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Investigation of influence factors on CO_(2) flowback characteristics and optimization of flowback parameters during CO_(2) dry fracturing in tight gas reservoirs

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Petroleum Science 2023年第6期20卷 3553-3566页

作者： Xiao-Mei Zhou Lei Li Yong-Quan Sun Ran Liu ying-chun guo Yong-Mao Hao Yu-Liang Su National Key Laboratory of Deep Oil and Gas China University of Petroleum(East China)Qingdao266580ShandongChina School of Petroleum Engineering China University of Petroleum(East China)Qingdao266580ShandongChina Shengli Oil Field Dongsheng Jinggong Petroleum Development(GROUP)Stock Co. Ltd.Dongying257000ShandongChina Exploration and Development Research Institute of Shengli Oilfield Company SinopecDongying257000ShandongChina

CO_(2) dry fracturing is a promising alternative method to water fracturing in tight gas reservoirs,especially in water-scarce areas such as the Loess *** CO_(2) flowback efficiency is a critical factor that affects the final gas production ***,there have been few studies focusing on the flowback characteristics after CO_(2) dry *** this study,an extensive core-to-field scale study was conducted to investigate CO_(2) flowback characteristics and CH_(4) production ***,to investigate the impact of core properties and production conditions on CO_(2) flowback,a series of laboratory experiments at the core scale were ***,the key factors affecting the flowback were analyzed using the grey correlation method based on field ***,taking the construction parameters of Well S60 as an example,a dual-permeability model was used to characterize the different seepage fields in the matrix and fracture for tight gas *** production parameters after CO_(2) dry fracturing were then *** results demonstrate that CO_(2) dry fracturing is more effective than slickwater fracturing,with a 9.2%increase in CH_(4) *** increase in core permeability plays a positive role in improving CH_(4) production and CO_(2) *** soaking process is mainly affected by CO_(2) diffusion,and the soaking time should be controlled within 12 *** the flowback pressure gradient results in a significant increase in both CH_(4) recovery and CO_(2) flowback ***,an increase in CO_(2) injection is not conducive to CH_(4) production and CO_(2) *** on the experimental and field data,the important factors affecting flowback and production were comprehensively and effectively *** results show that permeability is the most important factor,followed by porosity and effective *** flowback efficiency and the influence of proppant reflux,the injection volume should

关键词： CO_(2)fracturing Tight gas reservoir Fracturing fluid flowback Parameter optimization

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基于密度峰值的重叠社区发现算法

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吉林大学学报（工学版） 2017年第1期47卷 242-248页

作者：时小虎冯国香李牧李瑛吴春国吉林大学计算机科学与技术学院长春130012 吉林大学符号计算与知识工程教育部重点实验室长春130012 吉林大学珠海学院计算机科学与技术系广东珠海519041 吉林大学珠海学院符号计算与知识工程教育部重点实验室珠海分实验室广东珠海519041

根据基于快速搜索和发现密度峰值的聚类方法的思想,提出了基于密度峰值的重叠社区发现算法。首先定义新的距离矩阵算法,克服了邻接矩阵元素为整数的缺陷。然后用概率形式刻画每个节点属于不同类别的可能性,从而实现了重叠社区的划分。... 详细信息

根据基于快速搜索和发现密度峰值的聚类方法的思想,提出了基于密度峰值的重叠社区发现算法。首先定义新的距离矩阵算法,克服了邻接矩阵元素为整数的缺陷。然后用概率形式刻画每个节点属于不同类别的可能性,从而实现了重叠社区的划分。基于真实网络的实验结果验证了本文算法的可行性和有效性。

关键词：计算机应用复杂网络社区发现重叠社区小世界特性模块度

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三七总皂苷对载脂蛋白E基因敲除小鼠脾脏单个核细胞白细胞介素17A、白细胞介素10和肿瘤坏死因子α表达的影响

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中国动脉硬化杂志 2016年第10期24卷 978-982页

作者：刘桂林窦迎春郭雪峰李亨山东中医药大学第二附属医院心内科山东省济南市250001 山东中医药大学基础医学院山东省济南市250355 山东大学附属山东省千佛山医院山东省济南市250012

目的研究三七总皂苷(TPNS)对动脉粥样硬化(As)小鼠脾脏单个核细胞白细胞介素17A(IL-17A)、肿瘤坏死因子α(TNF-α)和白细胞介素10(IL-10)表达的影响。方法载脂蛋白E基因敲除(Apo E-/-)小鼠高脂饮食喂养,小鼠20周龄时分为模型组及TPNS大... 详细信息

目的研究三七总皂苷(TPNS)对动脉粥样硬化(As)小鼠脾脏单个核细胞白细胞介素17A(IL-17A)、肿瘤坏死因子α(TNF-α)和白细胞介素10(IL-10)表达的影响。方法载脂蛋白E基因敲除(Apo E-/-)小鼠高脂饮食喂养,小鼠20周龄时分为模型组及TPNS大、小剂量组。用药组分别给予TPNS 40 mg/kg、120 mg/kg灌胃8周。采用全自动生化分析仪检测各组小鼠血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDLC)浓度;HE染色观察斑块形态并计算斑块面积/管腔面积;ELISA法检测小鼠脾脏单个核细胞IL-17A、IL-10和TNF-α表达。结果 TPNS可以降低Apo E-/-小鼠的血清TC、TG、LDLC浓度,大剂量组TC、TG、LDLC浓度分别为16.4±2.2 mmol/L、1.36±0.23 mmol/L和5.9±1.2 mmol/L,模型组TC、TG、LDLC浓度分别为28.2±4.0 mmol/L、2.08±0.17 mmol/L和10.0±1.9 mmol/L,差异有显著性(P均<0.001)。TPNS有延缓As斑块形成的作用(模型组及大、小剂量TPNS组的斑块面积/管腔面积分别为31.3%±5.1%、14.1%±5.0%和24.2%±4.9%,P均<0.05)。大剂量TPNS可以提高小鼠脾脏单个核细胞的IL-10表达,与模型组相比差异有显著性(40.9±2.2比36.3±2.8,P<0.05),小剂量TPNS组略有升高趋势,但差异无统计学意义。TPNS可以降低小鼠脾脏单个核细胞IL-17A和TNF-α的表达,以大剂量组效果显著,差异有统计学意义(IL-17A 18.1±1.5比22.8±3.1,P<0.05;TNF-α18.3±1.2比22.9±0.7,P<0.001)。结论 TPNS可以降低Apo E-/-小鼠血清TC、TG、LDLC的水平,升高脾脏单个核细胞IL-10的表达,同时降低IL-17A和TNF-α的表达,这可能是其抗As的重要机制之一。

关键词：三七总皂苷动脉粥样硬化白细胞介素17A 白细胞介素10 肿瘤坏死因子α

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Effect of Nb-V microalloying on the hot deformation behavior of medium Mn steels

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 360-368页

作者： Yumeng Wang Qinyi guo Bin Hu Haiwen Luo School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China

The influence of Nb-V microalloying on the hot deformation behavior and microstructures of medium Mn steel(MMS)was investigated by uniaxial hot compression *** establishing the constitutive equations for simulating the measured flow curves,we successfully constructed deformation activation energy(Q)maps and processing maps for identifying the region of flow *** concluded the following consequences of Nb-V alloying for MMS.(i)The critical strain increases and the increment diminishes with the increasing deformation temperature,suggesting that NbC precipitates more efficiently retard dynamic recrystallization(DRX)in MMS compared with solute Nb.(ii)The deformation activation energy of MMS is significantly increased and even higher than that of some reported high Mn steels,suggesting that its ability to retard DRX is greater than that of the high Mn content.(iii)The hot workability of MMS is improved by narrowing the hot processing window for the unstable flow stress,in which fine recrystallized and coarse unrecrystallized grains are present.

关键词： medium manganese steel niobium-vanadium microalloying flow behavior dynamic recrystallization hot workability

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Rock fracture mechanism of buffer blasting with cushion layer at the borehole bottom

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 325-334页

作者： Xinguang Zhu Chenxi Ding Zhe Sui Hong Su Xu guo School of Civil and Resources Engineering University of Science and Technology BeijingBeijing 100083China Key Laboratory for Mechanics in Fluid Solid Coupling Systems Institute of MechanicsChinese Academy of SciencesBeijing 100190China School of Mechanics and Civil Engineering China University of Mining and Technology(Beijing)Beijing 100083China School of Chemical and Blasting Engineering Anhui University of Science and TechnologyHuainan 232001China

This study primarily investigates the rock fracture mechanism of bottom cushion layer blasting and explores the effects of the bottom cushion layer on rock *** involves analyses of the evolution patterns of blasting stress,characteristics of crack distribution,and rock fracture features in the ***,blasting model experiments were carried out using the dynamic caustics principle to investigate the influence of bottom cushion layers and initiation methods on the integrity of the bottom rock *** experimental results indicate that the combined use of bottom cushion layers and inverse initiation effectively protects the integrity of the bottom rock ***,the process of stress wave propagation and dynamic crack propagation in rocks was simulated using the continuum-discontinuum element method(CDEM)and the Landau explosion source model,with varying thicknesses of bottom cushion *** numerical simulation results indicate that with increasing cushion thickness,the absorption of energy generated by the explosion becomes more pronounced,resulting in fewer cracks in the bottom rock *** illustrates the positive role of the cushion layer in protecting the integrity of the bottom rock mass.

关键词： bottom cushion layer blasting crack propagation continuum-discontinuum element method dynamic stress intensity factor

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Reducing the measurement errors in nonadiabatic holonomic quantum computers

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 64-70页

作者： guo-Fu Xu Department of Physics Shandong University

Nonadiabatic holonomic quantum computers serve as the physical platform for nonadiabatic holonomic quantum *** quantum computation has entered the noisy intermediate-scale era, building accurate intermediate-scale nonadiabatic holonomic quantum computers is clearly necessary. Given that measurements are the sole means of extracting information, they play an indispensable role in nonadiabatic holonomic quantum computers. Accordingly, developing methods to reduce measurement errors in nonadiabatic holonomic quantum computers is of great importance. However, while much attention has been given to the research on nonadiabatic holonomic gates, the research on reducing measurement errors in nonadiabatic holonomic quantum computers is severely lacking. In this study, we propose a measurement error reduction method tailored for intermediate-scale nonadiabatic holonomic quantum computers. The reason we say this is because our method can not only reduce the measurement errors in the computer but also be useful in mitigating errors originating from nonadiabatic holonomic gates. Given these features,our method significantly advances the construction of accurate intermediate-scale nonadiabatic holonomic quantum computers.

关键词： quantum holonomy quantum computation measurement errors

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Loss-of-function mutations of microRNA-142-3p promote ASH1L expression to induce immune evasion and hepatocellular carcinoma progression

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World Journal of Gastroenterology 2025年第1期31卷 126-145页

作者： Xing-Hui Yu Yan Xie Jian Yu Kun-Ning Zhang Zhou-Bo guo Di Wang Zhao-Xian Li Wei-Qi Zhang Yu-ying Tan Li Zhang Wen-Tao Jiang School of Medicine Nankai UniversityTianjin 300192China Tianjin Key Laboratory of Molecular Diagnosis and Treatment of Liver Cancer Tianjin First Center HospitalTianjin 300192China Department of Liver Transplantation Tianjin First Center HospitalTianjin 300192China First Central Clinical School Tianjin Medical UniversityTianjin 300192China

BACKGROUND Hepatocellular carcinoma(HCC)has been a pervasive malignancy throughout the world with elevated *** therapeutic targets are beneficial to treat and predict the ***,the exact molecular mechanisms leading to the progression of HCC are still *** has shown that the microRNA-142-3p level decreases in HCC,whereas bioinformatics analysis of the cancer genome atlas database shows the ASH1L expression increased among liver tumor *** this paper,we will explore the effects and mechanisms of microRNA-142-3p and ASH1L affect the prognosis of HCC patients and HCC cell bioactivity,and the association between *** To investigate the effects and mechanisms of microRNA-142-3p and ASH1L on the HCC cell bioactivity and prognosis of HCC *** In this study,we grouped HCC patients according to their immunohistochemistry results of ASH1L with pathological tissues,and retrospectively analyzed the prognosis of HCC ***,explored the roles and mechanisms of microRNA-142-3p and ASH1L by cellular and animal experiments,which involved the following experimental methods:Immunohistochemical staining,western blot,quantitative real-time-polymerase chain reaction,flow cytometric analysis,tumor xenografts in nude mice,*** statistical methods involved in this study contained t-test,one-way analysis of variance,theχ^(2)test,the Kaplan-Meier approach and the log-rank *** In this study,we found that HCC patients with high expression of ASH1L possess a more recurrence rate as well as a decreased overall survival ***1L promotes the tumorigenicity of HCC and microRNA-142-3p exhibits reduced expression in HCC tissues and interacts with ASH1L through targeting the ASH1L 3′untranslated ***,microRNA-142-3p promotes apoptosis and inhibits proliferation,invasion,and migration of HCC cell lines in vitro via *** the exploration mechanism,we found ASH1L may promote an immunosuppressive mi

关键词： Hepatocellular carcinoma MicroRNA-142-3p ASH1L Immune evasion Tumor immune microenvironment Apoptosis

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“3+1”教学模式下的《离散数学》课程的教学改革研究

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现代计算机 2017年第10期23卷 54-56页

作者：李迎春郭秋吴建胜辽宁科技大学软件学院鞍山114051

"3+1"教学模式是为了适应社会发展而提出的新的教学模式,即将本科学生的四年在校学习时间压缩为三年,最后一年学生到企业实习,参与到企业的实际项目中去,以提高学生的实际动手能力。但教学时间的变化就会引发教学计划的调整,进而对课程... 详细信息

"3+1"教学模式是为了适应社会发展而提出的新的教学模式,即将本科学生的四年在校学习时间压缩为三年,最后一年学生到企业实习,参与到企业的实际项目中去,以提高学生的实际动手能力。但教学时间的变化就会引发教学计划的调整,进而对课程教学产生一定的影响。首先分析"3+1"教学模式对离散数学课程教学的影响,引发的问题,然后分别从教学内容和教学手段等方面,提出改革方案,并针对不同的问题给出具体的解决方案。

关键词： “3+1”教学模式离散数学课程改革

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Microstructural evolution during the progressive transformation-induced plasticity effect in a Fe-0.1C-5Mnmedium manganese steel

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 369-379页

作者： Mei Zhang Wenhao Li Yangfei Chen Yang Jiang Xiaofei guo Han Dong School of Materials Science and Engineering Shanghai UniversityShanghai 200444China State Key Laboratory of Advanced Special Steel Shanghai UniversityShanghai 200444China

The microstructural evolution of a cold-rolled and intercritical annealed medium-Mn steel(Fe-0.10C-5Mn)was investigated during uniaxial tensile ***-situ observations under scanning electron microscopy,transmission electron microscopy,and X-ray diffraction analysis were conducted to characterize the progressive transformation-induced plasticity process and associated fracture initiation *** findings were discussed with the local strain measurements via digital image *** results indicated that Lüders band formation in the steel was limited to 1.5%strain,which was mainly due to the early-stage martensitic phase transformation of a very small amount of the less stable large-sized retained austenite(RA),which led to localized stress concentrations and strain hardening and further retardation of *** small-sized RA exhibited high stability and progressively transformed into martensite and contributed to a stably extended Portevin-Le Chatelier *** volume fraction of RA gradually decreased from 26.8%to 8.2%prior to *** the late deformation stage,fracture initiation primarily occurred at the austenite/martensite and ferrite/martensite interfaces and the ferrite phase.

关键词： medium-Mn steel retained austenite progressive transformation-induced plasticity effect local strain fracture initiation

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Unraveling the significance of cobalt on transformation kinetics,crystallography and impact toughness in high-strength steels

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 380-390页

作者： Yishuang Yu Jingxiao Zhao Xuelin Wang Hui guo Zhenjia Xie Chengjia Shang Collaborative Innovation Center of Steel Technology University of Science and Technology BeijingBeijing 100083China School of Materials Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China State Key Laboratory for Advanced Metals and Materials University of Science and Technology BeijingBeijing 100083China

This work reveals the significant effects of cobalt(Co)on the microstructure and impact toughness of as-quenched highstrength steels by experimental characterizations and thermo-kinetic *** results show that the Co-bearing steel exhibits finer blocks and a lower ductile-brittle transition temperature than the steel without ***,the Co-bearing steel reveals higher transformation rates at the intermediate stage with bainite volume fraction ranging from around 0.1 to *** improved impact toughness of the Co-bearing steel results from the higher dense block boundaries dominated by the V1/V2 variant ***,the addition of Co induces a larger transformation driving force and a lower bainite start temperature(BS),thereby contributing to the refinement of blocks and the increase of the V1/V2 variant *** findings would be instructive for the composition,microstructure design,and property optimization of high-strength steels.

关键词： high-strength steel cobalt transformation kinetics crystallography impact toughness

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