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Research 2024年第1期2023卷 81-95页

作者： Fangxuan Chu Ruxin Tan Xin Wang Xiaoqing Zhou Ren ma Xiaoxu ma ying Li Ruixu Liu Chunlan Zhang Xu Liu Tao Yin Zhipeng Liu Institute of Biomedical Engineering Chinese Academy of Medical Sciences and Peking Union Medical CollegeTianjin300192China Tianjin Institutes of Health Science Tianjin301600China Neuroscience Center Chinese Academy of Medical Science&Peking Union Medical CollegeBeijing100730China

The neuropathological features of Alzheimer’s disease include amyloid *** emerging evidence suggests that Piezo1,a mechanosensitive cation channel,plays a critical role in transforming ultrasound-related mechanical stimuli through its trimeric propeller-like structure,but the importance of Piezo1-mediated mechanotransduction in brain functions is less ***,apart from mechanical stimulation,Piezo1 channels are strongly modulated by *** assume that Piezo1 may play a role in converting mechanical and electrical signals,which could induce the phagocytosis and degradation of Aβ,and the combined effect of mechanical and electrical stimulation is superior to single mechanical ***,we design a transcranial magneto-acoustic stimulation(TmaS)system,based on transcranial ultrasound stimulation(TUS)within a magnetic field that combines a magnetoacoustic coupling effect electric field and the mechanical force of ultrasound,and applied it to test the above hypothesis in 5xFAD *** tests,in vivo electrophysiological recordings,Golgi–Cox staining,enzyme-linked immunosorbent assay,immunofluorescence,immunohistochemistry,real-time quantitative PCR,Western blotting,RNA sequencing,and cerebral blood flow monitoring were used to assess whether TmaS can alleviate the symptoms of AD mouse model by activating Piezo1.

关键词： stimulation Alzheimer Piezo1

Wide temperature range,air stable,transparent,and self-powered photodetectors enabled by a hybrid film of graphene and singlewalled carbon nanotubes

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Nano Research 2024年第7期17卷 6582-6593页

作者： ying yue Di Zhang Pengyu Wang Xin Wu yuejuan Zhang Yanchun Wang Xiao Zhang Xiaojun Wei Huaping Liu Weiya Zhou Beijing National Laboratory for Condensed matter Physics and Institute of PhysicsChinese Academy of SciencesBeijing 100190China School of Physical Sciences and College of materials Science and Optoelectronic Technology University of Chinese Academy of SciencesBeijing 100049China Songshan Lake materials Laboratory Dongguan 523808China Beijing Key Laboratory for Advanced Functional materials and Structure Research Beijing 100190China

Transparent photovoltaic devices(TPVDs)have attracted increasing attention in emerging electronic *** the application scenarios extend,there raise higher requirements regarding the stability and operating temperature range of *** this work,a unique preparation strategy is proposed for air stable TPVD with a wide operating temperature range,i.e.,a nanoscale architecture termed as H-TPVD is constructed that integrates a free-standing and highly transparent conductive hybrid film of graphene and single-walled carbon nanotubes(G-SWNT TCF for short)with a metal oxide NiO/TiO_(2)*** preparation approach is suitable for scaling *** to the excellent transparent conductivity of the freestanding G-SWNT hybrid film and the ultrathin NiO/TiO_(2)heterojunction(100 nm),H-TPVD selectively absorbs the ultraviolet(UV)band of sunlight and has a transparency of up to 71%in the visible *** integrated nanoscale architecture manifests the significant holecollecting capability of the G-SWNT hybrid film and the efficient carrier generation and separation within the ultrathin NiO/TiO_(2)heterojunction,resulting in excellent performance of the H-TPVD with a specific detectivity of 2.7×10^(10) ***,the freestanding G-SWNT TCF is a super stable and non-porous two-dimensional film that can insulate gas molecules,thereby protecting the surface properties of NiO/TiO_(2)heterojunctions and enhancing the stability of *** subjected to 20,000 cycles and storage in air for three months,the performance parameters such as photo-response signal,output power,and specific detectivity show no noticeable *** particular,the as-fabricated self-powered H-TPVD can operate over a wide temperature range from −180 to 300℃,and can carry out solar-blind UV optical communication in this *** addition,the 4×4 array H-TPVD demonstrates clear optical *** results make it possible for H-TPVD to expand its potential application scenarios.

关键词： transparent photovoltaic devices hybrid films of graphene and single-walled carbon nanotubes metal oxides stability wide temperature range

Revealing the role of CCoAOMT1: fine-tuning bHLH transcription factors for optimal anther development

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Science China(Life Sciences) 2024年第3期67卷 565-578页

作者： Zesen Lai Jianzheng Wang ying Fu Menghan Wang Hong ma Shiqing Peng Fang Chang State Key Laboratory of Genetic Engineering Ministry of Education Key Laboratory of Biodiversity Sciences and Ecological Engineering and Institute of Biodiversity SciencesInstitute of Plant BiologySchool of Life SciencesFudan UniversityShanghai 200438China School of Tropical Agriculture and Forestry Agriculture-Rural Affairs and Rural RevitalizationHainan UniversityHaikou 570228China Key Laboratory of Biology and Genetic Resources of Tropical Crops Ministry of AgricultureInstitute of Tropical Bioscience and BiotechnologyChinese Academy of Tropical Agricultural SciencesHaikou 571101China Department of Biology Huck Institutes of the Life SciencesPennsylvania State UniversityUniversity ParkPA 16802USA

The tapetum,a crucial innermost layer encompassing male reproductive cells within the anther wall,plays a pivotal role in normal pollen *** transcription factors (TFs) bHLH010/089/091 redundantly facilitate the rapid nuclear accumulation of DYSFUNCTIONAL TAPETUM 1,a gatekeeper TF in the ***,the regulatory mechanisms governing the activity of bHLH010/089/091 remain *** this study,we reveal that caffeoyl coenzyme A O-methyltransferase 1 (CCoAOMT1) is a negative regulator affecting the nuclear localization and function of bHLH010 and bHLH089,probably through their K259 *** findings underscore that CCoAOMT1 promotes the nuclear export and degradation of bHLH010 and ***,elevated CCoAOMT1 expression resulted in defective pollen development,mirroring the phenotype observed in bhlh010 bhlh089 ***,our investigation revealed that the K259A mutation in the bHLH089 protein disrupted its translocation from the nucleus to the cytosol and impeded its degradation induced by ***,transgenic plants with the probHLH089::bHLH089^(K259A)construct failed to rescue proper pollen development or gene expression in bhlh010 bhlh089 ***,these findings emphasize the need to maintain balanced TF homeostasis for male *** firmly establish CCoAOMT1 as a pivotal regulator that is instrumental in achieving equilibrium between the induction of the tapetum transcriptional network and ensuring appropriate anther development.

关键词： anther development nuclear localization bHLH O-methyltransferase transcription factor homeostasis

北京2022年冬奥会六足冰壶机器人机构设计与运动规划

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Engineering 2024年第4期35卷 15-31页

作者： Ke Yin yue Gao Feng Gao Xianbao Chen yue Zhao Yuguang Xiao qiao Sun Jing Sun School of Electronic Information and Electrical Engineering Shanghai Jiao Tong UniversityShanghai 200240China Key Laboratory of Mechanical System and Vibration School of Mechanical EngineeringShanghai Jiao Tong UniversityShanghai 200240China

When a curling rock slides on an ice sheet with an initial rotation,a lateral movement occurs,which is known as the curling *** force of friction between the curling rock and the ice sheet changes continually with changes in the environment;thus,the sport of curling requires great skill and *** throwing of the curling rock is a great challenge in robot design and control,and existing curling robots usually adopt a combination scheme of a wheel chassis and gripper that differs significantly from human throwing movements.A hexapod curling robot that imitates human kicking,sliding,pushing,and curling rock rotating was designed and manufactured by our group,and completed a perfect show during the Beijing 2022 Winter Olympics *** switching between the walking and throwing tasks is realized by the robot’s morphology transformation based on leg configuration *** robot’s controlling parameters,which include the kicking velocity v_(k),pushing velocity v_(p),orientation angle θc,and rotation velocityω,are determined by aiming and sliding models according to the estimated equivalent friction coefficientμ_(equ)and ratio e of the front and back *** stable errors between the target and actual stopping points converge to 0.2 and 1.105 m in the simulations and experiments,respectively,and the error shown in the experiments is close to that of a well-trained wheelchair curling *** robot holds promise for helping ice-makers rectify ice sheet friction or assisting in athlete training.

关键词： Legged robot Curling robot Winter Olympics Mechanism design Motion planning

Global epidemiology of mental disorder in atrial fibrillation between 1998-2021:A systematic review and meta-analysis

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World Journal of Psychiatry 2024年第1期14卷 179-193页

作者： Shuai Zhang Na Zhang Liu Liu Wang Zheng Zi-Lin ma Si-Yu qiao ying-Li Zhao Yi-Hong Wei Gang Wu Qiu-Ting Yu Bing Deng Lin Shen Department of Cardiology LongHua Hospital Shanghai University of Traditional Chinese MedicineShanghai 200032China Department of Dermatology Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai 200437China

BACKGROUND As the burden of mental disorders among patients with atrial fibrillation(AF)increases,researchers are beginning to pay close attention to the risk and prevalence of these *** studies have independently analyzed the risk of comorbidity with depression and anxiety in patients with AF,no study has systematically focused on the global epidemiology of these two mental *** To explore the prevalence of depression and anxiety in patients with *** Five databases were searched from their date of establishment until January *** studies reporting the comorbidity of AF with depression and anxiety,were included in this *** information,such as the first author/publication year,study year,study type,and prevalence of depression and anxiety,were *** SE 15.1 was used to analyze the ***,meta-regression,and sensitivity analyses were performed to estimate study *** After a thorough search,26 studies were identified and included in this *** prevalence rates of depression and anxiety in adults with AF were 24.3%and 14.5%,*** adult males with AF,the prevalence was 11.7%and 8.7%,respectively,whereas in females it was 19.8%and 10.1%,*** older adults with AF,the prevalence rates of depression and anxiety were 40.3%and 33.6%,*** highest regional prevalence of depression and anxiety was observed in European(30.2%)and North American(19.8%)patients with *** In this study,we found that the prevalence of depression and anxiety among patients with AF varies with sex,region,and evaluation scales,suggesting the need for psychological interventions for patients with AF in clinical practice.

关键词： Atrial fibrillation Depression Anxiety Prevalence

Remediation of di(2-ethylhexyl)phthalate(DEHP)contaminated black soil by freeze-thaw aging biochar

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Journal of Environmental Sciences 2024年第1期135卷 681-692页

作者： Lei Wang Zeyu Dou Chaoran ma Xiaochen Jia Hongye Wang Wenjing Bao Lei Wang Jianhua Qu ying Zhang School of Resources and Environment Northeast Agricultural UniversityHarbin 150030China

Di(2-ethylhexyl)phthalate(DEHP),a complex structure with high toxicity,is a common organic *** study investigated the effects of fresh biochar(FBC),and freeze-thaw cycled aged biochar(FTC-BC)on DEHP-contaminated soils using a pot *** specific surface area of FBC increased from 145.20 to 303.50 m~2/g,and oxygen-containing functional groups increased from 1.26 to 1.48 mol/g after freeze-thaw cycles,greatly enhancing the adsorption of DEHP by biochar in the *** comprehensive radar chart evaluation showed that FBC and FTC-BC reduced DEHP growth stress and improved the soil *** with FBC,FTC-BC performed better in protecting the normal growth of pakchoi and improving soil *** addition,the application of biochar increased the diversity and abundance of bacteria in the DEHP-contaminated soil and changed the composition of the soil bacterial *** partial least squares path model(PLS-PM)showed that adding biochar as a soil remediation agent significantly positively impacted soil nutrients and indirectly reduced the DEHP levels in soil and plants by increasing soil microbial *** with FBC,FTC-BC creates a more satisfactory living environment for microorganisms and has a better effect on the degradation of DEHP in the *** study provides a theoretical basis for future biochar remediation of DEHP-contaminated soils in cold high-latitude regions.

关键词： DEHP Freeze-thaw cycles Biochar Soil restoration

Research on the development methodology for clinical practice guidelines for organic integration of traditional Chinese medicine and Western medicine

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Military Medical Research 2024年第3期11卷 313-322页

作者： ying-Hui Jin Yan-Ping Wang ying-Lan Xie Gui-Hua Tian Xiao-Yu Zhang Nan-Nan Shi Ke-Hu Yang Xin Sun Yao-Long Chen Da-Rong Wu Xin-Feng Guo Long Ge Chen Zhao Cheng Lu Yin Jiang Jing Guo Si-Yu Yan Yong-Bo Wang qiao Huang Xiang-ying Ren ying-yue Rao Yun-Yun Wang Meng-Qian Yuan Xian-Tao Zeng Hong-Cai Shang Center for Evidence-Based and Translational Medicine Zhongnan Hospital of Wuhan UniversityWuhan 430071China Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijing 100700China China Center for Evidence Based Traditional Chinese Medicine Beijing 100029China Hubei Provincial Hospital of Traditional Chinese Medicine Wuhan 430074China Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing Dongzhimen HospitalBeijing University of Chinese MedicineBeijing 100700China Evidence-Based Medicine Center School of Basic Medical SciencesLanzhou UniversityLanzhou 730000China China Center for Evidence-Based Medicine West China Hospital of Sichuan UniversityChengdu 610041China State Key Laboratory of Dampness Syndrome of Chinese Medicine the Second Affliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510120China Evidence-based Medicine Team Guangdong Provincial Hospital of Traditional Chinese MedicineGuangzhou 510120China Nanjing University of Chinese Medicine Nanjing 210023China Jiangsu Province Hospital of Chinese Medicine Nanjing 210029China

Integrated traditional Chinese medicine(TCM)and Western medicine(WM)is a new medical science grounded in the knowledge bases of both TCM and WM,which then forms a unique modern medical system in *** TCM and WM has a long history in China,and has made important achievements in the process of clinical diagnosis and ***,the methodological defects in currently published clinical practice guidelines(CPGs)limit its *** organic integration of TCM and WM is a deeper integration of TCM and *** realize the progression of"integration"to"organic integration",a targeted and standardized guideline development methodology is ***,the purpose of this study is to establish a standardized development procedure for clinical practice guidelines for the organic integration of TCM and WM to promote the systematic integration of TCM and WM research results into clinical practice guidelines in order to achieve optimal results as the whole is greater than the sum of the parts.

关键词： Methodology Traditional Chinese medicine Western medicine Organic integration Clinical practice guidelines(CPGs)

Intrahepatic portal venous systems in adult patients with cavernous transformation of portal vein: Imaging features and a new classification

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Hepatobiliary & Pancreatic Diseases International 2024年第5期23卷 481-486页

作者： Xin Huang Qian Lu yue-Wei Zhang Lin Zhang Zhi-Zhong Ren Xiao-Wei Yang ying Liu Rui Tang Hepatopancreatobiliary Center Beijing Tsinghua Changgung HospitalSchool of Clinical MedicineTsinghua UniversityBeijing 102218China

Background: Cavernous transformation of the portal vein(CTPV) due to portal vein obstruction is a rare vascular anomaly defined as the formation of multiple collateral vessels in the hepatic hilum. This study aimed to investigate the imaging features of intrahepatic portal vein in adult patients with CTPV and establish the relationship between the manifestations of intrahepatic portal vein and the progression of CTPV. Methods: We retrospectively analyzed 14 CTPV patients in Beijing Tsinghua Changgung Hospital. All patients underwent both direct portal venography(DPV) and computed tomography angiography(CTA) to reveal the manifestations of the portal venous system. The vessels measured included the left portal vein(LPV), right portal vein(RPV), main portal vein(MPV) and the portal vein bifurcation(PVB). Results: Nine males and 5 females, with a median age of 40.5 years, were included in the study. No significant difference was found in the diameters of the LPV or RPV measured by DPV and CTA. The visualization in terms of LPV, RPV and PVB measured by DPV was higher than that by CTA. There was a significant association between LPV/RPV and PVB/MPV in term of visibility revealed with DPV( P = 0.01), while this association was not observed with CTA. According to the imaging features of the portal vein measured by DPV, CTPV was classified into three categories to facilitate the diagnosis and treatment. Conclusions: DPV was more accurate than CTA for revealing the course of the intrahepatic portal vein in patients with CTPV. The classification of CTPV, that originated from the imaging features of the portal vein revealed by DPV, may provide a new perspective for the diagnosis and treatment of CTPV.

关键词： Cavernous transformation of the portal vein Classification Direct portal venography Intrahepatic portal venous system

Identifying coronary artery bypass grafting patients at high risk for adverse long-term prognosis using serial health-related quality of life assessments

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Chinese Medical Journal 2024年第9期137卷 1069-1077页

作者： Juncheng Wang Hanning Liu Chao yue Limeng Yang Kai Yang Yan Zhao Huan Ren ying Zhang Zhe Zheng National Clinical Research Center for Cardiovascular Diseases State Key Laboratory of Cardiovascular DiseaseFuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China Department of Cardiovascular Surgery Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China Department of Vascular Surgery Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China Department of Cardiac Surgery Wuhan Asia Heart HospitalWuhanHubei 430022China

Background:Patients who undergo coronary artery bypass grafting(CABG)are known to be at a significant risk of experiencing long-term adverse events,emphasizing the importance of regular *** health-related quality of life(HRQoL)serves as a direct method to gauge *** objective is to ascertain the prognostic significance of consecutive HRQoL assessments using the Physical Component Summary(PCS)and Mental Component Summary(MCS)derived from the Short-Form 36(SF-36)health survey in CABG ***:The study population consisted of 433 patients who underwent isolated elective CABG at Fuwai Hospital between 2012 and ***-36 assessments were conducted during both the hospitalization period and *** primary endpoint of the study was all-cause mortality,while the secondary outcome was a composite measure including death,myocardial infarction,stroke,and repeat *** assessed the relationships between the PCS and MCS at baseline,as well as their changes during the first 6 months after the surgery(referred to asΔPCS andΔMCS,respectively),and the observed ***:The patients were followed for an average of 6.28 years,during which 35 individuals(35/433,8.1%)*** adjusting for clinical variables,it was observed that baseline MCS scores(hazard ratio[HR]for a 1-standard deviation[SD]decrease,1.57;95%confidence interval[CI],1.07-2.30)andΔMCS(HR for a 1-SD decrease,1.67;95%CI,1.09-2.56)were associated with all-cause ***,baseline PCS scores andΔPCS did not exhibit a significant relationship with all-cause ***,there was a dose-response relationship observed betweenΔMCS and the likelihood of all-cause mortality(HRs for the 2nd,3rd and 4th quartiles compared to the 1st quartile,0.33,0.45 and 0.11,respectively).Conclusions:Baseline MCS and changes in MCS were independent predictors for long-term mortality of *** mental health status and recovery indicated better prognosis.

关键词： Coronary artery bypass grafting Coronary artery disease Prognosis Quality of life Short-Form 36 Risk factor Serial measurements

Diagnostic Accuracy of Computerized Bowel Sound Analysis with Non-Invasive Devices for Irritable Bowel Syndrome:A Systematic Review and Meta-Analysis

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Chinese Medical Sciences Journal 2024年第2期39卷 122-130页

作者： Xia-Xiao Yan yue-Lun Zhang Yu-Pei Zhang ying-Yun Yang Dong Wu Department of Gastroenterology State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Eight-Year Medical Doctor Program Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Medical Research Center Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China

Objective To assess the diagnostic accuracy of bowel sound analysis for irritable bowel syndrome(IBS)with a systematic review and *** We searched MEDLINE,Embase,the Cochrane Library,Web of Science,and IEEE Xplore databases until September ***-sectional and case-control studies on diagnostic accuracy of bowel sound analysis for IBS were *** estimated the pooled sensitivity,specificity,positive likelihood ratio,negative likeli-hood ratio,and diagnostic odds ratio with a 95% confidence interval(CI),and plotted a summary receiver operat-ing characteristic curve and evaluated the area under the *** Four studies were *** pooled diagnostic sensitivity,specificity,positive likelihood ratio,nega-tive likelihood ratio,and diagnostic odds ratio were 0.94(95%CI,0.87‒0.97),0.89(95%CI,0.81‒0.94),8.43(95%CI,4.81‒14.78),0.07(95%CI,0.03‒0.15),and 118.86(95%CI,44.18‒319.75),respectively,with an area under the curve of 0.97(95%CI,0.95‒0.98).Conclusions Computerized bowel sound analysis is a promising tool for ***,limited high-quality data make the results'validity and applicability *** is a need for more diagnostic test accuracy studies and better wearable devices for monitoring and analysis of IBS.

关键词： irritable bowel syndrome bowel sound analysis diagnostic accuracy systematic review meta-analysis