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Loss-of-function mutations of microRNA-142-3p promote ASH1L expression to induce immune evasion and hepatocellular carcinoma progression

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World Journal of Gastroenterology 2025年第1期31卷 126-145页

作者： Xing-Hui Yu Yan Xie Jian Yu Kun-Ning Zhang Zhou-Bo Guo Di Wang Zhao-Xian Li Wei-Qi Zhang Yu-ying tan Li Zhang Wen-Tao Jiang School of Medicine Nankai UniversityTianjin 300192China Tianjin Key Laboratory of Molecular Diagnosis and Treatment of Liver Cancer Tianjin First Center HospitalTianjin 300192China Department of Liver Transplantation Tianjin First Center HospitalTianjin 300192China First Central Clinical School Tianjin Medical UniversityTianjin 300192China

BACKGROUND Hepatocellular carcinoma(HCC)has been a pervasive malignancy throughout the world with elevated *** therapeutic targets are beneficial to treat and predict the ***,the exact molecular mechanisms leading to the progression of HCC are still *** has shown that the microRNA-142-3p level decreases in HCC,whereas bioinformatics analysis of the cancer genome atlas database shows the ASH1L expression increased among liver tumor *** this paper,we will explore the effects and mechanisms of microRNA-142-3p and ASH1L affect the prognosis of HCC patients and HCC cell bioactivity,and the association between *** To investigate the effects and mechanisms of microRNA-142-3p and ASH1L on the HCC cell bioactivity and prognosis of HCC *** In this study,we grouped HCC patients according to their immunohistochemistry results of ASH1L with pathological tissues,and retrospectively analyzed the prognosis of HCC ***,explored the roles and mechanisms of microRNA-142-3p and ASH1L by cellular and animal experiments,which involved the following experimental methods:Immunohistochemical staining,western blot,quantitative real-time-polymerase chain reaction,flow cytometric analysis,tumor xenografts in nude mice,*** statistical methods involved in this study contained t-test,one-way analysis of variance,theχ^(2)test,the Kaplan-Meier approach and the log-rank *** In this study,we found that HCC patients with high expression of ASH1L possess a more recurrence rate as well as a decreased overall survival ***1L promotes the tumorigenicity of HCC and microRNA-142-3p exhibits reduced expression in HCC tissues and interacts with ASH1L through targeting the ASH1L 3′untranslated ***,microRNA-142-3p promotes apoptosis and inhibits proliferation,invasion,and migration of HCC cell lines in vitro via *** the exploration mechanism,we found ASH1L may promote an immunosuppressive mi

关键词： Hepatocellular carcinoma MicroRNA-142-3p ASH1L Immune evasion Tumor immune microenvironment Apoptosis

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Design of Perfect Reconstruction Cosine Modulated Filter Bank with Linear Phase

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Journal of Systems Engineering and Electronics 1998年第1期9卷 24-30页

作者： tan, ying Univ of Science and Technology of China Hefei China

We propose the quadratic constrained formulas for the design of linear phase cosine modulated paraunitary filter banks given in references . Using these formulae, we can, directly, optimize the prototype filter coeff... 详细信息

关键词： Quadratic constrained formula Linear phase Perfect reconstruction Cosine modulated FB.

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A trigonometric series expansion method for the Orr-Sommerfeld equation

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Applied Mathematics and Mechanics(English Edition) 2019年第6期40卷 877-888页

作者： ying tan Weidong SU State Key Laboratory for Turbulence and Complex Systems Peking UniversityBeijing 100871China Department of Mechanics and Engineering Science College of EngineeringPeking UniversityBeijing 100871China

A trigonometric series expansion method and two similar modified methods for the Orr-Sommerfeld equation are presented. These methods use the trigonometric series expansion with an auxiliary function added to the highest order derivative of the unknown function and generate the lower order derivatives through successive integra- tions. The proposed methods are easy to implement because of the simplicity of the chosen basis functions. By solving the plane Poiseuille flow (PPF), plane Couette flow (PCF), and Blasius boundary layer flow with several homogeneous boundary conditions, it is shown that these methods yield results with the same accuracy as that given by the conventional Chebyshev collocation method but with better robustness, and that ob- tained by the finite difference method but with fewer modal number.

关键词： Orr-Sommerfeld equation spectral method trigonometric function parallel shear flow hydrodynamical stability eigenvalue problem

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A Novel Extremum Seeking Control to Enhance Convergence and Robustness in the Presence of Nonlinear Dynamic Sensors

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Journal of Systems Science & Complexity 2024年第1期37卷 3-21页

作者： LIU Hengchang tan ying OETOMO Denny School of Electrical Mechanical and Infrastructure EngineeringThe University of MelbourneParkville VIC 3010Australia

This paper focuses on optimizing an unknown cost function through extremum seeking(ES)control in the presence of a slow nonlinear dynamic sensor responsible for measuring the *** contrast to traditional perturbation-based ES control,which often suffers from sluggish convergence,the proposed method eliminates the time-scale separation between sensor dynamics and ES control by using the relative degree of the nonlinear sensor *** improve the convergence rate,the authors incorporate high-frequency dither signals and a *** enhance the robustness with the existence of rapid disturbances,an off-the-shelf linear high-gain differentiator is *** first result demonstrates that,for any desired convergence rate,with properly tuned parameters for the proposed ES algorithm,the input of the cost function can converge to an arbitrarily small neighborhood of the optimal solution,starting from any initial condition within any given compact ***,the second result shows the robustness of the proposed ES control in the presence of sufficiently fast,zero-mean periodic *** results substantiate these theoretical findings.

关键词： Averaging extremum seeking optimization singular perturbation time-scale separation

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On Edge Singularity and Eigenvectors of Mixed Graphs

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Acta Mathematica Sinica,English Series 2008年第1期24卷 139-146页

作者： ying ying tan Yi Zheng FAN School of Mathematics and Computation Sciences Anhui UniversityHefei 230039 P. R. China Department of Mathematics and Physics Anhui Institute of Architecture and Industry Hefei 230022 Po R. China

Let G be a mixed glaph which is obtained from an undirected graph by orienting some of its edges. The eigenvalues and eigenvectors of G are, respectively, defined to be those of the Laplacian matrix L（G） of G. As L（G） is positive semidefinite, the singularity of L（G） is determined by its least eigenvalue λ1 （G）. This paper introduces a new parameter edge singularity εs（G） that reflects the singularity of L（G）, which is the minimum number of edges of G whose deletion yields that all the components of the resulting graph are singular. We give some inequalities between εs（G） and λ1 （G）（and other parameters） of G. In the case of εs（G） = 1, we obtain a property on the structure of the eigenvectors of G corresponding to λ1 （G）, which is similar to the property of Fiedler vectors of a simple graph given by Fiedler.

关键词： mixed graphs edge singularity Laplacian eigenvectors

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A Lower Bound for the Algebraic Connectivity of a Graph in Terms of the Domination Number

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Acta Mathematicae Applicatae Sinica 2018年第4期34卷 752-760页

作者： Yi-Zheng FAN ying-ying tan School of Mathematical Sciences Anhui University Hefei 230601 P. R. China School of Mathematics and Physics Anhui Jianzhu University Hefei 230601 China

We investigate how the algebraic connectivity of a graph changes by relocating a connected branch from one vertex to another vertex, and then minimize the algebraic connectivity among all connected graphs of order n with fixed domination number γ≤（n＋2）/3, and finally present a lower bound for the algebraic connectivity in terms of the domination number. We also characterize the minimum algebraic connectivity of graphs with domination number half their order.

关键词： graph algebraic connectivity domination number

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Perfect State Transfer on Weighted Abelian Cayley Graphs

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Chinese Annals of Mathematics,Series B 2021年第4期42卷 625-642页

作者： Xiwang CAO Keqin FENG ying-ying tan Department of Mathematics Nanjing University of Aeronautics and Astronau-ticsNanjing 210016China Department of Mathematical Sciences Tsinghua UniversityBeijing 100084China School of Mathematics and Physics Anhui Jianzhu UniversityHefei 230601China

Recently,there are extensive studies on perfect state transfer(PST for short)on graphs due to their significant applications in quantum information processing and quantum ***,there is not any general characterization of graphs that have PST in *** this paper,the authors present a depiction on weighted abelian Cayley graphs having *** give a unified approach to describe the periodicity and the existence of PST on some specific graphs.

关键词： Perfect state transfer Cayley graph Eigenvalues of a graph Weighted graph Random walk

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SYNTHESIS AND CHARACTERIZATION OF RANDOM OR GRADIENT BUTADIENE-p-METHYLSTYRENE COPOLYMERS VIA ANIONIC POLYMERIZATION

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Chinese Journal of Polymer Science 2013年第12期31卷 1647-1659页

作者： Feng Liu Hai-ying tan 唐涛 State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied ChemistryChinese Academy of Sciences Graduate School of the Chinese Academy of Sciences

Copolymers of 1,3-butadiene and p-methylstyrene （p-MS） were synthesized via anionic polymerization. A benzophenone-potassium complex was added to tune the reactivity ratio of the two monomers, leading to random and gradient composition alonglthe copolymer chain. The overall composition and microstructure could be controlled and well characterized by GPC and H-NMR. The p-MS was distributed from gradient to random with increasing the content of the benzophenone-potassium complex, and the 1,2-microstrucmre in the polybutadiene sequence increased at the same time. The hydrogenation of the copolymer of 1,3-butadiene and p-MS resulted in the corresponding saturated copolymer with well- defined structure and narrow molecular weight distribution.

关键词： Anionic polymerization Butadiene p-Methylstyrene Random copolymer Gradient copolymer.

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Anomalous tqγCouplings and Radiative B Meson Decays

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Chinese Physics Letters 2020年第10期37卷 17-20页

作者： ying tan Chong-Xing Yue Department of Physics Liaoning Normal UniversityDalian 116029China

Motivated by the recent ATLAS results in terms of the branching ratios B r(t→qγ),we consider the effects of the anomalous t qγcouplings on the radiative B meson decays¯B→X Dγand B→Vγwith V being light vector mesonsρ,ω,ϕand K∗.Comparing with the corresponding experimental measured data,we obtain the constraints on anomalous t qγcouplings.

关键词： meson branching constraints

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On the nature of X-ray “unobscured” Seyfert 2 galaxies

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Science China(Physics,Mechanics & Astronomy) 2012年第12期55卷 2482-2491页

作者： tan ying WANG JunXian ZHANG Kai CAS Key Laboratory for Research in Galaxies and Cosmology Department of AstronomyUniversity of Science and Technology of ChinaHefei 230026China

We present a systematic study to reveal the effect of host galaxy contamination to the identification of X-ray "unobscured" Seyfert 2 *** compiled a sample of 14 X-ray "unobscured" Seyfert 2 galaxies and 29 X-ray obscured Seyfert 2s,with infrared [Ne II] and [O IV] emission line flux *** this work we classify Seyfert 2s as "unobscured" or obscured in X-ray simply based on X-ray spectral *** find that our X-ay "unobscured" Seyfert 2s have statistically higher [Ne II]/[O IV] line ratios,compared with obscured *** the [Ne II]/[O IV] line ratio reflects the relative strength of star formation activity comparing with the SMBH accretion,the observed differences in [Ne II]/[O IV] line ratios clearly indicate relatively stronger X-ray contamination from star formation in the host galaxies in X-ray "unobscured" Seyfert *** we could attribute the X-ray "unobscured" appearance to host galaxy contamination for most(if not all) of our X-ray "unobscured" Seyfert *** analysis indicates that "unobscured" Seyfert 2s have intrinsically lower AGN luminosity but similar star formation rates,compared with obscured *** is also consistent with previous studies showing most X-ray "unobscured" Seyfert 2s are at lower luminosities,and relatively stronger contaminations from the host galaxies are thus *** we develop a screening criterion to distinguish potential pure Seyfert 2s from X-ray "unobscured" appearances which could be caused by strong host galaxy contamination.

关键词： active galactic nuclei X-rays absorption star formation

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