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Formaldehyde up-regulates TRPV1 through MAPK and PI3K signaling pathways in a rat model of bone cancer pain

Neuroscience Bulletin 2012年第2期28卷 165-172页

作者： ying Han Yan Li Xlng Xlao Jia liu Xiang-Ling Meng Feng-Yu liu Guo-Gang xing You Wan Neurosczence Research Institute Department of Neurobiology School of Basic Medical Sciences Key Laboratory forNeuroscience The Ministry of Education / The Ministry of Health Peking University Beijing 100191 China

Objective Our previous study showed that tumor tissue-derived formaldehyde at low concentrations plays an important role in bone cancer pain through activating transient receptor potential vanilloid subfamily member 1 （TRPV 1）. The present study further explored whether this tumor tissue-derived endogenous formaldehyde regulates TRPV1 expres- sion in a rat model of bone cancer pain, and if so, what the possible signal pathways are during the development of this type of pain. Methods A rat model of bone cancer pain was established by injecting living MRMT-1 tumor cells into the tibia. The formaldehyde levels were determined by high performance liquid chromatography, and the expression of TRPV1 was examined with Western blot and RT-PCR. In primary cultured dorsal root ganglion （DRG） neurons, the ex- pression of TRPV1 was assessed after treatment with 100 ~tmol/L formaldehyde with or without pre-addition of PD98059 [an inhibitor for extracellular signal-regulated kinase], SB203580 （a p38 inhibitor）, SP600125 [an inhibitor for c-Jun N- terminal kinase], BIM [a protein kinase C （PKC） inhibitor] or LY294002 [a phosphatidylinositol 3-kinase （PI3K） inhibi- tor]. Results In the rat model of bone cancer pain, formaldehyde concentration increased in blood plasma, bone marrow and the spinal cord. TRPV1 protein expression was also increased in the DRG. In primary cultured DRG neurons, 100 p^mol/L formaldehyde significantly increased the TRPV1 expression level. Pre-incubation with PD98059, SB203580, SP600125 or LY294002, but not BIM, inhibited the formaldehyde-induced increase of TRPV1 expression. Conclusion Formaldehyde at a very low concentration up-regulates TRPV1 expression through mitogen-activated protein kinase and PI3K, but not PKC, signaling pathways. These results further support our previous finding that TRPV1 in peripheral after- ents plays a role in bone cancer pain.

关键词： formaldehyde TRPV1 cancer pain mitogen-activated protein kinase phosphatidylinositol 3-kinase

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Bibliometric analysis of glaucoma-related literature based on SCIE database:a 10-year literature analysis from 2009 to 2018

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International Journal of Ophthalmology(English edition) 2020年第12期13卷 1998-2006页

作者： Yun-Xiao Sun ying-Na liu ying Han Fan-Qi Kong Yue Zhang Siloka Arthur Labisi Kai Cao Beijing Ophthalmology and Visual Sciences Key Laboratory Beijing Tongren Eye CenterBeijing Tongren HospitalCapital Medical UniversityBeijingChina Beijing Institute of Ophthalmology Beijing Tongren HospitalCapital Medical UniversityBeijingChina Department of Ophthalmology University of California San FranciscoSan FranciscoCA 94143USA Allergan plc ShanghaiChina

AIM:To explore the global trends and focus of glaucoma research from 2009 to ***:Searching for glaucoma-related articles published in Science Citation Index Expanded(SCIE)database during 2009-2018,and describing the distribution of the published year,countries,authors,institutions,funding agencies,journals,impact factor,citation and hot research topic of articles by using bibliometric ***,we compared some of these indicators over two five-year periods,from 2009 to 2013 and from 2014 to ***:A total of 19609 glaucoma-related articles were retrieved and the global SCIE articles have increased yearly from 2009 to *** USA was the pioneer which has made great *** kept the second place and the number of publications has increased rapidly between 2014 and *** author with the highest number of publications was Weinreb,***-occurrence maps were built amongst the top 50 authors or the top 50 institutions with the most articles,which visualize the closer collaboration of international authors or *** journal Investigative Ophthalmology&Visual Science has published the most *** literature with an impact factor of 3-5 points accounted for the largest proportion(28.96%).The most frequently cited paper had 798 *** top three hot areas on glaucoma were intraocular pressure,optical coherence tomography(OCT)and retinal ganglion *** trabecular meshwork,primary angle-closure glaucoma and Spectral-domain OCT have become new hot research topics in recent five years during ***:Bibliometric analysis is an effective method to describe the global literature on *** a 10-year literature survey from 2009 to 2018,global glaucoma research has developed in a balanced manner,and the cooperation between various institutions and teams has become ***-related pathogenesis research,imaging examinations of OCT and surgery therapy have attracted most attention.

关键词： bibliometric analysis Science Citation Index Expanded glaucoma ocular hypertension

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Effect of the Coefficient on the Performance of A Two-Layer Boussinesq- Type Model

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China Ocean Engineering 2021年第1期35卷 36-47页

作者： SUN Jia-wen liu Zhong-bo WANG xing-gang FANG Ke-zhao DU xin-yuan WANG Ping State Environmental Protection Key Laboratory of Marine Ecosystem Restoration National Marine Environmental Monitoring CenterDalian 116023China Transportation Engineering College Dalian Maritime UniversityDalian 116026China Nanjing Hydraulic Research Institute Nanjing 210029China State Key Laboratory of Coastal and Offshore Engineering Dalian University of TechnologyDalian 116024China Liaoning natural resources Affairs Service Center Shenyang 110032China

The coefficients embodied in a Boussinesq-type model are very important since they are determined to optimize the linear and nonlinear *** most conventional Boussinesq-type models,these coefficients are assigned the specific *** for the multi-layer Boussinesq-type models with the inclusion of the vertical velocity,however,the effect of the different values of these coefficients on linear and nonlinear performances has never been investigated *** present study focuses on a two-layer Boussinesq-type model with the highest spatial derivatives being 2 and theoretically and numerically examines the effect of the coefficient on model *** analysis show that different values for(0.13≤α≤0.25)do not have great effects on the high accuracy of the linear shoaling,linear phase celerity and even third-order nonlinearity for water depth range of 0ying slope from deep to shallow water,regular wave propagation over submerged bar,bichromatic wave group and focusing wave propagation over deep water are *** comparison between numerical results using different values of,experimental data and analytical solutions confirm the theoretical *** flexibility and consistency of the two-layer Boussinesq-type model is therefore demonstrated theoretically and numerically.

关键词： two-layer Boussinesq-type model dispersion nonlinear properties shoaling amplitude

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Entropic force between two horizons of dilaton black holes with a power-Maxwell field

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Chinese Physics C 2021年第4期45卷 172-180页

作者： Hui-Hua Zhao Li-Chun Zhang ying Gao Fang liu Institute of Theoretical Physics Shanxi Datong UniversityDatong 037009 China School of Mathematics and Statistics Shanxi Datong UniversityDatong 037009China

In this paper,we consider(n+1)-dimensional topological dilaton de Sitter black holes with a powerMaxwell field as thermodynamic *** thermodynamic quantities corresponding to the black hole horizon and the cosmological horizon are ***,the total entropy of the space-time should be the sum of the entropies of the black hole horizon and the cosmological horizon plus a correction term which is produced by the association of the two *** analyze the entropic force produced by the correction term at given temperatures,which is affected by the parameters and dimensions of the *** is shown that the change of entropic force with the position ratio of the two horizons in some regions is similar to that of the variation of the Lennard-Jones force with the position of *** the effect of entropic force is similar to that of the Lennard-Jones force,and other forces are absent,the motion of the cosmological horizon relative to the black hole horizon should have an oscillating *** entropic force between the two horizons is probably one of the participants in driving the evolution of the universe.

关键词： entropy entropic force dilaton dS space-time

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Protective efficacy of an H5/H7 trivalent inactivated vaccine(H5-Re13,H5-Re14, and H7-Re4 strains) in chickens, ducks, and geese against newly detected H5N1, H5N6, H5N8, and H7N9 viruses

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Journal of Integrative Agriculture 2022年第7期21卷 2086-2094页

作者： ZENG Xian-ying HE xin-wen MENG Fei MA Qi WANG Yan BAO Hong-mei liu Yan-jing DENG Guo-hua SHI Jian-zhong LI Yan-bing TIAN Guo-bin CHEN Hua-lan State Key Laboratory of Veterinary Biotechnology National Poultry Laboratory Animal Resource CenterHarbin Veterinary Research InstituteChinese Academy of Agricultural SciencesHarbin 150069P.R.China

Some H5 viruses isolated in poultry or wild birds between 2020 and 2021 were found to be antigenically different from the vaccine strains(H5-Re11 and H5-Re12) used in China. In this study, we generated three new recombinant vaccine seed viruses by using reverse genetics and used them for vaccine production. The vaccine strain H5-Re13 contains the hemagglutinin(HA) and neuraminidase(NA) genes of an H5 N6 virus that bears the clade 2.***.4.4 h HA gene, H5-Re14 contains the HA and NA genes of an H5 N8 virus that bears the clade 2.***.4.4 b HA gene, and H7-Re4 contains the HA and NA genes of H7 N9 virus detected in 2021. We evaluated the protective efficacy of the novel H5/H7 trivalent inactivated vaccine in chickens, ducks, and geese. The inactivated vaccine was immunogenic and induced substantial antibody responses in the birds tested. Three weeks after vaccination, chickens were challenged with five different viruses detected in 2020 and 2021: three viruses(an H5 N1 virus, an H5 N6 virus, and an H5 N8 virus) bearing the clade 2.***.4.4 b HA gene, an H5 N6 virus bearing the clade 2.***.4.4 h HA gene, and an H7 N9 virus. All of the control birds shed high titers of virus and died within 4 days post-challenge, whereas the vaccinated chickens were completely protected from these viruses. Similar protective efficacy against H5 viruses bearing the clade 2.***.4.4 h or 2.***.4.4 b HA gene was observed in ducks and geese. Our study indicates that the newly updated H5/H7 vaccine can provide solid protection against the H5 and H7 N9 viruses that are currently circulating in nature.

关键词： avian influenza H5/H7 trivalent vaccine H5-Re13 H5-Re14 H7-Re4 strains protective efficacy chickens ducks and geese

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Three main dimensions reflected by national SDG performance

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The Innovation 2023年第6期4卷 83-91页

作者： Xutong Wu Bojie Fu Shuai Wang Yanxu liu ying Yao yingjie Li Zhenci Xu Jianguo liu State Key Laboratory of Earth Surface Processes and Resource Ecology Faculty of Geographical ScienceBejing Normal UniversityBeiling 100875China State Key Laboratory of Urban and Regional Ecology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBejing 100085China Natural Capital Project Stanford UniversityStanfordCA 94305USA Department of Geography The University of Hong KongHong Kong 999077China Center for Systems Integration and Sustainability Department of Fisheries and WildlifeMichigan State UniversityEast LansingMI 48823USA

Unraveling the complexity of the 17 inter acting sustainable development goals(SDGs)is crucial for their *** revealing the dimensions of the SDGs helps generalize the dominant features of SDGs and better understand their ***,using a database of 166 countries'progress toward achieving each individual SDG,we found that about 70%of the variability of national SDG performance can be captured by three dimensions:socioeconomic development at the expense of resource and climate,the environment,and development at the expense of ***,these dimensions are mainly affected by the economy,as gross domestic product(GDP)per capita increases,the first dimension increases monotonically,the environment dimension decreases and then increases,and the inequality dimension increases and then *** findings indicate a dim prospect of eventually achieving all SDGs because of the conflicts between economic growth and resource and cdimate goals under the current development paradigm,highlighting the importance of sustainable transformation.

关键词： dimensions dimension performance

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Relationship between Renalase Expression and Kidney Disease： an Observational Study in 72 Patients Undergoing Renal Biopsy

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Current Medical Science 2018年第2期38卷 268-276页

作者： Yi-sha HUANG Jian-bo LAP Sheng-fa LI Ting WANG ying-nan liu Qing-xia ZHANG Shu-yuan ZHANG Chun-han SUN Nan HU xin-zhou Zhang Department of Nephrology Shenzhen People 's Hospital Second Clinical Medical College of Jinan University Shenzhen 518000 China. Key Renal Laboratory of Shenzhen Shenzhen 518108 China. Department of Gastrointestinal Shenzhen People 's Hospital Second Clinical Medical College of Jinan University Shenzhen 518000 China. Department of Orthopedics Huizhou First Hospital Affiliated Hospital of Guangdong Medical University Huizhou 516000 China. Department of Cell Biology School of Basic Medical Science Southern Medical University Guangzhou 510515 China. Department of Hand Microsurgry Shenzhen People 's Hospital Second Clinical Medical College of Jinan University Shenzhen 518000 China.

The relationship between the levels of renalase and changes in proteinuria, hypertension, renal function, renal tubular epithelial cell apoptosis and B-cell lymphoma-2 （Bcl-2） expression was investigated in patients （chronic nephritis, primary nephrotic syndrome or other kidney disease） that underwent renal biopsy. The study group comprised 72 patients undergoing renal biopsy. Patient profiles and renal function were collected. Concentrations of renalase and Bcl-2 were measured by immunohistochemistry. Tubular injury was detected by periodic acid Schiff staining （PAS） and renal tubular epithelial cell apoptosis was assessed by TUNEL assay. The expression of renalase was significantly lower in renal biopsy specimens than in normal kidney tissues. There was a positive linear relationship between renalase and some serum and cardiac indices; a negative correlation was found between age, eGFR, Ccr and 24-h urinary protein. Renal tubule injury index and tubular epithelial cell apoptosis index showed a negative linear correlation with renalase. The results showed that renalase probably increased the expression of Bel-2. By two independent samples t-test, renalase levels were significantly increased in the non-hypertension group than in the hypertension group. One-way ANOVA showed that renalase expression was higher in samples with Lee＇s grade Ⅲ than in those with Lee＇s grade V. The expression of renalase was significantly decreased in patients who underwent renal biopsy, and was also associated with blood and renal function. The research proved that renalase may reduce renal tubular injury and apoptosis of renal tubular epithelial cells through the mitochondrial apoptosis pathway, finally achieving the purpose of delaying the progress of renal failure.

关键词： renalase kidney disease flavoprotein renal function renal puncture biopsy

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Modern deep learning in bioinformatics

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Journal of Molecular Cell Biology 2020年第11期12卷 823-827页

作者： Haoyang Li Shuye Tian Yu Li Qiming Fang Renbo Tan Yijie Pan Chao Huang ying Xu xin Gao Cancer Systems Biology Center The China-Japan Union HospitalJilin UniversityChangchun 130033China MOE Key Laboratory of Symbolic Computation and Knowledge Engineering College of Computer Science and TechnologyJilin UniversityChangchun 130012China Department of Biology Southern University of Science and TechnologyShenzhen 518055China Computational Bioscience Research Center(CBRC) Computer Electrical and Mathematical Sciences and Engineering(CEMSE)DivisionKing Abdullah University of Science and Technology(KAUST)Thuwal 23955Saudi Arabia School of Computer Science and Technology Hangzhou Dianzi UniversityHangzhou 310018China Ningbo Institute of Information Technology Application Chinese Academy of SciencesNingbo 315040China Computational Systems Biology Lab Department of Biochemistry and Molecular Biology and Institute of BioinformaticsUniversity of GeorgiaAthensGA 30602USA

Deep learning(DL)has shown explosive growth in its application to bioinformatics and has demonstrated thrillingly promising power to mine the complex relationship hidden in large-scale biological and biomedical data.A number of comprehensive reviews have been published on such applications,ranging from high-level reviews with future perspectives to those mainly serving as tutorials.

关键词： has such she

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NRN1 and CAT Gene Polymorphisms, Complex Noise, and Lifestyles interactively Affect the Risk of Noise-induced Hearing Loss

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Biomedical and Environmental Sciences 2021年第9期34卷 705-718页

作者： liu Shuang Yan SONG Wei Qin xin Jia Rui LI Zheng LEI Song CHEN ying Qi ZHAO Tian Yu WANG Hai Yan XU Liang Wen ZHANG Mei Bian HONG Yu YANG Lei Medical School Hangzhou Normal UniversityHangzhou 310000ZhejiangChina Ningbo Center for Disease Control and Prevention Ningbo 315700ZhejiangChina Central people's hospital of Zhanjiang Zhanjiang 524000ZhejiangChina Institute of Occupational Health and Radiation Protection Zhejiang Provincial Center for Disease Control and PreventionHangzhou 310000ZhejiangChina

Objective The effects of interactions between genetic and environmental factors on the noise-induced hearing loss(NIHL)are still *** study aimed to assess interactions among gene polymorphisms,noise metrics,and lifestyles on the risk of *** A case-control study was conducted using 307 patients with NIHL and 307 matched healthy individuals from five manufacturing *** demographic data,lifestyle details,and noise exposure levels were *** Kompetitive allele-specific polymerase chain reaction(KASP)was used to analyze the genotypes of 18 *** GMDR model demonstrated a relevant interaction between NRN1 rs3805789 and CAT rs7943316(P=0.0107).Subjects with T allele of rs3805789 or T allele of rs7943316 had higher risks of NIHL than those with the SNP pair of rs3805789-CC and rs7943316-AA(Pying both rs3805789-CT and rs7943316-TT or rs3805789-CT/TT and rs7943316-AA had higher risks of NIHL than those exposed to steady noise and carrying both rs3805789-CC and rs7943316-AA(P<0.05).The best six-locus model involving NRN1 rs3805789,CAT rs7943316,smoking,video volume,physical exercise,and working pressure for the risk of NIHL was found to be the interaction(P=0.0010).An interaction was also found among smoking,video volume,physical exercise,working pressure,and kurtosis(P=0.0107).Conclusion Concurrence of NRN1 and CAT constitutes a genetic risk factor for *** noise exposure significantly increases the risk of NIHL in subjects with a high genetic risk *** between genes and lifestyles as well as noise metrics and lifestyles affect the risk of NIHL.

关键词： Noise-induced hearing loss Kurtosis CAT NRN1 Lifestyle Interaction Generalized multifactor dimensionality reduction

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激光二极管抽运的Nd:NYW/LBO绿光激光器

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中国激光 2007年第5期34卷 646-648页

作者：王巍刘炘钢刘英同长春理工大学吉林长春130022 吉林省电子信息高级技术学校吉林长春130022

报道了用激光二极管(LD)抽运的掺钕钨酸钇钠[Nd3+:NaY(WO4)2](简称Nd:NYW)绿光激光器。腔内采用Ⅰ类临界相位匹配LBO(LiB3O5)作为倍频晶体,阈值抽运功率为410mW,在抽运功率为1.5W时获得了87mW的530nm连续激光输出,基频光-光转换效率大于... 详细信息

报道了用激光二极管(LD)抽运的掺钕钨酸钇钠[Nd3+:NaY(WO4)2](简称Nd:NYW)绿光激光器。腔内采用Ⅰ类临界相位匹配LBO(LiB3O5)作为倍频晶体,阈值抽运功率为410mW,在抽运功率为1.5W时获得了87mW的530nm连续激光输出,基频光-光转换效率大于25%,斜率效率为7.98%。

关键词：激光技术绿光激光器激光二极管抽运 Nd∶NYW晶体 LBO晶体

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