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Timing and Spectral Analysis of the Black Hole X-Ray Binary MAXI J1803-298 with Insight-HXMT Data

Research in Astronomy and Astrophysics 2024年第6期24卷 211-226页

作者： ying-chen xu Jin-Lu Qu M.Méndez Rui-Can Ma Long Ji Liang Zhang Yue Huang Qing-Cui Bu Li-Ming Song Key Laboratory of Particle Astrophysics Institute of High Energy Physics Chinese Academy of Sciences University of Chinese Academy of Sciences Chinese Academy of Sciences Kapteyn Astronomical Institute University of Groningen Dongguan Neutron Science Center School of Physics and Astronomy Sun Yat-Sen University Institut für Astronomie und Astrophysik Kepler Center for Astro and Particle Physics Eberhard Karls Universit?t

We present a comprehensive analysis of the 2021 outburst of MAXI J1803–298 utilizing observations of the Insight-Hard X-ray Modulation Telescope(Insight-HXMT) spanning from the low hard state to the high soft state.Within the Insight-HXMT data set, compared to the previous work, we identify a more prolonged presence of typeC quasi-periodic oscillations(QPOs) with centroid frequencies ranging from ～0.16 to 6.3 Hz, which present correlations with the hardness ratio and the photon index of the Comptonized component. For QPO frequencies less than ～2 Hz, the QPO phase lags are hard(photons of 10–19 keV arrive later than those of 1–4 keV), while at higher frequencies, the lags become soft at and above ～4 Hz. Furthermore, the spectra in all Insight-HXMT observations consist of a multi-color blackbody component and a Comptonized component, as commonly observed in classical black hole X-ray binaries. We analyze state transitions and the evolution of accretion geometry in this work. The fitted inner disk radius increases abnormally during the low hard state, hypothesized to result from the corona condensing onto the inner disk. Additionally, two significant drops in flux are observed during the soft intermediate state, maybe implying changes in the corona/jet and the disk, respectively.

关键词： accretion accretion disks stars: black holes X-rays: binaries

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Temporal and Spectral Characteristics of Persistent Emission and Special Bursts of Magnetar SGR J1935+2154 Based on Insight-HXMT

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Research in Astronomy and Astrophysics 2024年第6期24卷 227-235页

作者： xue-Feng Lu Li-Ming Song Ming-Yu Ge Shuang-Nan Zhang Jin-Lu Qu Ce Cai Cong-Zhan Liu cheng-Kui Li Yu-Cong Fu ying-chen xu Key Laboratory of Particle Astrophysics Institute of High Energy Physics University of Chinese Academy of Sciences Chinese Academy of Sciences College of Physics and Hebei Key Laboratory of Photophysics Research and Application Hebei Normal University Department of Astronomy Beijing Normal University

In October 2022, the magnetar SGR J1935+2154 entered the active outburst state. During the episode, the InsightHXMT satellite carried out a long observation that lasted for 20 days. More than 300 bursts were detected, and a certain amount of persistent radiation signals were also accumulated. This paper mainly introduces the results of persistent radiation profile folding and period search based on Insight-HXMT data. At the same time, the burst phase distribution characteristics, spectral lag results of burst, the spectral characteristics of zero-lag bursts and the time-resolved spectral evolution characteristics of high-flux bursts are reported. We found that there is no significant delay feature during different energy bands for the bursts of SGR J1935+2154. The observed zero-lag burst does not have a unique spectrum. The time-resolved spectrum of the individual burst has consistent spectral types and spectral parameters at different time periods of the burst. We also find that the burst number phase distribution and the burst photon phase distribution have the same tendency to concentrate in specific regions of the persistent emission profile.

关键词： dense matter magnetic fields radiation mechanisms: general

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Knockdown of Decoy Receptor 3 Impairs Growth and Invasiveness of Hepatocellular Carcinoma Cell Line of HepG2

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Chinese Medical Journal 2016年第21期129卷 2623-2629页

作者： Xiao-Na Zhou Guang-Ming Li ying-chen xu Tuan-Jie Zhao Ji-Xiang Wu Department of General Surgery Beijing Tongren Hospital Capital Medical University Beijing 100730 China Department of General Surgery Beijing Er Long Lu Hospital Beijing 100032 China

Background：Decoy receptor 3 （DcR3） binds to Fas ligand （FasL） and inhibits FasL-induced apoptosis.The receptor is overexpressed in hepatocellular carcinoma （HCC）,and it is associated with the growth and metastatic spread of tumors.DcR3 holds promises as a new target for the treatment of HCC,but little is known regarding the molecular mechanisms underlying the oncogenic properties of DcR3.The present work,therefore,examined the role of DcR3 in regulating the growth and invasive property of liver cancer cell HepG2.Methods：HepG2 cells were stably transfected with lentivirus-based short hairpin RNA vector targeting DcR3.After the knockdown of DcR3 was confirmed,cell proliferation,clone formation,ability of migrating across transwell membrane,and wound healing were assessed in vitro.Matrix metalloproteinase-9 （MMP 9） and vascular epithelial growth factor （VEGF）-C and D expressions of the DcR3 knockdown were also studied.Comparisons between multiple groups were done using one-way analysis of variance （ANOVA）,while pairwise comparisons were performed using Student＇s t test.P 〈 0.05 was regarded statistically significant.Results：DcR3 was overexpressed in HepG2 compared to other HCC cell lines and normal hepatocyte Lo-2.Stable knockdown of DcR3 slowed down the growth of HepG2 （P 〈 0.05） and reduced the number of clones formed by 50% compared to those without DcR3 knockdown （P 〈 0.05）.The knockdown also reduced the migration of HepG2 across transwell matrix membrane by five folds compared to the control （P 〈 0.05） and suppressed the closure of scratch wound （P 〈 0.05）.In addition,the messenger RNA levels of MMP 9,VEGF-C,and VEGF-D were significantly suppressed by DcR3 knockdown by 90% when compared with the mock control （P 〈 0.05）.Conclusions：Loss of DcR3 impaired the growth and invasive property of HCC cell line of HepG2.Targeting DcR3 may be a potential therapeutic approach for the treatment of HCC.

关键词： Decoy Receptor 3 Hepatocellular Carcinonia Matrix Metalloproteinase 9 Neoplasm Metastasis Vascular Endothelial Growth Factor C Vascular Endothelial Growth Factor D

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XB130 Knockdown Inhibits the Proliferation, Invasiveness, and Metastasis of Hepatocellular Carcinoma Cells and Sensitizes them to TRAIL-Induced Apoptosis

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Chinese Medical Journal 2018年第19期131卷 2320-2331页

作者： Guang-Ming Li Chao-Jie Liang Dong-Xin Zhang Li-Jun Zhang Ji-Xiang Wu ying-chen xu Department of General Surgery Beijing Tongren Hospital Capital Medical University Beijing 100730 China Department of General Surgery First Hospital/First Clinical Medical College of Shanxi Medical University Taiyuan Shanxi 030001 China

Background：XB 130 is a recently discovered adaptor protein that is highly expressed in many malignant tumors,but few studies have investigated its role in hepatocellular carcinoma （HCC）.Therefore,this study explored the relationship between this protein and liver cancer and investigated its molecular mechanism of action.Methods：The expression of XB 130 between HCC tissues and adjacent nontumor tissues was compared by real-time polymerase chain reaction,immunochemistry,and Western blotting.XB130 silencing was performed using small hairpin RNA.The effect of silencing XB130 was examined using Cell Counting Kit-8,colony assay,wound healing assay,and cell cycle analysis.Results：We found that XB 130 was highly expressed in HCC tissues （cancer tissues vs.adjacent tissues：0.23 ± 0.02 vs.0.17 ± 0.02,P 〈 0.05） and liver cancer cell lines,particularly MHCC97H and HepG2 （MHCC97H and HepG2 vs.normal liver cell line LO-2：2.35 ± 0.26 and 2.04 ± 0.04 vs.1.00 ± 0.04,respectively,all P 〈 0.05）.The Cell Counting Kit-8 assay,colony formation assay,and xenograft model in nude mice showed that silencing XB130 inhibited cell proliferative ability both in vivo and in vitro,with flow cytometry demonstrating that the cells were arrested in the G0/G1 phase in HepG2 （HepG2 XB130-silenced group [shA] vs.HepG2 scramble group [NA]：74.32 ± 5.86% vs.60.21 ± 3.07%,P 〈 0.05） and that the number of G2/M phase cells was decreased （HepG2 shA vs.HepG2 NA：8.06 ± 2.41% vs.18.36 ± 4.42%,P 〈 0.05）.Furthermore,the cell invasion and migration abilities were impaired,and the levels of the epithelial-mesenchymal transition-related indicators vimentin and N-cadherin were decreased,although the level of E-cadherin was increased after silencingXB130.Western blotting showed that the levels of phosphorylated phosphoinositide 3-kinase （PI3K） and phospho-protein kinase B （p-Akt） also increased,although the level of phosphorylated phosphatase and tensin homolog increased,indicating that XB 130 activated the PI3K/ Akt pathway.Furthermore,we found that a reduction in X

关键词： Apoptosis Hepatocellular Carcinoma PI3K/Akt TRAIL XB 130

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Anti-apoptosis Effect of Decoy Receptor 3 in Cholangiocarcinoma Cell Line TFK-1

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Chinese Medical Journal 2018年第1期131卷 82-87页

作者： ying-chen xu Jing Cui Li-Jun Zhang Dong-Xin Zhang Bing-chen Xing Xiong-Wei-Ye Huang Ji-Xiang Wu Chao-Jie Liang Guang-Ming Li Department of Hepatobiliary Surgery Surgical Laboratory Beijing Tong Ren Hospital Capital Medical University Beijing 100730 China Department of Pathology Capital Medical University Beijing 100069 China

Background： Decoy receptor 3 （DcR3） is a protein with anti-apoptotic effect that belongs to the tumor necrosis factor receptor superfamily. DcR3 is highly expressed in a variety of malignant tumors including cholangiocarcinoma and its expression was found to be related to the clinical stage, the invasion, and tile metastasis of the tumor. This in vitro study aimed to investigate the effect ofdownregulated expression of DcR3 on cell viability, cell apoptosis, and cell cycle in cholangiocarcinoma cell line TFK-1. Methods： Three different cell lines were cultured： human cholangiocarcinoma TFK-I, human biliary epithelial carcinoma HuCCT-1, and human cholangiocarcinoma RBE. The cholangiocarcinoma cell line with the highest expression of DcR3 was selected for further investigation. The expression of DcR3 was silenced/knocked down by transfection with DcR3-siRNA in the selected cell line. Various biological phenotype parameters such as cell viability, apoptosis, and cell cycle were observed. Results： The mRNA and protein levels of DcR3 were measured in the three cell lines, and TFK-1 was selected. After the treatment with DcR3-siRNA for 48 h, DcR3 mRNA and protein expression in the treatment group were 38.45% （P 〈 0.01 ） and 48.03% （P 〈 0.05） of that of＇the control, respectively. It was found that the cell viability decreased to 61.87% of the control group （P 〈 0.01 ） after the downregulation of DcR3 in cholangiocarcinoma cell line TFK- 1 by transfection with DcR3-siRNA, while tile percentage ofapoptotic cells was 2.98 times as compared with the control group （P 〈 0.05）. Compared with the control group the ratio of G0/G1 increased, and the ratio of G2/M dccreased in the treatment group. However, the differences were not statistically significant. Conclusions： The effect of DcR3 on the growth and apoptosis ofcholangiocarcinoma has been demonstrated. DcR3 is not only a predictive marker for malignant tumor but it is also likely to be a potential target for cancer gene therapy. Further studies should focus on exploring the

关键词： Apoptosis： Cell Cycle： Cholangiocarcinoma Decoy Receptor 3 TFK-1

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Biohythane production from two-stage anaerobic digestion of food waste:A review

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Journal of Environmental Sciences 2024年第5期139卷 334-349页

作者： Xiaona An ying xu Xiaohu Dai State Key Laboratory of Pollution Control and Resource Reuse School of Environmental Science and EngineeringTongji UniversityShanghai 200092China Shanghai Institute of Pollution Control and Ecological Security Shanghai 200092China

The biotransformation of food waste(FW)to bioenergy has attracted considerable research attention as a means to address the energy crisis and waste disposal problems.To this end,a promising technique is two-stage anaerobic digestion(TSAD),in which the FW is transformed to biohythane,a gaseous mixture of biomethane and biohydrogen.This review summarises the main characteristics of FW and describes the basic principle of TSAD.Moreover,the factors influencing the TSAD performance are identified,and an overview of the research status;economic aspects;and strategies such as pre-treatment,co-digestion,and regulation of microbial consortia to increase the biohythane yield from TSAD is provided.Additionally,the challenges and future considerations associated with the treatment of FW by TSAD are highlighted.This paper can provide valuable reference for the improvement and widespread implementation of TSAD-based FW treatment.

关键词： Two-stage anaerobic digestion(TSAD) Food waste(FW) Methane production Hydrogen production

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Development of small molecule drugs targeting immune checkpoints

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Cancer Biology & Medicine 2024年第5期21卷 382-399页

作者： Luoyi chen Xinchen Zhao Xiaowei Liu Yujie Ouyang Chuan xu ying Shi Department of Oncology Sichuan Academy of Medical SciencesSichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengdu 610054China Institute for Breast Health Medicine State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041China Acupuncture and Massage College Chengdu University of Traditional Chinese MedicineChengdu 611137China

Immune checkpoint inhibitors(ICIs)are used to relieve and refuel anti-tumor immunity by blocking the interaction,transcription,and translation of co-inhibitory immune checkpoints or degrading co-inhibitory immune checkpoints.Thousands of small molecule drugs or biological materials,especially antibody-based ICIs,are actively being studied and antibodies are currently widely used.Limitations,such as anti-tumor efficacy,poor membrane permeability,and unneglected tolerance issues of antibody-based ICIs,remain evident but are thought to be overcome by small molecule drugs.Recent structural studies have broadened the scope of candidate immune checkpoint molecules,as well as innovative chemical inhibitors.By way of comparison,small molecule drug-based ICIs represent superior oral bioavailability and favorable pharmacokinetic features.Several ongoing clinical trials are exploring the synergetic effect of ICIs and other therapeutic strategies based on multiple ICI functions,including immune regulation,anti-angiogenesis,and cell cycle regulation.In this review we summarized the current progression of small molecule ICIs and the mechanism underlying immune checkpoint proteins,which will lay the foundation for further exploration.

关键词： Immune checkpoints small molecule drugs programmed death protein 1 CD47 signal-regulatory proteinα

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Burst Phase Distribution of SGR J1935+2154 Based on Insight-HXMT

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Research in Astronomy and Astrophysics 2023年第3期23卷 68-74页

作者： xue-Feng Lu Li-Ming Song Ming-Yu Ge You-Li Tuo Shuang-Nan Zhang Jin-Lu Qu Ce Cai Sheng-Lun Xie Cong-Zhan Liu cheng-Kui Li Yu-Cong Fu ying-chen xu Tian-Ming Li Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsBeijing 100049China University of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100049China College of Physics and Hebei Key Laboratory of Photophysics Research and Application Hebei Normal UniversityShijiazhuang 050024China Institute of Astrophysics Central China Normal UniversityWuhan 430079China

On 2020 April 27,the soft gamma-ray repeater SGR J1935+2154 entered its intense outburst episode again.Insight-HXMT carried out about one month observation of the source.A total number of 75 bursts were detected during this activity episode by Insight-HXMT,and persistent emission data were also accumulated.We report on the spin period search result and the phase distribution of burst start times and burst photon arrival times of the Insight-HXMT high energy detectors and Fermi/Gamma-ray Burst Monitor(GBM).We find that the distribution of burst start times is uniform within its spin phase for both Insight-HXMT and Fermi/GBM observations,whereas the phase distribution of burst photons is related to the type of a burst’s energy spectrum.The bursts with the same spectrum have different distribution characteristics in the initial and decay episodes for the activity of magnetar SGR J1935+2154.

关键词： spectrum Fermi distribution

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Methods,Mechanisms,and Application Prospects for Enhancing Extracellular Vesicle Uptake

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Current Medical Science 2024年第2期44卷 247-260页

作者： ying-peng xu Tao JIANG Xiao-fan YANG Zhen-bing chen Department of Hand Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China

Extracellular vesicles(EVs)are considered to be a new generation of bioinspired nanoscale drug delivery systems due to their low immunogenicity,natural functionality,and excellent biocompatibility.However,limitations such as low uptake efficiency,insufficient production,and inhomogeneous performance undermine their potential.To address these issues,numerous researchers have put forward various methods and applications for enhancing EV uptake in recent decades.In this review,we introduce various methods for the cellular uptake of EVs and summarize recent advances on the methods and mechanisms for enhancing EV uptake.In addition,we provide further understanding regarding enhancing EV uptake and put forward prospects and challenges for the development of EV-based therapy in the future.

关键词： extracellular vesicles exosomes extracellular vesicle uptake extracellular vesiclebased therapy

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N-doping offering higher photodegradation performance of dissolved black carbon for organic pollutants: experimental and theoretical studies

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2024年第4期25卷 340-356页

作者： Yong GUO Mengxia chen Ting chen ying GUO Zixuan xu Guowei xu Soukthakhane SINSONESACK Keophoungeun KANMANY Key Laboratory of Integrated Regulation and Resource Development on Shallow Lakes Ministry of EducationCollege of EnvironmentHohai UniversityNanjing 210093China Key Laboratory of Environmental Engineering of Jiangsu Province Jiangsu Provincial Academy of Environmental ScienceNanjing 210036China State Key Laboratory of Pollution Control and Resource Reuse Nanjing UniversityNanjing 210023China Central Environmental Laboratory Natural Resources and Environment Research InstituteMinistry of Natural Resources and EnvironmentVientiane 999012Laos

We investigated the influence mechanism of N-doping for dissolved black carbon(DBC)photodegradation of organic pollutants.The degradation performance of N-doped dissolved black carbon(NDBC)for tetracycline(TC)(71%)is better than that for methylene blue(MB)(28%)under irradiation.These levels are both better than DBC degradation performances for TC(68%)and MB(18%)under irradiation.Reactive species quenching experiments suggest that h and-O,are the main reactive species for NDBC photodegraded TC,while-OH and h*are the main reactive species for NDBC photodegraded MB.-OH is not observed during DBC photodegradation of MB.This is likely because N-doping increases valence-band(VB)energy from 1.55 eV in DBC to 2.04 eV in NDBC;the latter is strong enough to oxidize water to form-OH.Additionally,N-doping increases the DBC band gap of 2.29 to 2.62 eV in NDBC,resulting in a higher separation efficiency of photo-generated electrons-holes in NDBC than in DBC.AIl these factors give NDBC stronger photodegradation performance for TC and MB than DBC.High-performance liquid chromatography-mass spectrometry(HPLC-MS)characterization and toxicity evaluation with the quantitative structure-activity relationship(QSAR)method suggest that TC photodegradation intermediates produced by NDBC have less aromatic structure and are less toxic than those produced by DBC.We adopted a theoretical approach to clarify the relationship between the surface groups of NDBC and the photoactive species produced.Our results add to the understanding of the photochemical behavior of NDBC.

关键词： Dissolved black carbon(DBC) N-doping Organic pollutants Band gap Photodegradation

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