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Flocculation properties of cohesive fine-grained sediment in the Three Gorges Reservoir under variable turbulent shear

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Journal of Mountain Science 2022年第8期19卷 2286-2296页

作者： liu Jie SHEN ying WANG xin National Inland Waterway Regulation Engineering Research Center Chongqing Jiaotong UniversityChongqing 400074China Tianjin Research Institute for Water Transport Engineering Tianjin 300000China National Key Laboratory of Hydraulic Engineering Simulation and Safety Tianjin UniversityTianjin 300072China

Sediment flocculation is a key process for the deposition of fine-grained sediments in the Three Gorges Reservoir(TGR)of *** flocculation influences the evolution of the river regime,but also hampers the smooth navigation in the long ***,the flocculation process and its controlling factors are poorly *** experimentally determined the flocculation properties of cohesive sediment of samples from the TGR(predominantly a mixture of clay and silt)over a range of turbulent shear rates and sediment *** experiments were conducted in an almost isotropic turbulence field,which was simulated by an array of horizontal oscillating grids in a water *** flocculation was recorded by a camera and investigated by image *** new data indicate that flocculation is generally a response in equilibrium median floc size(d_(f,50))to the increase of the shear rate *** peak value is attained at G=16.5 s^(-1),where d_(f,50) is 81.3μm(for the suspended sediment concentration(ssc)=0.4 g/L)and 107μm(for ssc=0.7 g/L),*** low shear rates(G<16.5 s^(-1)),the equilibrium floc sizes d_(f,50) increase with rising shear rate G and isinversely related to the Kolmogorov micro length scale η.We attribute this variability to an insufficient deposition time of the sediment flocs in the water *** velocities,calculated from our experimental data of the floc sizes,are almost consistent with in-situ measured settling velocities,and are ten times larger than the terminal settling velocity of primary particles as calculated from Stokes'law.

关键词： Cohesive sediment flocculation Floc properties Settling velocity Turbulent shear rate Three Gorges Reservoir(TGR)

Sine oculis homeobox homolog family function in gastrointestinal cancer:Progression and comprehensive analysis

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World Journal of Clinical Oncology 2025年第1期16卷 10-24页

作者： Yang-Zheng Lan Zheng Wu Wen-Jia Chen xin-Ning Yu Hua-Tao Wu Jing liu Department of The Breast Center Cancer Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina Department of General Surgery First Affiliated Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina

The sine oculis homeobox homolog(SIX)family,a group of transcription factors characterized by a conserved DNA-binding homology domain,plays a critical role in orchestrating embryonic development and organogenesis across various organisms,including *** six distinct members,from SIX1 to SIX6,each member contributes uniquely to the development and differentiation of diverse tissues and organs,underscoring the versatility of the SIX *** or mutations in SIX genes have been implicated in a spectrum of developmental disorders,as well as in tumor initiation and progression,highlighting their pivotal role in maintaining normal developmental trajectories and cellular *** to target the transcriptional complex of the SIX gene family have emerged as a promising strategy to inhibit tumor *** the development of inhibitors targeting this gene family is still in its early stages,the significant potential of such interventions holds promise for future therapeutic ***,this review aimed to comprehensively explore the advancements in understanding the SIX family within gastrointestinal cancers,focusing on its critical role in normal organ development and its implications in gastrointestinal cancers,including gastric,pancreatic,colorectal cancer,and hepatocellular *** conclusion,this review deepened the understanding of the functional roles of the SIX family and explored the potential of utilizing this gene family for the diagnosis,prognosis,and treatment of gastrointestinal cancers.

关键词： Sine oculis homeobox homolog Gastrointestinal cancer Transcription factor Development Regulation Diagnosis Therapeutics

Akt Gene Therapy Enhances Angiogenesis in Ischemic Hind Limb

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Chemical Research in Chinese Universities 2010年第3期26卷 409-414页

作者： HUO xin ZHANG Qiang liu ying Department of Geriatrics First Affiliated Hospital China Medical University Shenyang 110001 P. R. China

Both bone marrow-derived mesenchymal stem cells（MSCs） therapy and gene therapy have been applied to animal studies and clinical trials. The goal of this study was to compare the effects of three types of MSCs transplantation. In the first part of the study, MSCs were transduced with the pEGFP-C1 and transfected with the pEGFP-C1/Akt in a model of bilateral hind limb ischemia in rats. Following gene transduction, the production of Akt and VEGF protein was more in the culture media of GFP-Akt/MSCs group than that in those of the GFP/MSCs group In the second part of the study, Sprague-Dawley rats（n=10/group） underwent surgery to create bilateral hind limb ischemia and were randomized into two groups consisting of a GFP/Akt-MSCs group（MSCs suspension, 1×10^7 MSCs/100 μL transfected pEGFP-C1/Akt） and a GFP-MSCs group（MSCs suspension, 1 × 10^7 MSCs/100 μL）. These PEGFP-C1/Akt and PEGFP-C 1 transfected MSCs suspensions were slowly infused into the adductor muscles of the rat＇s left hind limb, while the rat＇s right hind limb in the control group received an equal volume of PBS. Endpoints includes angiographic analysis, evaluation of capillary density, immunohistochemistry for von Willebrand factor （vWF）, immunodetection of Akt and VEGF protein, RT-PCR of VEGF and Akt mRNA levels in vitro and in vivo. Our data indicate that the tissue perfusion can improve capillary density and the mature of vasculature in the GFP-Akt/MSCs group compared to that in the GFP-MSCs group or control group in the rat model of bilateral hind limb ischemia. Transplantation of MSCs transfected with Akt gene may become the future therapy for hind limb ischemia.

关键词： Bone mesenchymal stem cell pEGFP-C1/Akt Hindlimb Ischemia Angiogenesis

《分析化学仪器设备验证与综合评价指南》解读

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分析仪器 2017年第5期 143-146页

作者：高峰刘萤刘鑫刘来福云环赵靖敏范斐北京出入境检验检疫局检验检疫技术中心北京100026

本文对认证认可标准《分析化学仪器设备验证与综合评价指南》(RB/T160-2017)的目的和内容进行了解读,可帮助使用者更好的理解标准。

关键词：分析化学仪器设备验证综合评价

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玉米赤霉烯酮生物降解及其脱毒机制研究进展

食品科学 2025年第1期46卷 246-254页

作者：李凯龙刘昆仑辛颖杨趁仙王子坤河南工业大学粮油食品学院河南郑州450001 河南工业大学粮食和物资储备学院河南郑州450001

真菌毒素是一类严重危害谷物、食品、饲料安全的污染物,可造成大量资源浪费和严重经济损失。在霉变玉米、小麦等谷物中,玉米赤霉烯酮(zearalenone,ZEN)具有高检出率,其污染暴露可造成生殖毒性、肝毒性、肾毒性等危害。因其污染范围广泛... 详细信息

真菌毒素是一类严重危害谷物、食品、饲料安全的污染物,可造成大量资源浪费和严重经济损失。在霉变玉米、小麦等谷物中,玉米赤霉烯酮(zearalenone,ZEN)具有高检出率,其污染暴露可造成生殖毒性、肝毒性、肾毒性等危害。因其污染范围广泛、危害严重,成为食品安全的重大隐患。传统的物理化学方法在降解ZEN的同时也存在二次污染风险,因此,食品相关产业一直在寻求具有更高专一性、靶向性、安全性和适应性的生物降解技术。本文综述ZEN毒性及其危害、ZEN降解菌株与降解酶及现代生物技术在ZEN脱除中的应用,重点分析ZEN生物降解产物类型及其脱毒机制,并展望ZEN生物脱毒的潜在应用方向,为ZEN生物脱毒研究提供理论依据。

关键词：玉米赤霉烯酮生物降解脱毒机制

Advances in ethnopharmacology,phytochemistry and pharmacology of Erigerontis Herba and its Chinese medicine prescriptions

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Traditional Medicine Research 2025年第1期10卷 44-61页

作者： Yang Zhou Yuan-Yan Huang Ding-Yue Shang ying Chen Meng Tian Cheng-Yu Jin xin Lu Bing-Chun Yan Han-Qing Pang Institute of Translational Medicine School of MedicineYangzhou UniversityYangzhou 225009China Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases Yangzhou UniversityYangzhou 225009China School of Medicine Nanjing University of Chinese MedicineNanjing 210023China State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources Guangxi Normal UniversityGuiling 541004China.

Erigerontis Herba(EH),the dried whole plant of Erigeron breviscapus,is well-known for circulating blood,activating meridians to alleviate pain,expelling wind,and clearing away *** has been extensively utilized in southern China for the treatment of stroke hemiplegia,chest stuffiness and pains,rheumatic arthralgia,headache,and *** review focuses on the botany,ethnopharmacology,phytochemistry,pharmacology and toxicity of EH and its related prescriptions to offer new insights for prospective research of *** information about EH was retrieved from ancient records and books,PubMed,China National Knowledge Infrastructure,Chinese Pharmacopoeia,Web of Science,Doctoral and Master’s Theses,and various electronic *** is a member of Compositae family and is mainly grown in southern *** Chinese medicine records that EH has the effects of circulating blood and removing blood stasis,expelling wind,and removing cold,as well as relieving rigidity of muscle and relieving *** now,nearly 200 ingredients have been characterized from EH,including flavonoids,caffeoyls,aromatic acids,coumarins,pentacyclic terpenoids,volatile oil and other *** extracts,EH related prescriptions(Dengzhan Xixin injection,Dengzhan Shengmai capsules,etc.)or compounds(scutellarin,scutellarein,etc.)possessed obvious therapeutic effects of ischemic stroke,cerebral hemorrhage,myocardial infarction,Alzheimer’s disease,diabetes and its complications,gastric cancer,bone,and joint degenerative ***,the major active compound of EH,has been used as a quality *** no obvious toxicity of EH has been *** to its traditional applications,ethnopharmacology,phytochemistry,pharmacology,and toxicity,EH was applied as a valuable herb for clinical application in food and medicine *** several compounds have been shown to possess diverse biological activities,the underlying mechanisms of their actions remain *** fully exploi

关键词： Erigeron breviscapus traditional applications ethnopharmacology phytochemistry pharmacology

Arsenic uptake, accumulation and phytofiltration by duckweed (Spirodela polyrhiza L.)

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Journal of Environmental Sciences 2011年第4期23卷 601-606页

作者： xin Zhang ying Hu Yunxia liu Baodong Chen State key Laboratory of Urban and Regional Ecology Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100085 China

This study investigates arsenic （As） accumulation and tolerance of duckweed Spirodela polyrhiza L. and its potential for As phytofiltration. S. polyrhiza was able to survive in high concentration of As（V） solution. The EC 50 values （± SE） based on the external As（V） were （181.66 ± 20.12） μmol/L. It accumulated （999 ± 95） mg As/kg dw when exposed in 320 μmol/L As（V） solution for one week, and was able to take up appropriately 400 mg As/kg dw in tissues without a significant biomass loss. The EC 50 values （the effective concentration of As（V） in the nutrient solution that caused a 50% inhibition on biomass production） was （866 ± 68） mg/kg dw for the tissues, indicating that S. polyrhiza had a high capability of As accumulation and tolerance. The uptake kinetic parameters V max was （55.33 ± 2.24） nmol/（g dw·min） and K m was （0.144 ± 0.011） mmol/L. Within 72 hr, S. polyrhiza decreased As concentration in the solution from 190 to 113 ng/mL with a removal rate of 41%. The study suggested that this floating aquatic plant has some potential for As phytofiltration in contaminated water bodies or paddy soils.

关键词： arsenic duckweed phytofiltration Spirodela polyrhiza L.

Clathrate metal superhydrides under high-pressure conditions: enroute to room-temperature superconductivity

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National Science Review 2024年第7期11卷 33-46页

作者： ying Sun xin Zhong Hanyu liu Yanming Ma Key Laboratory of Material Simulation Methods&Software of Ministry of Education College of Physics Jilin University State Key Laboratory of Superhard Materials College of PhysicsJilin University International Center of Future Science Jilin University

Room-temperature superconductivity has been a long-held dream of mankind and a focus of considerable interest in the research field of superconductivity. Significant progress has recently been achieved in hydrogen-based superconductors found in superhydrides（hydrides with unexpectedly high hydrogen contents） that are stabilized under high-pressure conditions and are not capturable at ambient *** particular interest is the discovery of a class of best-ever-known superconductors in clathrate metal superhydrides that hold the record for high superconductivity(e.g. Tc= 250–260 K for LaH10) among known superconductors and have great promise to be those that realize the long-sought room-temperature superconductivity. In these peculiar clathrate superhydrides, hydrogen forms unusual ‘clathrate’ cages containing encaged metal atoms, of which such a kind was first reported in a calcium hexa-superhydride（CaH6） showing a measured high Tcof 215 K under a pressure of 170 GPa. In this review, we aim to offer an overview of the current status of research progress on the clathrate metal superhydride superconductors,discuss the superconducting mechanism and highlight the key features（e.g. structure motifs, bonding features, electronic structure, etc.） that govern the high-temperature superconductivity. Future research direction along this line to find room-temperature superconductors will be discussed.

关键词： clathrate superhydrides high-temperature superconductivity high-pressure conditions crystal structure prediction

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调谐短截线弯曲方环宽带带通滤波器设计

天津职业技术师范大学学报 2016年第3期26卷 40-42页

作者：李雅静冯立营刘新月天津职业技术师范大学天线与微波技术研究所天津300222

设计了一种紧凑的新型宽带双模带通滤波器。该滤波器基于一个直连馈线弯曲方环谐振器的带阻结构,加载调谐短截线构成带通滤波器,通过将所加载短截线弯曲实现滤波器的小型化。此外,方环1/4角上放置微扰并在侧面阻带位置激起的模式可以实... 详细信息

设计了一种紧凑的新型宽带双模带通滤波器。该滤波器基于一个直连馈线弯曲方环谐振器的带阻结构,加载调谐短截线构成带通滤波器,通过将所加载短截线弯曲实现滤波器的小型化。此外,方环1/4角上放置微扰并在侧面阻带位置激起的模式可以实现带通滤波器的选择性。实验结果表明:滤波器的中心频率为5.41 GHz,3 d B带宽为59.5%,插入损耗为0.16 d B,带内的反射损耗大于11 d B,符合设计要求。

关键词：双模调谐短截线带通滤波器弯曲方环谐振器