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Unraveling the mechanism of action of Shangxia Liangji formula for treating insomnia:a metabolomics and network pharmacology approach

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Traditional Medicine Research 2025年第2期10卷 16-29页

作者： Xia-Jie Quan Hao Liang Yong-Hong Tang Li Jiang xiong-ying Ji Feng-ying Zhang Ping Zhang Bo Ouyang Department of Information The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Neurology The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Gastroscopy The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Traditional Chinese Medicine The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China

Background:Insomnia is a prevalent clinical condition and Shangxia Liangji formula(SXLJF)is a well-established method of ***,the specific mechanism of action of SXLJF remains ***:The mouse model of insomnia was established by intraperitoneal injection of ***-two mice were randomly divided into a negative control group,model group,SXLJF group(18.72 g/kg/day),and positive control group(diazepam,2 mg/kg)and treated with the corresponding drugs for 7 consecutive *** open field test and pentobarbital-induced sleeping test were ***-MS-based untargeted metabolomics and network pharmacology were applied to explore the potential targets of SXLJF for treating ***,key targets were validated using ***:Behavioral tests demonstrated that SXLJF reduced the total distance,average velocity,central distance,and sleep latency,and prolonged sleep *** and network pharmacology revealed potential targets,signaling pathways,metabolic pathways,and metabolites associated with the anti-insomnia effects of ***,tyrosine hydroxylase(TH)and tyrosine metabolism emerged as crucial metabolic pathways and targets,***-qPCR results supported the role of TH in the mechanism of SXLJF in treating ***:In conclusion,TH and tyrosine metabolism may represent significant targets and pathways for SXLJF in treating insomnia.

关键词： Shangxia Liangji formula insomnia metabolomics network pharmacology tyrosine hydroxylase tyrosine metabolism

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Unsteady analysis of six-DOF motion of a 6:1 prolate spheroid in viscous fluid

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Science China(Physics,Mechanics & Astronomy) 2017年第11期60卷 24-40页

作者： ying xiong ying xiong Hui Guan ChuiJie Wu The Unite 91550 of People's Liberation Army of China Dalian 112023 China School of Aeronautics and Astronautics Dalian University of Technology Dalian 112024 China College of Meteorology and Oceanography National University of Defense Technology Nanjing 211101 China

Free-moving simulations of airplanes, submarines and other automobiles under extreme and emergency conditions are becoming increasingly important from operational and tactical perspectives. Such simulations are fairly challenging due to the extreme unsteady motions and high Re(Reynolds) numbers. The aim of this study is to perform a six-DOF motion simulation of a 6:1prolate spheroid that is falling in a fluid field. Prior to conducting the six-DOF simulation, some verification simulations were performed. First, a laminar flow past an inclined prolate spheroid at a Re number of 1000 and incidence angle of 45. with a tetrahedral mesh was simulated to verify the relevant targeted discrete method for an unstructured mesh. Second, to verify the LES(large eddy simulation) models and dependent parameters for the DDES(delayed detached eddy simulation), a turbulent flow past a sphere was performed at a subcritical Re number of 10000. Third, a steady maneuvering problem about a prolate spheroid pitching up from 0. to 30. incidence at a uniform angular velocity was established based on a dynamic tetrahedral mesh with changing topology and the ALE(arbitrary Lagrangian-Eulerian) method of fluid-structure coupling at a Re number of 4.2 × 10~***, two six-DOF motions of an inclined 6:1 prolate spheroid at an initial incidence of 45. were simulated at different Re numbers of 10000 and 4.2 × 10~6.

关键词： unsteady six-DOF tetrahedral dynamic mesh discrete method DDES

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Dynamic system uncertainty propagation using polynomial chaos

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Chinese Journal of Aeronautics 2014年第5期27卷 1156-1170页

作者： xiong Fenfen Chen Shishi xiong ying School of Aerospace Engineering Beijing Institute of Technology Bank of America

The classic polynomial chaos method（PCM）, characterized as an intrusive methodology,has been applied to uncertainty propagation（UP） in many dynamic systems. However, the intrusive polynomial chaos method（IPCM） requires tedious modification of the governing equations, which might introduce errors and can be impractical. Alternative to IPCM, the non-intrusive polynomial chaos method（NIPCM） that avoids such modifications has been developed. In spite of the frequent application to dynamic problems, almost all the existing works about NIPCM for dynamic UP fail to elaborate the implementation process in a straightforward way, which is important to readers who are unfamiliar with the mathematics of the polynomial chaos theory. Meanwhile, very few works have compared NIPCM to IPCM in terms of their merits and applicability. Therefore, the mathematic procedure of dynamic UP via both methods considering parametric and initial condition uncertainties are comparatively discussed and studied in the present paper. Comparison of accuracy and efficiency in statistic moment estimation is made by applying the two methods to several dynamic UP problems. The relative merits of both approaches are discussed and summarized. The detailed description and insights gained with the two methods through this work are expected to be helpful to engineering designers in solving dynamic UP problems.

关键词： Dynamic system Gliding trajectory Intrusive polynomial chaos Non-intrusive polynomial chaos Uncertainty propagation Uncertainty quantification

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Light People:Professor Che Ting Chan,curiosity drives to create the impossibilities

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Light(Science & Applications) 2024年第7期13卷 1229-1233页

作者： Tingting Sun ying xiong Light Publishing Group Changchun Institute of OpticsFine Mechanics and PhysicsChinese Academy of SciencesNo.3888 Dong Nanhu RoadChangchun 130033China College of Intelligence Science and Technology National University of Defense TechnologyNo.109 Deya RoadChangsha 410073China

Editorial“When something is said to be impossible,there are two points for researchers to initially clarify:whether it really is forbidden by the laws of nature;or whether it is simply that no material that currently exists in nature can do that.”Metamaterials are such magical beings,which have physical properties like invisibility,negative refraction,super-resolution,and perfect absorption that are absent from natural *** has been rated by Science as one of the top ten scientific and technological breakthroughs affecting human beings in the 21st *** this issue of Light People,we spoke with a“magic”creator,Professor Che Ting Chan,the Associate VicePresident(Research&Development)of the Hong Kong University of Science and Technology(HKUST),Member of the Hong Kong Academy of Sciences and Fellow of the American Physical *** has researched a number of theoretical problems in material physics,investigated the theory behind what they seek to achieve,and modulated light(electromagnetism)and acoustic waves through *** the following,let’s take a closer look at Professor Che Ting Chan’s research life,and appreciate his style and the background of his accomplishment.

关键词： breakthrough closer visibility

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Interception Algorithm of S-cubed Signal Model in Stealth Radar Equipment

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Chinese Journal of Aeronautics 2012年第3期25卷 416-422页

作者： ZENG Xiaodong TANG Bin xiong ying School of Electronic Engineering University of Electronic Science and Technology of ChinaChengdu 611731China

Radar equipment of stealth platforms such as aircraft have adopted the newest modem technology to design the signal waveforms. One of the important and effective methods is the hybrid waveform called spread spectrum stretch （S-cubed） which combines linear frequency modulation （LFM） and discrete phase code. In order to investigate the function of enemy＇s stealth radar equipment, the interception algorithm of S-cubed is needed. In this paper, a novel detection and parameter estimation approach for the reconnaissance S-cubed radar signal is presented. First, the generalized time-frequency representation of Zhao, Atlas, and Marks （ZAM-GTFR） and Hough transforms （HT） are applied to detecting the signal, and then the initial frequency and modulation slope of LFM are estimated from the ZAM-GTFR. On the basis of LFM information, the reconstructing signal is generated. Finally, the code rate of discrete phase code is extracted from the negative peaks of the ZAM-GTFR. Simulation results show that the proposed algorithm has higher estimation accuracy when the signal to noise ratio （SNR） is above 3 dB.

关键词： signal detection parameter estimation spread spectrum stretch (S-cubed) generalized time-frequency representation (GTFR) Hough transforms

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Effect of human settlements on urban thermal environment and factor analysis based on multi-source data:A case study of Changsha city

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Journal of Geographical Sciences 2021年第6期31卷 819-838页

作者： xiong ying ZHANG Fang College of Architecture Changsha University of Science and TechnologyChangsha 410076China Hunan Key Lab of Land Resource Evaluation&Utilization Changsha 410007China Research Center of Resource Environment and Urban Planning Changsha 410114China

In view of the lack of comprehensive evaluation and analysis from the combination of natural and human multi-dimensional factors,the urban surface temperature patterns of Changsha in 2000,2009 and 2016 are retrieved based on multi-source spatial data(Landsat 5 and Landsat 8 satellite image data,POI spatial big data,digital elevation model,etc.),and 12 natural and human factors closely related to urban thermal environment are quickly *** standard deviation ellipse and spatial principal component analysis(PCA)methods are used to analyze the effect of urban human residential thermal environment and its influencing *** results showed that the heat island area increased by 547 km~2 and the maximum surface temperature difference reached 10.1℃during the period 2000–*** spatial distribution of urban heat island was mainly concentrated in urban built-up areas,such as industrial and commercial agglomerations and densely populated urban *** spatial distribution pattern of heat island is gradually decreasing from the urban center to the *** were multiple high-temperature centers,such as Wuyi square business circle,Xingsha economic and technological development zone in Changsha County,Wangcheng industrial zone,Yuelu industrial agglomeration,and Tianxin industrial *** 2000 to 2016,the main axis of spatial development of heat island remained in the northeast-southwest *** center of gravity of heat island shifted 2.7 km to the southwest with the deflection angle of 54.9°in 2000–*** center of gravity of heat island shifted to the northeast by 4.8 km with the deflection angle of 60.9°in 2009–*** the whole,the change of spatial pattern of thermal environment in Changsha was related to the change of urban construction *** the PCA method,it was concluded that landscape pattern,urban construction intensity and topographic landforms were the main factors affecting the spatial pattern of urban thermal environmen

关键词： thermal environment natural-human factor multi-source data spatial PCA Changsha city

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An integral panel method for the hydrodynamic analysis of hybrid contra-rotating shaft pod propulsors

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Journal of Ocean Engineering and Science 2018年第3期3卷 175-185页

作者： Rui Wang ying xiong Department of Naval Engineering Naval University of EngineeringWuhan 430033China

The present work is devoted to developing an efficient method for the analysis and design of hybrid contra-rotating shaft pod(HCRSP)*** geometry of contra-rotating propulsor(CRP)was then analyzed,and a steady integral panel method that treats the forward and aft propellers as a whole part is *** the study,the control equation of the steady integral panel method for CRP is derived in *** the experience of developing an integral panel method for CRP,the characteristics of panel singularity strength in HCRSP propulsor was *** on this analysis,an integral panel method for HCRSP propulsor is developed and the wake model ***,the method is applied in the performance analysis of HCRSP *** between experimental data and numerical results shows that the steady integral panel method has good accuracy in terms of open water *** the latter,the error source in the steady integral panel method is discussed.

关键词： Hybrid contra-rotating shaft pod propulsor Surface panel method Integral calculation model Wake model.

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Convergence of the Cesaro Mean for Rational Orthonormal Bases

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Acta Mathematica Sinica,English Series 2009年第4期25卷 581-592页

作者： ying xiong FU Luo Qing LI Key Laboratory of Applied Mathematics Hubei ProvinceFaculty of Mathematics and Computer Science Hubei UniversityWuhan 430062 P. R. China

This paper deals with the convergence of the Cesaro mean for the rational orthonormal bases. Provided the set of zeroes of rational orthonormal bases is formed by a periodic repetition of the same finite sequence, the explicit expression of so-called block-Fejer kernel is available, and some properties of the block-Fejer kernel are discussed. Based on the convergence of the block-Cesaro mean, the convergence of Cesaro mean is also provided.

关键词： Cesaro mean trigonometric series rational orthonormal basis

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Dimension of Slices Through Fractals with Initial Cubic Pattern

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Chinese Annals of Mathematics,Series B 2017年第5期38卷 1145-1178页

作者： Lifeng XI Wen WU ying xiong Department of Mathematics Ningbo UniversityNingbo 315211ZhejiangChina School of Mathematics South China University of TechnologyGuangzhou 510641China

In this paper, the Hausdorff dimension of the intersection of self-similar fractals in Euclidean space R^n generated from an initial cube pattern with an(n-m)-dimensional hyperplane V in a fixed direction is discussed. The authors give a sufficient condition which ensures that the Hausdorff dimensions of the slices of the fractal sets generated by "multirules" take the value in Marstrand's theorem, i.e., the dimension of the self-similar sets minus one. For the self-similar fractals generated with initial cube pattern, this sufficient condition also ensures that the projection measure μVis absolutely continuous with respect to the Lebesgue measure L^m. When μV《 L^m, the connection of the local dimension ofμVand the box dimension of slices is given.

关键词： Slice Self-similar set Dimension Fractal

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Spatiotemporal influences of land use/cover changes on the heat island effect in rapid urbanization area

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Frontiers of Earth Science 2019年第3期13卷 614-627页

作者： ying xiong Fen PENG Bin ZOU Research Center of Resource Environment and Urban Planning Changsha 410114China School of Architecture Changsha University of Science & TechnologyChangsha 410114China School of Geosciences and Info-physics Central South UniversityChangsha 410083China

Rapid urban sprawl and growth led to substantial urban thermal environment changes and influenced the local climate, environment, and quality of life of residents. Taking the Chang-Zhu-Tan urban agglomeration in China as a case, this study firstly identified the spatiotemporal patterns of surface urban heat island intensity (SUHII) and the land use/cover changes (LUCC) based on multi-temporal Landsat TM satellite data over 21 years, and then investigated the relationship between LUCC and SUHII by methods of logistic regression model and centroid shift analysis. The results showed that green spaces (e.g., cropland, forestland) of 899.13 km2 had been converted to built-up land during the 1994—2015 period, which caused significant urban expansion. The SUHII was the highest for built-up land, high for unused land, low for cropland and grassland, and the lowest for forestland and open water. Many areas experienced extensive rapid urbanization because of the emergence of the urban agglomeration, which resulted in the loss of green spaces and increased SUHI effects over the 21-year study period. In addition, the results of centroid shift analysis found that the growth of SUHII and the expansion of high SUHII areas are closely related to the expansion of an existing urban area in Xiangtan, while the increases of building density and height in Changsha resulted in the decrease of SUHII and spatiotemporal change of high SUHII areas. The analysis of the effects of land use/cover types on the SUHII in this study will contribute to future urban land use allocation for the mitigation of SUHI formation.

关键词： land use/cover change urbanization remote sensing surface urban heat island intensity centroid shift analysis

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