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Chinese Journal of Natural Medicines 2018年第6期16卷 471-480页

作者： YU ying-Lan LI Ya-nan ZHANG Yong SUN Ru-ning TU Jia-Sheng SHEN Yan Department of Pharmaceutics School of PharmacyChina Pharmaceutical UniversityNanjing 210009China Children's Hospital of nanjing Medical University Nanjing 210008China Department of Professional Institute China Pharmaceutical UniversityNanjing 210009China

The therapeutic application of deoxypodophyllotoxin(DPT) is limited due to its poor water solubility and stability. In the present study, the micelles assembled by the amphiphilic block copolymers(m PEG-PDLLA) were constructed to improve the solubility and safety of DPT for their in vitro and in vivo application. The central composite design was utilized to develop the optimal formulation composed of 1221.41 mg m PEG-PDLLA, the weight ratio of 1 : 4(m PEG-PDLLA : DPT), 30 m L hydration volume and the hydration temperature at 40 oC. The results showed that the micelles exhibited uniformly spherical shape with the diameter of 20 nm. The drug-loading and entrapment efficiency of deoxypodophyllotoxin-polymeric micelles(DPT-PM) were about(20 ± 2.84)% and(98 ± 0.79)%, respectively, indicating that the mathematical models predicted well for the results. Compared to the free DPT, the cytotoxicity showed that blank micelles possessed great safety for Hela cells. In addition, the DPT loaded micelle formulation achieved stronger cytotoxicity at the concentration of 1 × 10^(-7) mol·L^(-1), which showed significant difference from free DPT(P nano-carriers for the anti-tumor therapy with DPT.

关键词： Deoxypodophyllotoxin Central composite design Micelles Cytotoxicity

Nonlinear flutter wind tunnel test and numerical analysis of folding fins with freeplay nonlinearities

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Chinese Journal of Aeronautics 2016年第1期29卷 144-159页

作者： Yang ning Wang nan Zhang Xin Liu Wei Beijing Institute of Electronic System Engineering Beijing 100854China

The flutter characteristics of folding control fins with freeplay are investigated by numer- ical simulation and flutter wind tunnel tests. Based on the characteristics of the structures, fins with different freeplay angles are designed. For a 0° angle of attack, wind tunnel tests of these fins are conducted, and vibration is observed by accelerometers and a high-speed camera. By the expansion of the connected relationships, the governing equations of fit for the nonlinear aeroelastic analysis are established by the free-interface component mode synthesis method. Based on the results of the wind tunnel tests, the flutter characteristics of fins with different freeplay angles are analyzed. The results show that the vibration divergent speed is increased, and the divergent speed is higher than the flutter speed of the nominal linear system. The vibration divergent speed is increased along with an increase in the freeplay angle. The developed free-interface component mode synthesis method could be used to establish governing equations and to analyze the characteristics of nonlinear aeroe- lastic systems. The results of the numerical simulations and the wind tunnel tests indicate the same trends and critical velocities.

关键词： Folding wing Freeplay nonlinearity Nonlinear aeroelasticity Free-interfa componentmode synthesis method Wind tunnel test

Multivariate stationary non-Gaussian process simulation for wind pressure fields

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Earthquake Engineering and Engineering Vibration 2016年第4期15卷 729-742页

作者： Sun ying Su ning Wu Yue Key Lab of Structures Dynamic Behavior and Control of the Ministry of Education Harbin Institute of Technology School of Civil Engineering Harbin Institute of Technology

Stochastic simulation is an important means of acquiring fluctuating wind pressures for wind induced response analyses in structural engineering. The wind pressure acting on a large-span space structure can be characterized as a stationary non-Gaussian field. This paper reviews several simulation algorithms related to the Spectral Representation Method （SRM） and the Static Transformation Method （STM）. Polynomial and Exponential transformation functions （PSTM and ESTM） are discussed. Deficiencies in current algorithms, with respect to accuracy, stability and efficiency, are analyzed, and the algorithms are improved for better practical application. In order to verify the improved algorithm, wind pressure fields on a large-span roof are simulated and compared with wind tunnel data. The simulation results fit well with the wind tunnel data, and the algorithm accuracy, stability and efficiency are shown to be better than those of current algorithms.

关键词： stochastic simulation non-Gaussian process static transformation method wind pressure field

Research Progress on Artemisinin and Its Derivatives against Hematological Malignancies

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Chinese Journal of Integrative Medicine 2020年第12期26卷 947-955页

作者： LI ying SHAN ning-ning SUI Xiao-hui Department of Hematology Shandong Provincial Hospital Affiliated to Shandong UniversityJinan(250021)China

Although current therapeutic methods against hematological malignancies are effective in the early stage,they usually lose their effectiveness because of the development of drug *** new drugs with significant therapeutic effects is one of the current research ***,an extract from the plant Artemisia annua Linne,and its derivatives have excellent antimalarial effects in clinical applications as well as excellent *** studies have documented that artemisinin and its derivatives(ARTs)also have significant effects against multiple types of tumours,including hematological *** review focuses on the latest research achievements of ARTs in the treatment of hematological malignancies as well as its mechanisms and future *** mechanisms of ARTs against different types of hematological malignancies mainly include cell cycle arrest,induction autophagy and apoptosis,inhibition of angiogenesis,production of reactive oxygen species,and induction of ***,the review also summarizes the anticancer effects of ARTs in many drug-resistant hematological malignancies and its synergistic effects with other drugs.

关键词： artemisinin artesunate dihydroartemisinin hematological malignancies review

Applications of pillarenes, an emerging class of synthetic macrocycles

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Science China Chemistry 2014年第9期57卷 1185-1198页

作者： SONG nan YANG ying-Wei State Key Laboratory of Supramolecular Structure and Materials College of ChemistryJilin University

Synthetic macrocycles, a typical type of building block for molecular recognition and self-assembly, are crucial to supramolecular chemistry and materials science. Since 2008, a new generation of synthetic macrocyclic hosts, pillarenes and their abundant derivatives, which consist of hydroquinone units linked by methylene bridges at 2,5-positions, have been the focus of much research. Numerous studies on their host-guest properties and the fabrication of supramolecular assemblies have demon- strated that pillarenes and their derivatives possess many advantages that facilitate their applications in many research fields. Herein we summarize and classitfy the applications of pillarenes in terms of artificial transmembrane channels, controlled delivery systems, dispersion of carbon hybrid materials, extraction and absorption, liquid crystals, metal-organic frameworks, sensing and detection, stabilization of nanoparticles （Au/Ag/CdTe）, and other typical biological applications. We also provide an overview of future developments in pillarene chemistry.

关键词： drug delivery host-guest interactions macrocycles pillarenes supramolecular materials

Effect of Zener-Hollomon Parameter on Microstructure and Mechanical Properties of Copper Subjected to Friction Stir Welding

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Acta Metallurgica Sinica(English Letters) 2020年第2期33卷 319-326页

作者： nan Xu Ruo-nan Feng Wen-Feng Guo Qi-ning Song Ye-Feng Bao College of Mechanical and Electrical Engineering Hohai UniversityChangzhou 213022China

In this work,the influence of the Zener-Hollomon(Z)parameter on the microstructure and mechanical properties of copper subjected to friction stir welding(FSW)was *** N2 cooling was conducted to control the cooling rate after the *** obtained results demonstrate that the Z parameter was dependent on the tool rotation rate during the FSW,i.e.,a higher tool rotating rate resulted in a lower Z *** grain size in the stir zone decreased with the increase in the Z *** relationship between the yield strength and the Z parameter is established asσ0.2=σ0+*** relationship exhibited two different plots under the conditions of air cooling and liquid N2 *** at a similar Z parameter,a significant yield strength difference occurred because massive dislocations,which were caused by the prevention of the post-annealing effect,were maintained in the stir *** study suggests that the influence of the post-annealing effect should not be neglected when analyzing the relationship between the Z parameter,micro structure,and mechanical properties.

关键词： Copper Friction stir welding Microstructure Mechanical properties

A stimuli-responsive pillar[5]arene-based hybrid material with enhanced tunable multicolor luminescence and ion-sensing ability

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National Science Review 2021年第6期8卷 60-69页

作者： Xin-Yue Lou nan Song ying-Wei Yang State Key Laboratory of Inorganic Synthesis and Preparative Chemistry International Joint Research Laboratory of Nano-Micro Architecture Chemistry (NMAC)College of ChemistryJilin University

Tunable luminescent materials are becoming more and more important owing to their broad application potential in various fields. Here we construct a pillar[5]arene-based hybrid material with stimuli-responsive luminescent properties and ion-sensing abilities from a pyridine-modified conjugated pillar[5]arene and a planar chromophore oligo(phenylenevinylene) upon coordination of Cd(II) metal cores. This new material not only shows an optimized luminescence due to the minimized π–π stacking and efficient charge transfer properties benefitting from the existence of pillar[5]arene rings, but also exhibits tunable multicolor emission induced by different external stimuli including solvent, ions and acid, indicating great application potential as a fluorescent sensory material, especially for Fe3+. With this pillar[5]arene-based dual-ligand hybrid material, valid optimization and regulation on the fluorescence of the original chromophore have been achieved, which demonstrates a plausible strategy for the design of tunable solid-state luminescent materials and also a prototypical model for the effective regulation of fluorescent properties of planarπ systems using synthetic macrocycle-based building blocks.

关键词： aggregation-induced emission supramolecular chemistry luminescent materials pillararenes macrocycles

Feeding of pea leafminer larvae simultaneously activates jasmonic and salicylic acid pathways in plants to release a terpenoid for indirect defense

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Insect Science 2021年第3期28卷 811-824页

作者： Jun-nan Yang Jia-ning Wei Le Kang State Key Laboratory of Integrated Management of Pest Insects and Rodents Institute of ZoologyChinese Academy of SciencesBeijingChina CAS Center for Excellence in Biotic Interactions University of Chinese Academy of SciencesBeijingChina

The pea leafminer,Liriomyza huidobrensis,is an important pest species affecting ornamental crops *** damage consists of oviposition and feeding punctures created by female adult flies as well as larva-bored mines in leaf mesophyll *** plants indirectly defend themselves from these two types of leafminer damage has not been sufficiently *** this study,we compared the indirect defense responses of bean plants infested by either female adults or *** of leaves by adults released green leaf volatiles and terpenoids,while larval feeding caused plants to additionally emit methyl salicylate and(E,E)-4,8,12-trimethyl-1,3,7,11-tridecatetraene(TMTT).Puncturing of plants by female adults induced increases in jasmonic acid(JA)and JA-related gene expressions but reduced the expressions of salicylic acid(SA)-related *** contrast,JA and SA and their-related gene expression levels were increased significantly by larval *** exogenous application of JA+SA significantly triggered TMTT emission,thereby significantly inducing the orientation behavior of *** study has confirmed that larval feeding can trigger TMTT emission through the activation of both JA and SA pathways to attract parasitoids;however,TMTT alone is less attractive than the complete blend of volatiles released by infested plants.

关键词： jasmonic acid Liriomyza huidobrensis parasitoids salicylic acid TMTT

The Weyl’s Theorem and Its Perturbations in Semisimple Banach Algebra

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Acta Mathematica Sinica,English Series 2021年第5期37卷 675-688页

作者： ying ying KONG Li ning JIANG Yan Xun REN School of Mathematics and Statistics Beijing Institute of TechnologyBeijing 100081P.R.China

Denote a semisimple Banach algebra with an identity e by *** paper studies the Fredholm,Weyl and Browder spectral theories in a semisimple Banach algebra,and meanwhile considers the properties of the Fredholm element,the Weyl element and the Browder ***,for a∈A,we give the Weyl’s theorem and the Browder’s theorem for a,and characterize necessary and sufficient conditions that both a and f(a)satisfy the Weyl’s theorem or the Browder’s theorem,where f is a complex-valued function analytic on a neighborhood ofσ(a).In addition,the perturbations of the Weyl’s theorem and the Browder’s theorem are investigated.

关键词： Semisimple Banach algebra Fredholm element Browder element Weyl’s theorem perturbation

Local Superderivations on Basic Classical Lie Superalgebras

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Algebra Colloquium 2017年第4期24卷 673-684页

作者： Haixian Chen ying Wang Jizhu nan School of Mathematical Sciences Dalian University of Technology Dalian Liaoning 116024 China

In this paper, we prove that every local superderivation on basic classical Lie superalgebras except for A（1, 1） over the complex number field C is a superderivation. Furthermore, we give an example of a class of ni... 详细信息

关键词： basic classical Lie superalgebra local superderivation superderivation