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Acute pancreatitis-induced thrombotic thrombocytopenic purpura:A case report

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World Journal of Clinical Cases 2022年第12期10卷 3808-3813页

作者： chun-Hua Wang Hai-Feng Jin Wen-Ge Liu ying guo Zhen Liu Department of Gastroenterology The 980^(th) Hospital of the People's Liberation Army Joint Service(Bethune International Peace Hospital)Shijiazhuang 050082Hebei ProvinceChina

BACKGROUND Thrombotic thrombocytopenic purpura(TTP)is a life-threatening but treatable *** pancreatitis is a well-described consequence of TTP,but TTP as a consequence of acute pancreatitis is *** SUMMARY A 32-year-old male developed acute pancreatitis due to a fatty diet and suffered splenectomy 3 years ago due to *** day 4 of his onset of pain the blood examination showed the platelet extremely reduced,bilirubin elevated and creatinine *** clinical suspicion of TTP was made and prompt initiation of plasma exchange was given followed intravenous drip *** 7 sessions of plasm exchange and the laboratory parameters were back to normal and the patient was discharged from the hospital on the 13th day of *** Patients develop acute pancreatitis with no apparent causes for hemolytic anemia and thrombocytopenia,the possibility of TTP should be *** for TTP including plasm exchange should be evaluated as soon as a diagnosis is made.

关键词： Thrombotic thrombocytopenic purpura Acute pancreatitis Case report Plasm exchange Glucocorticoid

Autophagy in pancreatic cancer

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Journal of Molecular Cell Biology 2021年第11期13卷 786-790页

作者： Congting guo ying Zhao Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function Department of Biochemistry and Molecular BiologySchool of Basic Medical SciencesPeking University Health Science CenterBeijing 100191China

Macroautophagy(hereafter referred to as autophagy)is a conserved eukaryotic process,in which dysfunctional proteins,organelles,and other macromolecules are wrapped in intracellular vesicles called autophagosomes and delivered to lysosomes for degradation(Mizushima et al.,2008;Mizushima and Komatsu,2011).Autophagy restores cellular energy and recycles cytoplasmic precursors,sustaining cell homeostasis and cell survival(Mizushima et al.,2008;Mizushima and Komatsu,2011).Elevated autophagy can be detected in both cancer cells and surrounding stromal cells in pancreatic cancer(PC),affecting tumor initiation and progression as well(Yang et al.,2011;Endo et al.,2017).The role of autophagy in PC is highly ***,we illustrate the multifactorial role of autophagy in PC,and the significance of autophagy will be emphasized not only in cancer cells but also in the tumor microenvironment.

关键词： al. cancer homeostasis

Efficient application of carbon-based nanomaterials for high-performance perovskite solar cells

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Rare Metals 2021年第10期40卷 2747-2762页

作者： ying-chun Niu Li-Feng Yang M.H.Aldamasy Meng Li Wen-Jie Lan Quan Xu Yuan Liu Shang-Lei Feng ying-guo Yang State Key Laboratory of Heavy Oil Processing China University of PetroleumBeijing 102249China Shanghai Synchrotron Radiation Facility(SSRF) Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201204China Shanghai Institute of Applied Physics Chinese Academy of SciencesUniversity of Chinese Academy of SciencesShanghai 201800China Helmholtz-Zentrum Berlin für Materialien und Energie Berlin 12489Germany M.H.Aldamasy Egyptian Petroleum Research InstituteCairo 11727Egypt Egyptian Petroleum Research Institute Cairo 11727Egypt Key Laboratory of the Ministry of Education for Optoelectronic Measurement Technology and Instrument Beijing Information Science and Technology UniversityBeijing 100192China

The power conversion efficiency of perovskite solar cells(PSCs) has rapidly risen from 3.8% to over25.0% in just about one decade, which attracts a lot of attention from the scientific and engineering ***, some challenges remain, hindering the progress of commercialization such as intrinsic and extrinsic(environmental) stabilities, which can be improved by an interface and structural engineering. In recent years, some reports indicate that the interfacial engineering using carbon-based nanomaterials additives plays a crucial role in the process of charge carriers and perovskite crystal growth and thereby enhances device performance and operational stability. Here, we review the development of the varieties of carbon-based nanomaterials applications in PSCs, such as hole-transporting layers(HTLs), electron-transporting layers(ETLs), perovskite bulk layer, and their ***, we proposed a further suggestion about the optimized preparation conditions for the preparation of PSCs, which may inspire the researcher to discover, design,and manufacture the more efficient perovskite solar cells in academic and industry.

关键词： Carbon-based nanomaterials Perovskite solar cells Stability Efficiency

Corrosion fatigue behavior of epoxy-coated Mg–3Al–1Zn alloy in NaCl solution

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Rare Metals 2014年第3期33卷 276-286页

作者： Xiu-Li He ying-Hui Wei Li-Feng Hou Zhi-Feng Yan chun-Li guo Peng-Ju Han College of Materials Science and Engineering Taiyuan University of Technology Department of Chemistry Luliang College

The corrosion fatigue behavior of epoxy-coated Mg-3Al-1Zn alloy was investigated in air and 3.5 wt%NaCl solution. Epoxy coating as a new method was used to improve the corrosion fatigue property of the *** show that the fatigue limit（FL） of the coated specimens is higher than that of the uncoated specimens in3.5 wt% NaCl solution because of the strengthening and blocking functions of the epoxy coating. The FL of the coated specimens in 3.5 wt% NaCl solution is as high as that in air. It implies that the coated specimens are not as sensitive to the environment as the magnesium alloy. The low tensile strength and the short elongation of the pure epoxy coating lead to that the fatigue crack of the coated specimen is always initiated from the epoxy-coating film Pores and pinholes accelerate the fatigue crack initiation process. Pinholes are caused by the corrosion reactions between the epoxy coating and the NaCl solution.

关键词： Epoxy coating Corrosion fatigue Magnesium alloy 3.5 wt% NaCl solution FatigueCrack initiation

Effects of the extrusion parameters on microstructure,texture and room temperature mechanical properties of extruded Mg-2.49Nd-1.82Gd-0.2Zn-0.2Zr alloy

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 136-146页

作者： Chenjin Zhang Guangyu Yang Lei Xiao Zhiyong Kan Jing guo Qiang Li Wanqi Jie State Key Laboratory of Solidification Processing Northwestern Polytechnical UniversityXi’an 710072China College of Materials Science and Engineering Fuzhou UniversityFuzhou 350108China College of Chemistry and Environmental Science Qujing Normal UniversityQujing 655011China

Microstructure,texture,and mechanical properties of the extruded Mg-2.49Nd-1.82Gd-0.2Zn-0.2Zr alloy were investigated at different extrusion temperatures(260 and 320℃),extrusion ratios(10:1,15:1,and 30:1),and extrusion speeds(3 and 6 mm/s).The experimental results exhibited that the grain sizes after extrusion were much finer than that of the homogenized alloy,and the second phase showed streamline distribution along the extrusion direction(ED).With extrusion temperature increased from 260 to 320℃,the microstructure,texture,and mechanical properties of alloys changed *** dynamic recrystallization(DRX)degree and grain sizes enhanced as the extrusion ratio increased from 10:1 to 30:1,and the strength gradually decreased but elongation(EL)*** the extrusion speed increased from 3 to 6 mm/s,the grain sizes and DRX degree increased significantly,and the samples presented the typical-rare-earth(RE)*** alloy extruded at 260℃ with extrusion ratio of 10:1 and extrusion speed of 3 mm/s showed the tensile yield strength(TYS)of 213 MPa and EL of 30.6%.After quantitatively analyzing the contribution of strengthening mechanisms,it was found that the grain boundary strengthening and dislocation strengthening played major roles among strengthening *** results provide some guidelines for enlarging the industrial application of extruded Mg-RE alloy.

关键词： Mg-rare earth alloys extrusion temperature extrusion ratio extrusion speed strengthening mechanisms

Ultra‑High Sensitivity Anisotropic Piezoelectric Sensors for Structural Health Monitoring and Robotic Perception

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Nano-Micro Letters 2025年第2期17卷 432-446页

作者： Hao Yin Yanting Li Zhiying Tian Qichao Li Chenhui Jiang Enfu Liang Yiping guo State Key Laboratory of Metal Matrix Composites School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240People’s Republic of China Beijing Vacuum Electronics Research Institute Beijing 100015People’s Republic of China Fundamental Science On Vibration Shock and Noise LaboratoryState Key Laboratory of Mechanical System and VibrationSchool of Mechanical EngineeringShanghai Jiao Tong UniversityShanghai 200240People’s Republic of China

Monitoring minuscule mechanical signals,both in magnitude and direction,is imperative in many application scenarios,e.g.,structural health monitoring and robotic sensing ***,the piezoelectric sensor struggles to satisfy the requirements for directional recognition due to the limited piezoelectric coefficient matrix,and achieving sensitivity for detecting micrometer-scale deformations is also ***,we develop a vector sensor composed of lead zirconate titanate-electronic grade glass fiber composite filaments with oriented arrangement,capable of detecting minute anisotropic *** as-prepared vector sensor can identify the deformation directions even when subjected to an unprecedented nominal strain of 0.06%,thereby enabling its utility in accurately discerning the 5μm-height wrinkles in thin films and in monitoring human pulse *** ultra-high sensitivity is attributed to the formation of porous ferroelectret and the efficient load transfer efficiency of continuous lead zirconate titanate ***,when integrated with machine learning techniques,the sensor’s capability to recognize multi-signals enables it to differentiate between 10 types of fine textures with 100%*** structural design in piezoelectric devices enables a more comprehensive perception of mechanical stimuli,offering a novel perspective for enhancing recognition accuracy.

关键词： Flexible piezoelectric filaments Anisotropic Ultra-high sensitivity Structural health detection Texture recognition

Structure and Thermal Stability of a One-dimensional Chain Cobalt Coordination Polymer [Co(phen)(2,4,6-TMBA)_2(H_2O)]_n

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Chinese Journal of Structural Chemistry 2006年第6期25卷 752-756页

作者： YANG ying-Qun LI Chang-Hong LI Wei ZHANG chun-Hua guo Dong-Cai KANG Yun-Fei Department of Chemistry and Materials Science Hengyang Normal University Hengyang 421008 China College of Chemistry and Chemical Engineering Hunan University Changsha 410082 China Department of Chemical Engineering Hunan Institute of Technology Hengyang 421008 China

A one-dimensional chain cobalt（Ⅱ） coordination polymer with 2,4,6-trimethylbenzoic acid, 1,10-phenanthroline and cobalt perchlorate anhydrous has been synthesized in the solvent mixture of water/methanol and characterized. Crystal data for this complex： tetragonal, space group I41, a = 2.0356（2）, c = 1.3779（3） nm, V= 5.7096（15） nm^3, Mr= 581.51,μ（MoKa） = 0.644, Dc = 1.353 g/cm^3, Z = 8, F（000） = 2424, final S = 1.005, R = 0.0404 and wR = 0.0865. The crystal structure shows that the cobalt ion is coordinated with two nitrogen atoms of one 1,10-phenanthroline molecule, three oxygen atoms from three 2,4,6-trimethylbenzoic acid molecules and one water molecule, giving a distorted octahedral coordination geometry. The result of TG analysis indicates that the title complex is stable till 200 ℃.

关键词： cobalt(Ⅱ) complex crystal structure thermal stability analysis

Early active immunization with Aβ3–10-KLH vaccine reduces tau phosphorylation in the hippocampus and protects cognition of mice

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Neural Regeneration Research 2020年第3期15卷 519-527页

作者： Jin-chun Wang Kun Zhu Hui-Yi Zhang guo-Qing Wang Hui-ying Liu Yun-Peng Cao Department of Neurology the Fifth People’s Hospital of ShenyangShenyangLiaoning ProvinceChina Department of Neurology the First Hospital of China Medical UniversityShenyangLiaoning ProvinceChina

Active and passive anti-Aβimmunotherapies have successfully been used for the prevention and treatment of Alzheimer’s disease animal ***,clinical use of these immunotherapies is not effective,because the vaccination is administered too *** 1 month of age,100μL of Aβ3–10-KLH peptide(vaccine,2μg/μL)was subcutaneously injected into the neck of an amyloid precursor protein/presenilin-1/tau transgenic(3×Tg-AD)mouse model.Aβ3–10-KLH peptide was re-injected at 1.5,2.5,3.5,4.5,5.5,and 6.5 months of *** levels of Aβantibody were detected by enzyme-linked immunosorbent assay,while spatial learning and memory ability were evaluated by Morris water *** was used to detect total tau with HT7 and phosphorylated tau with AT8(phosphorylation sites Ser202 and Thr205)and AT180(phosphorylation site Thr231)antibodies in the *** addition,western blot analysis was used to quantify AT8 and AT180 expression in the *** results showed that after vaccine injection,mice produced high levels of Aβantibody,cognitive function was significantly improved,and total tau and phosphorylated tau levels were significantly *** findings suggest that early active immunization with Aβ3–10-KLH vaccine can greatly reduce tau phosphorylation,thereby mitigating the cognitive decline of 3×Tg-AD *** study was approved by the Animal Ethics Committee of China Medical University,China(approval No.103-316)on April 2,2016.

关键词： 3×Tg-AD Aβ3–10-KLH vaccine Alzheimer’s disease amyloid precursor protein amyloid-beta cognitive decline tau phosphorylation transgenic mouse

Synthesis and electrochemical properties of a chiral silyl-substituted tetrathiafulvalene derivative

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Chinese Chemical Letters 2014年第4期25卷 579-582页

作者： guo-Qi Liang Zhong-Bao Zhang Hong-Qi Li Ya-Ping Wang chun-ying Xian College of Chemistry Chemical Engineering and BiotechnologyDonghua University

A new chiral tetrathiafulvalene （TTF） derivative and related silyl-substituted 1,3-dithiole-2-（thi）one compounds were synthesized and characterized by 1H NMR, 13C NMR, MS and IR spectra. Single crystal structure of the silyl-substituted 1,3-dithiole-2-one revealed the high degree of conjugation of the five- membered ring moiety in the compound. The electrochemical properties of the new TTF derivative were studied by cyclic voltammetry and the results indicated that the electron-donating ability of the chiral TI＂F derivative was similar to that of BEDT-TTF. The AE value for the new TTF derivative was smaller than those for TTF and BEDT-TrF, indicative of decreased Coulombic repulsion in the dicationic redox state. Formation of charge-transfer （CT） complex between the new donor and electron acceptor 2,3-dichloro-5,6-dicvano-1,4-benzocluinone （DDO） was demonstrated.

关键词： Tetrathiafulvalene Chiral Silyl Electrochemistry