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Classification of congenital cataracts based on multidimensional phenotypes and its association with visual outcomes

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International Journal of Ophthalmology(English edition) 2024年第3期17卷 473-479页

作者： Yuan tan ying-Shi Zou ying-Lin Yu Le-Yi Hu Ting Zhang Hui Chen Ling Jin Duo-Ru Lin Yi-Zhi Liu Hao-Tian Lin Zhen-Zhen Liu State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangdong Provincial Key Laboratory of Ophthalmology and Visual ScienceGuangdong Provincial Clinical Research Center for Ocular DiseasesGuangzhou 510060Guangdong ProvinceChina

●AIM:To establish a classification for congenital cataracts that can facilitate individualized treatment and help identify individuals with a high likelihood of different visual outcomes.●METHODS:Consecutive patients diagnosed with congenital cataracts and undergoing surgery between January 2005 and November 2021 were *** on visual outcomes and the phenotypic characteristics of ocular biometry and the anterior and posterior segments were extracted from the patients’medical records.A hierarchical cluster analysis was *** main outcome measure was the identification of distinct clusters of eyes with congenital cataracts.●RESULTS:A total of 164 children(299 eyes)were divided into two clusters based on their ocular *** 1(96 eyes)had a shorter axial length(mean±SD,19.44±1.68 mm),a low prevalence of macular abnormalities(1.04%),and no retinal abnormalities or posterior *** 2(203 eyes)had a greater axial length(mean±SD,20.42±2.10 mm)and a higher prevalence of macular abnormalities(8.37%),retinal abnormalities(98.52%),and posterior cataracts(4.93%).Compared with the eyes in Cluster 2(57.14%),those in Cluster 1(71.88%)had a 2.2 times higher chance of good best-corrected visual acuity[<0.7 logMAR;OR(95%CI),2.20(1.25–3.81);P=0.006].●CONCLUSION:This retrospective study categorizes congenital cataracts into two distinct clusters,each associated with a different likelihood of visual *** innovative classification may enable the personalization and prioritization of early interventions for patients who may gain the greatest benefit,thereby making strides toward precision medicine in the field of congenital cataracts.

关键词： classification congenital cataract phenotype visual acuity cluster analysis

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论中国特色社会主义基层直接民主对马克思直接民主观的继承和发展

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社会主义研究 2024年第05期 76-84页

作者：谭荧武汉科技大学马克思主义学院

马克思的直接民主观对中国特色社会主义基层民主政治建设有着重大和深远的影响。马克思基于人民主权理论的深刻阐释而提出“真正民主制”的发展理念，其思想精髓可概括为三个方面：人民规定制度而非从属于制度，人民通过普选制直接参与... 详细信息

马克思的直接民主观对中国特色社会主义基层民主政治建设有着重大和深远的影响。马克思基于人民主权理论的深刻阐释而提出“真正民主制”的发展理念，其思想精髓可概括为三个方面：人民规定制度而非从属于制度，人民通过普选制直接参与立法，实现政治国家、市民社会与普通个体的和谐统一。中国特色社会主义基层直接民主一方面创造性地继承了马克思直接民主观中蕴含的人民主权价值理念、民主集中的运行规则以及社会自治的实践内容；另一方面致力于人民民主实现形式的理念和经验创新，以全过程人民民主型构基层民主运转的过程机制，以民主与民生的双向互促提升基层民主建设的行动绩效，实现了对马克思直接民主观的创新性发展。

关键词：马克思直接民主基层直接民主全过程人民民主

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Malvidin-3-O-galactoside ameliorates small intestinal mucosal barrier function via Notch pathway

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Food Science and Human Wellness 2024年

作者： Yuehua Wang ying Zhang Bo Zhang Jiaying Zhang Hui tan Li Li Xinyao Jiao College of Food Science， Shenyang Agricultural University Liaoning Goldsun Technology Co.， Ltd Department of Basic Sciences， Dalian University of Science and Technology

The intestinal mucosa is the intestinal lumen tissue that protects the intestine from invasion， maintains intestinal barrier function， and participates in the immune response. Diseases such as inflammatory enteritis and intestinal infections can cause damage to the intestinal mucosal barrier and dysfunction. The aim of this study was to investigate the improvement mechanism of malvidin-3-O-galactoside (M3G) on small intestinal mucosal barrier function. C57BL/6J male mice were given dextran sodium sulfate (DSS) for 7 days to induce enteritis， and then were fed normally with or with M3G supplementation for another 7 days. The results showed that M3G supplementation significantly improved the disease activity index (DAI) score and small intestinal tissue injury in mice with DSS induced enteritis. M3G ameliorated the small intestinal mucosal mechanical barrier function by modulating the expression of mucin2 (MUC2)， zona occludens 1 (ZO-1)， Occludin， Claudin-1， intestinal fatty acid binding protein (iFABP)， and trefoil factor 3 (TFF3) in the small intestine mucosa， and the serum levels of D-lactic acid (D-LA)， lipopolysaccharide (LPS)， and diamine oxidase (DAO) were significantly decreased. Additionally， M3G also relieved the small intestinal immunologic barrier of mice by decreasing the immune protein levels of immunoglobulin A (IgA)， immunoglobulin M (IgM)， and immunoglobulin G (IgG) in serum， and secretory immunoglobulin A (SIgA) level in small intestine tissue. Furthermore， M3G inhibited the expression of Notch pathway-related proteins such as Notch1， notch intracellular domain (NICD)， delta-like ligand 4 (DLL4)， delta-like ligand 1 (DLL1)， and hairy/enhancer of split 1 (Hes1). In conclusion， the results demonstrated that M3G can improve intestinal mucosal barrier function by inhibiting Notch pathway.

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The Mechanics of Tumor Cells Dictate Malignancy via Cytoskeleton-Mediated APC/Wnt/β-Catenin Signaling

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Research 2024年第2期2023卷 659-673页

作者： Xi Chen Zichen Xu Kai tang Guanshuo Hu Pengyu Du Junfang Wang Cunyu Zhang ying Xin Keming Li Qiantang Zhang Jianjun Hu Zhuxue Zhang Mo Yang Guixue Wang Youhua tan The Hong Kong Polytechnic University Shenzhen Research Institute Shenzhen518057China Key Laboratory for Biorheological Science and Technology of Ministry of Education State and Local Joint Engineering Laboratory for Vascular ImplantsBioengineering College of Chongqing UniversityChongqing400030China Research Institute of Smart Ageing The Hong Kong Polytechnic UniversityHong KongChina Department of Biomedical Engineering The Hong Kong Polytechnic UniversityHong KongChina Department of Pathology Guizhou Provincial People's HospitalGuiyangGuizhou550002China

Tumor cells progressively remodel cytoskeletal structures and reduce cellular stiffness during tumor progression,implicating the correlation between cell mechanics and ***,the roles of tumor cell cytoskeleton and the mechanics in tumor progression remain incompletely *** report that softening/stiffening tumor cells by targeting actomyosin promotes/suppresses self-renewal in vitro and tumorigenic potential in ***/strengthening actin cytoskeleton impairs/reinforces the interaction between adenomatous polyposis coli(APC)andβ-catenin,which facilitatesβ-catenin nuclear/cytoplasmic ***β-catenin binds to the promoter of Oct4,which enhances its transcription that is crucial in sustaining self-renewal and *** results demonstrate that the mechanics of tumor cells dictate self-renewal through cytoskeleton-APC-Wnt/β-catenin-Oct4 signaling,which are correlated with tumor differentiation and patient *** study unveils an uncovered regulatory role of cell mechanics in self-renewal and malignancy,and identifies tumor cell mechanics as a hallmark not only for cancer diagnosis but also for mechanotargeting.

关键词： diagnosis skeleton APC

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LncFASA promotes cancer ferroptosis via modulating PRDX1 phase separation

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Science China(Life Sciences) 2024年第3期67卷 488-503页

作者： Xiao Fan Fangzhou Liu Xiang Wang ying Wang Yu Chen Chengyu Shi Xinwan Su Manman tan Qingfeng Yan Jinrong Peng Jianzhong Shao Yan Xiong Aifu Lin MOE Laboratory of Biosystem Homeostasis and Protection College of Life SciencesZhejiang UniversityHangzhou 310058China Key Laboratoryof Cancer Prevention and Intervention China National Ministry of EducationHangzhou 310009China Cancer Center Zhejiang UniversityHangzhou 310058China Key Laboratory for Cell and Gene Engineering of Zhejiang Province Hangzhou 310058China Department of Central Laboratory the First People's Hospital of HuzhouHuzhou 313000China Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province Affiliated Hangzhou First People's HospitalZhejiang University School of MedicineHangzhou 310006China MOE Key Laboratory for Molecular Animal Nutrition College of Animal SciencesZhejiang UniversityHangzhou 310058China Department of Orthopedic Surgery the Second Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310000China Breast Center of the First Affiliated Hospital School of MedicineZhejiang UniversityHangzhou 310003China International School of Medicine International Institutes of MedicineThe 4th Affiliated Hospital of Zhejiang University School of MedicineYiwu 322000China

Ferroptosis, a unique type of non-apoptotic cell death resulting from iron-dependent lipid peroxidation, has a potential physiological function in tumor suppression, but its underlying mechanisms have not been fully elucidated. Here, we report that the long non-coding RNA(lncRNA) LncFASA increases the susceptibility of triple-negative breast cancer(TNBC) to ferroptosis. As a tumor suppressor, LncFASA drives the formation of droplets containing peroxiredoxin1(PRDX1), a member of the peroxidase family, resulting in the accumulation of lipid peroxidation via the SLC7A11-GPX4 axis. Mechanistically, LncFASA directly binds to the Ahpc-TSA domain of PRDX1, inhibiting its peroxidase activity by driving liquid-liquid phase separation, which disrupts intracellular ROS homeostasis. Notably, high LncFASA expression indicates favorable overall survival in individuals with breast cancer, and LncFASA impairs the growth of breast xenograft tumors by modulating ferroptosis. Together, our findings illustrate the crucial role of this lncRNA in ferroptosis-mediated cancer development and provide new insights into therapeutic strategies for breast cancer.

关键词： long non-coding RNA peroxiredoxin liquid-liquid phase separation ferroptosis breast cancer

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Amorphous NiMo_(3)S_(13)/nickel foam integrated anode for lithium-ion batteries

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Tungsten 2024年第2期6卷 438-446页

作者： Ming-Xin Shi Min Wu Shan-Shan Xiao Shan-Ping Liu Rui-Qi Yao ying-Qi Li Yong-Hui Wang Yang-Guang Li Hua-Qiao tan Key Laboratory of Polyoxometalate and Reticular Material Chemistry of Ministry of Education Faculty of ChemistryNortheast Normal UniversityChangchun 130024China School of Materials Science and Engineering Jilin Jianzhu UniversityChangchun 130118China Institute Charles Gerhardt Montpellier Universite de MontpellierCentre National de la Recherche Scientifi quePlace E.Bataillon34095 Montpellier Cedex 05France

Although crystalline anode materials with long-range ordered lattice structure are in favor of facilitating the electron transfer,their structures are easily disrupted during long-term cycling due to the continuous embedding/de-embedding of lithium *** contrast,the amorphous materials have abundant defects and lithium ion storage sites,refl ecting a superior reaction kinetics and long-term cycling ***,we synthesize an integrated hybrid anode by in-situ loading amorphous NiMo_(3)S_(13)nanosheets on nickel foam *** ting from the introduction of Ni^(2+)that amorphizes the molybdenumsulfur clusters,the assembled lithium ion battery based on the integrated NiMo_(3)S_(13)/nickel foam anode delivers a specifi c capacity up to 1659 mA·h·g^(−1)at a current density of 0.6 A·g^(−1)and exhibits superior rate/cycling performance.

关键词： Molybdenum-sulfur clusters Amorphous Integrated anode Crystalline Lithium-ion batteries

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盐胁迫下根施AMF和褪黑素对紫花苜蓿生长、光合特征以及抗氧化系统的影响

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草业学报 2024年第6期33卷 64-75页

作者：谭英尹豪北京市朝阳区四得公园管理处北京100016 北京林业大学园林学院北京100083 城乡生态环境北京实验室北京100083

本试验旨在探究盐胁迫下根施丛枝菌根真菌(arbuscular mycorrhizal fungi,AMF)和褪黑素处理对紫花苜蓿生长、光合特征和抗氧化系统的影响。设置盐胁迫下(100 mmol·L^(-1)NaCl)对紫花苜蓿根施褪黑素(0、50、100、150、200μmol·L^(-1)... 详细信息

本试验旨在探究盐胁迫下根施丛枝菌根真菌(arbuscular mycorrhizal fungi,AMF)和褪黑素处理对紫花苜蓿生长、光合特征和抗氧化系统的影响。设置盐胁迫下(100 mmol·L^(-1)NaCl)对紫花苜蓿根施褪黑素(0、50、100、150、200μmol·L^(-1))并接种AMF变形球囊霉以及不接种对照共10个处理。结果表明,AMF与紫花苜蓿能形成稳定共生关系,根施褪黑素能够增加AMF菌根侵染率以及泡囊数,菌根侵染率最高达65.2%。在根施褪黑素100μmol·L^(-1)水平下,与对照相比,接种AMF处理的紫花苜蓿总生物量、叶绿素a、叶绿素b含量分别提高5.4%、7.3%和45.3%,根冠比下降39.5%;净光合速率(Pn)、蒸腾速率(Tr)、胞间CO_(2)浓度(Ci)和气孔导度(Gs)分别增加23.3%、28.3%、17.6%和14.1%;最大光化学效率(F_(v)/F_(m))和PSⅡ潜在活性(F_(v)/F_(o))分别提高19.6%和22.9%;叶片中氮、磷、钾含量分别是对照的1.4、1.1和1.2倍,钠含量比对照下降11.1%;紫花苜蓿铜锌超氧化物歧化酶(Cu/ZnSOD)基因表达量提高33.9%,POD基因表达量提高16.8%,CAT基因表达量提高6.4%,抗氧化酶系统中超氧化物歧化酶(SOD)、过氧化物酶(POD)、过氧化氢酶(CAT)活性也表现为一定幅度的增加。结论认为,AMF和褪黑素均能够增加紫花苜蓿对氮、磷、钾等养分的吸收量而降低对钠的吸收量,进而提高光合作用能力以及叶绿素a、b含量和叶绿素荧光参数,上调Cu/Zn-SOD、POD、CAT基因表达量并显著增加SOD、POD、CAT等活性,其中以接种AMF配合根施100μmol·L^(-1)褪黑素改善紫花苜蓿生长状况、光合特征,提高抗盐性的作用最为显著。

关键词：丛枝菌根真菌褪黑素紫花苜蓿光合叶绿素养分

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Main Controlling Factors and Evolution Models of Bioclastic Shoal Reservoirs of the Permian Changxing Formation in the Zhongjiang-Moxi Region

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Journal of Earth Science 2024年

作者： Jinhao Bai Hong Liu Song tang Benjian Zhang Xia Hua Dong Wang ying Yang Lei tan Sichuan Provincial Key Laboratory of Natural Gas Geology， Southwest Petroleum University Southwest Petroleum University， Division of Key Laboratory of Carbonate Reservoirs，CNPC School of Geoscience and Technology， Southwest Petroleum University Central Sichuan Oil & Gas Field of PetroChina Southwest Oil & Gas Field Company PetroChina Southwest Oil and Gas Field Company Exploration and Development Research Institute

The Upper Permian Changxing Formation in the Sichuan Basin has been a consistent hotspot for natural gas exploration. Previous studies of this formation focused on the platform-margin reef areas in the northeastern Sichuan Basin but rarely dealt with the main controlling factors of the reservoirs inside the platform. Here， taking the Changxing Formation in the Zhongjiang-Moxi region in the central Sichuan Basin as an example， the characteristics and main controlling factors of the bioclastic shoal reservoirs inside the platform are systematically analyzed via core observations， rock thin-section identification， well logging analyses， and three-dimensional seismic interpretation. The results show that， in the study area， the Changxing Formation primarily develops porous reservoirs of bioclastic limestone， with the storage space dominated by intragranular and intergranular dissolution pores and typical facies-controlled characteristics. The development degree of the reservoirs is mainly controlled by contemporaneous–penecontemporaneous karstification. Specifically， the thickness and stacking style of the reservoirs are determined by the multi-order sea level change cycles; the early exposure dissolution degree of the shoal reservoirs is further controlled by micro-paleogeomorphological differences， and the reservoirs are clearly improved by dolomitization. Accordingly， two evolution models of the Changxing Formation reservoirs inside the platform in the study area are established.

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Centralized Control Implementation Using Distributed Observer for Meglev Systems

Centralized Control Implementation Using Distributed Observe...

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第36届中国控制会议

作者： Qiang Chen ying tan Qing Yang Jie Li iven mareels College of Mechatronics Engineering and Automation National University of Defense Technology

ISBN: (纸本)9781538629185

In the control of maglev systems,decentralized control structure is widely used due to its *** to the existence of mechanical coupling,the performance of decentralized control is *** paper focuses on designing a centralized controller for a small maglev platform that already has a decentralized control structure.A distributed reduced-order observer is first proposed for one suspension point to estimate the state of other suspension points using the model of the ***,a centralized control is designed and implemented with the help of the proposed decentralized *** simulation results show that centralized control based on distributed observer can reject the state coupling of maglev system and improve the maglev control performances *** future,the proposed distributed observer based centralized controller will be tested on the small maglev platform.

关键词： Maglev Centralized Control Distributed Observer

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Effectiveness of mindfulness-based interventions on the well-being of healthcare workers:a systematic review and meta-analysis

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General Psychiatry 2024年第3期37卷 335-344页

作者： Natasha Yixuan Ong Finn Jing Jie Teo Jane Zi ying Ee Chun En Yau Julian Thumboo Hiang Khoon tan Qin Xiang Ng NUS Yong Loo Lin School of Medicine National University of SingaporeSingapore Health Services Research Unit Singapore General HospitalSingapore SingHealth Duke-NUS Medicine Academic Clinical Programme Duke-NUS Medical SchoolSingapore Singhealth Duke-NUS Global Health Institute Singapore Duke Global Health Institute Duke UniversityDurhamNorth CarolinaUSA Division of Surgery and Surgical Oncology Singapore General HospitalSingapore Saw Swee Hock School of Public Health National University of Singapore and National University Health SystemSingapore

Background Growing evidence attests to the efficacy of mindfulness-based interventions(MBIs),but their effectiveness for healthcare workers remains *** To evaluate the evidence for MBIs in improving healthcare workers’psychological *** A systematic literature search was conducted on Medline,Embase,Cumulative Index for Nursing and Allied Health Literature,PsycINFO and Cochrane Central Register of Controlled Trials up to 31 August 2022 using the keywords‘healthcare worker’,‘doctor’,‘nurse’,‘allied health’,‘mindfulness’,‘wellness’,‘workshop’and‘program’.Randomised controlled trials with a defined MBI focusing on healthcare workers and quantitative outcome measures related to subjective or psychological well-being were eligible for inclusion.R V.4.0.3 was used for data analysis,with the standardised mean difference as the primary outcome,employing DerSimonian and Laird’s random effects *** of Recommendations,Assessment,Development and Evaluation framework was used to evaluate the quality of ***’s Risk of Bias 2 tool was used to assess the risk of bias in the included *** A total of 27 studies with 2506 participants were included,mostly from the USA,involving various healthcare *** such as stress reduction programmes,apps,meditation and training showed small to large effects on anxiety,burnout,stress,depression,psychological distress and job strain outcomes of the *** effects were also seen in self-compassion,empathy,mindfulness and ***,long-term outcomes(1 month or longer postintervention)varied,and the effects were not consistently *** MBIs offer short-term benefits in reducing stress-related symptoms in healthcare *** review also highlights limitations such as intervention heterogeneity,reduced power in specific subgroup analyses and variable study quality.

关键词： nurse sustained workers

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