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Storage time affects the level and diagnostic efficacy of plasma biomarkers for neurodegenerative diseases

Neural Regeneration Research 2025年第8期20卷 2373-2381页

作者： Lifang Zhao Mingkai Zhang Qimeng Li Xuemin Wang Jie Lu ying han Yanning Cai Department of Clinical Biobank Xuanwu HospitalCapital Medical UniversityBeijingChina Beijing Geriatric Medical Research Center BeijingChina Department of Neurology Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Radiology and Nuclear Medicine Xuanwu HospitalCapital Medical UniversityBeijingChina Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics BeijingChina Key Laboratory of Neurodegenerative diseases Ministry of EducationBeijingChina School of Biomedical Engineering Hainan UniversityHaikouHainan ProvinceChina Center of Alzheimer’s Disease Beijing Institute for Brain DisordersBeijingChina National Clinical Research Center for Geriatric Diseases BeijingChina Institute of Biomedical Engineering Shenzhen Bay LaboratoryGaoke Innovation CenterShenzhenGuangdong ProvinceChina Department of Neurobiology Xuanwu HospitalCapital Medical UniversityBeijingChina

Several promising plasma biomarker proteins,such as amyloid-β(Aβ),tau,neurofilament light chain,and glial fibrillary acidic protein,are widely used for the diagnosis of neurodegenerative ***,little is known about the long-term stability of these biomarker proteins in plasma samples stored at-80°*** aimed to explore how storage time would affect the diagnostic accuracy of these biomarkers using a large *** samples from 229 cognitively unimpaired individuals,encompassing healthy controls and those experiencing subjective cognitive decline,as well as 99 patients with cognitive impairment,comprising those with mild cognitive impairment and dementia,were acquired from the Sino Longitudinal Study on Cognitive Decline *** samples were stored at-80°C for up to 6 years before being used in this *** results showed that plasma levels of Aβ42,Aβ40,neurofilament light chain,and glial fibrillary acidic protein were not significantly correlated with sample storage ***,the level of total tau showed a negative correlation with sample storage ***,in individuals without cognitive impairment,plasma levels of total protein and tau phosphorylated protein threonine 181(p-tau181)also showed a negative correlation with sample storage *** was not observed in individuals with cognitive ***,we speculate that the diagnostic accuracy of plasma p-tau181 and the p-tau181 to total tau ratio may be influenced by sample storage ***,caution is advised when using these plasma biomarkers for the identification of neurodegenerative diseases,such as Alzheimer's ***,in cohort studies,it is important to consider the impact of storage time on the overall results.

关键词： Alzheimer’s disease amyloid-β diagnostic ability glial fibrillary acidic protein neurodegeneration neurofilament light chain plasma biomarkers single molecule array storage time tau

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Environmental influence of Wuhan urban agglomeration development and strategies of environmental protection

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Journal of Environmental Sciences 2006年第3期18卷 616-623页

作者： GAO Qun LIU ying-tao MAO han-ying Institute of Geographic Sciences and Natural Resources Research Chinese Academy of Sciences Beijing 100101 China Chinese Academy of Agricultural Sciences Beijing 100081 China

In Wuhan urban agglomeration （WUA）, the population growth and concentration, the industrial development and urban sprawl have been affecting the environment ftmdamentally. Comparing with Yangtze delta metropolitan region, the level of urbanization and industrialization of WUA has lagged behind for about 10 years; but the problems in environmental protection and rehabilitation are commonly serious. In the future, WUA should avoid unnecessary mistakes and seek a win-win strategy for economy and environment in its large-scale development stage. Based on the analysis of the changing of main environmental pollutants and the coupled curves in past decades, the paper discussed the important links among the urban environmental pollutions, industry growth and urban sprawl in WUA. It is concluded that the integration of economic and environmental policies in urban development is more required and significant at the large urban agglomeration region. Four proactive and long-term strategies need to be adopted to provide prior guidance and better protection for the development of WUA.

关键词： environmental problem urban development Wuhan urban agglomeration strategies

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Bernstein type theorem of minimal Lagrangian graphs in quaternion Euclidean space H^n

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Applied Mathematics(A Journal of Chinese Universities) 2009年第1期24卷 114-118页

作者： han ying-bo Dept. of Math. Southeast Univ. Nanjing 211189 China

In this paper, a Bernstein type theorem for minimal Lagrangian submanifolds in quaternion Euclidean space H^n is studied.

关键词： Bernstein type theorem minimal Lagrangian graph

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New construction of special Lagrangian submanifolds in T~*R^n equipped with the standard metric

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Applied Mathematics(A Journal of Chinese Universities) 2008年第1期23卷 65-68页

作者： han ying-bo Dept. of Math. Southeast Univ. Nanjing 211189 China.

A class of twisted special Lagrangian submanifolds in T＊R^n and a kind of austere submanifold from conormal bundle of minimal surface of R^3 are constructed.

关键词： twisted special Lagrangian submanifold twisted normal bundle austere submanifold.

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Industry news:the additive manufacturing of nerve conduits for the treatment of peripheral nerve injury

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Bio-Design and Manufacturing 2022年第1期5卷 6-8页

作者： ying han Jun Yin The State Key Laboratory of Fluid Power and MechatronicSystems School of Mechanical EngineeringZhejiangUniversityHangzhou 310028China Key Laboratory of 3D Printing Process and Equipmentof Zhejiang Province School of Mechanical EngineeringZhejiang UniversityHangzhou 310028China

Peripheral nerve injury and nerve conduit manufacturing The global nerve injury repair and regeneration market is expected to reach$9.7 billion by 2025,a compound annual growth rate of 9.1%between 2020 and 2025[1].One component alone,peripheral nerve injury(PNI),encompasses 5 million new cases worldwide every year[2].Although nerve autograft is considered the gold standard for PNI repair,this process sufers because of a short supply of autologous nerves as well as potential harm caused to the *** recent decades,as a promising alternative to autografts。

关键词： injury nerves additive

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On Modular Vector Invariant Fields

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Algebra Colloquium 2020年第4期27卷 749-752页

作者： ying han Runxuan Zhang School of Mathematics and Statistics Northeast Normal University Changchun 130024China

Let F_(q)be a finite field of any characteristic and GL(n,F_(q))be the general linear group over F_(q).Suppose W denotes the standard representation of GL(n,F_(q)),and GL(n,F_(q))acts diagonally on the direct sum of W and its dual space W^(∗).Let G be any subgroup of GL(n,F_(q)).Suppose the invariant field F_(q)(W)G=F_(q)(f1,f2,…,fk),where f1,f2,…,fk in F_(q)[W]G are homogeneous invariant *** prove that there exist homogeneous polynomialsl1,l2,…,ln in the invariant ring F_(q)[W⊕W^(∗)]G such that the invariant field F_(q)(W⊕W^(∗))G is generated by{f1,f2,…,fk,l1,l2,…,ln}over F_(q).

关键词： modular invariants vector invariant fields finite classical groups

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MULTI-AGENT AGGREGATION BEHAVIOR ANALYSIS: THE DYNAMIC COMMUNICATION TOPOLOGY

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Journal of Systems Science & Complexity 2008年第2期21卷 209-216页

作者： Sheng CHEN Lindu ZHAO ying han Institute of Systems Engineering Southeast University Nanjing 210018 China

The authors extend the Gazi＇s swarm model with local neighbor rules and the dynamic communication topology, and study its aggregation properties. Results of analysis show that all agents in the models aggregate and eventually form a cohesive cluster of finite size around the swarm center or the appointed point. Finally, simulations are provided to testify some of the results. Models in the paper are more applicable to the reality for the advantage that each agent only needs the partial information of the entire dynamic system when making motion decision.

关键词： Aggregation behavior dynamic communication topology local neighbor rules multi-agent system.

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Hot Workability of the as-Cast 21Cr Economical Duplex Stainless Steel Through Processing Map and Microstructural Studies Using Different Instability Criteria

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Acta Metallurgica Sinica(English Letters) 2017年第11期30卷 1080-1088页

作者： Jing han Jia-Peng Sun ying han Huan Liu School of Mechanical and Electrical Engineering China University of Mining and Technology College of Mechanics and Materials Hohai University Key Laboratory of Advanced Structural Materials Ministry of EducationChangchun University of Technology

To develop a fundamental understanding of the flow behavior and optimal hot workability parameters of this material, the hot workability and deformation mechanisms of the as-cast 21Cr EDSS were studied using processing map technology combined with microstructure analysis and isothermal hot compression over the temperature range of 1000-1150 ℃ and strain rate range of 0.01-10 s-1. The processing maps and constitutive equation of peak stress were developed based on Prasad＇s and Murty＇s criteria. The results show that the processing maps exhibit a stable domain at 1000-1150 ℃ and 0.01-1 s-1. The instability domain is exhibited at high strain rates （≥1 s-l）. This implies that Murty＇s criterion can predict the unstable domain with high reliability. The detailed deformation mechanisms are also studied by microstructure observation, showing that the flow localization and microcracking are responsible for the flow instability.

关键词： Duplex stainless steel Constitutive relationship Processing map Hot deformation behavior

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Dynamical downscaling of regional climate: A review of methods and limitations

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Science China Earth Sciences 2019年第2期62卷 365-375页

作者： Zhongfeng XU ying han Zongliang YANG CAS Key Laboratory of Regional Climate-Environment for Temperate East Asia Institute of Atmospheric Physics Chinese Academy of Sciences Department of Geological Sciences Jackson School of Geosciences The University of Texas at Austin

The traditional dynamical downscaling (TDD) method employs continuous integration of regional climate models (RCM) with the general circulation model (GCM) providing the initial and lateral boundary conditions. Dynamical downscaling simulations are constrained by physical principles and can generate a full set of climate information, providing one of the important approaches to projecting fine spatial-scale future climate information. However, the systematic biases of climate models often degrade the TDD simulations and hinder the application of dynamical downscaling in the climate-change related studies. New methods developed over past decades improve the performance of dynamical downscaling simulations. These methods can be divided into four groups: the TDD method, the pseudo global warming method, dynamical downscaling with GCM bias corrections, and dynamical downscaling with both GCM and RCM bias corrections. These dynamical downscaling methods are reviewed and compared in this paper. The merits and limitations of each dynamical downscaling method are also discussed. In addition, the challenges and potential directions in progressing dynamical downscaling methods are stated.

关键词： Global circulation model Bias correction Regional climate model Downscaling Projection of regional climate

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Rutin pretreatment promotes microglial M1 to M2 phenotype polarization

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Neural Regeneration Research 2021年第12期16卷 2499-2504页

作者： Guang-Ping Lang Can Li ying-ying han Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education Zunyi Medical UniversityZunyiGuizhou ProvinceChina Special Key Laboratory of Oral Diseases Research Higher Education Institutions of Guizhou ProvinceZunyi Medical UniversityZunyiGuizhou ProvinceChina

Microglial cells are important resident innate immune components in the central nervous system that are often activated during *** microglia can display one of two phenotypes,M1 or M2,which each play distinct roles in ***,a dietary flavonoid,exhibits protective effects against ***,whether rutin is able to influence the M1/M2 polarization of microglia remains *** this study,in vitro BV-2 cell models of neuroinflammation were established using 100 ng/mL lipopolysaccharide to investigate the effects of 1-hour rutin pretreatment on microglial *** results revealed that rutin pretreatment reduced the expression of the proinflammatory cytokines tumor necrosis factor-α,interleukin-1β,and interleukin-6 and increased the secretion of *** pretreatment also downregulated the expression of the M1 microglial markers CD86 and inducible nitric oxide synthase and upregulated the expression of the M2 microglial markers arginase 1 and *** pretreatment inhibited the expression of Toll-like receptor 4 and myeloid differentiation factor 88 and blocked the phosphorylation of I kappa B kinase and nuclear factor-kappa *** results showed that rutin pretreatment may promote the phenotypic switch of microglia M1 to M2 by inhibiting the Toll-like receptor 4/nuclear factor-kappa B signaling pathway to alleviate lipopolysaccharide-induced neuroinflammation.

关键词： BV-2 cells flavonoid M1 microglia M2 microglia microglia activation microglia polarization neuroinflammation proinflammatory cytokines rutin TLR-4 signaling

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