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基于MRI完全型盘状半月板矢状位的形态分析

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实用骨科杂志 2024年第7期30卷 617-620页

作者：戴祝陈宇浠邬赫廖瑛吴彪黄文明誉南华大学附属第一医院骨科中心运动医学专科湖南衡阳421001

目的基于MRI观察完全型外侧盘状半月板(complete discoid lateral meniscus,CDLM)与正常外侧半月板矢状位的形态学差异,探索CDLM破裂的机制。方法收集2017年1月至2020年12月于南华大学附属第一医院行膝关节镜半月板手术的患者资料,选取... 详细信息

目的基于MRI观察完全型外侧盘状半月板(complete discoid lateral meniscus,CDLM)与正常外侧半月板矢状位的形态学差异,探索CDLM破裂的机制。方法收集2017年1月至2020年12月于南华大学附属第一医院行膝关节镜半月板手术的患者资料,选取符合纳入标准的95例99膝,其中男36例38膝,女59例61膝;年龄18~55岁,平均(45.63±6.81)岁。其中29例30膝CDLM破裂(A组),16例16膝CDLM未破裂(B组),51例53膝正常外侧半月板(C组)。分别测量半月板前后径(anteroposterior diameter,APD)以及外侧胫骨近端前后径(tibial diameter,TD),用组内相关系数(intraclass correlation coefficient,ICC)分析测量者之间的一致性,取两次测量的平均值,计算APD/TD比值,比较各组之间的差异。结果APD和TD测量的ICC值分别为0.782和0.972。A组和B组APD比较差异无统计学意义(P>0.05),但两组均小于C组(P0.05),但A组明显小于C组(P0.05),B组APD/TD比值小于C组(P<0.05)。结论CDLM的APD及TD均较正常半月板小,CDLM破裂后APD增大。

关键词：外侧盘状半月板核磁共振矢状位

Immunologic mechanisms and treatment of acute coronary syndromes

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Chinese Medical Journal 2006年第24期119卷 2108-2113页

作者： LIU ying liao Yu-hua CHENG Xiang Institute of Cardiology Union Hospital Tongji Medical College of Huazhong University of Sciences ＆ Technology Wuhan 430022 China

Acute coronary syndromes （ACS） consist of unstable angina pectoris, non-ST segment elevation myocardial infarction and ST segment elevation myocardial infarction. The pathogenic mechanism of ACS is most often based on thrombosis secondary to plaque rupture in atherosclerosis （AS）. Recent studies indicate that immune and inflammatory responses are associated with the plaque instability in AS.1 Here we review molecular and cellular immunologic processes linked to initiation and progression of ACS and discuss potential applications of immunosuppressant therapy and the possible beneficial immune effects of some cardiovascular medicines used commonly in ACS.

关键词： acute coronary syndrome immunity stents glucocorticosteroids rapamycin

Inhibitory effect on subretinal fibrosis by anti-placental growth factor treatment in a laser-induced choroidal neovascularization model in mice

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International Journal of Ophthalmology(English edition) 2022年第2期15卷 189-196页

作者： Yi Zhang Ding-ying liao Jian-Ming Wang Li-Jun Wang Xi-Ting Yang Ai-Yi Zhou Department of Ophthalmology the Second Affiliated Hospital of Xi’an Jiaotong University

AIM:To investigate whether anti-placental growth factor(PGF) can inhibit subretinal fibrosis and whether this effect is mediated by the inhibitory effect of PGF on epithelial-mesenchymal transition(EMT) of retinal pigment epithelial(RPE) ***:Subretinal fibrosis model was established in laser induced choroidal neovascularization(CNV) mice on day 21 after laser *** staining(IFS) of cryosections and enzyme-linked immunosorbent assay(ELISA) were used to detect the expression of *** of whole choroidal flat-mounts was used to detect the degree of subretinal *** of cryosections and ELISA were used to detect the expression of EMT related indicators in subretinal fibrosis ***:The expression of PGF protein in subretinal fibrosis lesions was significantly up-regulated(P<0.05),and mainly co-stained with pan-cytokeratin labeled RPE *** injection of anti-PGF neutralizing antibody reduced the area of subretinal fibrosis and the ratio of fibrotic/angiogenic area significantly at the concentrations of 0.25,0.5,1.0,and 2.0 μg/μL(all P<0.05).The expression of E-cadherin in the local RPE cells decreased,while α-SMA increased significantly in subretinal fibrosis lesions,and the application of anti-PGF neutralizing antibody could reverse these changes(P<0.05).CONCLUSION:The expression of PGF is up-regulated in the lesion site of subretinal fibrosis and mainly expressed in RPE *** injection of anti-PGF neutralizing antibody can significantly inhibit the degree of subretinal fibrosis in CNV mice,and this effect may be mediated by the inhibition of PGF on EMT of RPE cells.

关键词： placental growth factor subretinal fibrosis epithelial mesenchymal transformation choroidal neovascularization

Harnessing innate immune pathways for therapeutic advancement in cancer

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1506-1564页

作者： Ankang Hu Li Sun Hao Lin Yuheng liao Hui Yang ying Mao Department of Neurosurgery Huashan HospitalFudan UniversityShanghaiP.R.China Institute for Translational Brain Research Shanghai Medical CollegeFudan University ShanghaiPR.China National Center for Neurological Disorders Huashan HospitalShanghai Medical CollegeFudan UniversityShanghaiP.R.China Shanghai Key Laboratory of Brain Function Restoration and Neural Regeneration Shanghai Clinical Medical Center of NeurosurgeryNeurosurgical Institute of Fudan UniversityHuashan HospitalShanghai Medical CollegeFudan UniversityShanghaiP.R.China State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science and MOE Frontiers Center for Brain Science Institutes of Brain ScienceShanghai Medical CollegeFudan UniversityShanghaiP.R.China Shanghai Key Laboratory of Medical Epigenetics International Co-laboratory of Medical Epigenetics and Metabolism(Ministry of Science and Technology)and Key Laboratory of Metabolism and Molecular Medicine(Ministry of Education)and Molecular and Cell Biology LabInstitutes of Biomedical SciencesShanghai Medical College of Fudan UniversityShanghaiP.R.China

The innate immune pathway is receiving increasing attention in cancer *** pathway is ubiquitous across various cell types,not only in innate immune cells but also in adaptive immune cells,tumor cells,and stromal *** targeting the innate immune pathway have shown profound changes in the tumor microenvironment(TME)and improved tumor prognosis in preclinical ***,to date,the clinical success of drugs targeting the innate immune pathway remains ***,recent studies have shown that activation of the innate immune pathway can paradoxically promote tumor *** uncertainty surrounding the therapeutic effectiveness of targeted drugs for the innate immune pathway is a critical issue that needs immediate *** this review,we observe that the role of the innate immune pathway demonstrates heterogeneity,linked to the tumor development stage,pathway status,and specific cell *** propose that within the TME,the innate immune pathway exhibits multidimensional *** diversity is fundamentally rooted in cellular heterogeneity and is manifested as a variety of signaling *** pro-tumor effect of innate immune pathway activation essentially reflects the suppression of classical pathways and the activation of potential pro-tumor alternative *** our understanding of the tumor's innate immune pathway network and employing appropriate targeting strategies can enhance our ability to harness the anti-tumor potential of the innate immune pathway and ultimately bridge the gap from preclinical to clinicalapplication.

关键词： drugs therapeutic innate

The impact of honesty and trickery on a Bayesian quantum prisoners’ dilemma game

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Chinese Physics B 2020年第7期29卷 221-227页

作者： Bo-Yang Liu Xin Zhao Hong-Yi Dai Ming Zhang ying liao Xiao-Feng Guo Wei Gao Information Engineering University Zhengzhou 450001China College of Artificial Intelligence National University of Defense TechnologyChangsha 410073China Department of Physics College of ScienceNational University of Defense TechnologyChangsha 410073China Interdisciplinary Center for Quantum Information National University of Defense TechnologyChangsha 410073China

To explore the influence of quantum information on the common social problem of honesty and trickery,we propose a Bayesian model for the quantum prisoners’dilemma *** this model,the players’strategy formation is regarded as a negotiation of their move contract based on their types of decision policies,honesty or *** the implementation of quantum information cannot eliminate tricky players,players in our model can always end up with higher payoffs than in the classical *** a good proportion of a credibility parameter value,a rational player will take an honest action,which is in remarkable contrast to the observation that players tend to defect in the classical prisoners’dilemma *** research suggests that honesty will be promoted to enhance cooperation with the assistance of quantum information resources.

关键词： quantum game Bayesian game quantum contract

亚麻醉剂量艾司氯胺酮联合咪达唑仑对老年全麻手术患者血流动力学和术后谵妄发生的影响

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陕西医学杂志 2024年第2期53卷 243-246,261页

作者：周强裴小英匡龙祝廖英朱泉玉胡海燕成都西区医院麻醉科四川成都610036

目的:探讨亚麻醉剂量艾司氯胺酮联合咪达唑仑对老年全麻手术患者血流动力学和术后谵妄(POD)发生的影响。方法:选取老年髋关节置换术患者96例,根据信封法将其随机分为联合组和对照组,各48例。两组患者予以相同麻醉方法,联合组在手术结束... 详细信息

目的:探讨亚麻醉剂量艾司氯胺酮联合咪达唑仑对老年全麻手术患者血流动力学和术后谵妄(POD)发生的影响。方法:选取老年髋关节置换术患者96例,根据信封法将其随机分为联合组和对照组,各48例。两组患者予以相同麻醉方法,联合组在手术结束前及静脉自控镇痛(PCIA)药物中加用艾司氯胺酮。比较两组患者血流动力学指标、手术指标、炎症因子水平、POD和不良反应发生率。结果:联合组手术结束前20 min心率和平均动脉压均明显低于对照组(均P<0.05);联合组苏醒时间、拔管时间均少于对照组(均P<0.05);联合组术后C反应蛋白和白介素-6水平明显低于对照组(均P<0.05);联合组POD发生率明显低于对照组(P<0.05)。结论:亚麻醉剂量艾司氯胺酮联合咪达唑仑应用于老年全麻手术患者,有利于维持血流动力学稳定,缩短苏醒时间,降低POD发生率,控制机体炎性反应。

关键词：艾司氯胺酮咪达唑仑老年人全麻手术血流动力学术后谵妄

整合REV-LTR基因的MDV活疫苗与亲本CVI988/Rispens株的免疫效力比较

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中国动物传染病学报 2024年第1期32卷 73-81页

作者：张秀梅宋翠萍谭磊孙英杰刘炜玮廖瑛丁铲仇旭升罗廷荣广西大学动物科学技术学院南宁530004 中国农业科学院上海兽医研究所上海200241

利用同源重组技术将禽网状内皮组织增生症病毒(REV)的长末端重复序列(LTR)整合进CVI988/Rispens疫苗株基因组中所构建成的重组马立克氏病病毒株(r MDV-LTR株),具有较高的增殖效率。为比较r MDV-LTR株与亲本CVI988/Rispens株的免疫效力差... 详细信息

利用同源重组技术将禽网状内皮组织增生症病毒(REV)的长末端重复序列(LTR)整合进CVI988/Rispens疫苗株基因组中所构建成的重组马立克氏病病毒株(r MDV-LTR株),具有较高的增殖效率。为比较r MDV-LTR株与亲本CVI988/Rispens株的免疫效力差异,开展了对这两种疫苗的比较试验。试验将这两种疫苗分别按照三个不同剂量经颈背部皮下接种1日龄SPF鸡。接种后第7 d,攻毒马立克氏病强毒株rMd5,连续观察60 d后进行剖检。临床病理观察结果发现,以不低于250 PFU/羽剂量的rMDV-LTR株或CVI988/Rispens株免疫SPF雏鸡都可以提供大于80%的免疫保护效率;以125 PFU/羽剂量的两种疫苗虽均不能提供大于80%的免疫保护效力,但rMDV-LTR株免疫组试验鸡未出现死亡,仅有2只鸡出现消瘦,剖解脏器无肿瘤,而CVI988/Rispens株免疫组鸡出现2只死亡,其中1只剖解后检出肿瘤。rMDV-LTR株和CVI988/Rispens株免疫组的免疫保护指数分别为77.78%和66.67%。由实验结果可见,在较小免疫剂量下,rMDV-LTR株免疫保护率高于亲本CVI988/Rispens疫苗株。说明重组毒rMDV-LTR疫苗株可以作为一种安全的、有效的新型MDV疫苗。

关键词：马立克氏病重组病毒禽网状内皮组织增生症病毒的长末端重复序列攻毒保护免疫效力

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Joint Detection of Serum Vitamin D,Body Mass Index,and Tumor Necrosis Factor Alpha for the Diagnosis of Crohn’s Disease

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当代医学科学(英文) 2023年第3期43卷 496-504页

作者： ying ZHENG Jing-hong LI Shan-ying liao Yi-ming FU Yan-jun ZHANG Jun-long LIN Xin-bin CHEN Wei-hong SHA Shi-xue DAI Wen-jun MA Department of Nutrition Guangdong Provincial People's HospitalGuangdong Academy of Medical SciencesSouthern Medical UniversityGuangzhou510080China The Second School of Clinical Medicine Southern Medical UniversityGuangzhou 510080China Department of Gastroenterology Guangdong Provincial People's HospitalGuangdong Academy of Medical SciencesSouthern Medical UniversityGuangzhou 510080China The First School of Clinical Medicine&Nanfang Hospital Southern Medical UniversityGuangzhou 510080China Department of Gastroenterology Guangdong Provincial Geriatrics InstituteNational Key Clinical SpecialtyGuangdong Provincial People's HospitalGuangdong Academy of Medical SciencesSouthern Medical UniversityGuangzhou 510080China

Objective Vitamin D(VD)deficiency was reported to contribute to the progression of Crohn’s disease(CD)and affect the prognosis of CD *** study investigated the role of serum VD,body mass index(BMI),and tumor necrosis factor alpha(TNF-α)in the diagnosis of Crohn’s *** CD patients(n=76)and healthy subjects(n=76)were enrolled between May 2019 and December *** serum 25-hydroxyvitamin D[25(OH)D]levels,BMI,and TNF-αlevels,together with other biochemical parameters,were assessed before *** diagnostic efficacy of the single and joint detection of serum 25(OH)D,BMI,and TNF-αwas determined using receiver operating characteristic(ROC)*** The levels of 25(OH)D,BMI,and nutritional indicators,including hemoglobin,total protein,albumin,and high-density lipoprotein cholesterol,were much lower,and the TNF-αlevels were much higher in the CD patients than in the healthy subjects(P<0.05 for all).The areas under the ROC curve for the single detection of 25(OH)D,BMI,and TNF-αwere 0.887,0.896,and 0.838,respectively,with the optimal cutoff values being 20.64 ng/mL,19.77 kg/m^(2),and 6.85 fmol/mL,*** diagnostic efficacy of the joint detection of 25(OH)D,BMI,and TNF-αwas the highest,with an area under the ROC curve of 0.988(95%CI:0.968–1.000).Conclusion The joint detection of 25(OH)D,TNF-α,and BMI showed high sensitivity,specificity,and accuracy in CD diagnosis;thus,it would be effective for the diagnosis of CD in clinical practice.

关键词： Crohn’s disease vitamin D body mass index tumor necrosis factor alpha

高龄孕晚期产妇疾病不确定感现状及影响因素的调查分析

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护理实践与研究 2024年第6期21卷 847-852页

作者：熊伟熊渊丽肖丽英张晓玲刘丹陈钰廖英江西省妇幼保健院产科病房江西省南昌市330006 石家庄市人民医院河北省石家庄市050000

目的分析高龄孕晚期产妇疾病不确定感现状及相关影响因素,寻找减轻其疾病不确定感、改善母婴结局的干预方案。方法纳入2021年1月—2022年6月于江西省妇幼保健院进行产检的高龄孕晚期产妇146例为研究对象,采用疾病不确定感成人量表(MUI... 详细信息

目的分析高龄孕晚期产妇疾病不确定感现状及相关影响因素,寻找减轻其疾病不确定感、改善母婴结局的干预方案。方法纳入2021年1月—2022年6月于江西省妇幼保健院进行产检的高龄孕晚期产妇146例为研究对象,采用疾病不确定感成人量表(MUIS-A)评估其疾病不确定感情况,并采用自制基线资料调查表调查产妇基线资料,通过单因素及有序Logistic回归分析确定产妇疾病不确定感的影响因素。结果本研究共发放146份问卷,有效回收128份,有效回收率87.67%。128例产妇中疾病不确定感低水平24例,中等水平85例,高水平19例。单因素分析结果显示,产妇类型、受教育程度、妊娠期合并症、定期产检情况均为高龄孕晚期产妇疾病不确定感的影响因素(P<0.05);有序Logistic回归分析发现,产妇类型、受教育程度、妊娠期合并症、定期产检是高龄孕晚期产妇疾病不确定感影响因素(P<0.05)。结论高龄孕晚期产妇具有一定的疾病不确定感,产妇类型、受教育程度、妊娠期合并症、定期产检状况均是重要影响因素,建议医护人员据此尽早采取针对性干预措施降低产妇疾病不确定感。

关键词：高龄产妇孕晚期疾病不确定感现状影响因素调查分析