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A dual-protease-triggered chemiluminescent probe for precise tumor imaging

Chinese Chemical Letters 2025年第2期36卷 302-306页

作者： Zhihui Zhang Ru Sun Chong Bian Hongbo Wang Zhen Zhao Panpan Lv Jianzhong lu Haixin Zhang Hulie Zeng Yuanyuan chen Zhijuan Cao Department of Pharmaceutical Analysis School of PharmacyFudan University Minhang Branch Zhongshan HospitalFudan University China State Institute of Pharmaceutical Industry Shanghai Jahwa United Co. Ltd.

Imaging detection of interlinked dual proteases is imperative for precise tumor imaging, which remains challenging due to limited modification position of specific substrate and possible steric ***, we have developed a unimolecular chemiluminescent probe(LGP-CL) tandemly activated by two proteases interlinked with liver cancer to achieve precise tumor imaging. Probe LGP-CL consists of a phenoxy-dioxetane scaffold caged by a tripeptide substrate(LGP, leucine-glycine-proline) as the sensing layer, which can be cleaved sequentially by aminopeptidase N(APN) and dipeptidyl peptidase IV(DPPIV)to turn on a strong chemiluminescent signal, and silenced by specific inhibitor of each enzyme, which accounts for an integrated logic gate(AND, OR and INHIBIT). The successful cleavage of dual proteases on the metabolic site depends on the proper structure of the tripeptide substrate, as confirmed by two probes design. Probe LGP-CL(LGP as the substrate) enables the excellent “dual-lock-dual-key” fit with a382-fold enhancement of chemiluminescent emission while no obvious signal is observed by using GPLCL(GPL as the substrate). By virtue of its rapid response(several minutes), high sensitivity and good cell viability, probe LGP-CL has been utilized to evaluate upregulated levels of proteases in vitro and in living systems, especially to distinguish liver tumor cells(Hep G2) from others(LO2, MCF-7, MCF-10a and RAW264.7). Overall, the newly developed CL probe may facilitate rapid investigation into the role played by proteases in liver diseases, enabling timely selection appropriate treatment. Therefore, our work not only sheds light on the rational design of optical probes for dual protease imaging, but provides a promising tool for clinical diagnosis and even drug discovery.

关键词： Chemiluminescent Dual-protease imaging Logic gates Phenoxy-dioxetane scaffold Tripeptide substrate

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Nanoparticles for the treatment of spinal cord injury

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Neural Regeneration Research 2025年第6期20卷 1665-1680页

作者： Qiwei Yang Di lu Jiuping Wu Fuming Liang Huayi Wang Junjie Yang Ganggang Zhang chen Wang Yanlian Yang Ling Zhu Xinzhi Sun Department of Orthopedic Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina CAS Key Laboratory of Standardization and Measurement for Nanotechnology CAS Key Laboratory for Biomedical Effects of Nanomaterials and NanosafetyCAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijingChina University of Chinese Academy of Sciences BeijingChina Department of Neurosurgery The First Affiliated Hospital of Chongqing Medical UniversityChongqingChina

Spinal cord injuries lead to significant loss of motor, sensory, and autonomic functions, presenting major challenges in neural regeneration. Achieving effective therapeutic concentrations at injury sites has been a slow process, partly due to the difficulty of delivering drugs effectively. Nanoparticles, with their targeted delivery capabilities, biocompatibility, and enhanced bioavailability over conventional drugs, are garnering attention for spinal cord injury treatment. This review explores the current mechanisms and shortcomings of existing treatments, highlighting the benefits and progress of nanoparticle-based approaches. We detail nanoparticle delivery methods for spinal cord injury, including local and intravenous injections, oral delivery, and biomaterial-assisted implantation, alongside strategies such as drug loading and surface modification. The discussion extends to how nanoparticles aid in reducing oxidative stress, dampening inflammation, fostering neural regeneration, and promoting angiogenesis. We summarize the use of various types of nanoparticles for treating spinal cord injuries, including metallic, polymeric, protein-based, inorganic non-metallic, and lipid nanoparticles. We also discuss the challenges faced, such as biosafety, effectiveness in humans, precise dosage control, standardization of production and characterization, immune responses, and targeted delivery in vivo. Additionally, we explore future directions, such as improving biosafety, standardizing manufacturing and characterization processes, and advancing human trials. Nanoparticles have shown considerable progress in targeted delivery and enhancing treatment efficacy for spinal cord injuries, presenting significant potential for clinical use and drug development.

关键词： antioxidants axon regeneration biocompatible materials drug carriers nanoparticles nerve regeneration neuroinflammatory diseases neuroprotection spinal cord injury stem cells

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Single-cell RNA sequencing reveals the heterogeneity and interactions of immune cells and Müller glia during zebrafish retina regeneration

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Neural Regeneration Research 2025年第12期20卷 3635-3648页

作者： Hui Xu Lining Cao Yuxi chen Cuiping Zhou Jie Xu Zhuolin Zhang Xiangyu Li Lihua Liu Jianfeng lu Shanghai YangZhi Rehabilitation Hospital(Shanghai Sunshine Rehabilitation Center) Frontier Science Center for Stem Cell ResearchSchool of Life Sciences and TechnologyTongji UniversityShanghaiChina Key Lab of Neuroregeneration of Jiangsu and Ministry of Education Co-innovation Center of NeuroregenerationNMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology ProductsNantong UniversityNantongJiangsu ProvinceChina

Inflammation plays a crucial role in the regeneration of fish and avian ***,how inflammation regulates Müller glia(MG)reprogramming remains ***,we used single-cell RNA sequencing to investigate the cell heterogeneity and interactions of MG and immune cells in the regenerating zebrafish *** first showed that two types of quiescent MG(resting MG1 and MG2)reside in the uninjured *** retinal injury,resting MG1 transitioned into an activated state expressing known reprogramming genes,while resting MG2 gave rise to rod *** further showed that retinal microglia can be categorized into three subtypes(microglia-1,microglia-2,and proliferative)and pseudotime analysis demonstrated dynamic changes in microglial status following retinal *** of cell–cell interactions indicated extensive crosstalk between immune cells and MG,with many interactions shared among different immune cell ***,we showed that inflammation activated Jak1–Stat3 signaling in MG,promoting their transition from a resting to an activated *** study reveals the cell heterogeneity and crosstalk of immune cells and MG in zebrafish retinal repair,and may provide valuable insights into future mammalian retina regeneration.

关键词： immune cells inflammation Jak1-Stat3 signaling microglia Müller glia regeneration reprogramming retina single-cell RNAseq zebrafish

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负责任的社会科学数据治理的内涵、特征与层次

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现代情报 2025年第1期45卷 124-134页

作者：王英卢国强湖北大学历史文化学院湖北武汉430062 吉林大学商学与管理学院吉林长春130012

[目的/意义]“十四五”国家哲学社会科学发展规划的背景下,负责任的数据治理成为促进社会科学数据开放共享、推进社会科学研究与创新的重要驱动力,亟须探索负责任的社会科学数据治理的基础理论。[方法/过程]运用主题分析法,探寻负责任... 详细信息

[目的/意义]“十四五”国家哲学社会科学发展规划的背景下,负责任的数据治理成为促进社会科学数据开放共享、推进社会科学研究与创新的重要驱动力,亟须探索负责任的社会科学数据治理的基础理论。[方法/过程]运用主题分析法,探寻负责任的数据治理的概念要素及维度,按照国际标准ISO704:2009的概念关系,结合社会科学数据的特性,阐释负责任的社会科学数据治理的内涵及其与相关概念的关系、特征、层次与内容,旨在构建一个较为全面且系统的概念体系。[结果/结论]负责任的社会科学数据治理是多元主体在现有的数据治理环境之下,运用相应的治理机制和手段,将负责任的研究与创新的理念和原则融入社会科学数据全生命周期,以确保所有涉及社会科学数据的流程和成果的责任性的过程,具有责任性、反思性、前瞻性、开放性和工具性特征,可划分为战略层、数据层和活动层。

关键词：社会科学数据负责任的数据治理数据治理

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Modulated waveforms for harmonic minimization of far-field signals in amplitude-modulated heating of the ionosphere

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Earth and Planetary Physics 2025年第02期 387-399页

作者： ZhiJian lu Yong Li Hui Li Jian Wu JingFeng Yao XingBao Lyu chengXun Yuan ZhongXiang Zhou ying Wang School of Physics Harbin Institute of Technology China Research Institute of Radio Waves Propagation Heilongjiang Provincial Key Laboratory of Plasma Physics and Application Technology Heilongjiang Provincial Innovation Research Center for Plasma Physics and Application Technology (International Cooperation)

This paper establishes an amplitude modulation heating model, simulating the far-field radiation of ELF/VLF signals generated by modulation heating, as well as the specific location and longitudinal extent of the radiation source. We consider various modulation waveforms and find that square-wave modulation has the highest excitation efficiency for ELF/VLF signals, and that square-wave modulation with a smaller duty cycle(ying effective radiant power and modulation frequency, as long as the modulation waveform is unchanged, the energy ratio between the fundamental frequency signal generated by modulated heating and each harmonic is relatively fixed, with changes only in signal intensity and the location of the radiation source zone. This implies that one can first select modulation waveforms that make the signal less prone to distortion, then increase the effective radiated power to enhance the signal strength, without concern for harmonic interference of the fundamental signal.

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基于Neuman健康照顾模式的三级预防护理在肺癌放化疗患者压力管理中的应用

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医学信息 2023年第16期36卷 152-157页

作者：陈英璐肖伶天津市宝坻区人民医院外科三病区

目的探讨基于Neuman理论健康照顾模式的三级预防护理在肺癌放化疗患者压力管理中的应用效果。方法选择我院2021年6月-2022年8月收治的40例需要进行放化疗的肺癌患者作为研究对象，采用随机数字表法分为研究组和对照组，每组20例。对... 详细信息

目的探讨基于Neuman理论健康照顾模式的三级预防护理在肺癌放化疗患者压力管理中的应用效果。方法选择我院2021年6月-2022年8月收治的40例需要进行放化疗的肺癌患者作为研究对象，采用随机数字表法分为研究组和对照组，每组20例。对照组使用常规放化疗护理，研究组在对照组基础上使用基于Neuman理论健康照顾模式的三级预防护理，比较两组护理后心理压力（CPSS）评分、医学应对（MCMQ）评分、自我管理能力（AHSMSRS）评分、生活质量（GQOL-74）评分、癌因性疲乏评分以及护理满意度。结果研究组护理后紧张感、失控感及CPSS总分均低于对照组，差异有统计学意义（P<0.05）；研究组面对、回避、屈服评分均优于对照组，差异有统计学意义（P<0.05）；研究组自我管理认知、自我管理行为、自我管理环境评分均高于对照组，差异有统计学意义（P<0.05）；研究组躯体功能、社会功能、情绪功能以及整体健康评分均高于对照组，差异有统计学意义（P<0.05）；研究组躯体疲乏、心理疲乏和认知疲乏评分均低于对照组，差异有统计学意义（P<0.05）；研究组护理满意度高于对照组，差异有统计学意义（P<0.05）。结论在肺癌患者放化疗的过程中使用基于Neuman理论健康照顾模式的三级预防护理，能提高患者自我管理的能力、生活质量以及对整体护理的满意度，同时降低患者负面情绪和心理压力，值得临床应用。

关键词： Neuman理论健康照顾模式三级预防护理肺癌放化疗压力管理

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Dynamical complexity of Anosov systems driven by a quasi-periodic force

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Science China Mathematics 2025年第1期68卷 89-136页

作者： Wen Huang Zeng Lian Kening lu Department of Mathematics University of Science and Technology of ChinaHefei 230026China School of Mathematics Sichuan UniversityChengdu 610065China

Consider C^(2)Anosov systems on a compact manifold driven by a quasi-periodic *** study their dynamical complexity on various levels from the perspectives of both path-wise dynamics and stochastic *** that these systems are non-wandering(i.e.,every point in the phase space is nonwandering),we prove a set of results:(1)the existence of abundance of random periodic points;(2)a random Livsic theorem;(3)a random Mañé-Bousch-Conze-Guivarc'h lemma;(4)the existence of strong random ***,a concrete example constructed on a 2-dimensional torus is also given to uncover some interesting phenomena of the systems.

关键词： random Anosov systems Anosov system on bers entropy random periodic orbit random horseshoe cohomological equation random Livsic theorem random Bousch-Mañécohomology lemma

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Efficient photodegradation of perfluoroalkyl substances under visible light by hexagonal ZnIn_(2)S_(4) nanosheets

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Journal of Environmental Sciences 2025年第2期148卷 116-125页

作者： Fuyu Liu Hui Xue Tingshuo Kang Qiupei Lei Jiazhe chen Zhihong Zuo Bin Han Xize lu Xiao Yang Xiangcheng Shan Xiaoyang Song Qingzhe Zhang Yongguang Yin Yong Cai Shandong Key Laboratory of Environmental Processes and Health Qingdao Key Laboratory of Marine Pollutant PreventionSchool of Environmental Science and EngineeringShandong UniversityQingdao 266237China Research Center for Particle Science and Technology Institute of Frontier and Interdisciplinary ScienceShandong UniversityQingdao 266237China Shenzhen Research Institute of Shandong University A301 Virtual University Park in South DistrictShenzhen 518057China State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 10085China Department of Chemistry and Biochemistry Florida International UniversityMiamiFlorida 33199USA

Perfluoroalkyl substances(PFASs)are typical persistent organic pollutants,and their removal is urgently required but *** has shown potential in PFASs degradation due to the redox capabilities of photoinduced charge carriers in ***,hexagonal ZnIn_(2)S_(4)(ZIS)nanosheets were synthesized by a one-pot oil bath method and were well characterized by a series of *** the degradation of sodium p-perfluorous nonenoxybenzenesulfonate(OBS),one kind of representative PFASs,the assynthesized ZIS showed activity superior to P25 TiO_(2) under both simulated sunlight and visible-light *** good photocatalytic performance was attributed to the enhanced light absorption and facilitated charge *** pH conditions were found crucial in the photocatalytic process by influencing the OBS adsorption on the ZIS *** e−and h+were the main active species involved in OBS degradation in the ZIS *** work confirmed the feasibility and could provide mechanistic insights into the degradation and defluorination of PFASs by visible-light photocatalysis.

关键词： PFASs Defluorination Photocatalysis Visible light ZnIn_(2)S_(4)

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Electronic modulation towards MOFs as template derived CoP via engineered heteroatom defect for a highly effcient overall water splitting

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Journal of Energy Chemistry 2025年第2期101卷 598-607页

作者： Meijie Ding Zhiqiang Wei Dexue Liu Wenhua Zhao Qiang lu Zhiming Li Qingsong Yu chenggong lu Hua Yang State Key Laboratory of Advanced Processing and Recycling of Non-ferrous Metals Lanzhou University of Technology School of Science Lanzhou University of Technology

The reasonable design of material morphology and eco-friendly electrocatalysts are essential to highly efficient water *** is proposed that a promising strategy effectively regulates the electronic structure of the d-orbitals of CoP using cerium doping in this paper,thus significantly improving the intrinsic property and conductivity of CoP for water *** a result,the as-synthesize porous Ce-doped CoP micro-polyhedron composite derived from Ce-ZIF-67 as bifunctional electrocatalytic materials exhibits excellent electrocatalytic performance in both the oxygen evolution reaction（OER） and the hydrogen evolution reaction（HER）,overpotentials of about 152 mV for HER at 10 mA cm-2and about 352 mV for OER at 50 mA cm-2,and especially it shows outstanding long-term ***,an alkaline electrolyzer,using Ce0.04Co0.96P electrocatalyst as both the anode and cathode,delivers a cell voltage value of1.55 V at the current density of 10 mA *** calculation results of the density functional theory（DFT）demonstrate that the introduction of an appropriate amount of Ce into CoP can enhance the conductivity,and can induce the electronic modulation to regulate the selective adsorption of reaction intermediates on catalytic surface and the formation of O*intermediates（CoOOH）,which exhibits an excellent electrocatalytic *** study provides novel insights into the design of an extraordinary performance water-splitting of the multicomponent electrocatalysts.

关键词： Cerium Hydrogen evolution Oxygen evolution Phosphides Water splitting

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Cross-subcarrier precoder design for massive MIMO-OFDM downlink with symplectic optimization

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Science China(Information Sciences) 2025年第2期68卷 216-229页

作者： Yuxuan ZHANG An-An lu Xiang-Gen XIA Xiqi GAO National Mobile Communications Research Laboratory Southeast University Purple Mountain Laboratories Department of Electrical and Computer Engineering University of Delaware

We propose a cross-subcarrier precoder design(CSPD) for massive multiple-input multiple-output(MIMO) orthogonal frequency division multiplexing(OFDM) downlink. This work aims to significantly improve the channel estimation and signal detection performance by enhancing the smoothness of the frequency domain effective channel. This is accomplished by designing a few vectors known as the transform domain precoding vectors(TDPVs), which are then transformed into the frequency domain to generate the precoders for a set of subcarriers. To combat the effect of channel aging, the TDPVs are optimized under imperfect channel state information(CSI). The optimal precoder structure is derived by maximizing an upper bound of the ergodic weighted sum-rate(WSR) and utilizing the a posteriori beam-based statistical channel model(BSCM). To avoid the large-dimensional matrix inversion, we propose an algorithm with symplectic optimization. Simulation results indicate that the proposed cross-subcarrier precoder design significantly outperforms conventional methods.

关键词： massive MIMO-OFDM cross subcarrier precoder design transform domain precoding vectors effective channel symplectic optimization

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