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The MON1–CCZ1 complex plays dual roles in autophagic degradation and vacuolar protein transport in rice

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Journal of Integrative Plant Biology 2025年第1期67卷 35-54页

作者： Binglei zhang Yihua Wang Yun zhu Tian Pan Haigang Yan Xin Wang Ruonan Jing Hongming Wu fan Wang Yu zhang Xiuhao Bao Yongfei Wang Pengcheng zhang Yu Chen Erchao Duan Xiaohang Han Gexing Wan Mengyuan Yan Xiejun Sun Cailin lei Zhijun Cheng Zhichao Zhao Ling Jiang Yiqun Bao Yulong Ren Jianmin Wan State Key Laboratory of Crop Gene Resources and Breeding National Key Facility for Crop Gene Resources and Genetic ImprovementInstitute of Crop SciencesChinese Academy of Agricultural SciencesBeijing 100081China College of Life Sciences Nanjing Agricultural UniversityNanjing 210095China State Key Laboratory of Crop Genetics&Germplasm Enhancement and Utilization Nanjing Agricultural UniversityNanjing 210095China Zhongshan Biological Breeding Laboratory Nanjing 210095China

Autophagy is a highly conserved cellular program in eukaryotic cells which mediates the degradation of cytoplasmic components through the lysosome,also named the vacuole in ***,the molecular mechanisms underlying the fusion of autophagosomes with the vacuole remain ***,we report the functional characterization of a rice(Oryza sativa)mutant with defects in storage protein transport in endosperm cells and accumulation of numerous autophagosomes in root *** and immunocytochemical experiments showed that this mutant exhibits a defect in the fusion between autophagosomes and *** mutant harbors a loss-of-function mutation in the rice homolog of Arabidopsis thaliana MONENSIN SENSITIVITY1(MON1).Biochemical and genetic evidence revealed a synergistic interaction between rice MON1 and AUTOPHAGY-RELATED 8a in maintaining normal growth and *** addition,the rice mon1 mutant disrupted storage protein sorting to protein storage ***,quantitative proteomics verified that the loss of MON1 function influenced diverse biological pathways including autophagy and vacuolar transport,thus decreasing the transport of autophagic and vacuolar cargoes to ***,our findings establish a molecular link between autophagy and vacuolar protein transport,and offer insights into the dual functions of the MON1–CCZ1(CAFFEINE ZINC SENSITIVITY1)complex in plants.

关键词： autophagic degradation MON1–CCZ1 Rab7 rice vacuolar trafficking

Blocking the PD-1 signal transduction by occupying the phosphorylated ITSM recognition site of SHP-2

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Science China(Life Sciences) 2025年第1期68卷 189-203页

作者： Wenjie Li Wenyi Mei Hewei Jiang Jie Wang Xiaoli Li Lina Quan Yanyan Diao Yanni Ma Sisi fan zhuwei Xie Mengdie Gong Huan zhu Dewen Bi Feng zhang lei Ma Jian zhang Yufeng Gao Aris Paschalidis Honghuang Lin fangfang Liu Kangdong Liu Mingliang Ye Zhenjiang Zhao Yajun Duan zhuo Chen Yufang Xu Weilie Xiao Shengce Tao Lili zhu Honglin Li Shanghai Key Laboratory of New Drug Design School of PharmacyEast China University of Science&TechnologyShanghai 200237China Shanghai Center for Systems Biomedicine Key Laboratory of Systems Biomedicine(Ministry of Education)Shanghai Jiao Tong UniversityShanghai 200240China Key Laboratory of Medicinal Chemistry for Natural Resource Ministry of EducationYunnan Characteristic Plant Extraction LaboratoryYunnan Provincial Center for Research&Development of Natural ProductsState Key Laboratory for Conservation and Utilization of Bio-Resources in YunnanSchool of Pharmacy and School of Chemical Science and TechnologyYunnan UniversityKunming650500China CAS Key Laboratory of Separation Sciences for Analytical Chemistry National Chromatographic R&A CenterDalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China Department of Cardiology The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230027China Department of Infectious Diseases The First Affiliated Hospital of Anhui Medical UniversityHefei 230022China Department of Medicine University of Massachusetts Chan Medical SchoolWorcester MA 01655USA Department of Pathophysiology School of Basic Medical SciencesAcademy of Medical ScienceCollege of MedicineZhengzhou UniversityZhengzhou 450001China Innovation Center for AI and Drug Discovery East China Normal UniversityShanghai 200062China Lingang Laboratory Shanghai 200031China

Targeting the PD-1/PD-L1 axis with small-molecular inhibitors is a promising approach for ***,we identify a natural pentacyclic triterpenoid,Pygenic Acid A(PA),as a PD-1 signaling *** exerts anti-tumor activity in hPD-1 knock-in C57BL/6 mice and enhances effector functions of T cells to promote immune responses by disrupting the PD-1 signaling ***,we identify SHP-2 as the direct molecular target of PA for inhibiting the PD-1 signaling ***,mechanistic studies suggest that PA binds to a new druggable site in the phosphorylated PD-1 ITSM recognition site of SHP-2,inhibiting the recruitment of SHP-2 by *** together,our findings demonstrate that PA has a potential application in cancer immunotherapy and occupying the phosphorylated ITSM recognition site of SHP-2 may serve as an alternative strategy to develop PD-1 signaling *** addition,our success in target recognition provides a paradigm of target identification and confirmation for natural products.

关键词： pygenic acid A programmed death-1 immunoreceptor tyrosine-based switch motif SH2 domain-containing protein-tyrosine phosphatase-2 target identification site recognition

Estimating the Macroeconomic Costs of CO_2 Emission Reduction in China Based on Multi-objective Programming

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Advances in Climate Change Research 2010年第1期1卷 27-33页

作者： ying fan xiaobing zhang lei zhu Center for Energy ＆ Environmental Policy Research Institute of Policy ＆ Management Chinese Academy of Sciences Beijing 100190 China

This paper estimates the macroeconornic costs of CO2 emission reduction in China employing the input-output analysis with the multi-objective programming approach. The results show that the effect of reducing CO2 emissions on China＇s economy is significant. Under the present conditions, the estimated macroeconomic costs of CO2 emission reduction in 2010 for China are approximately 3,100-4,024 RMB t-1. The stronger the abatement actions, the higher the macroeconomic costs of per unit emission reduction would be. Excavation industry, oil industry, chemical industry, and metal smelting industry have high potential to abate their CO2 emissions.

关键词： CO2 emission reduction macroeconomic cost multi-objective programming input-output analysis

A NON-LINEAR MODEL FOR ESTIMATING THE COST OF ACHIEVING EMISSION REDUCTION TARGETS:THE CASE OF THE U.S.,CHINA AND INDIA

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Journal of Systems Science and Systems Engineering 2012年第3期21卷 297-315页

作者： lei zhu Xiao-Bing zhang ying fan Center for Energy & Environmental Policy Research Institute of Policy and Management Chinese Academy of Sciences Beijing 100190 China Department of Economics University of Gothenburg SE 40530 G teborg Sweden

With the world talking about climate change, the United States （U.S.）, China and India have announced their carbon emission reduction targets. For these three countries to achieve their targets, significant questions arise, shch as what will be the annual emission reduction efforts to achieve those targets, how much it would cost and what would be the economic effects. This paper puts the carbon intensity reduction targets of China and India together with the absolute emission reduction target of the U.S. into the same non-linear model to quantitatively study the optimal emission control strategies and associated total cost for achieving those targets by the year 2020, and estimate and compare the minimized total costs of the three countries to reach their targets. Our results show that the total cost for the U.S. to achieve its emission reduction target is greater than those of China and India in terms of absolute amount. However, in terms of proportion of total cost to GDP, China and India＇s ratios are significantly greater than that of the U.S., indicating that for the developing countries such as China and India, the achievement of emission reduction targets needs relatively greater effort.

关键词： Emission reduction cost analysis emission reduction strategy optimization model

Einstein Probe discovery of EP240408a:A peculiar X-ray transient with an intermediate timescale

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Science China(Physics,Mechanics & Astronomy) 2025年第1期68卷 218-236页

作者： Wenda zhang Weimin Yuan Zhixing Ling Yong Chen Nanda Rea Arne Rau Zhiming Cai Huaqing Cheng Francesco Coti Zelati Lixin Dai Jingwei Hu Shumei Jia Chichuan Jin Dongyue Li Paul O’Brien Rongfeng Shen Xinwen Shu Shengli Sun Xiaojin Sun Xiaofeng Wang lei Yang Bing zhang Chen zhang Shuang-Nan zhang Yonghe zhang Jie An David Buckley Alexis Coleiro Bertrand Cordier Liming Dou Rob Eyles-Ferris Zhou fan Hua Feng Shaoyu Fu Johan P.U.Fynbo Lluis Galbany Saurabh W.Jha Shuaiqing Jiang Albert Kong Erik Kuulkers Weihua lei Wenxiong Li Bifang Liu Mingjun Liu Xing Liu Yuan Liu zhu Liu Chandreyee Maitra Alessio Marino Itumeleng Monageng Kirpal Nandra Jeremy Sanders Roberto Soria Lian Tao Junfeng Wang Song Wang Tinggui Wang Zhongxiang Wang Qingwen Wu Xuefeng Wu Dong Xu Yanjun Xu Suijian Xue Yongquan Xue Zijian zhang Zipei zhu Hu Zou Congying Bao fansheng Chen Houlei Chen Tianxiang Chen Wei Chen Yehai Chen Yifan Chen Chenzhou Cui Weiwei Cui Yanfeng Dai Dongwei fan Ju Guan Dawei Han Dongjie Hou Haibo Hu Maohai Huang Jia Huo Zhenqing Jia Bowen Jiang Ge Jin Chengkui Li Junfei Li Longhui Li Maoshun Li Wei Li Zhengda Li Tianying Lian Congzhan Liu Heyang Liu Huaqiu Liu fangjun Lu Laidan Luo Jia Ma Xuan Mao Haiwu Pan Xin Pan Liming Song Hui Sun Yunyin Tan Qingjun Tang Yihan Tao Hao Wang Juan Wang lei Wang Wenxin Wang Yilong Wang Yusa Wang Qinyu Wu Haitao Xu Jingjing Xu Xinpeng Xu Yunfei Xu Zhao Xu Changbin Xue Yulong Xue Ailiang Yan Haonan Yang Xiongtao Yang Yanji Yang Juan zhang Mo zhang Wenjie zhang Zhen zhang Zhen zhang Ziliang zhang Donghua Zhao Haisheng Zhao Xiaofan Zhao Zijian Zhao Hongyan Zhou Yilin Zhou Yuxuan zhu Zhencai zhu National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China School of Astronomy and Space Sciences University of Chinese Academy of SciencesBeijing 100049China Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Institute of Space Sciences(ICE) CSICBarcelona E-08193Spain Institut d’Estudis Espacials de Catalunya(IEEC) Barcelona E-08034Spain Max Planck Institute for Extraterrestrial Physics Garching 85748Germany Innovation Academy for Microsatellites Chinese Academy of SciencesShanghai 201210China Department of Physics University of Hong KongHong Kong 999077China School of Physics and Astronomy University of LeicesterLeicester LE17RHUK School of Physics and Astronomy Sun Yat-sen UniversityZhuhai 519082China Department of Physics Anhui Normal UniversityWuhu 241002China Shanghai Institute of Technical Physics Chinese Academy of SciencesShanghai 200083China Physics Department Tsinghua UniversityBeijing 100084China Nevada Center for Astrophysics University of Nevada Las VegasLas Vegas NV 89154USA Department of Physics and Astronomy University of Nevada Las VegasLas Vegas NV 89154USA South African Astronomical Observatory Cape Town 7935South Africa Department of Astronomy University of Cape TownRondebosch 7701South Africa Department of Physics University of the Free StateBloemfontein 9300South Africa Universit´e Paris Cit´e CNRSAstroparticule et CosmologieParis F-75013France Universit´e Paris Cit´e CEA Paris-SaclayIRFU/DAp-AIMGif-sur-Yvette 91191France Department of Astronomy Guangzhou UniversityGuangzhou 510006China Cosmic Dawn Center(DAWN) Copenhagen 2200Denmark Niels Bohr Institute University of CopenhagenCopenhagen 2200Denmark Department of Physics and Astronomy Rutgersthe State University of New JerseyPiscataway NJ 08854-8019USA Institute for Cosmic Ray Research The University of TokyoKashiwa City 277-8582Japan ESA/ESTEC Noordwijk 2201 AZThe Netherlands Department of Astronom

We report the discovery of a peculiar X-ray transient,EP240408a,by Einstein Probe(EP)and follow-up studies made with EP,Swift,NICER,GROND,ATCA and other ground-based multiwavelength *** new transient was first detected with Wide-field X-ray Telescope(WXT)on board EP on April 8th,2024,manifested in an intense yet brief X-ray flare lasting for 12 *** flare reached a peak flux of 3:9×10^(−9) erg cm^(−2) s^(−1) in 0.5-4 keV,∼300 times brighter than the underlying X-ray emission detected throughout the *** and more precise follow-up observations by EP/FXT,Swift and NICER confirmed the finding of this new *** X-ray spectrum is non-thermal in 0.5-10 keV,with a power-law photon index varying within *** X-ray light curve shows a plateau lasting for∼4 d,followed by a steep decay till becoming undetectable∼10 d after the initial *** on its temporal property and constraints from previous EP observations,an unusual timescale in the range of 7-23 d is found for EP240408a,which is intermediate between the commonly found fast and long-term *** counterparts have been found in optical and near-infrared,with the earliest observation at 17 h after the initial X-ray detection,suggestive of intrinsically weak emission in these *** demonstrate that the remarkable properties of EP240408a are inconsistent with any of the transient types known so far,by comparison with,in particular,jetted tidal disruption events,gamma-ray bursts,X-ray binaries and fast blue optical *** nature of EP240408a thus remains an *** suggest that EP240408a may represent a new type of transients with intermediate timescales of the order of∼10 *** detection and follow-ups of more of such objects are essential for revealing their origin.

关键词： X-ray transients Einstein Probe

Efficient and selective extraction of sinomenine by deep eutectic solvents

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Chinese Journal of Chemical Engineering 2023年第5期57卷 109-117页

作者： Yunchang fan Chunyan zhu Sheli zhang lei zhang Qiang Wang Feng Wang College of Chemistry and Chemical Engineering Henan Polytechnic UniversityJiaozuo 454003China College of Science and Technology Jiaozuo Teachers CollegeJiaozuo 454000China

Sinomenine is the main bio-active ingredient of Sinomenii Caulis and usually produced by solventextraction techniques. However, the extraction of sinomenine suffers from the lack of highly efficient and environmentally-benign solvents. In this work, deep eutectic solvents(DESs) based on fragrances were synthesized, hydrogen-bond donors(HBDs) and hydrogen-bond acceptors(HBAs) components of DESs were identified and their extraction ability for sinomenine was evaluated and the extraction conditions were optimized by single-factor and orthogonal design experiments. It was found that the hydrogen-bonding interaction between sinomenine and DESs was the main extraction driving force and there was no explicit relationship between the extraction ability and the hydrophobicity of the DESs. The DESs could be recycled and sinomenine could be recovered quantitatively via backextraction. High-purity sinomenine((95.0 ± 2.3)%) could be produced. These findings suggest that DESs are highly-effective solvents for the isolation of sinomenine and exhibit great potential for the extraction of other bio-active compounds.

关键词： Sinomenine Solvent extraction Deep eutectic solvent(DES) Hydrogen-bonding interaction Regeneration Purification

Acetylation promotes BCAT2 degradation to suppress BCAA catabolism and pancreatic cancer growth

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Signal Transduction and Targeted Therapy 2020年第1期5卷 1769-1777页

作者： Ming-zhu lei Xu-Xu Li Ye zhang Jin-Tao Li fan zhang Yi-Ping Wang Miao Yin Jia Qu Qun-ying lei Department of Biochemistry and Molecular Biology School of Basic Medical SciencesShanghai Medical CollegeFudan University131 Dong’an RoadShanghai 200032China Cancer Metabolism Laboratory and the Shanghai Key Laboratory of Medical Epigenetics the International Co-laboratory of Medical Epigenetics and MetabolismMinistry of Science and TechnologyInstitutes of Biomedical SciencesShanghai Medical CollegeFudan University131 Dong’an RoadShanghai 200032China Cancer Institute Fudan University Shanghai Cancer Center and Department of OncologyShanghai Medical CollegeFudan University270 Dong’an RoadShanghai 200032China State Key Laboratory of Medical Neurobiology Fudan University131 Dong’an RoadShanghai 200032China

Pancreatic ductal adenocarcinoma(PDAC)is well-known for inefficient early diagnosis,with most patients diagnosed at advanced *** evidence indicates that elevated plasma levels of branched-chain amino acids(BCAAs)are associated with an increased risk of pancreatic ***-chain amino acid transaminase 2(BCAT2)is an important enzyme in BCAA catabolism that reversibly catalyzes the initial step of BCAA degradation to branched-chain ***,we show that BCAT2 is acetylated at lysine 44(K44),an evolutionarily conserved ***2 acetylation leads to its degradation through the ubiquitin–proteasome pathway and is stimulated in response to BCAA ***-responsive element-binding(CREB)-binding protein(CBP)and SIRT4 are the acetyltransferase and deacetylase for BCAT2,*** and SIRT4 bind to BCAT2 and control the K44 acetylation level in response to BCAA *** importantly,the K44R mutant promotes BCAA catabolism,cell proliferation,and pancreatic tumor ***,the data from our study reveal a previously unknown regulatory mechanism of BCAT2 in PDAC and provide a potential therapeutic target for PDAC treatment.

关键词： BCAA elevated diagnosis

Sequential interactive image segmentation

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Computational Visual Media 2023年第4期9卷 753-765页

作者： Zheng Lin Zhao zhang Zi-Yue zhu Deng-Ping fan Xia-lei Liu TKLNDST College of Computer ScienceNankai UniversityTianjinChina Computer Vision Lab ETH ZurichZurichSwitzerland

Interactive image segmentation(IIS)is an important technique for obtaining pixel-level *** many cases,target objects share similar ***,IIS methods neglect this connection and in particular the cues provided by representations of previously segmented objects,previous user interaction,and previous prediction masks,which can all provide suitable priors for the current *** this paper,we formulate a sequential interactive image segmentation(SIIS)task for minimizing user interaction when segmenting sequences of related images,and we provide a practical approach to this task using two pertinent *** first is a novel interaction *** annotating a new sample,our method can automatically propose an initial click proposal based on previous *** dramatically helps to reduce the interaction burden on the *** second is an online optimization strategy,with the goal of providing semantic information when annotating specific targets,optimizing the model with dense supervision from previously labeled *** demonstrate the effectiveness of regarding SIIS as a particular task,and our methods for addressing it.

关键词： interactive segmentation user interaction object segmentation

Corrosion Behaviour of a Non‑equiatomic CoCrFeNiMo High‑Entropy Alloy in H_(2)S‑Containing and H_(2)S‑Free Environments

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Acta Metallurgica Sinica(English Letters) 2023年第3期36卷 366-378页

作者： zhu Wang Guo‑Hui zhang Yong Yao Xue‑Hua fan Jie Jin lei zhang Yan‑Xia Du Institute for Advanced Materials and Technology University of Science and Technology BeijingBeijing 100083China CITIC Pacific Special Steel Group Co. LtdJiangsu 214429China China Petroleum Engineering&Construction Co. Ltd Beijing CompanyBeijing 100085China

The corrosion behaviour of a non-equiatomic CoCrFeNiMo high-entropy alloy(HEA)in H_(2)S-containing and H_(2)S-free environments was studied by electrochemical tests,surface characterization,and solution *** results showed that the HEA exhibited primary and secondary passivation in the H_(2)S-free environment,and the transition was owing to the enhanced dissolution of Fe *** with the primary passive film,the Cr/Fe ratio in the secondary passive film increased at the expense of the selective dissolution of ***,the corrosion resistance of HEA decreased with the applied *** was the most stable element in the film of HEA,regardless of H_(2)*** presence of H_(2)S accelerated the dissolution of all the cationic elements in the HEA.H_(2)S promoted the formation of thicker but less protective surface film and induced the loss of passivity.

关键词： High-entropy alloy(HEA) Corrosion H_(2)S Secondary passivation X-ray photoelectron spectroscopy(XPS) Induced coupled plasma(ICP)