检索结果-南通市图书馆

Regulatory effects of Poria on substance and energy metabolism in cold-deficiency syndrome compared with heat-deficiency syndrome in rats

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Natural Medicines 2018年第12期16卷 936-945页

作者： HAN Xue-ying WANG Ya-nan DOU De-Qiang College of Pharmacy Liaoning University of Traditional Chinese Medicine

Recent studies have revealed that the property of drug is mainly associated with the body's substance and energy metabolism. The present study aimed to evaluate the drug property of Poria, called Fuling(FL) in traditional Chinese medicine(TCM), in terms of its effects on the substance and energy metabolism in rat models of cold-deficiency and heat-deficiency syndromes, compared with Aconiti Lateralis Radix Praeparaia, called Fuzi(FZ) in TCM, with hot property, and Anemarrhenae Rhizoma, called Zhimu(ZM) in TCM, with cold property, as reference drugs, respectively. The appearance score, toe and rectal temperatures of the animals treated were assessed at different time points. Several indices in vivo correlated with substance and energy metabolism(glucokinas, phosphoglycerate kinase, cytochrome c reductase, cytochrome c oxydase, and Na^+-K^+-ATPase), endocrine system(triiodothyronine, thyroxine, and 17-hydroxycorticosteroid), nervous system(acetylcholin esterase), and cyclic nucleotide system were determined. The changes in appearance score and indices in vivo suggested the successful establishment of cold-deficiency and heat-deficiency syndrome models. FZ reversed the decreased levels of indices(substance and energy metabolism and endocrine system) and alleviated the syndrome of cold-deficiency model, and ZM showed obviously therapeutic effect on heat-deficiency syndrome(appearance score, substance and energy metabolism, and endocrine system). FL could alleviate cold-deficiency syndrome and raise the decreased levels of glucokinas, phosphoglycerate kinase, cytochrome c reductase and triiodothyronine in cold-deficiency model, but had no significant effect on heat-deficiency syndrome. Drug property of FL was inferred as trending to "flat and warm", which still need further study. It was advisable to adopt both cold-deficiency and heat-deficiency models to study the drugs with "flat" property.

关键词： Poria Substance metabolism Energy metabolism Cold-deficiency syndrome Heat-deficiency syndrome

A multiscale adaptive framework based on convolutional neural network:Application to fluid catalytic cracking product yield prediction

在线全文

学校读者我要写书评

暂无评论

Petroleum Science 2024年第4期21卷 2849-2869页

作者： nan Liu Chun-Meng Zhu Meng-Xuan Zhang Xing-ying Lan College of Artificial Intelligence China University of Petroleum(Beijing)Beijing102249China State Key Laboratory of Heavy Oil Processing China University of Petroleum(Beijing)Beijing102249China

Since chemical processes are highly non-linear and multiscale,it is vital to deeply mine the multiscale coupling relationships embedded in the massive process data for the prediction and anomaly tracing of crucial process parameters and production *** the integrated method of adaptive signal decomposition combined with time series models could effectively predict process variables,it does have limitations in capturing the high-frequency detail of the operation state when applied to complex chemical *** light of this,a novel Multiscale Multi-radius Multi-step Convolutional Neural Network(Msrt Net)is proposed for mining spatiotemporal multiscale ***,the industrial data from the Fluid Catalytic Cracking(FCC)process decomposition using Complete Ensemble Empirical Mode Decomposition with Adaptive Noise(CEEMDAN)extract the multi-energy scale information of the feature ***,convolution kernels with varying stride and padding structures are established to decouple the long-period operation process information encapsulated within the multi-energy scale ***,a reconciliation network is trained to reconstruct the multiscale prediction results and obtain the final *** Net is initially assessed for its capability to untangle the spatiotemporal multiscale relationships among variables in the Tennessee Eastman Process(TEP).Subsequently,the performance of Msrt Net is evaluated in predicting product yield for a 2.80×10^(6) t/a FCC unit,taking diesel and gasoline yield as *** conclusion,Msrt Net can decouple and effectively extract spatiotemporal multiscale information from chemical process data and achieve a approximately reduction of 30%in prediction error compared to other time-series ***,its robustness and transferability underscore its promising potential for broader applications.

关键词： Fluid catalytic cracking Product yield Data-driven modeling Multiscale prediction Data decomposition Convolution neural network

Quantitative method to determine the regional drinking water odorant regulation goals based on odor sensitivity distribution:Illustrated using 2-MIB

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2014年第7期26卷 1389-1394页

作者： Jianwei Yu Wei An nan Cao Min Yang Junong Gu Dong Zhang ning Lu State Key Laboratory of Environmental Aquatic Chemistry Research Center for Eco-Environmental SciencesChinese Academy of Sciences Beijing Waterworks (Group) Co. Ltd. Shanghai National Engineering Research Center of Urban Water Resources Co. Ltd.

Taste and odor （T/O） in drinking water often cause consumer complaints and are thus regulated in many countries. However, people in different regions may exhibit different sensitivities toward WO. This study proposed a method to determine the regional drinking water odorant regulation goals （ORGs） based on the odor sensitivity distribution of the local population. The distribution of odor sensitivity to 2-methylisobomeol （2-MIB） by the local population in Beijing, China was revealed by using a normal distribution function/model to describe the odor complaint response to a 2-MIB episode in 2005, and a 2-MIB concentration of 12.9 ng/L and FPA （flavor profile analysis） intensity of 2.5 was found to be the critical point to cause odor complaints. Thus the Beijing ORG for 2-MIB was determined to be 12.9 ng/L. Based on the assumption that the local FPA panel can represent the local population in terms of sensitivity to odor, and that the critical FPA intensity causing odor complaints was 2.5, this study tried to determine the ORGs for seven other cities of China by performing FPA tests using an FPA panel from the corresponding city. ORG values between 12.9 and 31.6 ng/L were determined, showing that a unified ORG may not be suitable for drinking water odor regulations. This study presents a novel approach for setting drinking water odor regulations.

关键词： Drinking water odorOdor sensitivity distributionOdor regulation goalFlavor profile analysisOdor episode

Improvement of the chirality near avoided resonance crossing in optical microcavity

在线全文

学校读者我要写书评

暂无评论

Science China(Physics,Mechanics & Astronomy) 2015年第11期58卷 55-62页

作者： SONG QingHai GU ZhiYuan ZHANG nan WANG KaiYang YI ning Bo XIAO ShuMin Department of Electrical and Information Engineering Harbin Institute of Technology State Key Laboratory on Tunable Laser Technology Harbin Institute of Technology

Chirality is one of the important phenomena at the vicinity of exceptional point(EP). The conventional understanding is that the chirality is determined by asymmetrical scattering efficiency(?), which reaches to zero only when the resonance approaches EP. Here we study the possibility to enhance the chirality in open systems with a more robust mechanism. By combining chirality with avoided resonance crossing, we show that the chirality and ? can be dramatically modified. Taking a spiral shaped annular cavity as an example, we show that the chirality of optical resonances can be significantly improved when two sets of chiral states approach each other. The imbalance between counterclockwise(CCW) components and clockwise(CW) components has been enhanced by more than an order of magnitude. Our research provides a new route to tailor and control the chirality in open systems.

关键词： microcavity chirality avoided resonance crossing mode coupling

Circulating tumor DNA analysis:potential to revise adjuvant therapy for stage II colorectal cancer

在线全文

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2022年第10期7卷 3613-3615页

作者： ning Zhu Hanguang Hu ying Yuan Department of Medical Oncology The Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiangChina Cancer Institute Key Laboratory of Cancer Prevention and InterventionMinistry of EducationThe Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiangChina Cancer Center Zhejiang UniversityHangzhouZhejiangChina

In the DYNAMIC multicenter phase 2 study recently published in The New England Journal of Medicine,Tie *** *** that a novel circulating tumor DNA(ctDNA)-guided regimen reduced the use of adjuvant chemotherapy without sacrificing recurrence-free survival in patients with stage II colorectal cancer(CRC).1 This was the first reported prospective,randomized,controlled trial of ctDNA-based interventional adjuvant treatment for stage II CRC.

关键词： adjuvant colorectal al.

Meta- analysis of association between K469E polymorphism of the ICAM-1 gene and retinopathy in type 2 diabetes

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2015年第3期8卷 603-607页

作者： Wen-ying Fan ning-Pu Liu Beijing Tongren Eye Center Beijing Tongren HospitalBeijing Ophthalmology and Visual Sciences Key LaboratoryCapital Medical University

AIM: To collectively evaluate the association of intercellular adhesion molecule-1(ICAM-1) gene K469 E polymorphism(rs5498) with diabetic retinopathy(DR) in patients with type 2 diabetic mellitus(T2DM). METHODS: Overall review of available literatures relating K469 E polymorphism to the risk of DR was conducted on 4 electronic databases. Meta-analysis was performed by Stata 12.0 to calculate pooled odds ratios(ORs). Potential sources of heterogeneity and bias were ***: Seven studies with genotype frequency data including 1120 cases with DR and 956 diabetic controls free of DR were included. Meta-analysis did not show significant association of K469 E polymorphism with DR(P >0.05). A statistically significant association was detected between the K469 E polymorphism and proliferative DR(PDR) in Asians only in dominant model(GG+AG vs AA) with pooled OR of 0.729(95%CI: 0.564-0.942, P=0.016, P heterogeneity=0.143), however, this association was not detected in recessive model(AG +AA vs GG;OR=1.178, 95%CI: 0.898-1.545, P =0.236, P heterogeneity=0.248)or allelic model(G vs A; OR=0.769, 95% CI: 0.576-1.026,P =0.074, P heterogeneity=0.094). No publication bias was found by Funnel plot, Begg’s and Egger’s test. CONCLUSION: This research found no statistically significant association between ICAM-1 gene K469 E polymorphism and DR in patients with T2 DM, but showed significant association of the K469 E polymorphism with PDR in Asian diabetic patients only in dominant model. Further investigation would be required to consolidate the conclusion.

关键词： K469E polymorphism rs5498 intercellular adhesion molecule-1 diabetic retinopathy type 2 diabetes Meta-analysis

Effect of Dai-Bai-Jie on the proliferation and migration of the A549 cells

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2020年第2期31卷 476-478页

作者： Binxin Lin Xinling Lu nan Li ning Xu Jin-Ming Lin Beijing Key Laboratory of Microanalytical Methods and Instrumentation Department of ChemistryTsinghua UniversityBeijing 100084China Department of Chemistry School of ScienceTianjin UniversityTianjin 300000China

Lung cancer is the most malignant tumor disease with the highest diagnosis and mortality rate in *** development of therapeutic drugs is the current research ***-Bai-Jie is a traditional medicine of the Dai nationality,which is commonly used in the treatment of decreasing swelling,alleviating pain and *** of the current researches focused on the component analysis of Dai-Bai-Jie,but few researches studied on its antitumor and pharmacological *** this study,we incubated A549 cells with different concentrations of *** cell proliferation experiment showed that the DaiBai-Jie solution inhibited the proliferation of A549 cells and caused cell *** this work,we confirmed that Dai-Bai-Jie had an inhibitory effect on the proliferation and migration of non-small cell lung cancer A549,which may be used as a novel candidate of anti-tumor therapy for lung cancer patients.

关键词： "Dai-Bai-Jie" Apoptosis Proliferation Migration Antineoplastic agents

Feasibility study of miniature near-infrared spectrometer for the measurement of solar irradiance within Arctic snow-cover sea ice

在线全文

学校读者我要写书评

暂无评论

Acta Oceanologica Sinica 2020年第9期39卷 115-124页

作者： Liwen nan Xiaoping Wang Hangzhou Wang Hongliang Zhou ying Chen Ocean College Zhejiang UniversityZhoushan 316021China Zhejiang Heli Electrical Engineering Co. Ltd.Taizhou 317000China

The extremely low temperature,high humidity and limited power supply pose considerable challenges when using spectrometers within the Arctic sea *** feasibility of using a miniature low-power near-infrared spectrometer module to measure solar radiation in Arctic sea ice environments was investigated in this *** and integration time dependences of the spectrometer module were examined over the entire target operating range of–50°C to 30°C,well below the specified operating range of this *** these observations,a dark output prediction model was developed to represent dark output as a function of temperature and integration ***-induced biases in the saturation output and linear operating range of the spectrometer were also *** and integration time dependences of the signal output were *** signal output correction models were developed and compared,to convert the signal output at any temperature within the operating temperature range and integration time to that measured at the reference temperature and integration *** overall performance of the spectrometer was evaluated by integrating it into a refined fiber optic spectrometry system and measuring solar irradiance distribution in the ice cover with thickness of 1.85 m in the Arctic during the 9th Chinese National Arctic Research *** general shape of the measured solar irradiance above the snow surface agreed well with that measured by other commercial oceanographic *** measured optical properties of the sea ice were generally comparable to those of similar ice measured using other *** approach provides a general framework for assessing the feasibility of using spectrometers for applications in cold environments.

关键词： near-infrared spectrometer low-temperature Arctic sea ice

Responses of nutrient biogeochemistry and nitrogen cycle to seasonal upwelling in coastal waters of the eastern Hainan Island

在线全文

学校读者我要写书评

暂无评论

Acta Oceanologica Sinica 2022年第6期41卷 99-113页

作者： nan Zhou Sumei Liu Guodong Song Yunyan Zhang Lingyan Wang Xiaoyan ning Frontiers Science Center for Deep Ocean Multispheres and Earth System and Key Laboratory of Marine Chemistry Theory and Technology of Ministry of EducationOcean University of ChinaQingdao 266100China Laboratory for Marine Ecology and Environmental Science Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao 266237China

The coastal upwelling has profound influence on the surrounding ecosystem by supplying the nutrient-replete water to the euphotic *** biogeochemistry was investigated in coastal waters of the eastern Hainan Island in summer 2015 and autumn *** perspectives of nutrient dynamics and physical transport,the nutrient fluxes entered the upper 50 m water depth(between the mixed layer and the euphotic zone)arisen from the upwelling were estimated to be 2.5-5.4 mmol/(m^(2)·d),0.15-0.28 mmol/(m^(2)·d),and 2.2-7.2 mmol/(m^(2)·d)for dissolved inorganic nitrogen(DIN),phosphate(DIP),and dissolved silicate(DSi),respectively,which were around 6-to 12-fold those in the background *** upwelled nutrients supported an additional plankton growth of(14.70±8.95)mg/m^(2)for chlorophyll a(Chl a).The distributions of nitrateδ^(15)N andδ^(18)O above the 300 m water depth(top of the North Pacific Intermediate Water)were different among the upwelling area,background area in summer,and the stations in autumn,and the difference of environmental and biogeochemical conditions between seasons should be the *** higher DIN/DIP concentration ratio,nitrate concentration anomaly,and lower nitrate isotope anomaly(Δ(15,18))in the upper ocean in summer than in autumn indicated the stronger nitrogen fixation and atmospheric deposition,and the following fixed nitrogen regeneration in *** higher values of Chl a and nitrateδ^(15)N andδ^(18)O within the euphotic zone in autumn than the background area in summer suggested the stronger nitrate assimilation in *** differences in relatively strength of the assimilation,nitrogen fixation and atmospheric deposition,and the following remineralization and nitrification between the two seasons made the higherδ^(18)O:δ^(15)N and larger difference of enzymatic isotope fractionation factors^(15)εand^(18)εfor nitrate assimilation in summer than in autumn above the North Pacific Tropical Water.

关键词： nutrients upwelling nitrateδ^(15)N andδ^(18)O nitrogen cycle South China Sea