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Anti-inflammatory effects of taraxasterol on animal models

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Anti-inflammatory effects of taraxasterol on animal models

第十一届全国免疫学学术大会

作者： Zhang Xuemei wang ying Liu Xinyu Xu Lu wang Shasha Yanbian University

Purpose: Traditional Chinese medicine Taraxacum officinale has been widely used to treat inflammatory diseases. Taraxasterol is one of main active components isolated from Taraxacum officinale. Recently, we have demonstrated that taraxasterol has the in vitro anti-inflammatory effects. This study aims to determine the anti-inflammatory effects of taraxasterol against animal models. Methods: Anti-inflammatory effects were assessed in four animal models by using dimethylbenzene-induced mouse ear edema, carrageenan-induced rat paw edema, acetic acid-induced mouse vascular permeability and cotton pellet-induced rat granuloma tests. Results: Our results demonstrated that taraxasterol dose-dependently attenuated dimethylbenzene-induced mouse ear edema and carrageenan-induced rat paw edema, decreased acetic acid-induced mouse vascular permeability and inhibited cotton pellet-induced rat granuloma ***: Our finding indicates that taraxasterol has obvious anti-inflammatory activity on in vivo animal models. It will provide experimental evidences for the traditional use of Taraxacum officinale and taraxasterol in inflammatory diseases.

关键词： Taraxasterol ear edema granuloma paw edema vascular permeability

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定性组合建模技术研究与实现

系统仿真学报 2007年第3期19卷 535-537,542页

作者：王莹王东锋肖洋 91413部队 63918部队

自动建模是定性仿真领域新的研究方向,其目标是寻求自动创建定性模型的有效方法。针对这一目标,提出了面向对象的组合建模技术思想,使用对象描述模型知识;提出模型假设的分层描述机制,并建立了模型片断库的结构模型;在模型假设研究的基... 详细信息

自动建模是定性仿真领域新的研究方向,其目标是寻求自动创建定性模型的有效方法。针对这一目标,提出了面向对象的组合建模技术思想,使用对象描述模型知识;提出模型假设的分层描述机制,并建立了模型片断库的结构模型;在模型假设研究的基础上,提出基于关联推理的组合建模算法;此外,建立了组合建模与仿真的框架模型,实现了相关的建模与仿真算法。

关键词：组合建模片断仿真模型假设算法

Transition-Metal-Free Oxidative C5 C-H-Halogenation of 8-Aminoquinolines using Sodium Halides

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Transition-Metal-Free Oxidative C5 C-H-Halogenation of 8-Ami...

中国化学会第十三届全国有机合成化学学术研讨会

作者： ying wang Yang wang Kai Jiang Qian Zhang Dong Li School of Materials and Chemical Engineering Hubei University of Technology

Quinoline is an important heterocyclic structure as it has been found in many natural products,pharmaceuticals,agrochemicals and functional materials.1 The use of quinolines as synthesis intermediates and ligands for transition-metal catalysis has also been widely investigated.2 Thus,facile and efficient synthesis of substituted quinolines has attracted much *** substitution of quinolines through C-H functionalization was a useful ***,the substitution on the C5 position of quinoline scaffolds still remains challenges.3 In this work,an oxidative C-H-halogenation（Cl,Br） of 8-aminoquinoline amides on C5 position has been developed,in which the low-cost and innoxious sodium halides（Na X,X= Cl,Br） was used as halogenation reagents and inorganic reagent oxone as *** method avoided the use of transition-metal catalysts as well as transition-metal or organic oxidants,and showed air and moisture tolerance,good functional groups compatibility,gave the highly selective C5-halogenated products in good to excellent *** provides a simple and efficient synthetic strategy for the construction of C5 functionalized quinolines and has good application foreground.

关键词： transition-metal-free C5-halogenation quinoline sodium halide

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泊洛妥珠单抗不良反应的回顾性分析

中国现代应用药学 2024年第8期41卷 1106-1110页

作者：李莹代婷婷王冬天津市肿瘤医院空港医院天津300308 天津医科大学肿瘤医院国家肿瘤临床医学研究中心天津市肿瘤防治重点实验室天津市恶性肿瘤临床医学研究中心天津300060

目的分析泊洛妥珠单抗(联合苯达莫司汀+利妥昔单抗)所致不良反应的发生情况及临床特点,为临床安全合理用药提供参考。方法检索医院信息系统,收集2021年1月—2022年8月在天津市肿瘤医院空港医院住院并使用泊洛妥珠单抗的所有患者的病... 详细信息

目的分析泊洛妥珠单抗(联合苯达莫司汀+利妥昔单抗)所致不良反应的发生情况及临床特点,为临床安全合理用药提供参考。方法检索医院信息系统,收集2021年1月—2022年8月在天津市肿瘤医院空港医院住院并使用泊洛妥珠单抗的所有患者的病历资料,记录患者基本信息、用药情况、不良反应发生情况等,进行回顾性分析。结果纳入分析的患者共7例,其中男性4例(57.1%)、女性3例(42.8%),主要不良反应包括中性粒细胞减少和白细胞减少。不良反应主要发生在首次用药后3个月内,经对症治疗或观察等待后均可恢复,未发生因不良反应死亡病例。结论临床合理使用泊洛妥珠单抗时,应加强临床工作者对不良反应的监测和管理,保障患者用药安全性。

关键词：泊洛妥珠单抗不良反应回顾性分析

基于AI视频图像处理的水电机组运转监测与智能报警技术研究

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电网与清洁能源 2022年第1期38卷 121-127,134页

作者：袁璞郭歌王莹刘悦熊磊国网陕西省安康水力发电厂陕西安康725029 西安理工大学陕西西安710048

水电机组作为水电站生产电能的主要动力设备,机组运行的稳定性不仅影响着水电站的经济效益,还影响着水电站和工作人员的安全问题。为了保障水电机组安全平稳运行、及时发现机组运行异常状态,该文针对基于AI视频技术的水电机组运转监测... 详细信息

水电机组作为水电站生产电能的主要动力设备,机组运行的稳定性不仅影响着水电站的经济效益,还影响着水电站和工作人员的安全问题。为了保障水电机组安全平稳运行、及时发现机组运行异常状态,该文针对基于AI视频技术的水电机组运转监测与报警系统做了一系列初步研究。首先,给出了系统的硬件设计方案;其次,重点研究并分析了视频图像预处理技术、目标检测以及目标跟踪等可用于水电机组运转监测的AI算法;最后,给出了机组运转监测与报警系统的软件设计方案。研究结果可以为后续研发的基于人工智能图像识别技术的水电机组运转监测与报警系统打下基础,为建设智慧水电厂提供参考。

关键词：水电机组人工智能视频图像监测算法运转监测与报警系统

枕下乙状窦后入路前庭神经鞘瘤术后短期和长期面神经功能的影响因素分析

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中华耳鼻咽喉头颈外科杂志 2023年第12期58卷 1183-1190页

作者：任军伟徐健黄翔徐铭陈明宇王莹王炜钟平复旦大学附属华山医院神经外科、国家神经疾病医学中心、上海市脑功能重塑及神经再生重点实验室、复旦大学神经外科研究所、复旦大学上海医学院上海200040 上海交通大学医学院附属第九人民医院整形外科上海200011

目的总结枕下乙状窦后入路手术切除前庭神经鞘瘤的术后短期和长期面神经功能情况及面神经保护经验,并分析其影响因素。方法收集2013年1月至2018年2月在复旦大学附属华山医院由颅底外科小组行显微镜下枕下乙状窦后入路手术的前庭神经鞘... 详细信息

目的总结枕下乙状窦后入路手术切除前庭神经鞘瘤的术后短期和长期面神经功能情况及面神经保护经验,并分析其影响因素。方法收集2013年1月至2018年2月在复旦大学附属华山医院由颅底外科小组行显微镜下枕下乙状窦后入路手术的前庭神经鞘瘤患者的临床资料,共纳入308例,其中男性132例、女性176例,年龄17~79岁,平均年龄47.9岁。记录患者临床表现、影像学表现、术中所见及术后面神经功能随访结果。使用SPSS 23.0统计软件,对短期及长期面神经功能及影响其恢复的变量进行单因素和多因素分析。结果304例肿瘤完全切除,4例近全切除;306例面神经解剖保留,2例面神经离断,术中均予行神经吻合一期重建。300例成功随访,8例失访。随访时间1~60个月(平均52.0个月)。术后2周内面神经功能良好[House-Brackmann(HB)分级Ⅰ~Ⅱ级]96例,功能不良(HB分级Ⅲ~Ⅵ级)212例;术后1年随访共295例,其中198例面神经功能良好,97例功能不良;术后3年随访共294例,其中面神经功能良好者219例,功能不良75例;随访到术后5年者共189例,其中面神经功能良好者155例,功能不良者34例。逻辑回归分析显示,影响术后短期面神经功能的相关因素有肿瘤直径(P=0.011)和术末面神经刺激阈值(P<0.001);影响术后长期面神经功能的相关因素包括肿瘤直径(P=0.005)、术末面神经刺激阈值(P=0.005)及面神经康复训练等。结论肿瘤直径是与术后面神经功能相关的独立因素,肿瘤越大术后面神经功能更差;术中电生理监测的肌电图微小电流刺激(刺激阈值≤0.05 mA)可以预测短期和长期的面神经功能预后;系统的面部康复训练能有效促进手术后面神经功能的恢复。

关键词：前庭神经鞘瘤显微外科手术面神经功能监测,手术中康复训练

COX健康行为互动模式干预对高血压脑出血后偏瘫患者精神状态和健康信念的影响

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中国健康心理学杂志 2023年第7期31卷 1057-1062页

作者：张敏敏谢书红王颖上海永慈康复医院护理部 201100 黄淮学院医学院护理学教研室

目的:探讨COX健康行为互动模式干预对高血压脑出血后偏瘫患者精神状态和健康信念的影响。方法:将2018年1月-2022年8月于某院住院治疗的126例高血压脑出血后偏瘫患者依据入院先后顺序分为对照组(n=63)和研究组(n=63)。对照组予以常规健... 详细信息

目的:探讨COX健康行为互动模式干预对高血压脑出血后偏瘫患者精神状态和健康信念的影响。方法:将2018年1月-2022年8月于某院住院治疗的126例高血压脑出血后偏瘫患者依据入院先后顺序分为对照组(n=63)和研究组(n=63)。对照组予以常规健康教育干预,研究组予以COX健康行为互动模式干预。比较两组干预前后的精神状态、健康信念、自我管理能力、日常生活活动能力,并评价两组患者对干预的满意度。结果:干预后,两组汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)评分均低于干预前,且研究组显著低于对照组(t=3.695,2.609;P<0.05);干预后,两组健康信念量表中感知到易感性、感知到严重性、感知到障碍、感知到益处、维护健康动机评分均升高,且研究组各评分显著高于对照组(t=6.150,7.383,3.593,4.922,3.773;P<0.05);干预后,两组自我管理能力各维度评分均升高,且研究组各评分显著高于对照组(t=5.633,4.628,5.705,5.003;P<0.05);干预后3个月,两组日常生活能力量表(ADL)评分和barthel指数评分均升高,且研究组ADL评分、barthel指数评分均显著高于对照组(t=3.772,4.778;P<0.05);研究组对干预的满意度为92.06%,显著高于对照组的74.60%(χ~2=6.914,P<0.05)。结论:对高血压脑出血后偏瘫患者应用COX健康行为互动模式干预能有效改善其精神状态,提升其健康信念及自我管理能力水平,提高患者的日常生活活动能力,且患者满意度高。

关键词：高血压脑出血偏瘫患者 COX健康行为互动模式精神状态健康信念日产生活活动能力

Tetracysteine as a Reporter for Gene Therapy

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Biomedical and Environmental Sciences 2009年第6期22卷 496-501页

作者： CHEN-YU XU ying GU wang-HENG HOU YU-QIONG QUE SHUANG-GUAN GAO TONG CHENG NING-SHAO XI National Institute of Diagnostics and Vaccine Development for Infectious Diseases School of Life Sciences Xiamen University Xiamen 361005 Fujian China Key Laboratory of Ministry of Education for Cell Biology and Tumor Cell Engineering School of Life Sciences Xiamen University Xiamen 361005 Fujian China

Objective To study the feasibility of using tetracysteine （TC） reporter in gene therapy. Methods Effects of TC reporter and conventional reporter genes encoding green fluorescence protein （GFP） and luciferase （Luc） on expression and function of the therapeutic gene MGMT^P140K were compared. Cytotoxicity and drug resistance were studied by Western blot. TC reporter used in therapy was analyzed by flow cytometry （FCM）. Results The TC reporter had no toxicity to cells and neither affected the expression or activity of therapeutic gene as compared to GFP and Luc. TC could be used in blood sample detection. Conclusion TC is a new kind of reporter gene for lentiviral vector in future gene therapy.

关键词： Tetracysteine Lentiviral vector Reporter Gene therapy

International experts consensus guidelines on robotic liver resection in 2023

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世界胃肠病学杂志:英文版 2023年第32期29卷 4815-4830页

作者： Rong Liu Mohammed Abu Hilal Go Wakabayashi Ho-Seong Han Chinnusamy Palanivelu Ugo Boggi Thilo Hackert Hong-Jin Kim Xiao-ying wang Ming-Gen Hu Gi Hong Choi Fabrizio Panaro Jin He Mikhail Efanov Xiao-Yu Yin Roland S Croner Yu-Man Fong Ji-Ye Zhu Zheng Wu Chuan-Dong Sun Jae Hoon Lee Marco V Marino Iyer Shridhar Ganpati Peng Zhu Zi-Zheng wang Ke-Hu Yang Jia Fan Xiao-Ping Chen Wan Yee Lau Faculty of Hepato-Pancreato-Biliary Surgery The First Medical Center of Chinese PLA General HospitalBeijing 100000China Hepatobiliary Pancreatic Robotic&Laparoscopic SurgeryPoliambulanza Foundation HospitalBrescia 25100Italy Center for Advanced Treatment of HBP Diseases Ageo Central General HospitalSaitama 362-0075Japan Department of Surgery Seoul National University Bundang HospitalSeoul National University College of MedicineSeoul 03080South Korea GEM Hospital&Research Centre GEM Hospital&Research CentreCoimbatore 641045India Division of General and Transplant Surgery University of PisaPisa 56126Italy Department of General Visceral and Thoracic SurgeryUniversity Hospital Hamburg-EppendorfHamburg 20251Germany Department of Surgery Yeungnam University HospitalDaegu 42415South Korea Department of Liver Surgery and Transplantation Liver Cancer InstituteZhongshan HospitalFudan UniversityShanghai 200032China Division of Hepato-Biliary-Pancreatic Surgery Department of SurgerySeverance HospitalYonsei UniversityCollege of MedicineSeoul 03722South Korea Department of Surgery/Division of Robotic and HBP Surgery Montpellier University Hospital-School of MedicineMontpellier 34090France Department of Surgery Johns Hopkins University School of MedicineBaltimoreMD 21218United States Department of Hepato-Pancreato-Biliary Surgery Moscow Clinical Scientific CenterMoscow 111123Russia Department of Pancreatobiliary Surgery The First Affiliated HospitalSun Yat-Sen UniversityGuangzhou 510080Guangdong ProvinceChina Department of General VisceralVascular and Transplant SurgeryUniversity Hospital MagdeburgMagdeburg 39120Germany Department of Surgery City of Hope Medical CenterDuarteCA 91010United States Department of Hepatobiliary Surgery Peking University People’s HospitalBeijing 100000China Department of Hepatobiliary Surgery The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina Department of Hepatobiliary and Pancreatic Surgery The Affiliated Ho

The robotic liver resection(RLR)has been increasingly applied in recent years and its benefits shown in some aspects owing to the technical advancement of robotic surgical system,however,controversies still *** on the foundation of the previous consensus statement,this new consensus document aimed to update clinical recommendations and provide guidance to improve the outcomes of RLR clinical *** guideline steering group and guideline expert group were formed by 29 international experts of liver surgery and evidence-based medicine(EBM).Relevant literature was reviewed and analyzed by the evidence evaluation *** to the WHO Handbook for Guideline Development,the Guidance Principles of Development and Amendment of the Guidelines for Clinical Diagnosis and Treatment in China 2022,a total of 14 recommendations were *** them were 8 recommendations formulated by the GRADE method,and the remaining 6 recommendations were formulated based on literature review and experts’opinion due to insufficient EBM *** international experts consensus guideline offered guidance for the safe and effective clinical practice and the research direction of RLR in future.

关键词： Robotic liver resection Laparoscopic liver resection Guidelines Expert consensus