ProvinceChina

BACKGROUND Colorectal cancer(CRC)is the third most common cancer and a significant cause of cancer-related mortality *** to chemotherapy,especially during CRC treatment,leads to reduced effectiveness of drugs and poor patient *** noncoding RNAs(lncRNAs)have been implicated in various pathophysiological processes of tumor cells,including chemotherapy resistance,yet the roles of many lncRNAs in CRC remain *** To identify and analyze the lncRNAs involved in oxaliplatin resistance in CRC and to understand the underlying molecular mechanisms influencing this *** Gene Expression Omnibus datasets GSE42387 and GSE30011 were reanalyzed to identify lncRNAs and mRNAs associated with oxaliplatin *** bioinformatics tools were employed to elucidate molecular *** expression levels of lncRNAs and mRNAs were assessed via quantitative reverse transcription-polymerase chain *** assays,including MTT,wound healing,and Transwell,were conducted to investigate the functional implications of lncRNA *** between lncRNAs and trans-cription factors were examined using RIP and luciferase reporter assays,while Western blotting was used to confirm downstream ***,a xenograft mouse model was utilized to study the in vivo effects of lncRNAs on chemotherapy *** LncRNA prion protein testis specific(PRNT)was found to be upregulated in oxaliplatin-resistant CRC cell lines and negatively correlated with homeodomain interacting protein kinase 2(HIPK2)*** was demonstrated to sponge transcription factor zinc finger protein 184(ZNF184),which in turn could regulate HIPK2 *** expression of PRNT influenced CRC cell sensitivity to oxaliplatin,with overexpression leading to decreased sensitivity and decreased expression reducing *** RIP and luciferase reporter assays indicated that ZNF184 and HIPK2 are targets of *** PRNT/ZNF184

关键词： Colorectal cancer Oxaliplatin resistance Prion protein testis specific Zinc finger protein 184 Homeodomain interacting protein kinase 2

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Feasibility of acupuncture as an adjunct intervention for ovulatory disorder infertility:A systematic review and meta-analysis

引用

World Journal of Clinical Cases 2024年第22期12卷 5108-5123页

作者： Yu-Qi Chen Tao shen ying Lv Mei-Hong shen Department of Acupuncture and Tuina Rehabilitation Kunshan Affiliated Hospital of Nanjing University of Traditional Chinese MedicineKunshan 210023Jiangsu ProvinceChina School of Acupuncture-Moxibustion and Tuina Nanjing University of Traditional Chinese MedicineNanjing 210023Jiangsu ProvinceChina Department of Traditional Chinese Medicine Kunshan Rehabilitation HospitalKunshan 215300Jiangsu ProvinceChina

BACKGROUND Acupuncture(AT)is widely used in treatment of ovulatory disorder infertility(ODI),but the safety and efficacy of AT for ODI still lack an evidence-based *** To evaluate the feasibility and effectiveness of AT as an adjunct intervention for *** The Cochrane Library,Embase,PubMed,VIP,China National Knowledge Infrastructure,WanFang Data,and Chinese biomedical literature databases were searched from inception to January 20,*** reviewers independently selected studies,collected data,and evaluated methodological quality through the Cochrane Risk of Bias *** 5.4 was used for meta-analysis,and the Grade system was performed to evaluate the level of evidence for the outcomes of the *** A total of 20 randomized controlled trials with 1677 ODI patients were *** with the clomiphene citrate(CC)group,the AT plus CC group exhibited significant improvement of the pregnancy rate[relative risk(RR)=1.68,95%confidence interval(CI):1.45-1.95,P<0.00001,I^(2)=23%],ovulation rate(RR=1.34,95%CI:1.22-1.47,P<0.00001,I^(2)=32%),serum E2 level[mean difference(MD)=31.36,95%CI:21.83-40.88,P<0.00001,I^(2)=97%],thickness of endometrium(MD=1.76,95%CI:0.71-2.81,P=0.001,I^(2)=98%)and decreasing miscarriage rate(RR=0.25,95%CI:0.09-0.65,P=0.005,I^(2)=0%),serum follicle-stimulating hormone level(MD=-2.10,95%CI:-3.27 to-0.94,P=0.0004,I^(2)=99%),serum luteinizing hormone level(MD=-6.94,95%CI:-9.89 to-4.00,P<0.00001,I^(2)=100%),and serum progesterone level(MD=-1.66,95%CI:-2.98 to-0.34,P=0.01,I^(2)=96%).The AT group had a more favorable effect than CC group for improving pregnancy rate(RR=1.52,95%CI:1.33-1.73,P<0.00001,I^(2)=0%),thickness of endometrium(MD=2.48,95%CI:2.15-2.81,P<0.00001,I^(2)=0%)and reducing miscarriage rate(RR=0.23,95%CI:0.13-0.44,P<0.00001,I^(2)=0%),serum follicle-stimulating hormone level(MD=-0.55,95%CI:-0.86 to-0.24,P=0.0005,I^(2)=0%),and serum progesterone level(MD=-0.24,95%CI:-0.28 to-0.20,P<0.00001).However,the leve

关键词： Acupuncture Ovulatory disorder Infertility Pregnancy Meta-analysis Systematic review

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Simultaneous fluorescence and Compton scattering computed tomography based on linear polarization X-ray

引用

NUCLEAR SCIENCE AND TECHNIQUES 2024年第10期35卷 1-10页

作者： Chi, Zhi-Jun Zhang, Hong-Ze Lin, Jin Zhang, Xuan-Qi Ding, hao Tian, Qi-Li Zhang, Zhi Du, ying-Chao Huang, Wen-Hui Tang, Chuan-Xiang Beijing Normal Univ Sch Phys & Astron Minist Educ Key Lab Beam Technol Beijing 100875 Peoples R China Tsinghua Univ Minist Educ Dept Engn Phys Key Lab Particle & Radiat Imaging Beijing 100084 Peoples R China

PurposeTo propose a method for simultaneous fluorescence and Compton scattering computed tomography by using linearly polarized *** Carlo simulations were adopted to demonstrate the feasibility of the proposed method. In the simulations, the phantom is a polytetrafluoroethylene cylinder inside which are cylindrical columns containing aluminum, water, and gold (Au)-loaded water solutions with Au concentrations ranging between 0.5 and 4.0 wt%, and a parallel-hole collimator imaging geometry was adopted. The light source was modeled based on a Thomson scattering X-ray source. The phantom images for both imaging modalities were reconstructed using a maximumlikelihood expectation maximization *** the X-ray fluorescence computed tomography (XFCT) and Compton scattering computed tomography (CSCT) images of the phantom were accurately reconstructed. A similar attenuation contrast problem for the different cylindrical columns in the phantom can be resolved in the XFCT and CSCT images. The interplay between XFCT and CSCT was analyzed, and the contrast-to-noise ratio (CNR) of the reconstruction was improved by correcting for the mutual influence between the two imaging modalities. Compared with K-edge subtraction imaging, XFCT exhibits a CNR advantage for the *** XFCT and CSCT can be realized by using linearly polarized X-rays. The synergy between the two imaging modalities would have an important application in cancer radiation therapy

关键词： X-ray fluorescence computed tomography Compton scattering computed tomography Linear polarization Thomson scattering X-ray source Monte Carlo simulation DUAL-ENERGY CT NANOPARTICLE-LOADED OBJECTS ATTENUATION COEFFICIENTS XFCT PARAMETRIZATION FEASIBILITY ELEMENTS

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Polarization-dependent photoinduced metal–insulator transitions in manganites

引用

Science Bulletin 2024年第2期69卷 183-189页

作者： Lina Deng Weiye Zhang Hanxuan Lin Lifen Xiang ying Xu Yadi Wang Qiang Li Yinyan Zhu Xiaodong Zhou Wenbin Wang Lifeng Yin Hangwen Guo Chuanshan Tian Jian shen State Key Laboratory of Surface Physics Institute for Nanoelectronic Devices and Quantum Computingand Department of PhysicsFudan UniversityShanghai 200433China Shanghai Research Center for Quantum Sciences Shanghai 201315China Zhangjiang Fudan International Innovation Center Fudan UniversityShanghai 201210China Collaborative Innovation Center of Advanced Microstructures Nanjing 210093China Shanghai Branch CAS Center for Excellence and Synergetic Innovation Center in Quantum Information and Quantum PhysicsShanghai 201315China

In correlated oxides,collaborative manipulation on light intensity,wavelength,pulse duration and polarization has yielded many exotic discoveries,such as phase transitions and novel quantum *** view of potential optoelectronic applications,tailoring long-lived static properties by light-induced effects is highly *** far,the polarization state of light has rarely been reported as a control parameter for this ***,we report polarization-dependent metal-to-insulator transition(MIT)in phaseseparated manganite thin films,introducing a new degree of freedom to control static ***,we observed giant photoinduced resistance jumps with striking features:(1)a single resistance jump occurs upon a linearly polarized light incident with a chosen polarization angle,and a second resistance jump occurs when the polarization angle changes;(2)the amplitude of the second resistance jump depends sensitively on the actual change of the polarization *** transmittance measurements reveal that the origin of the above phenomena is closely related to the coexistence of anisotropic *** results represent a first step to utilize light polarization as an active knob to manipulate static phase transitions,pointing towards new pathways for nonvolatile optoelectronic devices and sensors.

关键词： Metal-insulator phase transitions Polarization of light Electronic phase separation Selective domain controllability

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：