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Transferrin receptor-targeted immunostimulant for photodynamic immunotherapy against metastatic tumors through b-catenin/CREB interruption

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Acta Pharmaceutica Sinica B 2024年第9期14卷 4118-4133页

作者： Mengyi Yan Xiayun Chen Xiaotong Li Qianqian Liu Baixue Yu Yi Cen Wei zhang Yibin Liu Xinxuan Li ying Chen Tao Wang Shiying Li The Fifth Affiliated Hospital Guangdong Provincial Key Laboratory of Molecular Target&Clinical Pharmacologythe NMPA and State Key Laboratory of Respiratory Diseasethe School of Pharmaceutical SciencesGuangzhou Medical UniversityGuangzhou 511436China Department of Anesthesiology the Second Clinical School of Guangzhou Medical UniversityGuangzhou 511436China State Key Laboratory of Respiratory Diseases Guangdong Key Laboratory of Vascular DiseasesGuangzhou Institute of Respiratory Healththe first Affiliated HospitalGuangzhou Medical UniversityGuangzhou 510120China Department of Pulmonary and Critical Care Medicine Zhujiang HospitalSouthern Medical UniversityGuangzhou 510280China

The immunosuppressive phenotype of tumor cells extensively attenuates the immune activation effects of traditional *** this work,a transferrin receptor(TfR)targeted immunostimulant(PTI)is fabricated for photodynamic immunotherapy against metastatic tumors by interrupting b-catenin signal *** synthesize PTI,the photosensitizer conjugated TfR targeting peptide moiety(Palmitic-K(PpIX)-HAIYPRH)is unitized to encapsulate the transcription interrupter of *** the one hand,the recognition of PTI and TfR can promote drug delivery into tumor cells to destruct primary tumors through photodynamic therapy and initiate an immunogenic cell death with the release of tumorassociated *** the other hand,PTI will interrupt the binding between b-catenin andcAMP response element-binding protein(CREB),regulating the gene transcription to downregulate programmed death ligand 1(PD-L1)while upregulating CeC motif chemokine ligand 4(CCL4).Furthermore,the elevated CCL4 can recruit the dendritic cells to present tumor-specific antigens and promote T cells activation and infiltration,and the downregulated PD-L1 can avoid the immune evasion of tumor cells and activate systemic anti-tumor immunity to eradicate lung *** work may inspire the development of antibody antibody-free strategy to activate systemic immune response in consideration of immunosuppressive conditions.

关键词： Transferrin receptor b-Catenin signal pathway Tumor targeting Photodynamic therapy Immunotherapy Immunogenic cell death Programmed death ligand 1

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腕部高压电烧伤诊治的研究进展

中华创伤杂志 2021年第5期37卷 467-472页

作者：张颖沈余明北京积水潭医院烧伤科 100035

高压电烧伤是一种致死率、致残率极高的特殊类型烧伤,毁损严重,受到社会广泛关注。腕部高压电烧伤损伤重,损伤程度难于判定,治疗过程复杂,预后较差,给社会和家庭造成极大的负担。近年来影像学检查为高压电烧伤的诊断/分型提供更可靠的依... 详细信息

高压电烧伤是一种致死率、致残率极高的特殊类型烧伤,毁损严重,受到社会广泛关注。腕部高压电烧伤损伤重,损伤程度难于判定,治疗过程复杂,预后较差,给社会和家庭造成极大的负担。近年来影像学检查为高压电烧伤的诊断/分型提供更可靠的依据;显微外科技术的发展,也使创面修复有更多的选择。笔者就腕部高压电烧伤的流行病学、临床分型、损伤诊断、手术治疗进行综述,为腕部高压电烧伤的临床诊治提供借鉴。

关键词：烧伤,电诊断腕

Mice serum fatty acids composition correlates to hepatic fatty acids composition and NAFLD activity score induced by high-fat diet

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Mice serum fatty acids composition correlates to hepatic fat...

中国畜牧兽医学会兽医药理毒理学分会第十一届会员代表大会暨第十三次学术讨论会与中国毒理学会兽医毒理专业委员会第五次学术研讨会

作者： Xing-he Wang Chun-yan Li Xiu-ying zhang Faculty of Basic Veterinary Science College of Veterinary MedicineNortheast Agricultural University

Background & Aim:As the leading cause of liver dysfunction all over the world,non-alcoholic fatty liver disease(NAFLD) is a clinical metabolic syndrome with fatty accumulation in hepatocytes,nevertheless,without alcohol *** recent years,morbidity of NAFLD has grown in Eastern and Western countries,and the diet composition has become an important health *** and NASH are involved in the spectrum of NAFLD,NASH is easier develop into liver fibrosis,cirrhosis,and even hepatocellular *** clinical,hver biopsy as the gold standard to assess levels of steatosis,inflammation and fibrosis in NAFLD is invasive,costly and associated with possible *** kinds of noninvasive biomarkers for evaluating NAFLD have been investigated but none performed well ***,it is still interest to discover noninvasive method to help detecting *** published data showed that quality of fatty acids(FA) accumulated in liver is associated with the degree of liver damage in *** about serum FA variation in NAFLD is *** study aims to investigate the correlation between serum FA composition and the hepatic steatosis,inflammation,hepatocellular ballooning scores and even liver FA composition in the influence of high-fat diet(HFD) in ***:ICR mice(10mice/group) were fed with HFD or control diet(CD) for 4,6 or *** were collected for pathology and NAFLD activity score(NAS) *** and liver FA composition was analyzed by gas chromatography(GC).The correlation analysis was determined with Pearson correlation ***:Induced by HFD,mice got fatty liver disease of different level without obvious fibrosis,and the liver damage level increased as the HFD feeding time went *** could be diagnosed at the 4th week of HFD feeding and NASH could be diagnosed at the 6th and 8th *** fibrosis has not occurred from the beginning to the end of the *** composition analysis in mice serum and

关键词： Pearson correlation coefficient-serum FA composition-high-fat diet-NAFLD

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基于单颗粒气溶胶质谱技术的源解析新算法

中国环境科学 2022年第2期42卷 575-584页

作者：徐娇张邓毅张英磊冯银厂北京首创大气环境科技股份有限公司北京100176 南开大学环境科学与工程学院国家环境保护城市空气颗粒物污染防治重点实验室天津300071

针对现有单颗粒气溶胶质谱技术的颗粒物快速来源解析方法不能提供基于质量浓度单位源解析结果的问题,提出一种新型单颗粒快速源解析算法ArtPMF.选择淮河平原某能源工业城市2021年2~3月的单颗粒质谱监测数据对ArtPMF算法进行应用.结果表... 详细信息

针对现有单颗粒气溶胶质谱技术的颗粒物快速来源解析方法不能提供基于质量浓度单位源解析结果的问题,提出一种新型单颗粒快速源解析算法ArtPMF.选择淮河平原某能源工业城市2021年2~3月的单颗粒质谱监测数据对ArtPMF算法进行应用.结果表明监测期间二次源、工业源、机动车尾气源、燃煤源、扬尘源、生物质燃烧源和烟花燃放源对PM_(2.5)的贡献占比分别为23%、22%、20%、12%、10%、6%和6%.结合监测点位周边工业企业实际分布方位、气态污染物和气象监测数据等对模型结果评估表明,该模型解析的燃煤源、燃烧源、工业源、机动车尾气源贡献高值的方位分布均符合现场工业企业和功能区划的实际情况,说明该模型结果可信且能够为污染防治提供准确信息支撑.

关键词：大气颗粒物单颗粒气溶胶质谱仪 ArtPMF模型在线源解析

线偏振光和圆偏振光下ZrO_2和Al_2O_3陶瓷材料的飞秒激光烧蚀性能

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光子学报 2018年第6期47卷 143-151页

作者：张军战张媛敏刘永胜张颖刘乾西安建筑科技大学材料与矿资学院功能材料研究所西安710055 西北工业大学凝固技术国家重点实验室西安710072 西安中科微精光子制造科技有限公司西安710199

将不同脉冲数的飞秒激光作用于陶瓷材料表面,研究了线偏振和圆偏振激光对氧化锆和氧化铝陶瓷材料烧蚀阈值的影响,利用光学显微镜和扫描电子显微镜分析了烧蚀坑表面形貌,利用激光扫描共聚焦显微镜确定了烧蚀坑深度.结果表明:两种材料在... 详细信息

将不同脉冲数的飞秒激光作用于陶瓷材料表面,研究了线偏振和圆偏振激光对氧化锆和氧化铝陶瓷材料烧蚀阈值的影响,利用光学显微镜和扫描电子显微镜分析了烧蚀坑表面形貌,利用激光扫描共聚焦显微镜确定了烧蚀坑深度.结果表明:两种材料在线偏振光下的饱和烧蚀阈值均小于在圆偏振光下的值;当偏振态相同时,氧化锆饱和烧蚀阈值小于氧化铝.随脉冲数增加,线偏振和圆偏振光下氧化锆烧蚀坑表面结构均由无序向有序发展,出现了周期性环形波纹结构和纳米孔洞阵列.与线偏振光相比,圆偏振光对烧蚀坑深度的作用更明显,且烧蚀坑表面形貌对能量密度变化比较敏感,更容易产生周期性结构.

关键词：飞秒激光偏振态点烧蚀多脉冲氧化锆陶瓷氧化铝陶瓷

区域体育产业转型升级的逻辑理路、案例实证与实现路径——基于主体行为视角

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北京体育大学学报 2023年第3期46卷 62-72页

作者：张颖翁银山东大学(威海)体育教学部山东威海264200 山东大学体育学院山东济南250061

区域体育产业转型升级是体育产业高质量发展的重要之举,其现实路径探索是推进区域经济高质量发展的重要议题。研究基于主体行为视角,聚焦典型案例,采用理论思辨与案例分析相结合的研究方式,探寻区域体育产业转型升级的逻辑理路、案例证... 详细信息

区域体育产业转型升级是体育产业高质量发展的重要之举,其现实路径探索是推进区域经济高质量发展的重要议题。研究基于主体行为视角,聚焦典型案例,采用理论思辨与案例分析相结合的研究方式,探寻区域体育产业转型升级的逻辑理路、案例证据与实现路径。研究发现,区域体育产业转型升级过程中,主体行为转变后要素驱动更为明显,主体行为优化后路径导向更为明确,主体行为创新后内核支撑更为强劲。基于此,选取长三角、京津冀2个典型区域,发现主体行为对区域体育产业转型升级具有循环效应,且二者通过产生影响机制协同推进区域体育产业实现“质”性发展。据此,研究提出:转变政府职能,提升区域体育产业发展效率;培育多元市场主体,释放区域体育产业发展新动能;吸引社会资本参与,激发区域体育产业供给活力;促进多元主体协同,优化区域体育产业治理环境等推进区域体育产业转型升级的实现路径,为促进我国其他区域体育产业发展提供重要的学术参考依据。

关键词：区域体育产业转型升级主体行为实现路径

Fe^(3+),Cr^(3+)固溶尖晶石结构的红外辐射性能

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材料科学与工程学报 2007年第6期25卷 818-820页

作者：张英闻荻江苏州大学材料工程学院江苏苏州215012

用常规固相合成法成功地制备出Fe_2O_3和Cr_2O_3掺杂改性的尖晶石型红外辐射材料,并通过XRD、IR和IRE-2红外辐射仪测试了材料的微观结构,进而分析了材料的结构特征与红外辐射性能的关系,发现Fe_2O_3和Cr_2O_3的掺杂导致Fe^(3+)和Cr^(3+... 详细信息

用常规固相合成法成功地制备出Fe_2O_3和Cr_2O_3掺杂改性的尖晶石型红外辐射材料,并通过XRD、IR和IRE-2红外辐射仪测试了材料的微观结构,进而分析了材料的结构特征与红外辐射性能的关系,发现Fe_2O_3和Cr_2O_3的掺杂导致Fe^(3+)和Cr^(3+)分别以一定的配位形式进入体系中,并形成了(Mg,Fe)(Cr,Al)_2O_4混合型尖晶石结构,且随着体系中Fe2O3含量的提高,Cr_2O_3含量的降低,材料的红外辐射性能得到了很大改善,体系在全波段的辐射率为0.91,在<8μm波段具有较低的红外辐射率,而在8～25μm波段的具有较高的辐射率,可达0.97。

关键词：红外辐射性能尖晶石 Fe2O3 Cr2O3

湖南地区≥30岁社区人群高同型半胱氨酸血症现状及影响因素分析

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中国公共卫生 2019年第4期35卷 393-397页

作者：张影洪秀琴湖南省人民医院长沙410005

目的了解湖南地区≥30岁社区人群血浆同型半胱氨酸(Hcy)水平现状及相关影响因素,为湖南地区心脑血管疾病防治提供科学依据。方法采用分层整群随机抽样方法,于2013年6月—2014年5月对湖南地区≥30岁常住居民4 012人进行调查。内容包括人... 详细信息

目的了解湖南地区≥30岁社区人群血浆同型半胱氨酸(Hcy)水平现状及相关影响因素,为湖南地区心脑血管疾病防治提供科学依据。方法采用分层整群随机抽样方法,于2013年6月—2014年5月对湖南地区≥30岁常住居民4 012人进行调查。内容包括人口学特征、体格检查和实验室检测等资料。通过χ2检验和多因素logistic回归分析,探讨高同型半胱氨酸血症(HHcy)现状及影响因素。结果调查人群总Hcy水平为(13.77±7.68)μmol/L,HHcy患病率为35.4%,其中男性为45.3%,女性为28.5%。HHcy组与非HHcy组人群性别、年龄、吸烟、饮酒、高血压患病率及尿酸、肌酐、甘油三酯(TG)、胆固醇(TC)含量差异有统计学意义(均P <0.01);Pearson积差相关分析结果显示,Hcy水平分别与年龄、肌酐、尿酸、TC、TG呈正相关(r=0.068、0.072、0.138、0.109、0.266,均P <0.01)。多因素logistic回归分析结果显示,男性(OR=1.307,95%CI=1.078～1.585)、吸烟(OR=1.294,95%CI=1.053～1.589)、高血压(OR=3.707,95%CI=3.195～4.302)、高胆固醇(OR=1.276,95%CI=1.175～1.386)、高甘油三酯(OR=3.993,95%CI=2.960～5.388)、高尿酸(OR=1.002,95%CI=1.001～1.003)、高肌酐血症(OR=1.004,95%CI=1.001～1.008)是HHcy的影响因素。结论 HHcy患病率男性高于女性,并随年龄增长而升高。男性、吸烟、高血压、高胆固醇、高甘油三酯、高尿酸、高肌酐血症是HHcy的影响因素。

关键词：同型半胱氨酸(Hcy) 高同型半胱氨酸血症(HHcy) 影响因素

Assessing and Improving the Quality of Undergraduates in Preschool Education Programs in China:The Course Experience

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教育技术与创新 2024年第3期6卷 31-46页

作者： Linxi zhang Lei Zheng ying Zhou School of Educational Sciences Kaili UniversityChina Business School Nankai UniversityTianjingChina Institute of IR4.0 Universiti Kebangsaan MalaysiaMalaysia

This study investigated the current status of course satisfaction among 416 undergraduate students majoring in preschool education from four universities in *** it explored the predictive effects of five influencing factors(teacher instruction,course management,course setting,course environment,and course resources)on student *** SPSS data analysis,the findings revealed that:*** mean value of course experience was M=3.861(out of 5);*** were differences in the satisfaction of undergraduate students'course experience by different background variables;***,course resources,and loyalty had significant predictive power on undergraduate students'satisfaction with course experience;*** instruction(TI)did not significantly predict students'satisfaction with course experience(SCES)(p>0.001);*** instruction(TI)in this study had the highest mean satisfaction score(M=4.191)and the mean satisfaction score was only(M=3.861).The results show that the current status of course satisfaction among Chinese preschool undergraduates is at an moderate level,and there is more space for improvement;although students'satisfaction with teacher instruction(TI)is high,effective teacher instruction does not have a substantial impact on the acquisition of SCES or general competencies,and this passive learning and teaching style leads to a lack of independent learning and active participation among Chinese preschool undergraduate students.

关键词： Higher education Preschool education program Satisfaction Course experience